Sudarshan Rajagopal

Department of Medicine, Duke University Medical Center

Affiliated withDuke University Medical Center

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 35	2016

Other Publications

Article	Year
The LOV domain family: photoresponsive signaling modules coupled to diverse output domains. Biochemistry\| PubMed ID: 12515534	2003
Crystal structure of a photoactive yellow protein from a sensor histidine kinase: conformational variability and signal transduction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12563032	2003
Application of singular value decomposition to the analysis of time-resolved macromolecular x-ray data. Biophysical journal\| PubMed ID: 12609912	2003
Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15041745	2004
Analysis of experimental time-resolved crystallographic data by singular value decomposition. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 15103131	2004
Chromophore conformation and the evolution of tertiary structural changes in photoactive yellow protein. Structure (London, England : 1993)\| PubMed ID: 15274923	2004
Analytical trapping: extraction of time-independent structures from time-dependent crystallographic data. Journal of structural biology\| PubMed ID: 15450291	2004
Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli. Photochemistry and photobiology\| PubMed ID: 15453820	2004
A structural pathway for signaling in the E46Q mutant of photoactive yellow protein. Structure (London, England : 1993)\| PubMed ID: 15642261	2005
Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15870207	2005
Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit. Protein science : a publication of the Protein Society\| PubMed ID: 17660260	2007
Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20018651	2010
Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nature reviews. Drug discovery\| PubMed ID: 20431569	2010
Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20686112	2010
Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends in molecular medicine\| PubMed ID: 21183406	2011
Quantifying ligand bias at seven-transmembrane receptors. Molecular pharmacology\| PubMed ID: 21610196	2011
Multiple ligand-specific conformations of the β2-adrenergic receptor. Nature chemical biology\| PubMed ID: 21857662	2011
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature\| PubMed ID: 21857681	2011
Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Science signaling\| PubMed ID: 21868357	2011
Quantifying biased agonism: understanding the links between affinity and efficacy. Nature reviews. Drug discovery\| PubMed ID: 23681006	2013
Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors. The Journal of biological chemistry\| PubMed ID: 24145037	2013
Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography\| PubMed ID: 24508364	2014
Comprehensive assessment of right ventricular function in patients with pulmonary hypertension with global longitudinal peak systolic strain derived from multiple right ventricular views. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography\| PubMed ID: 24656881	2014
Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry. Nature protocols\| PubMed ID: 24810039	2014
What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling. Trends in pharmacological sciences\| PubMed ID: 25448316	2014
The influence of angle of insonation and target depth on speckle-tracking strain. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography\| PubMed ID: 25655402	2015
Use of outcome measures in pulmonary hypertension clinical trials. American heart journal\| PubMed ID: 26385024	2015
Safety and Tolerability of High-dose Inhaled Treprostinil in Pulmonary Hypertension. Journal of cardiovascular pharmacology\| PubMed ID: 26828324	2016
The β-arrestins: Multifunctional regulators of G protein-coupled receptors. The Journal of biological chemistry\| PubMed ID: 26984408	2016