Sergei Sukharev

Department of Biology, University of Maryland

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2015

Other Publications

Article	Year
Purification of the small mechanosensitive channel of Escherichia coli (MscS): the subunit structure, conduction, and gating characteristics in liposomes. Biophysical journal\| PubMed ID: 12080120	2002
A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension. Nature structural biology\| PubMed ID: 12172538	2002
On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL. The Journal of general physiology\| PubMed ID: 12601086	2003
Mechanosensitive channels: multiplicity of families and gating paradigms. Science's STKE : signal transduction knowledge environment\| PubMed ID: 14872099	2004
Gating of the large mechanosensitive channel in situ: estimation of the spatial scale of the transition from channel population responses. Biophysical journal\| PubMed ID: 15111402	2004
Water dynamics and dewetting transitions in the small mechanosensitive channel MscS. Biophysical journal\| PubMed ID: 15111405	2004
Mechanosensitive channels: what can we learn from 'simple' model systems? Trends in neurosciences\| PubMed ID: 15165739	2004
The "dashpot" mechanism of stretch-dependent gating in MscS. The Journal of general physiology\| PubMed ID: 15657299	2005
Gain-of-function mutations reveal expanded intermediate states and a sequential action of two gates in MscL. The Journal of general physiology\| PubMed ID: 15684093	2005
Explicit channel conductance: can it be computed? Biophysical journal\| PubMed ID: 15764668	2005
Capping transmembrane helices of MscL with aromatic residues changes channel response to membrane stretch. Biochemistry\| PubMed ID: 16156671	2005
2,2,2-Trifluoroethanol changes the transition kinetics and subunit interactions in the small bacterial mechanosensitive channel MscS. Biophysical journal\| PubMed ID: 17277184	2007
Characterization of the resting MscS: modeling and analysis of the closed bacterial mechanosensitive channel of small conductance. Biophysical journal\| PubMed ID: 17981908	2008
Straightening and sequential buckling of the pore-lining helices define the gating cycle of MscS. Nature structural & molecular biology\| PubMed ID: 18037888	2007
Mechanosensitive channel MscS in the open state: modeling of the transition, explicit simulations, and experimental measurements of conductance. The Journal of general physiology\| PubMed ID: 18591417	2008
The membrane lateral pressure-perturbing capacity of parabens and their effects on the mechanosensitive channel directly correlate with hydrophobicity. Biochemistry\| PubMed ID: 18795793	2008
State-stabilizing Interactions in Bacterial Mechanosensitive Channel Gating and Adaptation. The Journal of biological chemistry\| PubMed ID: 19383606	2009
The tension-transmitting 'clutch' in the mechanosensitive channel MscS. Nature structural & molecular biology\| PubMed ID: 20208543	2010
Gadolinium ions block mechanosensitive channels by altering the packing and lateral pressure of anionic lipids. Biophysical journal\| PubMed ID: 20303859	2010
Adaptive behavior of bacterial mechanosensitive channels is coupled to membrane mechanics. The Journal of general physiology\| PubMed ID: 20513760	2010
Mechanosensitive channels in microbes. Annual review of microbiology\| PubMed ID: 20825352	2010
Effects of GsMTx4 on bacterial mechanosensitive channels in inside-out patches from giant spheroplasts. Biophysical journal\| PubMed ID: 21044584	2010
Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models. Channels (Austin, Tex.)\| PubMed ID: 21057213	2011
Structural models of TREK channels and their gating mechanism. Channels (Austin, Tex.)\| PubMed ID: 21084863	2011
Adaptive MscS gating in the osmotic permeability response in E. coli: the question of time. Biochemistry\| PubMed ID: 21456519	2011
The pathway and spatial scale for MscS inactivation. The Journal of general physiology\| PubMed ID: 21670207	2011
Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules. Biochemistry\| PubMed ID: 21736305	2011
Molecular force transduction by ion channels: diversity and unifying principles. Journal of cell science\| PubMed ID: 22797911	2012
The mechanoelectrical response of the cytoplasmic membrane of Vibrio cholerae. The Journal of general physiology\| PubMed ID: 23797422	2013
The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells. Blood\| PubMed ID: 24659632	2014
The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding. The Journal of general physiology\| PubMed ID: 24778428	2014
Properties of diphytanoyl phospholipids at the air-water interface. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 25474305	2015
Catalytic Role of the Substrate Defines Specificity of Therapeutic l-Asparaginase. Journal of molecular biology\| PubMed ID: 26142822	2015
Membrane Affinity of Platensimycin and Its Dialkylamine Analogs. International journal of molecular sciences\| PubMed ID: 26247942	2015
Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations. Biochimica et biophysica acta\| PubMed ID: 26342676	2015
Activation of bacterial channel MscL in mechanically stimulated droplet interface bilayers. Scientific reports\| PubMed ID: 26348441	2015