Francois Villinger

Department of Pathology and Laboratory Medicine, Emory University School of Medicine

Affiliated withEmory University School of Medicine Yerkes National Primate Research Center

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 51	2016

Other Publications

Article	Year
Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status. Blood\| PubMed ID: 11781243	2002
A DNA vaccine encoding the 42 kDa C-terminus of merozoite surface protein 1 of Plasmodium falciparum induces antibody, interferon-gamma and cytotoxic T cell responses in rhesus monkeys: immu... Immunology letters\| PubMed ID: 11841841	2002
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Vaccine\| PubMed ID: 11983252	2002
Stimulation of both humoral and cellular immune responses to HIV-1 gp120 by interleukin-12 in Rhesus macaques. Vaccine\| PubMed ID: 12009285	2002
Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine. Journal of virology\| PubMed ID: 12021347	2002
Innate differences between simian-human immunodeficiency virus (SHIV)(KU-2)-infected rhesus and pig-tailed macaques in development of neurological disease. Virology\| PubMed ID: 12033765	2002
Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines. Journal of virology\| PubMed ID: 12097576	2002
Neuropathogenesis of lentiviral infection in macaques: roles of CXCR4 and CCR5 viruses and interleukin-4 in enhancing monocyte chemoattractant protein-1 production in macrophages. The American journal of pathology\| PubMed ID: 12213709	2002
Slowly declining levels of viral RNA and DNA in DNA/recombinant modified vaccinia virus Ankara-vaccinated macaques with controlled simian-human immunodeficiency virus SHIV-89.6P challenges. Journal of virology\| PubMed ID: 12239289	2002
ELISpot and ELISA analysis of spontaneous, mitogen-induced and antigen-specific cytokine production in cynomolgus and rhesus macaques. Journal of immunological methods\| PubMed ID: 12379341	2002
Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques. Journal of virology\| PubMed ID: 12477806	2003
Cytokines as clinical adjuvants: how far are we? Expert review of vaccines\| PubMed ID: 12899581	2003
Microarray analysis of cytokine and chemokine genes in the brains of macaques with SHIV-encephalitis. Journal of medical primatology\| PubMed ID: 14498983	2003
IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques. AIDS research and human retroviruses\| PubMed ID: 14585220	2003
Gp120-alum boosting of a Gag-Pol-Env DNA/MVA AIDS vaccine: poorer control of a pathogenic viral challenge. AIDS research and human retroviruses\| PubMed ID: 14585221	2003
Magnetic resonance imaging of activated proliferating rhesus macaque T cells labeled with superparamagnetic monocrystalline iron oxide nanoparticles. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 14707787	2004
Dysregulation of the polo-like kinase pathway in CD4+ T cells is characteristic of pathogenic simian immunodeficiency virus infection. Journal of virology\| PubMed ID: 14722302	2004
Magnitude of alloresponses to MHC class I/II expressing human cardiac myocytes is limited by their intrinsic ability to process and present antigenic peptides. Clinical & developmental immunology\| PubMed ID: 14768954	2003
Signaling through Toll-like receptors triggers HIV-1 replication in latently infected mast cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15034054	2004
Genetic analysis of cytokine promoters in nonhuman primates: implications for Th1/Th2 profile characteristics and SIV disease pathogenesis. Clinical & developmental immunology\| PubMed ID: 15154610	2004
Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS. Immunologic research\| PubMed ID: 15181266	2004
Inhibition of pathogenic SHIV replication in macaques treated with antisense DNA of interleukin-4. Blood\| PubMed ID: 15618469	2005
Simian human immunodeficiency virus-associated pneumonia correlates with increased expression of MCP-1, CXCL10, and viral RNA in the lungs of rhesus macaques. The American journal of pathology\| PubMed ID: 15681820	2005
Ancient co-speciation of simian foamy viruses and primates. Nature\| PubMed ID: 15772660	2005
Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques. Journal of virology\| PubMed ID: 15795273	2005
Enhancement of cell mediated immune responses using lipid depleted lentivirus as immunogen: a novel approach for inducing recognition of new viral epitopes. Vaccine\| PubMed ID: 15955600	2005
Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques. Virology\| PubMed ID: 16185742	2005
Central memory CD4 T cells are the predominant cell subset resistant to anergy in SIV disease resistant sooty mangabeys. AIDS (London, England)\| PubMed ID: 16511410	2006
Therapy of "SHIV" infected macaques with liposomes delivering antisense interleukin-4 DNA. AIDS (London, England)\| PubMed ID: 16691063	2006
IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. The Journal of clinical investigation\| PubMed ID: 16691294	2006
Studies on GM-CSF DNA as an adjuvant for neutralizing Ab elicited by a DNA/MVA immunodeficiency virus vaccine. Virology\| PubMed ID: 16740288	2006
Optimization of in vitro expansion of macaque CD4 T cells using anti-CD3 and co-stimulation for autotransfusion therapy. Journal of medical primatology\| PubMed ID: 16872281	2006
Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro. Clinical and vaccine immunology : CVI\| PubMed ID: 16988005	2006
Pathogenic and apathogenic courses of SIV infection are associated with distinct and characteristic regulatory patterns of G1/S and G2/M cell cycle checkpoints in CD4+ T cells. AIDS research and human retroviruses\| PubMed ID: 17147499	2006
Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17339444	2007
Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination. Journal of virology\| PubMed ID: 17376899	2007
CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species: involvement of p300 and CREB at the proximal ... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17548609	2007
Anti-CD3/28 mediated expansion of macaque CD4+ T cells is polyclonal and provides extended survival after adoptive transfer. Journal of medical primatology\| PubMed ID: 17669209	2007
GM-CSF DNA: an adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine. Virology\| PubMed ID: 17698160	2007
Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus. The Journal of experimental medicine\| PubMed ID: 17954572	2007
IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18097036	2008
Impact of glycosylation on antigenicity of simian immunodeficiency virus SIV239: induction of rapid V1/V2-specific non-neutralizing antibody and delayed neutralizing antibody following infec... The Journal of general virology\| PubMed ID: 18198387	2008
Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection. Immunology\| PubMed ID: 18266718	2008
Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates. Cellular immunology\| PubMed ID: 18331725	2007
Delipidated retroviruses as potential autologous therapeutic vaccines--a pilot experiment. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 18408147	2008
Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates. AIDS research and human retroviruses\| PubMed ID: 18426337	2008
Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys. The Journal of clinical investigation\| PubMed ID: 18497876	2008
Melatonin and ulcerative colitis: evidence, biological mechanisms, and future research. Inflammatory bowel diseases\| PubMed ID: 18626968	2009
Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19155491	2009
Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal chall... Virology\| PubMed ID: 19193388	2009
Preclinical studies of human immunodeficiency virus/AIDS vaccines: inverse correlation between avidity of anti-Env antibodies and peak postchallenge viremia. Journal of virology\| PubMed ID: 19224993	2009
Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loads. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19265142	2009
Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis. The Journal of experimental medicine\| PubMed ID: 19546246	2009
A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. Annals of the New York Academy of Sciences\| PubMed ID: 19751399	2009
Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19786533	2009
Characterization of T-cell responses in macaques immunized with a single dose of HIV DNA vaccine. Journal of virology\| PubMed ID: 19923181	2010
Dengue virus-induced hemorrhage in a nonhuman primate model. Blood\| PubMed ID: 20042723	2010
Genetic characterization of HIV type 1 Nef-induced vesicle secretion. AIDS research and human retroviruses\| PubMed ID: 20156100	2010
Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via di... The Journal of infectious diseases\| PubMed ID: 20214475	2010
AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4. Journal of medical primatology\| PubMed ID: 20412378	2010
Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20622118	2010
Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV. PloS one\| PubMed ID: 20652030	2010
R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models. PloS one\| PubMed ID: 20657739	2010
Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies. Retrovirology\| PubMed ID: 20716359	2010
Role of IL-12 in HIV infection and vaccine. European cytokine network\| PubMed ID: 20719709	2010
Development of a tier 1 R5 clade C simian-human immunodeficiency virus as a tool to test neutralizing antibody-based immunoprophylaxis. Journal of medical primatology\| PubMed ID: 21044092	2011
Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21149598	2011
Infection, viral dissemination, and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV. Journal of virology\| PubMed ID: 21325416	2011
Programming the magnitude and persistence of antibody responses with innate immunity. Nature\| PubMed ID: 21350488	2011
An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV. PloS one\| PubMed ID: 21483815	2011
Prevention of infection by a granulocyte-macrophage colony-stimulating factor co-expressing DNA/modified vaccinia Ankara simian immunodeficiency virus vaccine. The Journal of infectious diseases\| PubMed ID: 21628671	2011
Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine\| PubMed ID: 21693155	2011
IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques. Blood\| PubMed ID: 21757617	2011
Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection. PloS one\| PubMed ID: 21799765	2011
The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point? PLoS pathogens\| PubMed ID: 21852945	2011
High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure: prevention of viremia. AIDS (London, England)\| PubMed ID: 21941166	2012
In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins. Virology\| PubMed ID: 21982221	2011
Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell fu... Vaccine\| PubMed ID: 21996099	2011
Infection of bone marrow cells by dengue virus in vivo. Experimental hematology\| PubMed ID: 22193689	2012
Sexual Transmission of XMRV: A Potential Infection Route. Advances in virology\| PubMed ID: 22312360	2011
Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for vi... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22387550	2012
Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation. Blood\| PubMed ID: 22550346	2012
Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control. Journal of virology\| PubMed ID: 22718828	2012
Role of CD61+ cells in thrombocytopenia of dengue patients. International journal of hematology\| PubMed ID: 22987294	2012
Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques. Blood\| PubMed ID: 22990011	2012
Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow. PloS one\| PubMed ID: 23300812	2012
Re-evaluation of PD-1 expression by T cells as a marker for immune exhaustion during SIV infection. PloS one\| PubMed ID: 23555918	2013
Relationships between IL-17(+) subsets, Tregs and pDCs that distinguish among SIV infected elite controllers, low, medium and high viral load rhesus macaques. PloS one\| PubMed ID: 23620737	2013
Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission. AIDS (London, England)\| PubMed ID: 23775002	2013
Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21. PLoS pathogens\| PubMed ID: 23853592	2013
In vivo administration of a JAK3 inhibitor to chronically siv infected rhesus macaques leads to NK cell depletion associated with transient modest increase in viral loads. PloS one\| PubMed ID: 23923040	2013
Therapeutic vaccination against the rhesus lymphocryptovirus EBNA-1 homologue, rhEBNA-1, elicits T cell responses to novel epitopes in rhesus macaques. Journal of virology\| PubMed ID: 24089556	2013
Live attenuated Rev-independent Nef¯SIV enhances acquisition of heterologous SIVsmE660 in acutely vaccinated rhesus macaques. PloS one\| PubMed ID: 24098702	2013
Can non-human primates serve as models for investigating dengue disease pathogenesis? Frontiers in microbiology\| PubMed ID: 24130557	2013
Expression of functional folate receptors by human parathyroid cells. Surgery\| PubMed ID: 24206618	2013
In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24227774	2013
Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose. Retrovirology\| PubMed ID: 24444350	2014
A two years longitudinal study of a transgenic Huntington disease monkey. BMC neuroscience\| PubMed ID: 24581271	2014
In vivo administration of a JAK3 inhibitor during acute SIV infection leads to significant increases in viral load during chronic infection. PLoS pathogens\| PubMed ID: 24603870	2014
Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques. PLoS pathogens\| PubMed ID: 24604066	2014
PAS-positive extracellular deposits within germinal centers of hyperplastic follicles during SIV infection in a rhesus macaque. Journal of medical primatology\| PubMed ID: 24628065	2014
Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24907346	2014
Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation. Cell host & microbe\| PubMed ID: 24981333	2014
Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection. PLoS pathogens\| PubMed ID: 24991927	2014
Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie\| PubMed ID: 25153024	2014
Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus. Journal of medical primatology\| PubMed ID: 25174584	2015
Multimodality vaccination against clade C SHIV: partial protection against mucosal challenges with a heterologous tier 2 virus. Vaccine\| PubMed ID: 25245933	2014
Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25246494	2014
Long-term central and effector SHIV-specific memory T cell responses elicited after a single immunization with a novel lentivector DNA vaccine. PloS one\| PubMed ID: 25337803	2014
Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection. Nature medicine\| PubMed ID: 25419708	2014
Vaccine-induced plasmablast responses in rhesus macaques: phenotypic characterization and a source for generating antigen-specific monoclonal antibodies. Journal of immunological methods\| PubMed ID: 25445326	2015
Association of Cytokines With Exosomes in the Plasma of HIV-1-Seropositive Individuals. The Journal of infectious diseases\| PubMed ID: 25512626	2015
CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection. Journal of virology\| PubMed ID: 25653428	2015
Up-regulation of Tim-3 on T cells during acute simian immunodeficiency virus infection and on antigen specific responders. AIDS (London, England)\| PubMed ID: 25715103	2015
Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques. Nature methods\| PubMed ID: 25751144	2015
Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge. Vaccine\| PubMed ID: 25769884	2015
Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25948815	2015
Suppression of the Insulin Receptors in Adult Schistosoma japonicum Impacts on Parasite Growth and Development: Further Evidence of Vaccine Potential. PLoS neglected tropical diseases\| PubMed ID: 25961574	2015
Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimod... Journal of virology\| PubMed ID: 26018167	2015
Relationship of menstrual cycle and vaginal infection in female rhesus macaques challenged with repeated, low doses of SIVmac251. Journal of medical primatology\| PubMed ID: 26054016	2015
Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26116502	2015
Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle. PloS one\| PubMed ID: 26468886	2015
Hallmarks of HIV-1 pathogenesis are modulated by Nef's Secretion Modification Region. Journal of AIDS & clinical research\| PubMed ID: 26523240	2015
TIM-3, a Possible Target for Immunotherapy in Cancer and Chronic Viral Infections. Austin virology and retro virology\| PubMed ID: 26539564	2014
Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. The Journal of clinical investigation\| PubMed ID: 26551680	2015
SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like factor 2 (KLF2) and Endothelial Dysfunction. The Journal of infectious diseases\| PubMed ID: 26671887	2015
Antibody mediated rejection in sensitized non-human primates: modeling human biology. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 26705099	2015