Francesco Colucci

Francesco Colucci

Department of Obstetrics and Gynaecology, University of Cambridge

Affiliated withUniversity of CambridgeUniversity of Cambridge School of Clinical Medicine

Research Area

Biography

Professor Francesco Colucci’s work has helped to understand how natural killer (NK) cells develop and function and how they recognize cancer cells. Since 2006, he has focused on how NK cells in the womb regulate healthy reproduction and fetal growth. Trained as a physician at Bari University in the late 80’s, Francesco moved to Umeå University in 1992 with a research scholarship from the Swedish Institute. There he learned to use tetraparental chimeras to study cellular mechanisms of disease. This became the subject of his PhD under the supervision of Takeshi Matsunaga and Dan Holmberg. He then moved to Jim Di Santo’s lab in Paris at the Necker Hospital in 1997. The lab relocated to the Pasteur Institute, where Francesco became associate professor in 2000. In 2004 he moved to Cambridge, UK as a group leader at the Babraham Institute to then move into his current post at the University Department of Obstetrics and Gynaecology in 2010. Francesco is also fellow, director of studies in medicine and graduate tutor at King's College, manager of the Centre for Trophoblast Research in Cambridge, advisor to the advanced school of immunology Ruggero Ceppellini in Naples and visiting professor at the University of Turin.

JoVE Journal Publications

ArticleTotal : 2
Year
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Publication title

Cited by 27

2015
2021

Other Publications

Article
Year
Identification of the earliest prethymic bipotent T/NK progenitor in murine fetal liver.

Blood| PubMed ID: 11781226

2002
2002
2002
2003
2003
What does it take to make a natural killer?

Nature reviews. Immunology| PubMed ID: 12766763

2003
2003
2003
2003
2004
2004
2004
2004
2005
2005
2006
2006
E2-2 regulates the expansion of pro-B cells and follicular versus marginal zone decisions.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 17082585

2006
2007
2007
2007
Unexpected partnership between IL-15 and DAP10.

Nature immunology| PubMed ID: 18026080

2007
Unique receptor repertoire in mouse uterine NK cells.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 18941204

2008
p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 19297623

2009
2009
Dicer-dependent microRNA pathway controls invariant NKT cell development.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 19625646

2009
PI3K signaling in lymphocyte migration.

Cell cycle (Georgetown, Tex.)| PubMed ID: 19838082

2009
A simple method to measure NK cell cytotoxicity in vivo.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 20033651

2010
Analysis of uterine natural killer cells in mice.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 20033660

2010
Taming killer cells may halt diabetes progression.

Nature immunology| PubMed ID: 20084067

2010
2010
2010
Immature NK cells, capable of producing IL-22, are present in human uterine mucosa.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 20802153

2010
Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 21300875

2011
2011
2011
Guardian of the genome turns on genes that alert natural killer cells.

Cell cycle (Georgetown, Tex.)| PubMed ID: 22142860

2011
2012
2012
Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation.

The Journal of clinical investigation| PubMed ID: 24091323

2013
2014
Uterine NK cells: active regulators at the maternal-fetal interface.

The Journal of clinical investigation| PubMed ID: 24789879

2014
Medawar and the immunological paradox of pregnancy: 60 years on.

European journal of immunology| PubMed ID: 25042825

2014
2014
A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 25561558

2015
2015
2015
2015
2015
2015
2015
Tissue-Specific Education of Decidual NK Cells.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 26320253

2015
Composition, Development, and Function of Uterine Innate Lymphoid Cells.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 26371244

2015
2015
2015
2016
Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 27815424

2016
2017
2017
2017
2017
2018
2018
2018
2018
2019
The immunological code of pregnancy.

Science (New York, N.Y.)| PubMed ID: 31467207

2019
2019
2020
2020
2020
2021
2021
2021
2021