Ernst Lengyel

Department of Obstetrics and Gynecology, University of Chicago

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 20	2015

Other Publications

Article	Year
c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer research\| PubMed ID: 17308108	2007
Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy. International journal of radiation oncology, biology, physics\| PubMed ID: 16757127	2006
Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor. Journal of cell science\| PubMed ID: 12244126	2002
Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointe... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12796395	2003
Single-agent pulse dactinomycin has only modest activity for methotrexate-resistant gestational trophoblastic neoplasia. Gynecologic oncology\| PubMed ID: 15262143	2004
C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu. International journal of cancer. Journal international du cancer\| PubMed ID: 15455388	2005
Isolation and characterization of Rac1 pseudogenes (psi1Rac1-psi4Rac1) in the human genome. Gene\| PubMed ID: 15474301	2004
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene\| PubMed ID: 15516977	2004
Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected colorec... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16361535	2005
Tyrosine kinase mutations in human cancer. Current molecular medicine\| PubMed ID: 17311534	2007
Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer. Molecular cancer research : MCR\| PubMed ID: 17510314	2007
Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum. International journal of cancer. Journal international du cancer\| PubMed ID: 17546601	2007
Let-7 expression defines two differentiation stages of cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17600087	2007
Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell cycle (Georgetown, Tex.)\| PubMed ID: 17957144	2007
Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. The Journal of biological chemistry\| PubMed ID: 18048360	2008
The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin. The Journal of clinical investigation\| PubMed ID: 18340378	2008
Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. Cancer research\| PubMed ID: 18381440	2008
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes & development\| PubMed ID: 18381893	2008
A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings. Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry\| PubMed ID: 18815565	2009
Does equal treatment yield equal outcomes? The impact of race on survival in epithelial ovarian cancer. Gynecologic oncology\| PubMed ID: 18823649	2008
A special key for unlocking the door to targeted therapies of breast cancer. TheScientificWorldJournal\| PubMed ID: 18836657	2008
MMP-2 functions as an early response protein in ovarian cancer metastasis. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19221481	2009
Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation. Endocrinology\| PubMed ID: 19497979	2009
Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation. Human molecular genetics\| PubMed ID: 19584084	2009
The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer. Fertility and sterility\| PubMed ID: 19643405	2010
Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 19737983	2009
Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis. Cancer treatment and research\| PubMed ID: 19763444	2009
{beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer. The American journal of pathology\| PubMed ID: 19808644	2009
The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions. Molecular and cellular endocrinology\| PubMed ID: 20036708	2010
An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis. Neoplasia (New York, N.Y.)\| PubMed ID: 20072648	2010
CD95 promotes tumour growth. Nature\| PubMed ID: 20505730	2010
Ovarian cancer development and metastasis. The American journal of pathology\| PubMed ID: 20651229	2010
Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21149615	2011
The expression of hepatocyte growth factor (HGF) and c-Met in uterine serous carcinoma. Gynecologic oncology\| PubMed ID: 21168200	2011
A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer. Gynecologic oncology\| PubMed ID: 21276608	2011
Acute inflammatory reaction following placement of sodium hyaluronate-carboxymethylcellulose barrier in a young woman undergoing gynecologic surgery: a case report. The Journal of reproductive medicine\| PubMed ID: 21366131	2011
Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21551255	2011
Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1. International journal of cancer. Journal international du cancer\| PubMed ID: 21618519	2012
FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society\| PubMed ID: 21682576	2011
Rethinking ovarian cancer: recommendations for improving outcomes. Nature reviews. Cancer\| PubMed ID: 21941283	2011
The effects of 17β-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis. Gynecologic oncology\| PubMed ID: 21996264	2012
The first line of intra-abdominal metastatic attack: breaching the mesothelial cell layer. Cancer discovery\| PubMed ID: 22013555	2011
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nature medicine\| PubMed ID: 22037646	2011
Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity. Obstetrics and gynecology\| PubMed ID: 22183212	2012
Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure. Gynecologic oncology\| PubMed ID: 22835717	2012
HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. The Journal of clinical investigation\| PubMed ID: 22945634	2012
MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer discovery\| PubMed ID: 23171795	2012
Serial sectioning of the fallopian tube allows for improved identification of primary fallopian tube carcinoma. Gynecologic oncology\| PubMed ID: 23237768	2013
miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression. The American journal of pathology\| PubMed ID: 23499550	2013
Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochimica et biophysica acta\| PubMed ID: 23500888	2013
Summary of the 2013 American Association for Cancer Research (AACR) Annual Meeting. Gynecologic oncology\| PubMed ID: 23926600	2013
Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy. Molecular cancer therapeutics\| PubMed ID: 24061648	2013
Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype. The American journal of pathology\| PubMed ID: 24332016	2014
Three-dimensional modeling of ovarian cancer. Advanced drug delivery reviews\| PubMed ID: 25034878	2014
Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: a retrospective cohort analysis. PloS one\| PubMed ID: 25118694	2014
Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. The Journal of clinical investigation\| PubMed ID: 25202979	2014
Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models. American journal of obstetrics and gynecology\| PubMed ID: 25446664	2015
Old drug, new trick: repurposing metformin for gynecologic cancers? Gynecologic oncology\| PubMed ID: 25455733	2014
Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Nature communications\| PubMed ID: 25653139	2015
Molecular pathways: trafficking of metabolic resources in the tumor microenvironment. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25691772	2015
Patterns and utility of routine surveillance in high grade endometrial cancer. Gynecologic oncology\| PubMed ID: 25838164	2015
The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma. Oncotarget\| PubMed ID: 25839163	2015
Whole-genome characterization of chemoresistant ovarian cancer. Nature\| PubMed ID: 26017449	2015
Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma. Gynecologic oncology\| PubMed ID: 26115975	2015
Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer. Oncotarget\| PubMed ID: 26172303	2015
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nature reviews. Cancer\| PubMed ID: 26493647	2015
Corrigendum: Whole-genome characterization of chemoresistant ovarian cancer. Nature\| PubMed ID: 26503049	2015