Yoshitsugu Aoki

Department of Molecular Therapy, National Center of Neurology and Psychiatry

Affiliated withNational Center of Neurology and Psychiatry

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 23	2016
Publication title	2020
Publication title Cited by 6	2020

Other Publications

Article	Year
Restoring Dystrophin Expression in Duchenne Muscular Dystrophy: Current Status of Therapeutic Approaches. Journal of personalized medicine\| PubMed ID: 30621068	2019
Relationship between diffusion tensor imaging and brain morphology in patients with myotonic dystrophy. Neuroscience letters\| PubMed ID: 16978781	2006
[Videofluorographic evaluation of dysphagia in a patient with myasthenia gravis]. Rinshō shinkeigaku = Clinical neurology\| PubMed ID: 18095502	2007
Antisense PMO found in dystrophic dog model was effective in cells from exon 7-deleted DMD patient. PloS one\| PubMed ID: 20805873	2010
In-frame dystrophin following exon 51-skipping improves muscle pathology and function in the exon 52-deficient mdx mouse. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20823833	2010
Synthesis of 2'-O-[2-(N-methylcarbamoyl)ethyl]ribonucleosides using oxa-Michael reaction and chemical and biological properties of oligonucleotide derivatives incorporating these modified ri... The Journal of organic chemistry\| PubMed ID: 21425877	2011
Identification of muscle-specific microRNAs in serum of muscular dystrophy animal models: promising novel blood-based markers for muscular dystrophy. PloS one\| PubMed ID: 21479190	2011
Bodywide skipping of exons 45-55 in dystrophic mdx52 mice by systemic antisense delivery. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22869723	2012
Extensive and prolonged restoration of dystrophin expression with vivo-morpholino-mediated multiple exon skipping in dystrophic dogs. Nucleic acid therapeutics\| PubMed ID: 22888777	2012
Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse. Molecular & cellular proteomics : MCP\| PubMed ID: 23297347	2013
Highly efficient in vivo delivery of PMO into regenerating myotubes and rescue in laminin-α2 chain-null congenital muscular dystrophy mice. Human molecular genetics\| PubMed ID: 23882132	2013
Mutation types and aging differently affect revertant fiber expansion in dystrophic mdx and mdx52 mice. PloS one\| PubMed ID: 23894429	2013
Extracellular microRNAs are dynamic non-vesicular biomarkers of muscle turnover. Nucleic acids research\| PubMed ID: 23945935	2013
Development of multiexon skipping antisense oligonucleotide therapy for Duchenne muscular dystrophy. BioMed research international\| PubMed ID: 23984357	2013
Oligonucleotide-Based Therapy for FTD/ALS Caused by the C9orf72 Repeat Expansion: A Perspective. Journal of nucleic acids\| PubMed ID: 24349764	2013
Three novel serum biomarkers, miR-1, miR-133a, and miR-206 for Limb-girdle muscular dystrophy, Facioscapulohumeral muscular dystrophy, and Becker muscular dystrophy. Environmental health and preventive medicine\| PubMed ID: 25150707	2014
Long-term efficacy of systemic multiexon skipping targeting dystrophin exons 45-55 with a cocktail of vivo-morpholinos in mdx52 mice. Molecular therapy. Nucleic acids\| PubMed ID: 25647512	2015
Oligonucleotide therapies: the future of amyotrophic lateral sclerosis treatment? Neurodegenerative disease management\| PubMed ID: 25894871	2015
Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides. Nano letters\| PubMed ID: 26042553	2015
Serum Osteopontin as a Novel Biomarker for Muscle Regeneration in Duchenne Muscular Dystrophy. The American journal of pathology\| PubMed ID: 26963343	2016
Deletion of exons 3-9 encompassing a mutational hot spot in the DMD gene presents an asymptomatic phenotype, indicating a target region for multiexon skipping therapy. Journal of human genetics\| PubMed ID: 27009627	2016
Recent advances in innovative therapeutic approaches for Duchenne muscular dystrophy: from discovery to clinical trials. American journal of translational research\| PubMed ID: 27398133	2016
Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors. Drug design, development and therapy\| PubMed ID: 27621596	2016
Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. International journal of molecular sciences\| PubMed ID: 27754374	2016
C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia. Brain : a journal of neurology\| PubMed ID: 28334866	2017
Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28364245	2017
Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28373570	2017
Quantitative Antisense Screening and Optimization for Exon 51 Skipping in Duchenne Muscular Dystrophy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28865998	2017
Exon Skipping Therapy Using Phosphorodiamidate Morpholino Oligomers in the mdx52 Mouse Model of Duchenne Muscular Dystrophy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29067660	2018
Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs. Frontiers in chemistry\| PubMed ID: 29094037	2017
Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy. Science translational medicine\| PubMed ID: 29669851	2018
Antisense PMO cocktails effectively skip dystrophin exons 45-55 in myotubes transdifferentiated from DMD patient fibroblasts. PloS one\| PubMed ID: 29771942	2018
In Vitro Multiexon Skipping by Antisense PMOs in Dystrophic Dog and Exon 7-Deleted DMD Patient. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30171540	2018
In Vivo Evaluation of Single-Exon and Multiexon Skipping in mdx52 Mice. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30171548	2018
In Vivo Evaluation of Multiple Exon Skipping with Peptide-PMOs in Cardiac and Skeletal Muscles in Dystrophic Dogs. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30171554	2018
Exon Skipping Using Antisense Oligonucleotides for Laminin-Alpha2-Deficient Muscular Dystrophy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30171567	2018
Truncated dystrophin ameliorates the dystrophic phenotype of mdx mice by reducing sarcolipin-mediated SERCA inhibition. Biochemical and biophysical research communications\| PubMed ID: 30236982	2018
Efficacy of Multi-exon Skipping Treatment in Duchenne Muscular Dystrophy Dog Model Neonates. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 30448197	2019
Accelerometric outcomes of motor function related to clinical evaluations and muscle involvement in dystrophic dogs. PloS one\| PubMed ID: 30533017	2018
Scavenger Receptor Class A1 Mediates Uptake of Morpholino Antisense Oligonucleotide into Dystrophic Skeletal Muscle. Molecular therapy. Nucleic acids\| PubMed ID: 30763772	2019
Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride. Scientific reports\| PubMed ID: 30846748	2019
Peptide-conjugate antisense based splice-correction for Duchenne muscular dystrophy and other neuromuscular diseases. EBioMedicine\| PubMed ID: 31257147	2019
Autoimmune response and its long-term consequences after exon-skipping therapy in a Duchenne muscular dystrophy mouse model. The Journal of pathology\| PubMed ID: 31322741	2019
Exons 45-55 Skipping Using Mutation-Tailored Cocktails of Antisense Morpholinos in the DMD Gene. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 31416775	2019
Potential Therapies Using Myogenic Stem Cells Combined with Bio-Engineering Approaches for Treatment of Muscular Dystrophies. Cells\| PubMed ID: 31514443	2019
Amelioration of intracellular Ca regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes. Biochemical and biophysical research communications\| PubMed ID: 31585729	2019
Application of Urine-Derived Stem Cells to Cellular Modeling in Neuromuscular and Neurodegenerative Diseases. Frontiers in molecular neuroscience\| PubMed ID: 31920531	2019
Publisher Correction: Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride. Scientific reports\| PubMed ID: 32034287	2020
Severe cardiac involvement with preserved truncated dystrophin expression in Becker muscular dystrophy by +1G>A DMD splice-site mutation: a case report. Journal of human genetics\| PubMed ID: 32504006	2020
Novel EGFP reporter cell and mouse models for sensitive imaging and quantification of exon skipping. Scientific reports\| PubMed ID: 32572084	2020
Development of LNA Gapmer Oligonucleotide-Based Therapy for ALS/FTD Caused by the C9orf72 Repeat Expansion. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32865792	2020