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JoVE Journal
Genetics

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Exon Skipping in Directly Reprogrammed Myotubes Obtained from Human Urine-Derived Cells
 

Exon Skipping in Directly Reprogrammed Myotubes Obtained from Human Urine-Derived Cells

Article doi: 10.3791/60840
May 7th, 2020

Summary May 7th, 2020

In this article, we describe a detailed protocol for efficient modelling of Duchenne muscular dystrophy muscle using MYOD1-converted urine-derived cells to evaluate the restoration of dystrophin mRNA and protein levels after exon skipping.

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