Hermann Lage

Institute of Pathology, Charité Campus Mitte

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 18	2010

Other Publications

Article	Year
Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance. Breast cancer research : BCR\| PubMed ID: 16168133	2005
Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. International journal of cancer. Journal international du cancer\| PubMed ID: 16217747	2006
Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase. Cancer research\| PubMed ID: 16397260	2006
Novel three-pronged strategy to enhance cancer cell killing in glioblastoma cell lines: histone deacetylase inhibitor, chemotherapy, and oncolytic adenovirus dl520. Human gene therapy\| PubMed ID: 16409125	2006
High antineoplastic activity of new heterocyclic compounds in cancer cells with resistance against classical DNA topoisomerase II-targeting drugs. International journal of cancer. Journal international du cancer\| PubMed ID: 16450374	2006
Potential applications of RNA interference technology in the treatment of cancer. Future oncology (London, England)\| PubMed ID: 16555980	2005
Analysis of gene expression profiles in melanoma cells with acquired resistance against antineoplastic drugs. Melanoma research\| PubMed ID: 16567970	2006
Maspin expression is characteristic for cisplatin-sensitive ovarian cancer cells and for ovarian cancer cases of longer survival rates. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 16633061	2006
CD24 expression is specific for tamoxifen-resistant ductal breast cancer cases. Anticancer research\| PubMed ID: 16739331	2006
MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance. Current drug targets\| PubMed ID: 16842213	2006
Inhibition of the multidrug-resistant phenotype by targeting YB-1 with a conditionally oncolytic adenovirus: implications for combinatorial treatment regimen with chemotherapeutic agents. Cancer research\| PubMed ID: 16849566	2006
RNA interference-triggered reversal of ABCC2-dependent cisplatin resistance in human cancer cells. Biochemical and biophysical research communications\| PubMed ID: 16876126	2006
A Web-based data warehouse on gene expression in human malignant melanoma. The Journal of investigative dermatology\| PubMed ID: 16946712	2007
Complete reversal of ABCG2-depending atypical multidrug resistance by RNA interference in human carcinoma cells. Oligonucleotides\| PubMed ID: 16978089	2006
ABCC2 (MRP2, cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcome. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17145840	2006
CD46 expression is indicative of shorter revival-free survival for ovarian cancer patients. Anticancer research\| PubMed ID: 17214367	2006
Taxol-resistance-associated gene-3 (TRAG-3/CSAG2) expression is predictive for clinical outcome in ovarian carcinoma patients. Virchows Archiv : an international journal of pathology\| PubMed ID: 17216190	2007
Nuclear metallothionein expression correlates with cisplatin resistance of ovarian cancer cells and poor clinical outcome. Virchows Archiv : an international journal of pathology\| PubMed ID: 17235562	2007
Expression of factors involved in regulation of DNA mismatch repair- and apoptosis pathways in ovarian cancer patients. Oncology reports\| PubMed ID: 17273726	2007
Regulation of MDR1 gene expression in multidrug-resistant cancer cells is independent from YB-1. Biochemical and biophysical research communications\| PubMed ID: 17418094	2007
Estradiol, tamoxifen and ICI 182,780 alter alpha3 and beta1 integrin expression and laminin-1 adhesion in oral squamous cell carcinoma cell cultures. Oral oncology\| PubMed ID: 17418616	2008
Resistance to chemotherapy in ovarian carcinoma. Recent results in cancer research. Fortschritte der Krebsforschung. ProgrÃ¨s dans les recherches sur le cancer\| PubMed ID: 17607916	2007
Overcoming the classical multidrug resistance phenotype by adenoviral delivery of anti-MDR1 short hairpin RNAs and ribozymes. International journal of oncology\| PubMed ID: 17611700	2007
Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes. Journal of gastroenterology and hepatology\| PubMed ID: 17645459	2007
Occurence of stromal myofibroblasts in the invasive ductal breast cancer tissue is an unfavourable prognostic factor. Anticancer research\| PubMed ID: 17695471	2007
Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17878902	2008
The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients. Neoplasia (New York, N.Y.)\| PubMed ID: 17898867	2007
Impact of radiation therapy on the oncolytic adenovirus dl520: implications on the treatment of glioblastoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology\| PubMed ID: 17967494	2008
Three new jatrophane polyesters and antiproliferative constituents from Euphorbia tuckeyana. Planta medica\| PubMed ID: 18176909	2008
Decreased expression of p16 in ovarian cancers represents an unfavourable prognostic factor. Histology and histopathology\| PubMed ID: 18283637	2008
Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone. Cancer research\| PubMed ID: 18593931	2008
Acquired cisplatin resistance in the head-neck cancer cell line Cal27 is associated with decreased DKK1 expression and can partially be reversed by overexpression of DKK1. International journal of cancer. Journal international du cancer\| PubMed ID: 18688867	2008
Novel insight in structure-activity relationship and bioanalysis of P-glycoprotein targeting highly potent tetrakishydroxymethyl substituted 3,9-diazatetraasteranes. Journal of medicinal chemistry\| PubMed ID: 18714979	2008
Impact of novel MDR modulators on human cancer cells: reversal activities and induction studies. Pharmaceutical research\| PubMed ID: 18972190	2009
Positive correlation between cyclooxygenase 2 and the expression of ABC transporters in non-small cell lung cancer. Anticancer research\| PubMed ID: 19031941	2008
Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 19270648	2009
Therapeutic potential of RNA interference in drug-resistant cancers. Future oncology (London, England)\| PubMed ID: 19284376	2009
A prognostic gene expression index in ovarian cancer - validation across different independent data sets. The Journal of pathology\| PubMed ID: 19294737	2009
Interleukin-1 beta and tumor necrosis factor-alpha increase ABCG2 expression in MCF-7 breast carcinoma cell line and its mitoxantrone-resistant derivative, MCF-7/MX. Inflammation research : official journal of the European Histamine Research Society ... [et al.]\| PubMed ID: 19333723	2009
Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. Molecules (Basel, Switzerland)\| PubMed ID: 19396022	2009
Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis. Histopathology\| PubMed ID: 19438741	2009
Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines. Biochemical pharmacology\| PubMed ID: 19447222	2009
Evaluation of microarray preprocessing algorithms based on concordance with RT-PCR in clinical samples. PloS one\| PubMed ID: 19461970	2009
Delivery of short hairpin RNAs by transkingdom RNA interference modulates the classical ABCB1-mediated multidrug-resistant phenotype of cancer cells. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19770582	2009
Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas. Oncology reports\| PubMed ID: 19885582	2009
Overcoming multidrug resistance by RNA interference. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19949936	2010
Phenolic compounds as selective antineoplasic agents against multidrug-resistant human cancer cells. Planta medica\| PubMed ID: 20157880	2010
Effect of YB-1 on the regulation of micro RNA expression in drug-sensitive and drug-resistant gastric carcinoma cells. Anticancer research\| PubMed ID: 20332481	2010
Regulation of mRNA expression in drug-sensitive and drug-resistant gastric carcinoma cells is independent of YB-1 expression. Anticancer research\| PubMed ID: 20332492	2010
Jet-injection of short hairpin RNA-encoding vectors into tumor cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20387147	2010
Influence of tamoxifen on cisplatin-sensitivity and estrogen receptors expression in ovarian carcinoma cell lines. Ginekologia polska\| PubMed ID: 20486538	2010
Novel structure-activity relationships and selectivity profiling of cage dimeric 1,4-dihydropyridines as multidrug resistance (MDR) modulators. Bioorganic & medicinal chemistry\| PubMed ID: 20598550	2010
Multidrug resistance reversal properties and cytotoxic evaluation of representatives of a novel class of HIV-1 protease inhibitors. The Journal of pharmacy and pharmacology\| PubMed ID: 21054396	2010
YB-1 dependent virotherapy in combination with temozolomide as a multimodal therapy approach to eradicate malignant glioma. International journal of cancer. Journal international du cancer\| PubMed ID: 21086421	2010
Proteomic approaches for investigation of therapy resistance in cancer. Proteomics. Clinical applications\| PubMed ID: 21136994	2009
Estrogen receptor alpha expression in ovarian cancer predicts longer overall survival. Pathology oncology research : POR\| PubMed ID: 21207255	2011
Loss of estrogen receptor beta expression correlates with shorter overall survival and lack of clinical response to chemotherapy in ovarian cancer patients. Anticancer research\| PubMed ID: 21378361	2011
Osteogenic potential of mesenchymal cells embedded in the provisional matrix after a 6-week healing period in augmented and non-augmented extraction sockets: an immunohistochemical prospecti... Clinical oral implants research\| PubMed ID: 21435013	2012
Betulinic acid exhibits stronger cytotoxic activity on the normal melanocyte NHEM-neo cell line than on drug-resistant and drug-sensitive MeWo melanoma cell lines. Molecular medicine reports\| PubMed ID: 21475863	2009
Healing of ungrafted and grafted extraction sockets after 12 weeks: a prospective clinical study. The International journal of oral & maxillofacial implants\| PubMed ID: 21483892	2011
CD46 Expression is an unfavorable prognostic factor in breast cancer cases. Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry\| PubMed ID: 21617523	2011
YB-1 dependent virotherapy in combination with temozolomide as a multimodal therapy approach to eradicate malignant glioma. International journal of cancer. Journal international du cancer\| PubMed ID: 21710499	2011
Elevated YB-1 expression is a new unfavorable prognostic factor in non-Hodgkin's lymphomas. Anticancer research\| PubMed ID: 21868545	2011
ABCC2 (MRP2, cMOAT) Localized in the Nuclear Envelope of Breast Carcinoma Cells Correlates with Poor Clinical Outcome. Pathology oncology research : POR\| PubMed ID: 21986666	2011
YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter. The Journal of biological chemistry\| PubMed ID: 11788582	2002
Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells. International journal of cancer. Journal international du cancer\| PubMed ID: 11857350	2002
Study of therapy resistance in cancer cells with functional proteome analysis. Clinical chemistry and laboratory medicine : CCLM / FESCC\| PubMed ID: 12005211	2002
Transport of phosphatidylserine via MDR1 (multidrug resistance 1)P-glycoprotein in a human gastric carcinoma cell line. The Biochemical journal\| PubMed ID: 12071854	2002
Modulation of the atypical multidrug-resistant phenotype by a hammerhead ribozyme directed against the ABC transporter BCRP/MXR/ABCG2. Cancer gene therapy\| PubMed ID: 12082458	2002
Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells. Journal of cancer research and clinical oncology\| PubMed ID: 12136248	2002
Association of genomic imbalances with drug resistance and thermoresistance in human gastric carcinoma cells. International journal of cancer. Journal international du cancer\| PubMed ID: 12516094	2003
Identification of differentially expressed genes in classical and atypical multidrug-resistant gastric carcinoma cells. Anticancer research\| PubMed ID: 12530067	2002
Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi). FEBS letters\| PubMed ID: 12804765	2003
Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin. The Journal of investigative dermatology\| PubMed ID: 12839578	2003
Study of the development of chemoresistance in melanoma cell lines using proteome analysis. Electrophoresis\| PubMed ID: 12874874	2003
Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 12885834	2003
Homozygous mutation Arg768Trp in the ABC-transporter encoding gene MRP2/cMOAT/ABCC2 causes Dubin-Johnson syndrome in a Caucasian patient. Journal of human genetics\| PubMed ID: 12942343	2003
Enhanced exposure of phosphatidylserine in human gastric carcinoma cells overexpressing the half-size ABC transporter BCRP (ABCG2). The Biochemical journal\| PubMed ID: 12946267	2003
ABC-transporters: implications on drug resistance from microorganisms to human cancers. International journal of antimicrobial agents\| PubMed ID: 13678820	2003
Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A. International journal of cancer. Journal international du cancer\| PubMed ID: 14566821	2003
Glypican-3 is involved in cellular protection against mitoxantrone in gastric carcinoma cells. Oncogene\| PubMed ID: 14661052	2004
Multidrug-resistant cancer cells facilitate E1-independent adenoviral replication: impact for cancer gene therapy. Cancer research\| PubMed ID: 14729641	2004
Study of the development of thermoresistance in human pancreatic carcinoma cell lines using proteome analysis. Electrophoresis\| PubMed ID: 14730581	2004
Molecular analysis of therapy resistance in gastric cancer. Digestive diseases (Basel, Switzerland)\| PubMed ID: 14752223	2003
Proteomics in cancer cell research: an analysis of therapy resistance. Pathology, research and practice\| PubMed ID: 15237919	2004
RNA expression of MDR1/P-glycoprotein, DNA-topoisomerase I, and MRP2 in ovarian carcinoma patients: correlation with chemotherapeutic response. Gynecologic oncology\| PubMed ID: 15262134	2004
Effective knock down of very high ABCG2 expression by a hammerhead ribozyme. Anticancer research\| PubMed ID: 15330166	2004
Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference. Cancer gene therapy\| PubMed ID: 15375376	2004
Chromosomal imbalances associated with drug resistance and thermoresistance in human pancreatic carcinoma cells. European journal of cell biology\| PubMed ID: 15679104	2004
Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells. International journal of cancer. Journal international du cancer\| PubMed ID: 15688364	2005
Reversal of different drug-resistant phenotypes by an autocatalytic multitarget multiribozyme directed against the transcripts of the ABC transporters MDR1/P-gp, MRP2, and BCRP. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15771954	2005
Overexpression of cathepsin B in gastric cancer identified by proteome analysis. Proteomics\| PubMed ID: 15789341	2005
Transcriptome analysis of different multidrug-resistant gastric carcinoma cells. In vivo (Athens, Greece)\| PubMed ID: 15875780	2005
Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients. Virchows Archiv : an international journal of pathology\| PubMed ID: 15968547	2005
Significance of cyclooxygenase 2 and MDR1/P-glycoprotein coexpression in ovarian cancers. Cancer letters\| PubMed ID: 15970376	2006
Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival. Oncogene\| PubMed ID: 16044152	2005
Prognostic value of immunohistochemical estimation of CD24 and Ki67 expression in cisplatin and paclitaxel treated ovarian carcinoma patients. Polish journal of pathology : official journal of the Polish Society of Pathologists\| PubMed ID: 16092668	2005