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Bacterial Delivery of RNAi Effectors

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Article DOI: 10.3791/2099
August 18th, 2010


Summary August 18th, 2010

For development of RNA interference (RNAi)-based therapies, a novel strategy was developed, transkingdom RNAi (tkRNAi). This technology uses non-pathogenic bacteria to produce and deliver therapeutic short hairpin RNA (shRNA) into target cells. Here, tkRNAi was successfully applied for reversal of classical ABCB1-mediated multidrug resistance (MDR) of cancer cells.

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