David Ornitz

Department of Developmental Biology, Washington University School of Medicine

Affiliated withWashington University School of Medicine

Research Area

Biography

David Ornitz has not added Biography.
If you are David Ornitz and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2016

Other Publications

Article	Year
Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes & development\| PubMed ID: 11937493	2002
FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes & development\| PubMed ID: 12080084	2002
Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14. Neuron\| PubMed ID: 12123606	2002
Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. The Journal of biological chemistry\| PubMed ID: 12145306	2002
Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Developmental cell\| PubMed ID: 12361605	2002
Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains. Development (Cambridge, England)\| PubMed ID: 12441294	2003
Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell\| PubMed ID: 12553906	2003
Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12574417	2003
Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Human molecular genetics\| PubMed ID: 12651873	2003
A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12702769	2003
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development (Cambridge, England)\| PubMed ID: 12756187	2003
Expression and function of FGF10 in mammalian inner ear development. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 12761848	2003
Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. The Journal of biological chemistry\| PubMed ID: 12815063	2003
Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. Human molecular genetics\| PubMed ID: 14681299	2004
Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development. Bone\| PubMed ID: 14751559	2004
A twist code determines the onset of osteoblast differentiation. Developmental cell\| PubMed ID: 15030764	2004
Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts. The Journal of biological chemistry\| PubMed ID: 15073186	2004
Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron\| PubMed ID: 15091338	2004
Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development (Cambridge, England)\| PubMed ID: 15229180	2004
FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Cell\| PubMed ID: 15260994	2004
Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice. Hearing research\| PubMed ID: 15276677	2004
Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions. Developmental biology\| PubMed ID: 15328018	2004
Evolution of the Fgf and Fgfr gene families. Trends in genetics : TIG\| PubMed ID: 15475116	2004
Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development (Cambridge, England)\| PubMed ID: 15576404	2005
Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio. Developmental biology\| PubMed ID: 15581873	2004
Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Developmental cell\| PubMed ID: 15621532	2005
Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation. American journal of human genetics\| PubMed ID: 15625620	2005
Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 15778993	2005
FGF signaling in the developing endochondral skeleton. Cytokine & growth factor reviews\| PubMed ID: 15863035	2005
Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development (Cambridge, England)\| PubMed ID: 15975938	2005
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Endocrinology\| PubMed ID: 16081635	2005
Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels. The Journal of physiology\| PubMed ID: 16166153	2005
Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development (Cambridge, England)\| PubMed ID: 16308329	2006
Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans. The Journal of biological chemistry\| PubMed ID: 16373332	2006
Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development. Brain research\| PubMed ID: 16529728	2006
FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development (Cambridge, England)\| PubMed ID: 16540513	2006
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. The Journal of biological chemistry\| PubMed ID: 16597617	2006
Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti. Electrophoresis\| PubMed ID: 16609936	2006
Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes & development\| PubMed ID: 16778080	2006
Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation. Developmental biology\| PubMed ID: 16815385	2006
FGF signalling generates ventral telencephalic cells independently of SHH. Development (Cambridge, England)\| PubMed ID: 16818446	2006
A model for the pharmacological treatment of crouzon syndrome. Neurosurgery\| PubMed ID: 16823318	2006
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development (Cambridge, England)\| PubMed ID: 16887829	2006
FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Developmental biology\| PubMed ID: 17014841	2007
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes & development\| PubMed ID: 17050674	2006
Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 17169545	2007
Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14. Molecular and cellular neurosciences\| PubMed ID: 17208450	2007
Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Development (Cambridge, England)\| PubMed ID: 17215304	2007
Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14. Neurobiology of disease\| PubMed ID: 17236779	2007
Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization. Trends in cardiovascular medicine\| PubMed ID: 17418368	2007
FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Developmental biology\| PubMed ID: 17544391	2007
Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17606897	2007
Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron\| PubMed ID: 17678857	2007
Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17687036	2007
FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network. Development (Cambridge, England)\| PubMed ID: 17881491	2007
The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17978045	2007
Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center. Trends in genetics : TIG\| PubMed ID: 18054407	2008
Functional evolutionary history of the mouse Fgf gene family. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 18058912	2008
FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis. Development (Cambridge, England)\| PubMed ID: 18094024	2008
Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members. BMC evolutionary biology\| PubMed ID: 18254951	2008
Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 18297725	2008
Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue. Molecular and cellular endocrinology\| PubMed ID: 18396371	2008
Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Developmental biology\| PubMed ID: 18455718	2008
An FGF-WNT gene regulatory network controls lung mesenchyme development. Developmental biology\| PubMed ID: 18533146	2008
Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. The Journal of clinical investigation\| PubMed ID: 18568073	2008
Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development (Cambridge, England)\| PubMed ID: 18653563	2008
Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development. Development (Cambridge, England)\| PubMed ID: 18725519	2008
FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons. Neurobiology of disease\| PubMed ID: 18930825	2009
Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature. Circulation research\| PubMed ID: 19179669	2009
FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion. Nature genetics\| PubMed ID: 19219044	2009
Fibroblast growth factor expression during skeletal fracture healing in mice. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 19235733	2009
Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels. The Journal of biological chemistry\| PubMed ID: 19406745	2009
FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels. Molecular and cellular neurosciences\| PubMed ID: 19465131	2009
Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix. Molecular and cellular biology\| PubMed ID: 19564416	2009
Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133659	2010
Healing of non-displaced fractures produced by fatigue loading of the mouse ulna. Bone\| PubMed ID: 20215063	2010
Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development (Cambridge, England)\| PubMed ID: 20215350	2010
Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis. The Journal of cell biology\| PubMed ID: 20308431	2010
Regulation of cellular calcium in vestibular supporting cells by otopetrin 1. Journal of neurophysiology\| PubMed ID: 20554841	2010
In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure. Hearing research\| PubMed ID: 20595020	2010
FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice. Gastroenterology\| PubMed ID: 20603121	2010
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. Journal of biochemistry\| PubMed ID: 20940169	2011
Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells. Molecular and cellular neurosciences\| PubMed ID: 21236346	2011
Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses. BMC evolutionary biology\| PubMed ID: 21261979	2011
Histomorphological study of palatal shelf elevation during murine secondary palate formation. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 21618642	2011
Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development. Development (Cambridge, England)\| PubMed ID: 21750028	2011
FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium. Development (Cambridge, England)\| PubMed ID: 21750042	2011
Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS biology\| PubMed ID: 22235191	2012
Signaling networks regulating development of the lower respiratory tract. Cold Spring Harbor perspectives in biology\| PubMed ID: 22550231	2012
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Developmental cell\| PubMed ID: 22698282	2012
Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling. Development (Cambridge, England)\| PubMed ID: 22833125	2012
Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell\| PubMed ID: 22980976	2012
FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin. Journal of cell science\| PubMed ID: 22992463	2012
Development of the endochondral skeleton. Cold Spring Harbor perspectives in biology\| PubMed ID: 23284041	2013
Delineating a conserved genetic cassette promoting outgrowth of body appendages. PLoS genetics\| PubMed ID: 23358455	2013
Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes & development\| PubMed ID: 23431057	2013
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nature medicine\| PubMed ID: 23727932	2013
Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3. Cancer research\| PubMed ID: 23867472	2013
FGF14 localization and organization of the axon initial segment. Molecular and cellular neurosciences\| PubMed ID: 23891806	2013
Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy. PloS one\| PubMed ID: 24349409	2013
Osx-Cre targets multiple cell types besides osteoblast lineage in postnatal mice. PloS one\| PubMed ID: 24454809	2014
In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90. PloS one\| PubMed ID: 24748133	2014
FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Development (Cambridge, England)\| PubMed ID: 24924191	2014
Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin. American journal of respiratory cell and molecular biology\| PubMed ID: 24988442	2015
Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo. PloS one\| PubMed ID: 25093726	2014
Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25139991	2014
OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells. Blood\| PubMed ID: 25267199	2014
Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25349429	2014
Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma. The Journal of pathology\| PubMed ID: 25413587	2015
Fibroblast growth factor 2 is an essential cardioprotective factor in a closed-chest model of cardiac ischemia-reperfusion injury. Physiological reports\| PubMed ID: 25626875	2015
Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development. Developmental biology\| PubMed ID: 25678108	2015
The Fibroblast Growth Factor signaling pathway. Wiley interdisciplinary reviews. Developmental biology\| PubMed ID: 25772309	2015
Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling. eLife\| PubMed ID: 25915623	2015
Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25926453	2015
Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma. PLoS genetics\| PubMed ID: 25978641	2015
Fibroblast growth factor signaling in skeletal development and disease. Genes & development\| PubMed ID: 26220993	2015
Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 26250517	2015
Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26586661	2016
Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development. Cell reports\| PubMed ID: 26725121	2016
Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 26747503	2016
A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development. Developmental biology\| PubMed ID: 26794256	2016
Proteomic analysis of native cerebellar iFGF14 complexes. Channels (Austin, Tex.)\| PubMed ID: 26889602	2016
Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival. Scientific reports\| PubMed ID: 26987296	2016
Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application. Journal of pharmaceutical sciences\| PubMed ID: 27019961	2016
FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth. Development (Cambridge, England)\| PubMed ID: 27052727	2016
Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody. Disease models & mechanisms\| PubMed ID: 27056048	2016