Journal
/
Medicine
/
Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer
JoVE Journal
Medicine
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Medicine
Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

DOI:
10.3791/53904-v

•

11:31 min

•

May 20, 2016

•

, , , , , ,
1Division of Pulmonary Medicine,Keio University School of Medicine, 2Department of Developmental Biology,Washington University School of Medicine

Chapters

  • 00:05Title
  • 00:58Micro-CT Imaging of Mice
  • 03:21Micro-CT Image Analysis
  • 05:03Experimental Treatment and Follow-up Scanning
  • 07:05Lung Collection
  • 08:33Results: Assessing Lung Tumor Formation and Inhibition using CT-Scans and Histological Confirmation
  • 10:15Conclusion

Summary

Automatic Translation

Automatic Translation

We describe a method for the detection of tumor nodule development in the lungs of an adenocarcinoma mouse model using micro-computed tomography and its use for monitoring changes in nodule size over time and in response to treatment. The accuracy of the assessment was confirmed with end-point histological quantification.

Tags

Keywords: Micro-CTTumor AssessmentLung CancerMouse ModelTumor DevelopmentTreatment ResponseReal-time MonitoringNon-invasive ImagingImage AnalysisAnesthesiaAnimal Handling

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

check_url/53904?article_type=v

Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
check_url/53904?article_type=v

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
check_url/53904?article_type=v

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
check_url/53904?article_type=v

The Measurement and Treatment of Suppression in Amblyopia
check_url/53904?article_type=v

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model
check_url/53904?article_type=v

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
check_url/53904?article_type=v

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
check_url/53904?article_type=v

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
check_url/53904?article_type=v

Assessment of Viability of Human Fat Injection into Nude Mice with Micro-Computed Tomography
check_url/53904?article_type=v

Isolation and Propagation of Circulating Tumor Cells from a Mouse Cancer Model

Read Article