Louis H. Philipson

Committee on Molecular Metabolism and Nutrition, The University of Chicago

Affiliated withThe University of Chicago

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 235	2010

Other Publications

Article	Year
TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells. Diabetes\| PubMed ID: 11815479	2002
Insulin secretory deficiency and glucose intolerance in Rab3A null mice. The Journal of biological chemistry\| PubMed ID: 12510060	2003
Visualizing superoxide production in normal and diabetic rat islets of Langerhans. The Journal of biological chemistry\| PubMed ID: 12514170	2003
Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 12644446	2003
Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses. Diabetes\| PubMed ID: 12882916	2003
Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15197259	2004
Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells? Diabetes\| PubMed ID: 15277370	2004
FRET-based voltage probes for confocal imaging: membrane potential oscillations throughout pancreatic islets. American journal of physiology. Cell physiology\| PubMed ID: 15758044	2005
5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways. Biochemical and biophysical research communications\| PubMed ID: 15823553	2005
Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 15985450	2005
Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16014354	2005
Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells. Diabetes\| PubMed ID: 16249428	2005
Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches. Annals of the New York Academy of Sciences\| PubMed ID: 16533924	2005
Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. Science (New York, N.Y.)\| PubMed ID: 16556844	2006
Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16621893	2006
Functional MR microimaging of pancreatic beta-cell activation. Cell transplantation\| PubMed ID: 16719054	2006
Visualizing calcium signaling in cells by digitized wide-field and confocal fluorescent microscopy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 16719350	2006
Cold climate genes and the prevalence of type 2 diabetes mellitus. Medical hypotheses\| PubMed ID: 16797871	2006
Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Diabetes\| PubMed ID: 17130468	2006
Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate. The Journal of biological chemistry\| PubMed ID: 17197450	2007
Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17264231	2007
Ethics of hematopoietic stem cell transplantation in type 1 diabetes mellitus. JAMA : the journal of the American Medical Association\| PubMed ID: 17635886	2007
Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell metabolism\| PubMed ID: 17767909	2007
Insulin gene mutations as a cause of permanent neonatal diabetes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17855560	2007
Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17895289	2008
Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach. American journal of physiology. Cell physiology\| PubMed ID: 17928534	2007
Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood... Diabetes\| PubMed ID: 18162506	2008
Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. Diabetes\| PubMed ID: 18192540	2008
Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis. Current diabetes reviews\| PubMed ID: 18220630	2006
When BAD is good for beta cells. Cell metabolism\| PubMed ID: 18396130	2008
Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells. Cell calcium\| PubMed ID: 18452988	2008
Diagnosis and treatment of neonatal diabetes: a United States experience. Pediatric diabetes\| PubMed ID: 18662362	2008
The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18974218	2008
The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing. Diabetes\| PubMed ID: 19171747	2009
Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Molecular and cellular biology\| PubMed ID: 19289493	2009
Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect. Diabetes care\| PubMed ID: 19435956	2009
A nanoporous, transparent microcontainer for encapsulated islet therapy. Journal of diabetes science and technology\| PubMed ID: 19746206	2009
The granular chloride channel ClC-3 is permissive for insulin secretion. Cell metabolism\| PubMed ID: 19808024	2009
In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 19952343	2010
Update in neonatal diabetes. Current opinion in endocrinology, diabetes, and obesity\| PubMed ID: 19952737	2010
Neonatal diabetes mellitus: a model for personalized medicine. Trends in endocrinology and metabolism: TEM\| PubMed ID: 20434356	2010
Glucose sensing in the pancreatic beta cell: a computational systems analysis. Theoretical biology & medical modelling\| PubMed ID: 20497556	2010
Blood sugar measurement in zebrafish reveals dynamics of glucose homeostasis. Zebrafish\| PubMed ID: 20515318	2010
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature\| PubMed ID: 20562852	2010
Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. The Journal of physiology\| PubMed ID: 20643768	2010
Glucose-induced ERM protein activation and translocation regulates insulin secretion. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 20739507	2010
Conditional gene targeting in mouse pancreatic ÃŸ-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes\| PubMed ID: 20802254	2010
Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene. Reviews in endocrine & metabolic disorders\| PubMed ID: 20938745	2010
The cost-effectiveness of personalized genetic medicine: the case of genetic testing in neonatal diabetes. Diabetes care\| PubMed ID: 21273495	2011
Erratum to: Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene. Reviews in endocrine & metabolic disorders\| PubMed ID: 21286820	2011
Who should have genetic testing for maturity-onset diabetes of the young? Clinical endocrinology\| PubMed ID: 21521318	2011
Creation of the Web-based University of Chicago Monogenic Diabetes Registry: using technology to facilitate longitudinal study of rare subtypes of diabetes. Journal of diabetes science and technology\| PubMed ID: 21880229	2011
Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis. Progress in biophysics and molecular biology\| PubMed ID: 21920379	2011
Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment. Current diabetes reports\| PubMed ID: 21993633	2011
SUMO down-regulates GLP-1 stimulated cAMP generation and insulin secretion. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 22234371	2012