Bernhard Bettler

Dept. of Biomedicine, University of Basel

Research Area

Biography

Bernhard Bettler has not added Biography.
If you are Bernhard Bettler and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2016

Other Publications

Article	Year
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. The Journal of biological chemistry\| PubMed ID: 11711539	2002
Distinct localization of GABA(B) receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. The European journal of neuroscience\| PubMed ID: 11849296	2002
The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors. Molecular pharmacology\| PubMed ID: 12021399	2002
The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor. Molecular pharmacology\| PubMed ID: 12130687	2002
Ligands for expression cloning and isolation of GABA(B) receptors. Farmaco (Società chimica italiana : 1989)\| PubMed ID: 12620413	2003
Altered expression of GABAB receptors in the hippocampus after kainic-acid-induced seizures in rats. Brain research. Molecular brain research\| PubMed ID: 12750012	2003
GABA(B) receptors as potential therapeutic targets. Current drug targets. CNS and neurological disorders\| PubMed ID: 12871035	2003
Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses. Molecular and cellular neurosciences\| PubMed ID: 14572452	2003
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice. The European journal of neuroscience\| PubMed ID: 14656321	2003
Glioblastomas on the move. Science's STKE : signal transduction knowledge environment\| PubMed ID: 15100429	2004
Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15113848	2004
Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15240800	2004
Molecular structure and physiological functions of GABA(B) receptors. Physiological reviews\| PubMed ID: 15269338	2004
Independent maturation of the GABA(B) receptor subunits GABA(B1) and GABA(B2) during postnatal development in rodent brain. The Journal of comparative neurology\| PubMed ID: 15305362	2004
Altered hippocampal expression of calbindin-D-28k and calretinin in GABA(B(1))-deficient mice. Biochemical pharmacology\| PubMed ID: 15451404	2004
Determination of the minimal functional ligand-binding domain of the GABAB1b receptor. The Biochemical journal\| PubMed ID: 15482257	2005
Floxed allele for conditional inactivation of the GABAB(1) gene. Genesis (New York, N.Y. : 2000)\| PubMed ID: 15493018	2004
Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15550547	2004
Effect of androgens on sexual differentiation of pituitary gamma-aminobutyric acid receptor subunit GABA(B) expression. Neuroendocrinology\| PubMed ID: 15591793	2004
Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits. Neuroreport\| PubMed ID: 15706241	2005
The RXR-type endoplasmic reticulum-retention/retrieval signal of GABAB1 requires distant spacing from the membrane to function. Molecular pharmacology\| PubMed ID: 15805225	2005
Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors. The Journal of biological chemistry\| PubMed ID: 16081421	2005
Expression of gamma-aminobutyric acid B receptor subunits in hypothalamus of male and female developing rats. Brain research. Developmental brain research\| PubMed ID: 16297450	2005
Adenohypophyseal and hypothalamic GABA B receptor subunits are downregulated by estradiol in adult female rats. Life sciences\| PubMed ID: 16516242	2006
Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice. Journal of neurochemistry\| PubMed ID: 16606363	2006
Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16624949	2006
Molecular diversity, trafficking and subcellular localization of GABAB receptors. Pharmacology & therapeutics\| PubMed ID: 16644017	2006
GABA(B1) knockout mice reveal alterations in prolactin levels, gonadotropic axis, and reproductive function. Neuroendocrinology\| PubMed ID: 16682806	2005
Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron\| PubMed ID: 16701209	2006
The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons. Neuron\| PubMed ID: 16701210	2006
WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes. Endocrinology\| PubMed ID: 16728489	2006
Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nature neuroscience\| PubMed ID: 16819521	2006
GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16928868	2006
GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16990508	2006
Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety. Psychopharmacology\| PubMed ID: 17171558	2007
GABA(B) receptors: synaptic functions and mechanisms of diversity. Current opinion in neurobiology\| PubMed ID: 17433877	2007
Specific roles of GABA(B(1)) receptor isoforms in cognition. Behavioural brain research\| PubMed ID: 17498817	2007
Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells an... The Journal of biological chemistry\| PubMed ID: 17591780	2007
Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17611272	2007
Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes. Endocrinology\| PubMed ID: 17615148	2007
GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17620617	2007
Functional mapping of GABA(B)-receptor subtypes in the thalamus. Journal of neurophysiology\| PubMed ID: 17881477	2007
Trace amine-associated receptor 1 modulates dopaminergic activity. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18083911	2008
Altered peripheral myelination in mice lacking GABAB receptors. Molecular and cellular neurosciences\| PubMed ID: 18206390	2008
The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function. The Journal of biological chemistry\| PubMed ID: 18765663	2008
Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers. Journal of the Association for Research in Otolaryngology : JARO\| PubMed ID: 18925381	2009
No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. Journal of molecular endocrinology\| PubMed ID: 19103720	2009
The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19193888	2009
Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19246384	2009
The pros of not being competitive. Current neuropharmacology\| PubMed ID: 19305796	2007
Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice. Hepatology (Baltimore, Md.)\| PubMed ID: 19551907	2009
Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. Journal of neurochemistry\| PubMed ID: 19558451	2009
A mouse model for visualization of GABA(B) receptors. Genesis (New York, N.Y. : 2000)\| PubMed ID: 19603512	2009
The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19892733	2009
Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo. Molecular pain\| PubMed ID: 19925671	2009
Lack of functional GABA(B) receptors alters GnRH physiology and sexual dimorphic expression of GnRH and GAD-67 in the brain. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 20009027	2010
The Sushi domains of GABAB receptors function as axonal targeting signals. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20107064	2010
Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature\| PubMed ID: 20400944	2010
NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20643921	2010
GABAB receptors: physiological functions and mechanisms of diversity. Advances in pharmacology (San Diego, Calif.)\| PubMed ID: 20655485	2010
Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling. The EMBO journal\| PubMed ID: 20859254	2010
Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20962240	2010
Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain. The Journal of comparative neurology\| PubMed ID: 21452234	2011
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21525407	2011
The oligomeric state sets GABA(B) receptor signalling efficacy. The EMBO journal\| PubMed ID: 21552208	2011
Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21880914	2011
A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters. PloS one\| PubMed ID: 22253858	2012
Early-life stress induces visceral hypersensitivity in mice. Neuroscience letters\| PubMed ID: 22326388	2012
Regulation of neuronal GABA(B) receptor functions by subunit composition. Nature reviews. Neuroscience\| PubMed ID: 22595784	2012
Acute behavioural responses to nicotine and nicotine withdrawal syndrome are modified in GABA(B1) knockout mice. Neuropharmacology\| PubMed ID: 22727822	2012
Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart. Cardiovascular research\| PubMed ID: 22865640	2012
GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22993424	2012
Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization. The Journal of biological chemistry\| PubMed ID: 23035119	2012
Constitutive Notch2 signaling induces hepatic tumors in mice. Hepatology (Baltimore, Md.)\| PubMed ID: 23175466	2013
GABAB receptor subtypes differentially modulate synaptic inhibition in the dentate gyrus to enhance granule cell output. British journal of pharmacology\| PubMed ID: 23186302	2013
Distinct roles of GABAB1a- and GABAB1b-containing GABAB receptors in spontaneous and evoked termination of persistent cortical activity. The Journal of physiology\| PubMed ID: 23266934	2013
Postnatal development of the endocrine pancreas in mice lacking functional GABAB receptors. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 23531612	2013
Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23637187	2013
Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12). The Journal of biological chemistry\| PubMed ID: 23843457	2013
Activation of presynaptic GABA(B(1a,2)) receptors inhibits synaptic transmission at mammalian inhibitory cholinergic olivocochlear-hair cell synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24068816	2013
Lack of functional GABAB receptors alters Kiss1 , Gnrh1 and Gad1 mRNA expression in the medial basal hypothalamus at postnatal day 4. Neuroendocrinology\| PubMed ID: 24080944	2013
GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24155320	2013
GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors. Development (Cambridge, England)\| PubMed ID: 24284211	2014
Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice. Endocrinology\| PubMed ID: 24424047	2014
Deletion of GABA-B receptor in Schwann cells regulates remak bundles and small nociceptive C-fibers. Glia\| PubMed ID: 24474699	2014
Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches. Neuropharmacology\| PubMed ID: 24486711	2014
Auxiliary GABAB receptor subunits uncouple G protein βγ subunits from effector channels to induce desensitization. Neuron\| PubMed ID: 24836506	2014
GABAB receptor phosphorylation regulates KCTD12-induced K⁺ current desensitization. Biochemical pharmacology\| PubMed ID: 25065880	2014
Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress. Journal of neurochemistry\| PubMed ID: 25113583	2014
Pharmacological characterization of GABAB receptor subtypes assembled with auxiliary KCTD subunits. Neuropharmacology\| PubMed ID: 25196734	2015
GABAB(1) receptor subunit isoforms differentially regulate stress resilience. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25288769	2014
Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal. Neuropharmacology\| PubMed ID: 25479464	2015
Mechanisms of fast desensitization of GABA(B) receptor-gated currents. Advances in pharmacology (San Diego, Calif.)\| PubMed ID: 25637440	2015
GABA blocks pathological but not acute TRPV1 pain signals. Cell\| PubMed ID: 25679765	2015
Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25904796	2015
GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26056260	2015
Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology\| PubMed ID: 26372541	2015
Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine. Behavioural brain research\| PubMed ID: 26518330	2016
A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes. Cancer cell\| PubMed ID: 26669487	2015
Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics. Nature neuroscience\| PubMed ID: 26691831	2016
Presynaptic GABAB Receptors Regulate Hippocampal Synapses during Associative Learning in Behaving Mice. PloS one\| PubMed ID: 26848590	2016
KCTD12 Auxiliary Proteins Modulate Kinetics of GABAB Receptor-Mediated Inhibition in Cholecystokinin-Containing Interneurons. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 27073217	2016
Presynaptic Excitation via GABAB Receptors in Habenula Cholinergic Neurons Regulates Fear Memory Expression. Cell\| PubMed ID: 27426949	2016