Xiangru Lu

Department of Physiology and Pharmacology, Western University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 37	2016

Other Publications

Article	Year
Early and persistent activation of myocardial apoptosis, bax and caspases: insights into mechanisms of progression of heart failure. Pathophysiology : the official journal of the International Society for Pathophysiology / ISP\| PubMed ID: 12039650	2002
Development of heart failure and congenital septal defects in mice lacking endothelial nitric oxide synthase. Circulation\| PubMed ID: 12176963	2002
Deficiency in endothelial nitric oxide synthase impairs myocardial angiogenesis. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12388304	2002
Endothelial nitric-oxide synthase enhances lipopolysaccharide-stimulated tumor necrosis factor-alpha expression via cAMP-mediated p38 MAPK pathway in cardiomyocytes. The Journal of biological chemistry\| PubMed ID: 12506117	2003
Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovascular research\| PubMed ID: 14553829	2003
Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15191894	2004
In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15205165	2004
Endogenous heme oxygenase induction is a critical mechanism attenuating apoptosis and restoring microvascular perfusion following limb ischemia/reperfusion. Surgery\| PubMed ID: 15232541	2004
NADH oxidase signaling induces cyclooxygenase-2 expression during lipopolysaccharide stimulation in cardiomyocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15546960	2005
Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression. Circulation\| PubMed ID: 15795323	2005
Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. Circulation\| PubMed ID: 15851596	2005
Role of tumor necrosis factor-alpha in myocardial dysfunction and apoptosis during hindlimb ischemia and reperfusion. Critical care medicine\| PubMed ID: 16424732	2006
Lack of endothelial nitric oxide synthase decreases cardiomyocyte proliferation and delays cardiac maturation. American journal of physiology. Cell physiology\| PubMed ID: 16822949	2006
Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase. Cardiovascular research\| PubMed ID: 16904088	2006
Role of neuronal nitric oxide synthase in lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal mouse cardiomyocytes. Cardiovascular research\| PubMed ID: 17466955	2007
Endothelial nitric oxide synthase promotes neonatal cardiomyocyte proliferation by inhibiting tissue inhibitor of metalloproteinase-3 expression. Cardiovascular research\| PubMed ID: 17553475	2007
Longitudinal follow-up of cardiac structure and functional changes in an infarct mouse model using retrospectively gated micro-computed tomography. Investigative radiology\| PubMed ID: 18580335	2008
Role of heme oxygenase-1 in the cardioprotective effects of erythropoietin during myocardial ischemia and reperfusion. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 18996987	2009
JNK1/c-fos inhibits cardiomyocyte TNF-alpha expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia. Cardiovascular research\| PubMed ID: 19043087	2009
Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling. American journal of physiology. Cell physiology\| PubMed ID: 19211917	2009
Endothelial nitric oxide synthase promotes bone marrow stromal cell migration to the ischemic myocardium via upregulation of stromal cell-derived factor-1alpha. Stem cells (Dayton, Ohio)\| PubMed ID: 19353524	2009
Cardiomyocyte-specific overexpression of human stem cell factor improves cardiac function and survival after myocardial infarction in mice. Circulation\| PubMed ID: 19738140	2009
Neuronal nitric oxide synthase protects against myocardial infarction-induced ventricular arrhythmia and mortality in mice. Circulation\| PubMed ID: 19770398	2009
Effects of anemia and blood transfusion in acute myocardial infarction in rats. Transfusion\| PubMed ID: 19778337	2010
Comparison of initial cell retention and clearance kinetics after subendocardial or subepicardial injections of endothelial progenitor cells in a canine myocardial infarction model. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 20150266	2010
Rac1 activation induces tumour necrosis factor-α expression and cardiac dysfunction in endotoxemia. Journal of cellular and molecular medicine\| PubMed ID: 20518848	2011
NOX2 deficiency protects against streptozotocin-induced beta-cell destruction and development of diabetes in mice. Diabetes\| PubMed ID: 20627937	2010
Erythropoietin is equally effective as fresh-blood transfusion at reducing infarct size in anemic rats. Critical care medicine\| PubMed ID: 20693887	2010
Deficiency in TIMP-3 increases cardiac rupture and mortality post-myocardial infarction via EGFR signaling: beneficial effects of cetuximab. Basic research in cardiology\| PubMed ID: 21243368	2011
North American ginseng protects the heart from ischemia and reperfusion injury via upregulation of endothelial nitric oxide synthase. Pharmacological research\| PubMed ID: 21621617	2011
Transfusion of fresh but not old stored blood reduces infarct size and improves cardiac function after acute myocardial infarction in anemic rats*. Critical care medicine\| PubMed ID: 22001589	2012
Mitogen-activated protein kinase phosphatase-1 inhibits myocardial TNF-α expression and improves cardiac function during endotoxemia. Cardiovascular research\| PubMed ID: 22198506	2012
Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia. Basic research in cardiology\| PubMed ID: 22351078	2012
Nitric oxide synthase-3 deficiency results in hypoplastic coronary arteries and postnatal myocardial infarction. European heart journal\| PubMed ID: 23048191	2014
Cardiomyocyte-specific overexpression of human stem cell factor protects against myocardial ischemia and reperfusion injury. International journal of cardiology\| PubMed ID: 23680593	2013
Recombinant human annexin A5 inhibits proinflammatory response and improves cardiac function and survival in mice with endotoxemia. Critical care medicine\| PubMed ID: 24145837	2014
Nitric oxide synthase-3 promotes embryonic development of atrioventricular valves. PloS one\| PubMed ID: 24204893	2013
N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes. Cardiovascular diabetology\| PubMed ID: 24533448	2014
Cardiac-specific overexpression of human stem cell factor promotes epicardial activation and arteriogenesis after myocardial infarction. Circulation. Heart failure\| PubMed ID: 25107671	2014
Rac1 signaling is critical to cardiomyocyte polarity and embryonic heart development. Journal of the American Heart Association\| PubMed ID: 25315346	2014
Pregestational diabetes induces fetal coronary artery malformation via reactive oxygen species signaling. Diabetes\| PubMed ID: 25422104	2015
Rac1 Signaling Is Required for Anterior Second Heart Field Cellular Organization and Cardiac Outflow Tract Development. Journal of the American Heart Association\| PubMed ID: 26722124	2016
Inhibition of Rac1 reduces store overload-induced calcium release and protects against ventricular arrhythmia. Journal of cellular and molecular medicine\| PubMed ID: 27222313	2016
North American ginseng inhibits myocardial NOX2-ERK1/2 signaling and tumor necrosis factor-α expression in endotoxemia. Pharmacological research\| PubMed ID: 27317946	2016