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Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
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Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

DOI:
10.3791/54100-v

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07:48 min

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May 24, 2016

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, , ,
1Department of Physiology and Pharmacology,Western University

Chapters

  • 00:05Title
  • 00:51Surgery
  • 03:31Myocardial Infarct (MI) and Cardiac Function Measurement
  • 05:38Results: Representative Neonatal Left Anterior Descending Coronary Artery (LAD) Ligation Analyses
  • 06:47Conclusion

Summary

Automatic Translation

Automatic Translation

This protocol describes a highly reproducible model of cardiac regeneration by surgical induction of myocardial infarction in the left ventricle of postnatal day 1 mice. The method involves induction of hypothermic anesthesia and ligation of the left anterior descending coronary artery.

Tags

Keywords: Myocardial InfarctionNeonatal MiceCardiac RegenerationLeft Anterior Descending Coronary ArteryLAD LigationEchocardiographyThoracotomySutureIschemiaNylon SuturesAnesthesiaMaternal Rejection

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