Bharath Wootla

Department of Neurology, Mayo Clinic

Research Area

Biography

Bharath Wootla has not added Biography.
If you are Bharath Wootla and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2016

Other Publications

Article	Year
Pathophysiology of catalytic antibodies. Immunology letters\| PubMed ID: 16427704	2006
Physiopathology of catalytic antibodies: the case for factor VIII-hydrolyzing immunoglobulin G. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis\| PubMed ID: 16651863	2006
Catalytic IgG from patients with hemophilia A inactivate therapeutic factor VIII. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16818797	2006
VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors. Blood\| PubMed ID: 16985172	2007
Immune response against therapeutic factor VIII in hemophilia A patients--a survey of probable risk factors. Immunology letters\| PubMed ID: 17467813	2007
A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17502612	2007
Molecular characterization of human B domain-specific anti-factor VIII monoclonal antibodies generated in transgenic mice. Thrombosis and haemostasis\| PubMed ID: 17598006	2007
Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation. Haematologica\| PubMed ID: 18166789	2008
Factor VIII hydrolysis mediated by anti-factor VIII autoantibodies in acquired hemophilia. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18490775	2008
Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18523313	2008
Varied immune response to FVIII: presence of proteolytic antibodies directed to factor VIII in different human pathologies. Clinical reviews in allergy & immunology\| PubMed ID: 19160072	2009
Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia. FEBS letters\| PubMed ID: 19595998	2009
NHE4 is critical for the renal handling of ammonia in rodents. The Journal of clinical investigation\| PubMed ID: 20484819	2010
Tissue kallikrein permits early renal adaptation to potassium load. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20624970	2010
Catalytic antibodies and severe sepsis. Discovery medicine\| PubMed ID: 20704912	2005
Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: a mechanism underlying the beneficial effect of ... Journal of autoimmunity\| PubMed ID: 20970960	2011
Proteolytic antibodies activate factor IX in patients with acquired hemophilia. Blood\| PubMed ID: 21131590	2011
Autoantibodies with enzymatic properties in human autoimmune diseases. Journal of autoimmunity\| PubMed ID: 21624820	2011
Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis. Neurology research international\| PubMed ID: 21961063	2011
Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis. Brain pathology (Zurich, Switzerland)\| PubMed ID: 22335434	2012
Need for a paradigm shift in therapeutic approaches to CNS injury. Expert review of neurotherapeutics\| PubMed ID: 22449213	2012
Is multiple sclerosis an autoimmune disease? Autoimmune diseases\| PubMed ID: 22666554	2012
High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance. Analytical chemistry\| PubMed ID: 22762372	2012
PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor. The Journal of clinical investigation\| PubMed ID: 22886306	2012
The road to remyelination in demyelinating diseases: current status and prospects for clinical treatment. Expert review of clinical immunology\| PubMed ID: 23730884	2013
CD8(+) T cells in multiple sclerosis. Expert opinion on therapeutic targets\| PubMed ID: 23829711	2013
IVIg treatment reduces catalytic antibody titers of renal transplanted patients. PloS one\| PubMed ID: 23967092	2013
Polyclonal and monoclonal antibodies in clinic. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24037837	2014
Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire. Expert review of neurotherapeutics\| PubMed ID: 24053345	2013
Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases. Expert review of neurotherapeutics\| PubMed ID: 24625008	2014
Deletion of Virus-specific T-cells Enhances Remyelination in a Model of Multiple Sclerosis. Journal of neurology & translational neuroscience\| PubMed ID: 25383388	2014
Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice. Nucleic acid therapeutics\| PubMed ID: 25536292	2015
Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders. Journal of neurochemistry\| PubMed ID: 25866077	2015
A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis. Journal of neuroinflammation\| PubMed ID: 25924771	2015
Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal mice. PloS one\| PubMed ID: 26020269	2015
A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis. Disease models & mechanisms\| PubMed ID: 26035393	2015
Naturally Occurring Monoclonal Antibodies and Their Therapeutic Potential for Neurologic Diseases. JAMA neurology\| PubMed ID: 26389734	2015
Antibody-Mediated Oligodendrocyte Remyelination Promotes Axon Health in Progressive Demyelinating Disease. Molecular neurobiology\| PubMed ID: 26409478	2015
Tryptophan Metabolites and Their Impact on Multiple Sclerosis Progression. Current pharmaceutical design\| PubMed ID: 26667001	2015
Tryptophan Catabolites and Their Impact on Multiple Sclerosis Progression. Current pharmaceutical design\| PubMed ID: 26899126	2016
Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis. Expert opinion on biological therapy\| PubMed ID: 26914737	2016
Generation of Catalytic Antibodies Is an Intrinsic Property of an Individual's Immune System: A Study on a Large Cohort of Renal Transplant Patients. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27067006	2016
A monoclonal natural human IgM protects axons in the absence of remyelination. Journal of neuroinflammation\| PubMed ID: 27126523	2016