Nicholas R. Lemoine

Center for Molecular Oncology, Queen Mary University of London

Affiliated withQueen Mary University of London Zhengzhou University Queen Mary University of London

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 13	2016

Other Publications

Article	Year
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. The Journal of biological chemistry\| PubMed ID: 11602612	2002
Use of DNA fingerprinting to detect genetic rearrangements in human cancer. Methods in molecular medicine\| PubMed ID: 11901496	2002
Sex chromosome anomalies in pancreatic endocrine tumors. International journal of cancer\| PubMed ID: 11920612	2002
Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas. Virchows Archiv : an international journal of pathology\| PubMed ID: 11964045	2002
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Molecular and cellular biology\| PubMed ID: 11997495	2002
Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas. The American journal of pathology\| PubMed ID: 12000726	2002
Expression profiling of microdissected pancreatic adenocarcinomas. Oncogene\| PubMed ID: 12085237	2002
Adenovirus biodistribution and noninvasive imaging of gene expression in vivo by positron emission tomography using human sodium/iodide symporter as reporter gene. Human gene therapy\| PubMed ID: 12396625	2002
DNA fingerprinting from cells captured by laser microdissection. Methods in enzymology\| PubMed ID: 12418207	2002
Recombinant E. coli efficiently delivers antigen and maturation signals to human dendritic cells: presentation of MART1 to CD8+ T cells. International journal of cancer\| PubMed ID: 12767067	2003
Sodium iodide symporter: a new strategy to target cancer? Lancet (London, England)\| PubMed ID: 12788591	2003
Procaspase 3 expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant-negative mutant, survivin T34A; a combination gene therapy strategy... Oncogene\| PubMed ID: 12789262	2003
Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer. Oncogene\| PubMed ID: 12802281	2003
Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent. The Journal of pathology\| PubMed ID: 12950018	2003
Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells. Molecular and cellular biology\| PubMed ID: 14560006	2003
Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics\| PubMed ID: 14625861	2003
Clinical trials with GDEPT: cytosine deaminase and 5-fluorocytosine. Methods in molecular medicine\| PubMed ID: 14657578	2004
Role of Bim in the survival pathway induced by Raf in epithelial cells. Oncogene\| PubMed ID: 14676826	2004
Quantitative imaging of Na/I symporter transgene expression using positron emission tomography in the living animal. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15006611	2004
A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu ... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15131034	2004
Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS). Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 15143088	2004
Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite. International journal of oncology\| PubMed ID: 15202003	2004
Noninvasive imaging of the transcriptional activities of human telomerase promoter fragments in mice. Cancer research\| PubMed ID: 15256462	2004
Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. International journal of cancer\| PubMed ID: 15305381	2004
Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor. Oncogene\| PubMed ID: 15334066	2004
Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene. Cellular microbiology\| PubMed ID: 15469435	2004
Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway. Oncogene\| PubMed ID: 15637593	2005
Antithrombotic therapy in cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 15699474	2005
Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15837765	2005
Peanut-like 1 (septin 5) gene expression in normal and neoplastic human endocrine pancreas. Neuroendocrinology\| PubMed ID: 16179808	2005
Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation. International journal of oncology\| PubMed ID: 16273218	2005
Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma. Gastroenterology\| PubMed ID: 16285947	2005
Analysis of p53 mutations for a mutational signature in human intrahepatic cholangiocarcinoma. International journal of oncology\| PubMed ID: 16596244	2006
Quantifying the activity of adenoviral E1A CR2 deletion mutants using renilla luciferase bioluminescence and 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography imaging. Cancer research\| PubMed ID: 16982761	2006
The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells. Proteomics\| PubMed ID: 17469085	2007
Cytotoxic action of phorbol esters on human pancreatic cancer cells. International journal of cancer\| PubMed ID: 17582609	2007
S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer. Cancer research\| PubMed ID: 17638890	2007
The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D. Cancer research\| PubMed ID: 17875703	2007
Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets. BMC genomics\| PubMed ID: 18045474	2007
Biological approaches to therapy of pancreatic cancer. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]\| PubMed ID: 18724071	2008
Therapeutic potential of replication-selective oncolytic adenoviruses on cells from familial and sporadic desmoid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18829497	2008
Genome-wide analysis of pancreatic cancer using microarray-based techniques. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]\| PubMed ID: 19077451	2009
SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms. Bioinformatics (Oxford, England)\| PubMed ID: 19098027	2009
AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19228731	2009
A web-based platform for mining pancreatic expression datasets. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]\| PubMed ID: 19451743	2009
Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nature reviews. Gastroenterology & hepatology\| PubMed ID: 19506583	2009
Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer. International journal of cancer\| PubMed ID: 20104527	2010
Online resources of cancer data: barriers, benefits and lessons. Briefings in bioinformatics\| PubMed ID: 20348133	2011
Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts. Human gene therapy\| PubMed ID: 20497039	2010
Oncolytic Viruses for Cancer Therapy: Overcoming the Obstacles. Viruses\| PubMed ID: 20543907	2010
Novel therapies for pancreatic cancer: setbacks and progress. Future oncology (London, England)\| PubMed ID: 20624116	2010
The Pancreatic Expression database: 2011 update. Nucleic acids research\| PubMed ID: 20959292	2011
Analysis of the urine proteome in patients with pancreatic ductal adenocarcinoma. Proteomics. Clinical applications\| PubMed ID: 21136905	2008
Using BioMart as a framework to manage and query pancreatic cancer data. Database : the journal of biological databases and curation\| PubMed ID: 21666272	2011
A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws. Nucleic acids research\| PubMed ID: 21724610	2011
AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D. Cancer research\| PubMed ID: 21948970	2011
Modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22086234	2012
Systemic delivery of oncolytic viruses: hopes and hurdles. Advances in virology\| PubMed ID: 22400027	2012
SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update). Nucleic acids research\| PubMed ID: 22544707	2012
O-miner: an integrative platform for automated analysis and mining of -omics data. Nucleic acids research\| PubMed ID: 22600742	2012
S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells. Clinical & experimental metastasis\| PubMed ID: 23007696	2013
A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23091113	2012
Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway. Journal of virology\| PubMed ID: 23269798	2013
Molecular analysis of precursor lesions in familial pancreatic cancer. PloS one\| PubMed ID: 23372777	2013
A practical guide for the functional annotation of genetic variations using SNPnexus. Briefings in bioinformatics\| PubMed ID: 23395730	2013
The pancreatic expression database: recent extensions and updates. Nucleic acids research\| PubMed ID: 24163255	2014
Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging. Cancer research\| PubMed ID: 24285724	2014
STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus. Journal of virology\| PubMed ID: 24335311	2014
Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion. EMBO molecular medicine\| PubMed ID: 24503018	2014
A vaccinia virus armed with interleukin-10 is a promising therapeutic agent for treatment of murine pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25416195	2015
A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. Genome medicine\| PubMed ID: 25587357	2014
New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer. Oncoimmunology\| PubMed ID: 26405610	2015
Vaccinia virus, a promising new therapeutic agent for pancreatic cancer. Immunotherapy\| PubMed ID: 26595180	2015
Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma. The Journal of pathology\| PubMed ID: 27061193	2016