Jake A. Kushner

Division of Endocrinology and Diabetes, University of Pennsylvania-School of Medicine

Affiliated withUniversity of Pennsylvania-School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 48	2010

Other Publications

Article	Year
Pdx1 restores beta cell function in Irs2 knockout mice. The Journal of clinical investigation\| PubMed ID: 11994408	2002
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12904469	2003
Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes\| PubMed ID: 14693698	2004
Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Lancet\| PubMed ID: 15337404	2004
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. The Journal of clinical investigation\| PubMed ID: 15467829	2004
Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15689562	2005
Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Molecular and cellular biology\| PubMed ID: 15831479	2005
Very slow turnover of beta-cells in aged adult mice. Diabetes\| PubMed ID: 16123343	2005
Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. The Journal of biological chemistry\| PubMed ID: 16170201	2005
Beta-cell growth: an unusual paradigm of organogenesis that is cyclin D2/Cdk4 dependent. Cell cycle (Georgetown, Tex.)\| PubMed ID: 16410729	2006
Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes\| PubMed ID: 17130466	2006
Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough. Annals of the New York Academy of Sciences\| PubMed ID: 17376841	2007
Growth and regeneration of adult beta cells does not involve specialized progenitors. Developmental cell\| PubMed ID: 17488631	2007
Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival. Molecular and cellular biology\| PubMed ID: 17636024	2007
Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology\| PubMed ID: 17673522	2007
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature\| PubMed ID: 17728714	2007
Beta-cell mass and type 1 diabetes: going, going, gone? Diabetes\| PubMed ID: 18971435	2008
Irs2 inactivation suppresses tumor progression in Pten+/- mice. The American journal of pathology\| PubMed ID: 19095950	2009
Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes\| PubMed ID: 19265026	2009
Cyclin D2 protein stability is regulated in pancreatic beta-cells. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 19628581	2009
Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology\| PubMed ID: 20032056	2010
Ductal origin hypothesis of pancreatic regeneration under attack. Cell metabolism\| PubMed ID: 20085728	2010
Calcineurin signaling regulates human islet {beta}-cell survival. The Journal of biological chemistry\| PubMed ID: 20943662	2010
Aging induces a distinct gene expression program in mouse islets. Islets\| PubMed ID: 21099336	2010
Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: control of islet vasculature and vascular endothelial growth factor by glucose. Diabetes\| PubMed ID: 21307078	2011