Mehmet Toner

Havard Medical School, MGH - Massachusetts General Hospital

Affiliated withMGH - Massachusetts General Hospital Harvard Medical School, Massachusetts General Hospital Shriners Hospitals for Children, Boston

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 5	2007
Publication title Cited by 1	2007
Publication title	2007
Publication title Cited by 2	2019

Other Publications

Article	Year
Beneficial effect of microinjected trehalose on the cryosurvival of human oocytes. Fertility and sterility\| PubMed ID: 11779606	2002
Metabolic pre-conditioning of cultured cells in physiological levels of insulin: generating resistance to the lipid-accumulating effects of plasma in hepatocytes. Biotechnology and bioengineering\| PubMed ID: 12001167	2002
Storage and translational issues in reparative medicine. Annals of the New York Academy of Sciences\| PubMed ID: 12081912	2002
Storage and translational issues in reparative medicine: breakout session summary. Annals of the New York Academy of Sciences\| PubMed ID: 12081917	2002
Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nature biotechnology\| PubMed ID: 12091913	2002
Antiproteolytic action of insulin in burn-injured rats. The Journal of surgical research\| PubMed ID: 12121712	2002
Bioartificial liver process monitoring and control systems with integrated systems capability. Tissue engineering\| PubMed ID: 12167233	2002
A microfabrication-based dynamic array cytometer. Analytical chemistry\| PubMed ID: 12199564	2002
Cryopreservation of fetal skin is improved by extracellular trehalose. Cryobiology\| PubMed ID: 12237087	2002
The glass transition temperature of mixtures of trehalose and hydroxyethyl starch. Cryobiology\| PubMed ID: 12237095	2002
Interferon gamma modulates trauma-induced muscle wasting and immune dysfunction. Annals of surgery\| PubMed ID: 12409672	2002
Overview of the Alliance for Cellular Signaling. Nature\| PubMed ID: 12478301	2002
Osmometric behavior of mouse oocytes in the presence of different intracellular sugars. Cryobiology\| PubMed ID: 12482383	2002
Desiccation tolerance of spermatozoa dried at ambient temperature: production of fetal mice. Biology of reproduction\| PubMed ID: 12606475	2003
Influence of insulin therapy on burn wound healing in rats. The Journal of surgical research\| PubMed ID: 12643849	2003
Measurement of trehalose loading of mammalian cells porated with a metal-actuated switchable pore. Biotechnology and bioengineering\| PubMed ID: 12652476	2003
Bioengineering of liver assist devices. Journal of hepato-biliary-pancreatic surgery\| PubMed ID: 12658402	2002
Quantitative microinjection of trehalose into mouse oocytes and zygotes, and its effect on development. Cryobiology\| PubMed ID: 12686202	2003
Efficacy of an extracorporeal flat-plate bioartificial liver in treating fulminant hepatic failure. The Journal of surgical research\| PubMed ID: 12842448	2003
Long-term function of cryopreserved rat hepatocytes in a coculture system. Cell transplantation\| PubMed ID: 15129765	2004
Cryopreservation of stem cells using trehalose: evaluation of the method using a human hematopoietic cell line. Stem cells and development\| PubMed ID: 15186725	2004
Dynamic gene expression profiling using a microfabricated living cell array. Analytical chemistry\| PubMed ID: 15253648	2004
Use of sugars in cryopreserving human oocytes. Reproductive biomedicine online\| PubMed ID: 15333248	2004
Single-cell chemical lysis in picoliter-scale closed volumes using a microfabricated device. Analytical chemistry\| PubMed ID: 15481964	2004
Hepatic tissue engineering for adjunct and temporary liver support: critical technologies. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society\| PubMed ID: 15497161	2004
Continuous flow microfluidic device for rapid erythrocyte lysis. Analytical chemistry\| PubMed ID: 15516115	2004
The influence of microtextured basal lamina analog topography on keratinocyte function and epidermal organization. Journal of biomedical materials research. Part A\| PubMed ID: 15543632	2005
Effect of flow and surface conditions on human lymphocyte isolation using microfluidic chambers. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 15595794	2004
Development of a microfabricated cytometry platform for characterization and sorting of individual leukocytes. Lab on a chip\| PubMed ID: 15616737	2005
Cryopreservation of isolated primary rat hepatocytes: enhanced survival and long-term hepatospecific function. Annals of surgery\| PubMed ID: 15622000	2005
Cryopreservation of starfish oocytes. Cryobiology\| PubMed ID: 15710368	2005
Analysis of desiccation and vitrification characteristics of carbohydrate films by shear-wave resonators. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 15779957	2005
Application of genome-wide expression analysis to human health and disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15781863	2005
Microfabricated grooved substrates as platforms for bioartificial liver reactors. Biotechnology and bioengineering\| PubMed ID: 15834948	2005
Designing a hepatocellular microenvironment with protein microarraying and poly(ethylene glycol) photolithography. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 15875819	2004
Progressive elimination of microinjected trehalose during mouse embryonic development. Reproductive biomedicine online\| PubMed ID: 15901459	2005
Mouse sperm desiccated and stored in trehalose medium without freezing. Biology of reproduction\| PubMed ID: 15930320	2005
Isothermal desiccation and vitrification kinetics of trehalose-dextran solutions. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 15986695	2004
Blood-on-a-chip. Annual review of biomedical engineering\| PubMed ID: 16004567	2005
Enrichment using antibody-coated microfluidic chambers in shear flow: model mixtures of human lymphocytes. Biotechnology and bioengineering\| PubMed ID: 16037988	2005
Trehalose loading through the mitochondrial permeability transition pore enhances desiccation tolerance in rat liver mitochondria. Biochimica et biophysica acta\| PubMed ID: 16242115	2005
Selective enhancement of cytochrome p-450 activity in rat hepatocytes by in vitro heat shock. Tissue engineering\| PubMed ID: 16259607	2005
Thermal characterization of Nakagata's mouse sperm freezing protocol. Cryobiology\| PubMed ID: 16332363	2006
Trehalose uptake through P2X7 purinergic channels provides dehydration protection. Cryobiology\| PubMed ID: 16338230	2006
Microfluidic diffusive filter for apheresis (leukapheresis). Lab on a chip\| PubMed ID: 16372073	2006
Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. Lab on a chip\| PubMed ID: 16450027	2006
Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16493048	2006
Cell handling using microstructured membranes. Lab on a chip\| PubMed ID: 16511616	2006
Cryo-injury and biopreservation. Annals of the New York Academy of Sciences\| PubMed ID: 16533923	2005
Nonmetabolizable glucose compounds impart cryotolerance to primary rat hepatocytes. Tissue engineering\| PubMed ID: 16579691	2006
Antiproteolytic action of orally delivered insulin using pH-responsive hydrogels in a rat burn model. The Journal of surgical research\| PubMed ID: 16616764	2006
Universal microfluidic gradient generator. Analytical chemistry\| PubMed ID: 16689552	2006
Magnetically and biologically active bead-patterned hydrogels. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 16700603	2006
Size-based microfluidic enrichment of neonatal rat cardiac cell populations. Biomedical microdevices\| PubMed ID: 16732418	2006
Treatment of fulminant hepatic failure in rats using a bioartificial liver device containing porcine hepatocytes producing interleukin-1 receptor antagonist. Tissue engineering\| PubMed ID: 16771644	2006
Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes. Analytical chemistry\| PubMed ID: 16808435	2006
Panning of multiple subsets of leukocytes on antibody-decorated poly(ethylene) glycol-coated glass slides. Journal of immunological methods\| PubMed ID: 16822521	2006
Polyelectrolyte nano-scaffolds for the design of layered cellular architectures. Tissue engineering\| PubMed ID: 16846351	2006
Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Analytical chemistry\| PubMed ID: 16878882	2006
3-O-methyl-D-glucose improves desiccation tolerance of keratinocytes. Tissue engineering\| PubMed ID: 16889517	2006
Oxygen uptake rates and liver-specific functions of hepatocyte and 3T3 fibroblast co-cultures. Biotechnology and bioengineering\| PubMed ID: 17054120	2007
A bioartificial liver device secreting interleukin-1 receptor antagonist for the treatment of hepatic failure in rats. The Journal of surgical research\| PubMed ID: 17081566	2007
A high-throughput microfluidic real-time gene expression living cell array. Lab on a chip\| PubMed ID: 17180208	2007
A microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects. Lab on a chip\| PubMed ID: 17268618	2007
Multifunctional encoded particles for high-throughput biomolecule analysis. Science (New York, N.Y.)\| PubMed ID: 17347435	2007
Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates. Macromolecular bioscience\| PubMed ID: 17370273	2007
A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 17414933	2007
Elevated hepatocyte-specific functions in fetal rat hepatocytes co-cultured with adult rat hepatocytes. Tissue engineering\| PubMed ID: 17518664	2006
Engineering complex tissues. Tissue engineering\| PubMed ID: 17518671	2006
Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices. Lab on a chip\| PubMed ID: 17538717	2007
Long-term storage of mouse spermatozoa after evaporative drying. Reproduction (Cambridge, England)\| PubMed ID: 17616722	2007
Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates. Biotechnology and bioengineering\| PubMed ID: 17626294	2008
Microfabrication-based modulation of embryonic stem cell differentiation. Lab on a chip\| PubMed ID: 17653344	2007
Osmotic selection of human mesenchymal stem/progenitor cells from umbilical cord blood. Tissue engineering\| PubMed ID: 17665999	2007
Thermal performance of quartz capillaries for vitrification. Cryobiology\| PubMed ID: 17919532	2007
Phenotypic analysis of C57BL/6J and FVB/NJ mice generated using evaporatively dried spermatozoa. Comparative medicine\| PubMed ID: 17974129	2007
Role of trehalose in prevention of giant vesicle adsorption and encapsulated solute leakage in anhydrobiotic preservation. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 17983248	2007
Continuous inertial focusing, ordering, and separation of particles in microchannels. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18025477	2007
Polar stimulation and constrained cell migration in microfluidic channels. Lab on a chip\| PubMed ID: 18030401	2007
Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments. Lab on a chip\| PubMed ID: 18094768	2008
Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature\| PubMed ID: 18097410	2007
Invention, innovation, entrepreneurship in academic medical centers. Surgery\| PubMed ID: 18242329	2008
Equilibrium separation and filtration of particles using differential inertial focusing. Analytical chemistry\| PubMed ID: 18275222	2008
Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clinical chemistry\| PubMed ID: 18375483	2008
Elastomeric microchip electrospray emitter for stable cone-jet mode operation in the nanoflow regime. Analytical chemistry\| PubMed ID: 18419138	2008
Rotationally oscillating drill (Ros-Drill) for mouse ICSI without using mercury. Molecular reproduction and development\| PubMed ID: 18437690	2008
Vitrification by ultra-fast cooling at a low concentration of cryoprotectants in a quartz micro-capillary: a study using murine embryonic stem cells. Cryobiology\| PubMed ID: 18462712	2008
Cell-cell interaction modulates neuroectodermal specification of embryonic stem cells. Neuroscience letters\| PubMed ID: 18467031	2008
Desiccation kinetics and biothermodynamics of glass forming trehalose solutions in thin films. Annals of biomedical engineering\| PubMed ID: 18500553	2008
Enhanced differentiation of embryonic stem cells using co-cultivation with hepatocytes. Biotechnology and bioengineering\| PubMed ID: 18571804	2008
'Living cantilever arrays' for characterization of mass of single live cells in fluids. Lab on a chip\| PubMed ID: 18584076	2008
Detection of mutations in EGFR in circulating lung-cancer cells. The New England journal of medicine\| PubMed ID: 18596266	2008
Microflow and crack formation patterns in drying sessile droplets of liposomes suspended in trehalose solutions. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 18613701	2008
Controlled encapsulation of single-cells into monodisperse picolitre drops. Lab on a chip\| PubMed ID: 18651066	2008
Successful cryopreservation of mouse oocytes by using low concentrations of trehalose and dimethylsulfoxide. Biology of reproduction\| PubMed ID: 18815355	2009
Neutrophil migration assay from a drop of blood. Lab on a chip\| PubMed ID: 19023468	2008
Microvortex for focusing, guiding and sorting of particles. Lab on a chip\| PubMed ID: 19023476	2008
Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19050288	2008
Stop-flow lithography for the production of shape-evolving degradable microgel particles. Journal of the American Chemical Society\| PubMed ID: 19215127	2009
Occurrence of mitochondria-targeted Late Embryogenesis Abundant (LEA) gene in animals increases organelle resistance to water stress. The Journal of biological chemistry\| PubMed ID: 19228698	2009
The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patients. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 19247082	2009
High-throughput single cell arrays as a novel tool in biopreservation. Cryobiology\| PubMed ID: 19303403	2009
Desiccation tolerance in bovine sperm: a study of the effect of intracellular sugars and the supplemental roles of an antioxidant and a chelator. Cryobiology\| PubMed ID: 19318090	2009
Comparison between ideal and nonideal solution models for single-cell cryopreservation protocols. The journal of physical chemistry. B\| PubMed ID: 19338369	2009
Further optimization of mouse spermatozoa evaporative drying techniques. Cryobiology\| PubMed ID: 19375415	2009
Particle segregation and dynamics in confined flows. Physical review letters\| PubMed ID: 19392526	2009
Enhancing the performance of a point-of-care CD4+ T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics. Lab on a chip\| PubMed ID: 19417901	2009
Adaptive-control model for neutrophil orientation in the direction of chemical gradients. Biophysical journal\| PubMed ID: 19450463	2009
Nucleation and solidification in static arrays of monodisperse drops. Lab on a chip\| PubMed ID: 19532960	2009
Chemical gradient-mediated melting curve analysis for genotyping of SNPs. Electrophoresis\| PubMed ID: 19593749	2009
Dynamic effect of heat shock pretreatment on apoptotic responses to TNF-alpha in liver cells. Journal of biomechanical engineering\| PubMed ID: 19640128	2009
High throughput single cell bioinformatics. Biotechnology progress\| PubMed ID: 19830811	2009
A robust electrical microcytometer with 3-dimensional hydrofocusing. Lab on a chip\| PubMed ID: 19865723	2009
Concentration and purification of human immunodeficiency virus type 1 virions by microfluidic separation of superparamagnetic nanoparticles. Analytical chemistry\| PubMed ID: 19954210	2010
Spontaneous migration of cancer cells under conditions of mechanical confinement. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023765	2009
Genome-wide transcriptome analysis of 150 cell samples. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023796	2009
Surface topography induces 3D self-orientation of cells and extracellular matrix resulting in improved tissue function. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023803	2009
Layered patterning of hepatocytes in co-culture systems using microfabricated stencils. BioTechniques\| PubMed ID: 20078427	2010
Concentration of glycerol in aqueous microdroplets by selective removal of water. Analytical chemistry\| PubMed ID: 20102162	2010
Ultra-rapid vitrification of mouse oocytes in low cryoprotectant concentrations. Reproductive biomedicine online\| PubMed ID: 20113958	2010
Microfluidic isolation and transcriptome analysis of serum microvesicles. Lab on a chip\| PubMed ID: 20126692	2010
MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133671	2010
A study of the effect of sorbitol on osmotic tolerance during partial desiccation of bovine sperm. Cryobiology\| PubMed ID: 20233588	2010
Particle focusing in staged inertial microfluidic devices for flow cytometry. Analytical chemistry\| PubMed ID: 20373755	2010
Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer. Science translational medicine\| PubMed ID: 20424012	2010
Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20479259	2010
Metabolic preconditioning of cells with AICAR-riboside: improved cryopreservation and cell-type specific impacts on energetics and proliferation. Cryobiology\| PubMed ID: 20510224	2010
Controlled induction of distributed microdeformation in wounded tissue via a microchamber array dressing. Journal of biomedical materials research. Part A\| PubMed ID: 20607869	2010
Directional decisions during neutrophil chemotaxis inside bifurcating channels. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20676444	2010
Burn injury reduces neutrophil directional migration speed in microfluidic devices. PloS one\| PubMed ID: 20689600	2010
Clinical microfluidics for neutrophil genomics and proteomics. Nature medicine\| PubMed ID: 20802500	2010
Differential inertial focusing of particles in curved low-aspect-ratio microchannels. New journal of physics\| PubMed ID: 20862272	2009
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20930119	2010
LEA proteins during water stress: not just for plants anymore. Annual review of physiology\| PubMed ID: 21034219	2011
A microfabricated electrical differential counter for the selective enumeration of CD4+ T lymphocytes. Lab on a chip\| PubMed ID: 21283908	2011
A spin-drying technique for lyopreservation of mammalian cells. Annals of biomedical engineering\| PubMed ID: 21293974	2011
Circulating tumor cells: approaches to isolation and characterization. The Journal of cell biology\| PubMed ID: 21300848	2011
Metabolic restructuring during energy-limited states: insights from Artemia franciscana embryos and other animals. Journal of insect physiology\| PubMed ID: 21335009	2011
Spatially Invariant Vector Quantization: A pattern matching algorithm for multiple classes of image subject matter including pathology. Journal of pathology informatics\| PubMed ID: 21383936	2011
Nanoporous elements in microfluidics for multiscale manipulation of bioparticles. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 21413145	2011
A 3D aligned microfibrous myocardial tissue construct cultured under transient perfusion. Biomaterials\| PubMed ID: 21570112	2011
Squishy non-spherical hydrogel microparticles. Macromolecular rapid communications\| PubMed ID: 21590884	2010
Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess. Journal of pathology informatics\| PubMed ID: 21773056	2011
Microfluidic proportional flow controller. Journal of micromechanics and microengineering : structures, devices, and systems\| PubMed ID: 21874096	2010
Controlled loading of cryoprotectants (CPAs) to oocyte with linear and complex CPA profiles on a microfluidic platform. Lab on a chip\| PubMed ID: 21887438	2011
Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 21931299	2011
Cryopreservation of spin-dried mammalian cells. PloS one\| PubMed ID: 21966385	2011
Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance. Bioconjugate chemistry\| PubMed ID: 22043803	2011
On a chip. IEEE pulse\| PubMed ID: 22147065	2011
Trehalose transporter from African chironomid larvae improves desiccation tolerance of Chinese hamster ovary cells. Cryobiology\| PubMed ID: 22155480	2012
Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science (New York, N.Y.)\| PubMed ID: 22174129	2012
Preservation of mouse sperm by convective drying and storing in 3-o-methyl-d-glucose. PloS one\| PubMed ID: 22272261	2012
Epithelial cell guidance by self-generated EGF gradients. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 22314635	2012
Clusters of circulating tumor cells traverse capillary-sized vessels. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27091969	2016
Controlled ice nucleation using freeze-dried Pseudomonas syringae encapsulated in alginate beads. Cryobiology\| PubMed ID: 28315320	2017
Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells. Scientific reports\| PubMed ID: 28883519	2017
A highly-occupied, single-cell trapping microarray for determination of cell membrane permeability. Lab on a chip\| PubMed ID: 29068447	2017
Janus-faced role of water in defining nanostructure of choline chloride/glycerol deep eutectic solvent. Physical chemistry chemical physics : PCCP\| PubMed ID: 30024584	2018
Role of synthetic antifreeze agents in catalyzing ice nucleation. Cryobiology\| PubMed ID: 30144407	2018
On-chip oocyte denudation from cumulus-oocyte complexes for assisted reproductive therapy. Lab on a chip\| PubMed ID: 30465050	2018