Takeshi Senga

Department of Cancer Biology, Nagoya University Graduate School of Medicine

Affiliated withNagoya University Graduate School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2016

Other Publications

Article	Year
Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11891291	2002
Possible activation of the renin-angiotensin system in the feto-placental unit in preeclampsia. The Journal of clinical endocrinology and metabolism\| PubMed ID: 11932332	2002
Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer research\| PubMed ID: 11956105	2002
Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90. Cancer research\| PubMed ID: 12124327	2002
LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3. Blood\| PubMed ID: 12393494	2003
Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells. Oncogene\| PubMed ID: 12444555	2002
Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array. International journal of oncology\| PubMed ID: 12469201	2003
A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling. Oncogene\| PubMed ID: 12483539	2002
Cysteine residues in the C-terminal lobe of Src: their role in the suppression of the Src kinase. Oncogene\| PubMed ID: 12618767	2003
Secretion of matrix metalloproteinase-9 by the proinflammatory cytokine, IL-1beta: a role for the dual signalling pathways, Akt and Erk. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 12786942	2003
SH2 domain containing protein tyrosine phosphatase 2 regulates concanavalin A-dependent secretion and activation of matrix metalloproteinase 2 via the extracellular signal-regulated kinase a... Cancer research\| PubMed ID: 14559821	2003
Stat3-dependent induction of interleukin-3 receptor expression in leukemia inhibitory factor-stimulated M1 mouse leukemia cells. Cytokine\| PubMed ID: 14698140	2004
Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells. Oncology reports\| PubMed ID: 15069547	2004
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. Molecular cell\| PubMed ID: 15260975	2004
A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8. Oncology reports\| PubMed ID: 16142341	2005
PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. The Journal of biological chemistry\| PubMed ID: 16407252	2006
A role for focal adhesion kinase signaling in tumor necrosis factor-alpha-dependent matrix metalloproteinase-9 production in a cholangiocarcinoma cell line, CCKS1. Cancer research\| PubMed ID: 16818654	2006
SHP-2-Erk signaling regulates concanavalin A-dependent production of TIMP-2. Biochemical and biophysical research communications\| PubMed ID: 16904070	2006
FAK signaling in neoplastic disorders: a linkage between inflammation and cancer. Annals of the New York Academy of Sciences\| PubMed ID: 17185517	2006
SIRPalpha1 and SIRPalpha2: their role as tumor suppressors in breast carcinoma cells. Biochemical and biophysical research communications\| PubMed ID: 17632076	2007
Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. Genes & development\| PubMed ID: 17761813	2007
A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 17825046	2007
Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma. Cancer research\| PubMed ID: 17942892	2007
The cysteine-cluster motif of c-Src: its role for the heavy metal-mediated activation of kinase. Cancer science\| PubMed ID: 18177487	2008
MEK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth. Cancer letters\| PubMed ID: 18346844	2008
The cysteine-cluster motif of c-Yes, Lyn and FAK as a suppressive module for the kinases. Oncology reports\| PubMed ID: 18357384	2008
Nek2 as a novel molecular target for the treatment of breast carcinoma. Cancer science\| PubMed ID: 19038001	2009
A role for AP-1 in matrix metalloproteinase production and invadopodia formation of v-Crk-transformed cells. Experimental cell research\| PubMed ID: 19268464	2009
Characterization of interaction between CLP36 and palladin. The FEBS journal\| PubMed ID: 19366376	2009
Phosphorylation of histone H3 at Ser10: its role in cell transformation by v-Src. Biochemical and biophysical research communications\| PubMed ID: 19540193	2009
Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling. International journal of oncology\| PubMed ID: 19578744	2009
Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivo. Cancer science\| PubMed ID: 19860840	2010
Three-dimensional cell culture array using magnetic force-based cell patterning for analysis of invasive capacity of BALB/3T3/v-src. Lab on a chip\| PubMed ID: 19904404	2009
S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion. The Journal of biological chemistry\| PubMed ID: 19948721	2010
Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin. Cancer science\| PubMed ID: 20345485	2010
Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis. Cancer letters\| PubMed ID: 20381954	2010
Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing. The FEBS journal\| PubMed ID: 20637038	2010
PI3K/Akt signaling is involved in the disruption of gap junctional communication caused by v-Src and TNF-α. Biochemical and biophysical research communications\| PubMed ID: 20727856	2010
The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading. Molecular biology of the cell\| PubMed ID: 20926685	2010
Disruption of cell spreading by the activation of MEK/ERK pathway is dependent on AP-1 activity. Nagoya journal of medical science\| PubMed ID: 20942268	2010
FLT3/ ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling. European journal of haematology\| PubMed ID: 21114537	2011
Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP α1/SHP-2 signaling system. Cancer research\| PubMed ID: 21169408	2011
ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility. Molecular biology of the cell\| PubMed ID: 21865595	2011
The loss of endoglin promotes the invasion of extravillous trophoblasts. Endocrinology\| PubMed ID: 21914777	2011
Role of palladin phosphorylation by extracellular signal-regulated kinase in cell migration. PloS one\| PubMed ID: 22216253	2011
Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis. The Journal of biological chemistry\| PubMed ID: 22665485	2012
Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration. PloS one\| PubMed ID: 22844530	2012
S100A10 is required for the organization of actin stress fibers and promotion of cell spreading. Molecular and cellular biochemistry\| PubMed ID: 23129259	2013
ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells. Cancer research\| PubMed ID: 23288509	2013
The expression and characterization of endoglin in uterine leiomyosarcoma. Clinical & experimental metastasis\| PubMed ID: 23397382	2013
The Aurora-B-mediated phosphorylation of SHCBP1 regulates cytokinetic furrow ingression. Journal of cell science\| PubMed ID: 23704356	2013
The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing. Journal of cell science\| PubMed ID: 23750008	2013
Peptide-based inhibition of the HOXA9/PBX interaction retards the growth of human meningioma. Cancer chemotherapy and pharmacology\| PubMed ID: 24141373	2014
Silencing of TBC1D15 promotes RhoA activation and membrane blebbing. Molecular and cellular biochemistry\| PubMed ID: 24337944	2014
Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 24590270	2014
B7-H4 overexpression correlates with a poor prognosis for cervical cancer patients. Molecular and clinical oncology\| PubMed ID: 24649336	2014
PLAGL2 regulates actin cytoskeletal architecture and cell migration. Carcinogenesis\| PubMed ID: 24675530	2014
Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells. Molecular cancer therapeutics\| PubMed ID: 24928850	2014
GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth. Oncology reports\| PubMed ID: 24992906	2014
Silencing of STRN4 suppresses the malignant characteristics of cancer cells. Cancer science\| PubMed ID: 25250919	2014
Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells. Cancer medicine\| PubMed ID: 25450007	2015
SHCBP1 is required for midbody organization and cytokinesis completion. Cell cycle (Georgetown, Tex.)\| PubMed ID: 25486361	2014
Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells. Oncology reports\| PubMed ID: 25522823	2015
Special AT-rich sequence-binding protein 2 suppresses invadopodia formation in HCT116 cells via palladin inhibition. Experimental cell research\| PubMed ID: 25523619	2015
Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration. Scientific reports\| PubMed ID: 25573059	2015
SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling. The FEBS journal\| PubMed ID: 25662172	2015
YAP is essential for tissue tension to ensure vertebrate 3D body shape. Nature\| PubMed ID: 25778702	2015
EML4 promotes the loading of NUDC to the spindle for mitotic progression. Cell cycle (Georgetown, Tex.)\| PubMed ID: 25789526	2015
HOXB13 and ALX4 induce SLUG expression for the promotion of EMT and cell invasion in ovarian cancer cells. Oncotarget\| PubMed ID: 25944620	2015
Activation of Yes-Associated Protein in Low-Grade Meningiomas Is Regulated by Merlin, Cell Density, and Extracellular Matrix Stiffness. Journal of neuropathology and experimental neurology\| PubMed ID: 26049897	2015
UBE2S is associated with malignant characteristics of breast cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 26245992	2016
Arginine methylation of ubiquitin-associated protein 2-like is required for the accurate distribution of chromosomes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 26381755	2016
FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 26503212	2016
Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells. Oncology letters\| PubMed ID: 26622761	2015
SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer. Oncotarget\| PubMed ID: 26701851	2016
CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains. Cancer immunology research\| PubMed ID: 26822025	2016
Erratum to: UBE2S is associated with malignant characteristics of breast cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 26825978	2016
Erratum to: FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion and colony formation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 26825979	2016
α-Bisabolol Inhibits Invasiveness and Motility in Pancreatic Cancer Through KISS1R Activation. Anticancer research\| PubMed ID: 26851012	2016
Nek2 siRNA therapy using a portal venous port-catheter system for liver metastasis in pancreatic cancer. Cancer science\| PubMed ID: 27316377	2016
A regulatory subunit of protein phosphatase 2A, PPP2R5E, regulates the abundance of microtubule crosslinking factor 1. The FEBS journal\| PubMed ID: 27521566	2016
An immuno-wall microdevice exhibits rapid and sensitive detection of IDH1-R132H mutation specific to grade II and III gliomas. Science and technology of advanced materials\| PubMed ID: 27877908	2016