Edith Heard

Unité de Génétique et Biologie du Développement, Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934

Affiliated withInstitut Curie, PSL Research University, CNRS UMR 3215, INSERM U934 EMBL: European Molecular Biology Laboratory Collège de France

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 2	2016
Publication title Cited by 3	2022

Other Publications

Article	Year
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nature genetics\| PubMed ID: 11740495	2002
Antisense RNA in imprinting: spreading silence through Air. Trends in genetics : TIG\| PubMed ID: 12175797	2002
Relationship of XIST expression and responses of ovarian cancer to chemotherapy. Molecular cancer therapeutics\| PubMed ID: 12492109	2002
Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center. The Journal of biological chemistry\| PubMed ID: 12586828	2003
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell\| PubMed ID: 12809602	2003
Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (New York, N.Y.)\| PubMed ID: 14671313	2004
X-chromosome inactivation in mouse embryonic stem cells: analysis of histone modifications and transcriptional activity using immunofluorescence and FISH. Methods in enzymology\| PubMed ID: 14975321	2004
Recent advances in X-chromosome inactivation. Current opinion in cell biology\| PubMed ID: 15145348	2004
Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Molecular and cellular biology\| PubMed ID: 15169908	2004
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development (Cambridge, England)\| PubMed ID: 15753215	2005
Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte. EMBO reports\| PubMed ID: 16007070	2005
Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome. Current opinion in genetics & development\| PubMed ID: 16107314	2005
Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice. Nature\| PubMed ID: 16227973	2005
Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nature cell biology\| PubMed ID: 16434960	2006
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Molecular and cellular biology\| PubMed ID: 16537902	2006
Dosage compensation in mammals: fine-tuning the expression of the X chromosome. Genes & development\| PubMed ID: 16847345	2006
A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced. Genes & development\| PubMed ID: 16912274	2006
[Cross talk between the Xics]. Médecine sciences : M/S\| PubMed ID: 17101084	2006
Non-rigid registration of 3D multi-channel microscopy images of cell nuclei. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention\| PubMed ID: 17354977	2006
The ins and outs of gene regulation and chromosome territory organisation. Current opinion in cell biology\| PubMed ID: 17467967	2007
X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors. Cancer research\| PubMed ID: 17545591	2007
A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18227505	2008
Chromosome structural proteins and RNA-mediated epigenetic silencing. Developmental cell\| PubMed ID: 18539109	2008
[Inactivation of X chromosome: cells know how to count two X chromosomes]. Médecine sciences : M/S\| PubMed ID: 18601875	2008
Combined immunofluorescence, RNA fluorescent in situ hybridization, and DNA fluorescent in situ hybridization to study chromatin changes, transcriptional activity, nuclear organization, and ... Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18951174	2008
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Molecular and cellular biology\| PubMed ID: 19223465	2009
Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19273861	2009
X inactivation and the complexities of silencing a sex chromosome. Current opinion in cell biology\| PubMed ID: 19477626	2009
High-resolution analysis of epigenetic changes associated with X inactivation. Genome research\| PubMed ID: 19581487	2009
Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation. PLoS genetics\| PubMed ID: 19714213	2009
Foreword: Coping with sex chromosome imbalance. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology\| PubMed ID: 19760092	2009
Lessons from comparative analysis of X-chromosome inactivation in mammals. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology\| PubMed ID: 19802706	2009
X chromosome inactivation: when dosage counts. Cell\| PubMed ID: 19945374	2009
Epigenetic mechanisms in development and disease. Seminars in cell & developmental biology\| PubMed ID: 20079450	2010
LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation. Cell\| PubMed ID: 20550932	2010
Dynamic plasticity of large-scale chromatin structure revealed by self-assembly of engineered chromosome regions. The Journal of cell biology\| PubMed ID: 20819934	2010
Ten years of genetics and genomics: what have we achieved and where are we heading? Nature reviews. Genetics\| PubMed ID: 20820184	2010
Girafe--an R/Bioconductor package for functional exploration of aligned next-generation sequencing reads. Bioinformatics (Oxford, England)\| PubMed ID: 20861030	2010
Nuclear organization and dosage compensation. Cold Spring Harbor perspectives in biology\| PubMed ID: 20943757	2010
[Establishing transcriptional silencing of the X chromosome during early embryogenesis]. Biologie aujourd'hui\| PubMed ID: 20950563	2010
Rnf12--a jack of all trades in X inactivation? PLoS genetics\| PubMed ID: 21298029	2011
Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development. Nature\| PubMed ID: 21471966	2011
Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation. Cell\| PubMed ID: 21529716	2011
Regulation of X-chromosome inactivation by the X-inactivation centre. Nature reviews. Genetics\| PubMed ID: 21587299	2011
Evolutionary diversity and developmental regulation of X-chromosome inactivation. Human genetics\| PubMed ID: 21687993	2011
The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA. Genes & development\| PubMed ID: 21690198	2011
Function of the sex chromosomes in mammalian fertility. Cold Spring Harbor perspectives in biology\| PubMed ID: 21730045	2011
Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PloS one\| PubMed ID: 21731673	2011
Fifty years of X-inactivation research. Development (Cambridge, England)\| PubMed ID: 22069183	2011
Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles. RNA (New York, N.Y.)\| PubMed ID: 22201644	2012
MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell stem cell\| PubMed ID: 22226354	2012
Deep-sequencing protocols influence the results obtained in small-RNA sequencing. PloS one\| PubMed ID: 22384282	2012
Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature\| PubMed ID: 22495304	2012
Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome. Developmental cell\| PubMed ID: 22841499	2012
HiTC: exploration of high-throughput 'C' experiments. Bioinformatics (Oxford, England)\| PubMed ID: 22923296	2012
ncPRO-seq: a tool for annotation and profiling of ncRNAs in sRNA-seq data. Bioinformatics (Oxford, England)\| PubMed ID: 23044543	2012
Recent advances in X-chromosome inactivation research. Current opinion in cell biology\| PubMed ID: 23142477	2012
Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells. Development (Cambridge, England)\| PubMed ID: 23362347	2013
Role and control of X chromosome dosage in mammalian development. Current opinion in genetics & development\| PubMed ID: 23465885	2013
The dynamics of epigenetic changes in a range of organisms. Current topics in developmental biology\| PubMed ID: 23587246	2013
Small RNAs derived from structural non-coding RNAs. Methods (San Diego, Calif.)\| PubMed ID: 23684746	2013
Cell nucleus. Current opinion in cell biology\| PubMed ID: 23746906	2013
Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Molecular and cellular biology\| PubMed ID: 23754746	2013
Segmental folding of chromosomes: a basis for structural and regulatory chromosomal neighborhoods? BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 23832846	2013
The pluripotent genome in three dimensions is shaped around pluripotency factors. Nature\| PubMed ID: 23883933	2013
Live-cell imaging combined with immunofluorescence, RNA, or DNA FISH to study the nuclear dynamics and expression of the X-inactivation center. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23979997	2013
Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments. Genome research\| PubMed ID: 24002784	2013
RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells. PLoS genetics\| PubMed ID: 24244175	2013
Changes in the organization of the genome during the mammalian cell cycle. Genome biology\| PubMed ID: 24368000	2013
Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome. Molecular cell\| PubMed ID: 24462204	2014
The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network. Cell stem cell\| PubMed ID: 24506884	2014
Developmental dynamics and disease potential of random monoallelic gene expression. Developmental cell\| PubMed ID: 24576422	2014
Transgenerational epigenetic inheritance: myths and mechanisms. Cell\| PubMed ID: 24679529	2014
Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription. Cell\| PubMed ID: 24813616	2014
MOF-associated complexes ensure stem cell identity and Xist repression. eLife\| PubMed ID: 24842875	2014
X-chromosome inactivation in development and cancer. FEBS letters\| PubMed ID: 24937141	2014
Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation. Annual review of cell and developmental biology\| PubMed ID: 25000994	2014
[Initiation of X chromosome inactivation during early embryogenesis in mice and in humans]. Bulletin de l'Académie nationale de médecine\| PubMed ID: 25163344	2013
High-resolution 3D DNA FISH using plasmid probes and computational correction of optical aberrations to study chromatin structure at the sub-megabase scale. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25555574	2015
Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation. Molecular cell\| PubMed ID: 25620564	2015
The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer. Genome research\| PubMed ID: 25653311	2015
Systematic discovery of Xist RNA binding proteins. Cell\| PubMed ID: 25843628	2015
Correction: RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells. PLoS genetics\| PubMed ID: 25973973	2015
X-chromosome inactivation: new insights into cis and trans regulation. Current opinion in genetics & development\| PubMed ID: 26004255	2015
[The legacy of Mary F. Lyon (1925-2014)]. Médecine sciences : M/S\| PubMed ID: 26152175	2015
Structural and functional diversity of Topologically Associating Domains. FEBS letters\| PubMed ID: 26348399	2015
HiC-Pro: an optimized and flexible pipeline for Hi-C data processing. Genome biology\| PubMed ID: 26619908	2015
Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation. eLife\| PubMed ID: 26836306	2016
Structural Fluctuations of the Chromatin Fiber within Topologically Associating Domains. Biophysical journal\| PubMed ID: 27028634	2016
Random monoallelic expression of genes on autosomes: Parallels with X-chromosome inactivation. Seminars in cell & developmental biology\| PubMed ID: 27101886	2016
Structural organization of the inactive X chromosome in the mouse. Nature\| PubMed ID: 27437574	2016
LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation. Cell\| PubMed ID: 27471971	2016
Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming. Nature communications\| PubMed ID: 27507283	2016
Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes. Genome research\| PubMed ID: 27510564	2016
A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nature structural & molecular biology\| PubMed ID: 30962582	2019
Advances in epigenetics link genetics to the environment and disease. Nature\| PubMed ID: 31341302	2019
Xist RNA in action: Past, present, and future. PLoS genetics\| PubMed ID: 31537017	2019
A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary. Molecular cell\| PubMed ID: 31759823	2020
SPEN integrates transcriptional and epigenetic control of X-inactivation. Nature\| PubMed ID: 32025035	2020
Parental-to-embryo switch of chromosome organization in early embryogenesis. Nature\| PubMed ID: 32238933	2020
Locus specific epigenetic modalities of random allelic expression imbalance. Nature communications\| PubMed ID: 34504093	2021
Noncoding RNAs: biology and applications-a Keystone Symposia report. Annals of the New York Academy of Sciences\| PubMed ID: 34791665	2021
Gene regulation in time and space during X-chromosome inactivation. Nature reviews. Molecular cell biology\| PubMed ID: 35013589	2022
The X chromosome from telomere to telomere: key achievements and future opportunities. Faculty reviews\| PubMed ID: 35088059	2021
Molecular biology for green recovery-A call for action. PLoS biology\| PubMed ID: 35452449	2022
XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation. Cell\| PubMed ID: 35597241	2022