David Margulies

Department of Organic Chemistry, Weizmann Institute of Science

Affiliated withWeizmann Institute of Science

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2016

Other Publications

Article	Year
Binding of the natural killer cell inhibitory receptor Ly49A to its major histocompatibility complex class I ligand. Crucial contacts include both H-2Dd AND beta 2-microglobulin. The Journal of biological chemistry\| PubMed ID: 11696552	2002
Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination. Annual review of immunology\| PubMed ID: 11861620	2002
MHC class I recognition by Ly49 natural killer cell receptors. Molecular immunology\| PubMed ID: 11955594	2002
Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family. Journal of molecular biology\| PubMed ID: 12096910	2002
Bidentate ligation of heme analogues; novel biomimetics of peroxidase active site. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 12360943	2002
Rapid induction of apoptosis in CD8+ HIV-1 envelope-specific murine CTLs by short exposure to antigenic peptide. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12444171	2002
A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen. Journal of receptor and signal transduction research\| PubMed ID: 12680588	2003
CD28, costimulator or agonist receptor? The Journal of experimental medicine\| PubMed ID: 12707298	2003
Magnetic tuning of biquadratic exchange coupling in magnetic thin films. Physical review letters\| PubMed ID: 14525207	2003
Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b). Nature immunology\| PubMed ID: 14595439	2003
Molecular interactions: stiff or floppy (or somewhere in between?). Immunity\| PubMed ID: 14670294	2003
Spontaneous organ-specific Th2-mediated autoimmunity in TCR transgenic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14978094	2004
Resistance to viral infection by intraepithelial lymphocytes in HIV-1 P18-I10-specific T-cell receptor transgenic mice. Biochemical and biophysical research communications\| PubMed ID: 15020225	2004
Chemical input multiplicity facilitates arithmetical processing. Journal of the American Chemical Society\| PubMed ID: 15563165	2004
Monoclonal antibodies: producing magic bullets by somatic cell hybridization. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15728445	2005
Backbone and side chain resonance assignmentsof a TRAV14-3 mouse T cell receptor domain. Journal of biomolecular NMR\| PubMed ID: 15803407	2005
Fluorescein as a model molecular calculator with reset capability. Nature materials\| PubMed ID: 16155575	2005
Crystal structure of the murine cytomegalovirus MHC-I homolog m144. Journal of molecular biology\| PubMed ID: 16500675	2006
A molecular full-adder and full-subtractor, an additional step toward a moleculator. Journal of the American Chemical Society\| PubMed ID: 16594723	2006
A molecular keypad lock: a photochemical device capable of authorizing password entries. Journal of the American Chemical Society\| PubMed ID: 17212414	2007
Avidity of CD8 T cells sharpens immunodominance. International immunology\| PubMed ID: 17376783	2007
Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153. The Journal of biological chemistry\| PubMed ID: 17897947	2007
Role of alpha3 domain of class I MHC molecules in the activation of high- and low-avidity CD8+ CTLs. International immunology\| PubMed ID: 17981793	2007
The TLR3 signaling complex forms by cooperative receptor dimerization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18172197	2008
Estimation of low frequency antigen-presenting cells with a novel RELISPOT assay. Journal of immunological methods\| PubMed ID: 18294650	2008
Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage. Immunologic research\| PubMed ID: 19011767	2009
Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis. European journal of immunology\| PubMed ID: 19039784	2008
Protein recognition by an ensemble of fluorescent DNA G-quadruplexes. Angewandte Chemie (International ed. in English)\| PubMed ID: 19173368	2009
The behavioral organization, temporal characteristics, and diagnostic concomitants of rage outbursts in child psychiatric inpatients. Current psychiatry reports\| PubMed ID: 19302766	2009
Home schooling of NK cells. Immunity\| PubMed ID: 19303382	2009
A single residue, arginine 65, is critical for the functional interaction of leukocyte-associated inhibitory receptor-1 with collagens. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19380792	2009
Antigen-processing and presentation pathways select antigenic HIV peptides in the fight against viral evolution. Nature immunology\| PubMed ID: 19448656	2009
Rages--what are they and who has them? Journal of child and adolescent psychopharmacology\| PubMed ID: 19519263	2009
Digital analysis of protein properties by an ensemble of DNA quadruplexes. Journal of the American Chemical Society\| PubMed ID: 19566086	2009
Rages or temper tantrums? The behavioral organization, temporal characteristics, and clinical significance of angry-agitated outbursts in child psychiatry inpatients. Child psychiatry and human development\| PubMed ID: 19568928	2009
Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19620307	2009
Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19625641	2009
Surface binding inhibitors of the SCF-KIT protein-protein interaction. Chembiochem : a European journal of chemical biology\| PubMed ID: 19637142	2009
Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms. Biochemistry\| PubMed ID: 20166740	2010
Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies. Infection and immunity\| PubMed ID: 20308304	2010
Liquid risperidone in the treatment of rages in psychiatrically hospitalized children with possible bipolar disorder. Bipolar disorders\| PubMed ID: 20402713	2010
Combinatorial protein recognition as an alternative approach to antibody-mimetics. Current opinion in chemical biology\| PubMed ID: 20829097	2010
Counterpoint: Do not opine before it's time. Nature biotechnology\| PubMed ID: 21390023	2011
How the virus outsmarts the host: function and structure of cytomegalovirus MHC-I-like molecules in the evasion of natural killer cell surveillance. Journal of biomedicine & biotechnology\| PubMed ID: 21765638	2011
Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB. PloS one\| PubMed ID: 22102880	2011
High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism. PloS one\| PubMed ID: 22558107	2012
Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity. AIDS (London, England)\| PubMed ID: 22617051	2012
Will disruptive mood dysregulation disorder reduce false diagnosis of bipolar disorder in children? Bipolar disorders\| PubMed ID: 22713098	2012
The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22753930	2012
Medication detection by a combinatorial fluorescent molecular sensor. Angewandte Chemie (International ed. in English)\| PubMed ID: 23065749	2012
Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1γ reveals a paradigm for MHC/MHC interaction in immune evasion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23169621	2012
A structural and molecular dynamics approach to understanding the peptide-receptive transition state of MHC-I molecules. Molecular immunology\| PubMed ID: 23200143	2013
Authorizing multiple chemical passwords by a combinatorial molecular keypad lock. Journal of the American Chemical Society\| PubMed ID: 24088016	2013
Mutation of KCNJ8 in a patient with Cantú syndrome with unique vascular abnormalities - Support for the role of K(ATP) channels in this condition. European journal of medical genetics\| PubMed ID: 24176758	2013
Callous-unemotional traits, proactive aggression, and treatment outcomes of aggressive children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry\| PubMed ID: 24290461	2013
Development of a scalable pharmacogenomic clinical decision support service. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science\| PubMed ID: 24303299	2013
iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls. Trends in molecular medicine\| PubMed ID: 24374161	2014
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome biology\| PubMed ID: 24667040	2014
Targeted protein surface sensors as a tool for analyzing small populations of proteins in biological mixtures. Angewandte Chemie (International ed. in English)\| PubMed ID: 24841443	2014
The in-betweeners: MAIT cells join the innate-like lymphocytes gang. The Journal of experimental medicine\| PubMed ID: 25071161	2014
The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family. Structure (London, England : 1993)\| PubMed ID: 25126960	2014
Enzyme-Artificial Enzyme Interactions as a Means for Discriminating among Structurally Similar Isozymes. Journal of the American Chemical Society\| PubMed ID: 25819325	2015
The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex. European journal of immunology\| PubMed ID: 25944482	2015
Protein-Protein Communication and Enzyme Activation Mediated by a Synthetic Chemical Transducer. Journal of the American Chemical Society\| PubMed ID: 25955617	2015
The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism. Structure (London, England : 1993)\| PubMed ID: 26365803	2015
Sensing Protein Surfaces with Targeted Fluorescent Receptors. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26382918	2015
Sensing Protein Surfaces with Targeted Fluorescent Receptors. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26398521	2015
A Novel MHC-I Surface Targeted for Binding by the MCMV m06 Immunoevasin Revealed by Solution NMR. The Journal of biological chemistry\| PubMed ID: 26463211	2015
Artificial signal transduction therapy: a futuristic approach to disease treatment. Future medicinal chemistry\| PubMed ID: 26510968	2015
William E. Paul 1936-2015. Nature immunology\| PubMed ID: 26580498	2015
Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures. Molecular autism\| PubMed ID: 26697163	2015
Prevalence and Treatment Outcomes of Persistent Negative Mood Among Children with Attention-Deficit/Hyperactivity Disorder and Aggressive Behavior. Journal of child and adolescent psychopharmacology\| PubMed ID: 26745211	2016
Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26869717	2016
Orthogonal NGS for High Throughput Clinical Diagnostics. Scientific reports\| PubMed ID: 27090146	2016
Message in a molecule. Nature communications\| PubMed ID: 27138465	2016
Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock. Immunity\| PubMed ID: 27261276	2016
Genetic Misdiagnoses and the Potential for Health Disparities. The New England journal of medicine\| PubMed ID: 27532831	2016