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Mimicking the Function of Signaling Proteins

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Article DOI: 10.3791/54396
September 29th, 2016


Summary September 29th, 2016

We present guidelines for developing synthetic 'chemical transducers' that can induce communication between naturally unrelated proteins. In addition, detailed protocols are presented for synthesizing and testing a specific 'transducer' that enables a growth factor to activate a detoxifying enzyme and consequently, to regulate the cleavage of an anticancer prodrug.


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