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JoVE Journal
Biochemistry

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Mimicking the Function of Signaling Proteins
 

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Article DOI: 10.3791/54396
September 29th, 2016

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Summary September 29th, 2016

We present guidelines for developing synthetic 'chemical transducers' that can induce communication between naturally unrelated proteins. In addition, detailed protocols are presented for synthesizing and testing a specific 'transducer' that enables a growth factor to activate a detoxifying enzyme and consequently, to regulate the cleavage of an anticancer prodrug.

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