Ursula Jakob

Department of Molecular, University of Michigan

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2016

Other Publications

Article	Year
Overexpression of two different GTPases rescues a null mutation in a heat-induced rRNA methyltransferase. Journal of bacteriology\| PubMed ID: 11976298	2002
Active site in RrmJ, a heat shock-induced methyltransferase. The Journal of biological chemistry\| PubMed ID: 12181314	2002
The roles of the two zinc binding sites in DnaJ. The Journal of biological chemistry\| PubMed ID: 12941935	2003
Thioredoxin 2, an oxidative stress-induced protein, contains a high affinity zinc binding site. The Journal of biological chemistry\| PubMed ID: 12952960	2003
Not every disulfide lasts forever: disulfide bond formation as a redox switch. Antioxidants & redox signaling\| PubMed ID: 13678530	2003
Identification of a redox-regulated chaperone network. The EMBO journal\| PubMed ID: 14685279	2004
Activation of the redox-regulated chaperone Hsp33 by domain unfolding. The Journal of biological chemistry\| PubMed ID: 15023991	2004
The zinc-dependent redox switch domain of the chaperone Hsp33 has a novel fold. Journal of molecular biology\| PubMed ID: 15328602	2004
Substrate binding analysis of the 23S rRNA methyltransferase RrmJ. Journal of bacteriology\| PubMed ID: 15375145	2004
The crystal structure of the reduced, Zn2+-bound form of the B. subtilis Hsp33 chaperone and its implications for the activation mechanism. Structure (London, England : 1993)\| PubMed ID: 15458638	2004
Protein thiol modifications visualized in vivo. PLoS biology\| PubMed ID: 15502869	2004
Severe oxidative stress causes inactivation of DnaK and activation of the redox-regulated chaperone Hsp33. Molecular cell\| PubMed ID: 15694339	2005
Beyond transcription--new mechanisms for the regulation of molecular chaperones. Critical reviews in biochemistry and molecular biology\| PubMed ID: 15763707	2004
Transarterial chemoembolization in the treatment of hepatoblastoma in children. European radiology\| PubMed ID: 16003511	2006
CoSMoS: Conserved Sequence Motif Search in the proteome. BMC bioinformatics\| PubMed ID: 16433915	2006
XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. Molecular cell\| PubMed ID: 16543147	2006
Global methods to monitor the thiol-disulfide state of proteins in vivo. Antioxidants & redox signaling\| PubMed ID: 16771668	2006
Zinc center as redox switch--new function for an old motif. Antioxidants & redox signaling\| PubMed ID: 16771674	2006
The redox-switch domain of Hsp33 functions as dual stress sensor. Nature structural & molecular biology\| PubMed ID: 17515905	2007
Nitrosative stress treatment of E. coli targets distinct set of thiol-containing proteins. Molecular microbiology\| PubMed ID: 17919278	2007
Quantifying changes in the thiol redox proteome upon oxidative stress in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18287020	2008
Special issue: redox regulation of protein folding. Preface. Biochimica et biophysica acta\| PubMed ID: 18395585	2008
Thiol-based redox switches in eukaryotic proteins. Antioxidants & redox signaling\| PubMed ID: 18999917	2009
Structural plasticity of an acid-activated chaperone allows promiscuous substrate binding. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19321422	2009
Redox-regulated chaperones. Biochemistry\| PubMed ID: 19368357	2009
Interplay of cellular cAMP levels, {sigma}S activity and oxidative stress resistance in Escherichia coli. Microbiology (Reading, England)\| PubMed ID: 19372151	2009
Heme regulatory motifs in heme oxygenase-2 form a thiol/disulfide redox switch that responds to the cellular redox state. The Journal of biological chemistry\| PubMed ID: 19473966	2009
Thermodynamic analysis of a molecular chaperone binding to unfolded protein substrates. Biochemistry\| PubMed ID: 20073505	2010
Protein refolding by pH-triggered chaperone binding and release. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080625	2010
Unfolding of metastable linker region is at the core of Hsp33 activation as a redox-regulated chaperone. The Journal of biological chemistry\| PubMed ID: 20139072	2010
Effects of oxidative stress on behavior, physiology, and the redox thiol proteome of Caenorhabditis elegans. Antioxidants & redox signaling\| PubMed ID: 20649472	2011
Is overoxidation of peroxiredoxin physiologically significant? Antioxidants & redox signaling\| PubMed ID: 20964547	2011
Are zinc-finger domains of protein kinase C dynamic structures that unfold by lipid or redox activation? Antioxidants & redox signaling\| PubMed ID: 21067413	2011
The redoxome: Proteomic analysis of cellular redox networks. Current opinion in chemical biology\| PubMed ID: 21130023	2011
Chlorinated phenols control the expression of the multidrug resistance efflux pump MexAB-OprM in Pseudomonas aeruginosa by interacting with NalC. Molecular microbiology\| PubMed ID: 21231970	2011
Genetic selection designed to stabilize proteins uncovers a chaperone called Spy. Nature structural & molecular biology\| PubMed ID: 21317898	2011
Using quantitative redox proteomics to dissect the yeast redoxome. The Journal of biological chemistry\| PubMed ID: 21976664	2011
E. coli chaperones DnaK, Hsp33 and Spy inhibit bacterial functional amyloid assembly. Prion\| PubMed ID: 22156728	2011
Hsp33 confers bleach resistance by protecting elongation factor Tu against oxidative degradation in Vibrio cholerae. Molecular microbiology\| PubMed ID: 22296329	2012
Order out of disorder: working cycle of an intrinsically unfolded chaperone. Cell\| PubMed ID: 22385960	2012
Redox, haem and CO in enzymatic catalysis and regulation. Biochemical Society transactions\| PubMed ID: 22616859	2012
Quantitative in vivo redox sensors uncover oxidative stress as an early event in life. Molecular cell\| PubMed ID: 22819323	2012
Conditional disorder in chaperone action. Trends in biochemical sciences\| PubMed ID: 23018052	2012
Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked. Journal of cell science\| PubMed ID: 23203805	2013
Redox control: A black hole for oxidized glutathione. Nature chemical biology\| PubMed ID: 23334544	2013
Time line of redox events in aging postmitotic cells. eLife\| PubMed ID: 23390587	2013
The roles of conditional disorder in redox proteins. Current opinion in structural biology\| PubMed ID: 23477949	2013
NemR is a bleach-sensing transcription factor. The Journal of biological chemistry\| PubMed ID: 23536188	2013
Nonnative disulfide bond formation activates the σ32-dependent heat shock response in Escherichia coli. Journal of bacteriology\| PubMed ID: 23585533	2013
Bacterial responses to reactive chlorine species. Annual review of microbiology\| PubMed ID: 23768204	2013
Oxidant sensing by reversible disulfide bond formation. The Journal of biological chemistry\| PubMed ID: 23861395	2013
The RclR protein is a reactive chlorine-specific transcription factor in Escherichia coli. The Journal of biological chemistry\| PubMed ID: 24078635	2013
Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function. Chemical reviews\| PubMed ID: 24502763	2014
Polyphosphate is a primordial chaperone. Molecular cell\| PubMed ID: 24560923	2014
Thiol-based redox switches. Biochimica et biophysica acta\| PubMed ID: 24657586	2014
Bile salts act as effective protein-unfolding agents and instigators of disulfide stress in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24706920	2014
About the dangers, costs and benefits of living an aerobic lifestyle. Biochemical Society transactions\| PubMed ID: 25109979	2014
The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions. Molecular cell\| PubMed ID: 25242142	2014
The 'mitoflash' probe cpYFP does not respond to superoxide. Nature\| PubMed ID: 25341790	2014
HdeB functions as an acid-protective chaperone in bacteria. The Journal of biological chemistry\| PubMed ID: 25391835	2015
Oxidative stress protection by polyphosphate--new roles for an old player. Current opinion in microbiology\| PubMed ID: 25589044	2015
Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25646478	2015
Protein quality control under oxidative stress conditions. Journal of molecular biology\| PubMed ID: 25698115	2015
Does the Transcription Factor NemR Use a Regulatory Sulfenamide Bond to Sense Bleach? Antioxidants & redox signaling\| PubMed ID: 25867078	2015
HdeB functions as an acid-protective chaperone in bacteria. The Journal of biological chemistry\| PubMed ID: 25888567	2015
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Nature communications\| PubMed ID: 26612684	2015
Protein unfolding as a switch from self-recognition to high-affinity client binding. Nature communications\| PubMed ID: 26787517	2016
Do nucleic acids moonlight as molecular chaperones? Nucleic acids research\| PubMed ID: 27105849	2016
Polyphosphate: A Conserved Modifier of Amyloidogenic Processes. Molecular cell\| PubMed ID: 27570072	2016