Janet L. Smith

Bioscience Division, Millipore Inc

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 56	2010

Other Publications

Article	Year
A biologist's guide to synchrotron facilities: the BioSync web resource. Trends in biochemical sciences\| PubMed ID: 11943550	2002
Identification of four candidate cGMP targets in Dictyostelium. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12011437	2002
A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium. The EMBO journal\| PubMed ID: 12198158	2002
Dictyostelium discoideum has a single diacylglycerol kinase gene with similarity to mammalian theta isoforms. The Biochemical journal\| PubMed ID: 12296770	2002
Differential functional properties of calmodulin-dependent protein kinase IIgamma variants isolated from smooth muscle. The Biochemical journal\| PubMed ID: 12603201	2003
cGMP signalling: different ways to create a pathway. Trends in genetics : TIG\| PubMed ID: 12615006	2003
A defined protein-detergent-lipid complex for crystallization of integral membrane proteins: The cytochrome b6f complex of oxygenic photosynthesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12702760	2003
Toward understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerolphosphate synthase: crystal structures of a ternary complex and the free enzyme. Biochemistry\| PubMed ID: 12795595	2003
Substrate-induced changes in the ammonia channel for imidazole glycerol phosphate synthase. Biochemistry\| PubMed ID: 12795596	2003
The purine repressor of Bacillus subtilis: a novel combination of domains adapted for transcription regulation. Journal of bacteriology\| PubMed ID: 12837783	2003
Functional dissection of the Bacillus subtilis pur operator site. Journal of bacteriology\| PubMed ID: 12837784	2003
Signaling pathways regulating Dictyostelium myosin II. Journal of muscle research and cell motility\| PubMed ID: 12952069	2002
Structure of the cytochrome b6f complex of oxygenic photosynthesis: tuning the cavity. Science (New York, N.Y.)\| PubMed ID: 14526088	2003
Regulatory mechanism of Dictyostelium myosin light chain kinase A. The Journal of biological chemistry\| PubMed ID: 14570871	2004
Crystal structure of imidazole glycerol-phosphate dehydratase: duplication of an unusual fold. The Journal of biological chemistry\| PubMed ID: 14724278	2004
The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15070734	2004
Evolution of photosynthesis: time-independent structure of the cytochrome b6f complex. Biochemistry\| PubMed ID: 15147175	2004
[Structure and function of the cytochrome b6f complex of oxygenic photosynthesis]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 15242052	2004
Cytochrome bc complexes: a common core of structure and function surrounded by diversity in the outlying provinces. Current opinion in structural biology\| PubMed ID: 15313237	2004
Design, expression, and purification of a Flaviviridae polymerase using a high-throughput approach to facilitate crystal structure determination. Protein science : a publication of the Protein Society\| PubMed ID: 15388860	2004
Structure of the nucleotide complex of PyrR, the pyr attenuation protein from Bacillus caldolyticus, suggests dual regulation by pyrimidine and purine nucleotides. Journal of bacteriology\| PubMed ID: 15716449	2005
A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase. The Journal of biological chemistry\| PubMed ID: 15911615	2005
Identification of potent and selective RNA antagonists of the IFN-gamma-inducible CXCL10 chemokine. Biochemistry\| PubMed ID: 15938634	2005
Structure of the cytochrome b6f complex: new prosthetic groups, Q-space, and the 'hors d'oeuvres hypothesis' for assembly of the complex. Photosynthesis research\| PubMed ID: 15977064	2005
The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase. Biochemistry\| PubMed ID: 16026156	2005
Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing. Journal of virology\| PubMed ID: 16051820	2005
Myosin light chain kinase A is activated by cGMP-dependent and cGMP-independent pathways. FEBS letters\| PubMed ID: 16546177	2006
The dictyostelium kinome--analysis of the protein kinases from a simple model organism. PLoS genetics\| PubMed ID: 16596165	2006
Transmembrane traffic in the cytochrome b6f complex. Annual review of biochemistry\| PubMed ID: 16756511	2006
At a crossroad: standing still and moving forward. American journal of community psychology\| PubMed ID: 16832607	2006
Structural basis for macrolactonization by the pikromycin thioesterase. Nature chemical biology\| PubMed ID: 16969372	2006
Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels. Nature chemical biology\| PubMed ID: 16969373	2006
Catalytic core of alphavirus nonstructural protein nsP4 possesses terminal adenylyltransferase activity. Journal of virology\| PubMed ID: 17005674	2006
Clearing the skies over modular polyketide synthases. ACS chemical biology\| PubMed ID: 17168537	2006
Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease. The Journal of biological chemistry\| PubMed ID: 17337448	2007
Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. The Journal of biological chemistry\| PubMed ID: 17928301	2007
GNAT-like strategy for polyketide chain initiation. Science (New York, N.Y.)\| PubMed ID: 17991863	2007
pyr RNA binding to the Bacillus caldolyticus PyrR attenuation protein - characterization and regulation by uridine and guanosine nucleotides. The FEBS journal\| PubMed ID: 18190533	2008
Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18296644	2008
A 7Î¼m mini-beam improves diffraction data from small or imperfect crystals of macromolecules. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 18391409	2008
Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection. Journal of virology\| PubMed ID: 18495773	2008
Biochemistry. An enzyme assembly line. Science (New York, N.Y.)\| PubMed ID: 18772425	2008
Mocr: a novel fusion tag for enhancing solubility that is compatible with structural biology applications. Protein expression and purification\| PubMed ID: 18824232	2009
Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro. Virology\| PubMed ID: 19036396	2009
Proteins: ever larger, stranger and more dynamic. Current opinion in structural biology\| PubMed ID: 19041238	2008
Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway. The Journal of biological chemistry\| PubMed ID: 19103602	2009
Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. ACS chemical biology\| PubMed ID: 19146481	2009
Mini-beam collimator enables microcrystallography experiments on standard beamlines. Journal of synchrotron radiation\| PubMed ID: 19240333	2009
Metamorphic enzyme assembly in polyketide diversification. Nature\| PubMed ID: 19494914	2009
Insights into tRNA-dependent amidotransferase evolution and catalysis from the structure of the Aquifex aeolicus enzyme. Journal of molecular biology\| PubMed ID: 19520089	2009
Identification of inhibitors of yellow fever virus replication using a replicon-based high-throughput assay. Antimicrobial agents and chemotherapy\| PubMed ID: 19651907	2009
Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. Journal of the American Chemical Society\| PubMed ID: 19835378	2009
Insights into the reactivation of cobalamin-dependent methionine synthase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19846791	2009
Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure (London, England : 1993)\| PubMed ID: 20152156	2010
Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20547879	2010
Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. Angewandte Chemie (International ed. in English)\| PubMed ID: 20623733	2010
Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20660778	2010
A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins. Bioorganic & medicinal chemistry letters\| PubMed ID: 20801036	2010
Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21081698	2010
New ligation-independent cloning vectors compatible with a high-throughput platform for parallel construct expression evaluation using baculovirus-infected insect cells. Protein expression and purification\| PubMed ID: 21262364	2011
Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. The Journal of biological chemistry\| PubMed ID: 21357626	2011
JBluIce-EPICS control system for macromolecular crystallography. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 21358048	2011
Radiation damage in protein crystals is reduced with a micron-sized X-ray beam. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21444772	2011
Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor. The Journal of biological chemistry\| PubMed ID: 21543318	2011
Heterologous production, purification and characterization of enzymatically active Sindbis virus nonstructural protein nsP1. Protein expression and purification\| PubMed ID: 21693190	2011
Structural basis of multifunctionality in a vitamin B12-processing enzyme. The Journal of biological chemistry\| PubMed ID: 21697092	2011
Fast fluorescence techniques for crystallography beamlines. Journal of applied crystallography\| PubMed ID: 21808424	2011
A resource for discovering specific and universal biomarkers for distributed stem cells. PloS one\| PubMed ID: 21818293	2011
Automated sample-scanning methods for radiation damage mitigation and diffraction-based centering of macromolecular crystals. Journal of synchrotron radiation\| PubMed ID: 21862850	2011
A new structural form in the SAM/metal-dependent oâ€‘methyltransferase family: MycE from the mycinamicin biosynthetic pathway. Journal of molecular biology\| PubMed ID: 21884704	2011
A new generation of crystallographic validation tools for the protein data bank. Structure (London, England : 1993)\| PubMed ID: 22000512	2011
Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein science : a publication of the Protein Society\| PubMed ID: 22124946	2012
Targeting phosphoinositide 3-kinase Î´ for allergic asthma. Biochemical Society transactions\| PubMed ID: 22260698	2012