Daniele Piomelli

Drug Discovery and Development, Istituto Italiano di Tecnologia

Affiliated withIstituto Italiano di Tecnologia University of California, Irvine School of Medicine University of California, Irvine

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2016
Publication title	2025

Other Publications

Article	Year
Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain. PloS one\| PubMed ID: 21931796	2011
Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. Molecular pharmacology\| PubMed ID: 16051747	2005
The challenge of brain lipidomics. Prostaglandins & other lipid mediators\| PubMed ID: 16099388	2005
Targeted lipidomics: signaling lipids and drugs of abuse. Prostaglandins & other lipid mediators\| PubMed ID: 16099407	2005
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nature neuroscience\| PubMed ID: 16116451	2005
QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation. Chemical communications (Cambridge, England)\| PubMed ID: 16136230	2005
Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (New York, N.Y.)\| PubMed ID: 16224028	2005
Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure. Endocrinology\| PubMed ID: 16269455	2006
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. Neuropharmacology\| PubMed ID: 16316669	2006
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. British journal of pharmacology\| PubMed ID: 16331291	2006
Postprandial increase of oleoylethanolamide mobilization in small intestine of the Burmese python (Python molurus). American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 16373434	2006
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia. Neuroscience letters\| PubMed ID: 16378681	2006
Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 16541083	2006
Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16702440	2006
Molecular composition of the endocannabinoid system at glutamatergic synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16723519	2006
Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue. The Journal of biological chemistry\| PubMed ID: 16785227	2006
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS drug reviews\| PubMed ID: 16834756	2006
Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring. ChemMedChem\| PubMed ID: 16892344	2006
The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues. Pharmacological research\| PubMed ID: 16935521	2006
Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16997973	2006
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides? European journal of pharmacology\| PubMed ID: 17027744	2006
Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase. Biophysical journal\| PubMed ID: 17098788	2007
Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. Psychopharmacology\| PubMed ID: 17111174	2007
Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. The Journal of biological chemistry\| PubMed ID: 17121838	2007
Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry. Analytical biochemistry\| PubMed ID: 17196922	2007
The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but no... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17210800	2007
Regulation of brain anandamide by acute administration of ethanol. The Biochemical journal\| PubMed ID: 17302558	2007
The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17412883	2007
Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. European journal of pharmacology\| PubMed ID: 17434479	2007
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biological psychiatry\| PubMed ID: 17511970	2007
The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors. Anesthesia and analgesia\| PubMed ID: 17513659	2007
Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17565008	2007
Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use. Schizophrenia research\| PubMed ID: 17566707	2007
A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Molecular pharmacology\| PubMed ID: 17584991	2007
Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry\| PubMed ID: 17649977	2007
The anandamide transport inhibitor AM404 reduces ethanol self-administration. The European journal of neuroscience\| PubMed ID: 17650118	2007
A neuroscientist's guide to lipidomics. Nature reviews. Neuroscience\| PubMed ID: 17882252	2007
The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology\| PubMed ID: 17904589	2008
Enhancement of endocannabinoid signaling and the pharmacotherapy of depression. Pharmacological research : the official journal of the Italian Pharmacological Society\| PubMed ID: 17945507	2007
Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. Journal of lipid research\| PubMed ID: 17957091	2008
Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Annali di chimica\| PubMed ID: 17970304	2007
The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat. Psychopharmacology\| PubMed ID: 17992520	2008
Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors. Journal of mass spectrometry : JMS\| PubMed ID: 18085570	2007
Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling. Chemical communications (Cambridge, England)\| PubMed ID: 18092091	2008
URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chemistry & biology\| PubMed ID: 18096504	2007
Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. Journal of psychopharmacology (Oxford, England)\| PubMed ID: 18308802	2008
Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18367664	2008
Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 18434444	2008
Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. Psychopharmacology\| PubMed ID: 18446329	2008
Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. Journal of medicinal chemistry\| PubMed ID: 18507372	2008
An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters. Psychopharmacology\| PubMed ID: 18545985	2008
The element of surprise. Nature medicine\| PubMed ID: 18607371	2008
The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology\| PubMed ID: 18691603	2009
Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18725543	2008
Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. Biological psychiatry\| PubMed ID: 18814866	2008
The lipid messenger OEA links dietary fat intake to satiety. Cell metabolism\| PubMed ID: 18840358	2008
Distribution and function of monoacylglycerol lipase in the gastrointestinal tract. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 18948437	2008
The collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with biological activity. Journal of mass spectrometry : JMS\| PubMed ID: 19034887	2009
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorganic & medicinal chemistry letters\| PubMed ID: 19128970	2009
Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid. Journal of neural transmission (Vienna, Austria : 1996)\| PubMed ID: 19137236	2009
Rapid pain modulation with nuclear receptor ligands. Brain research reviews\| PubMed ID: 19162071	2009
Responses to stress: from the periphery to the brain. Current opinion in pharmacology\| PubMed ID: 19162545	2009
Lipidomic analysis of endocannabinoid metabolism in biological samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 19171504	2009
Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. The British journal of psychiatry : the journal of mental science\| PubMed ID: 19336792	2009
An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics. Psychopharmacology\| PubMed ID: 19343330	2009
Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia. European journal of pharmacology\| PubMed ID: 19386271	2009
Fat-induced satiety factor oleoylethanolamide enhances memory consolidation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416833	2009
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability. ChemMedChem\| PubMed ID: 19554599	2009
Targeted lipidomics as a tool to investigate endocannabinoid function. International review of neurobiology\| PubMed ID: 19607960	2009
The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs. International review of neurobiology\| PubMed ID: 19607961	2009
A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo. ChemMedChem\| PubMed ID: 19637155	2009
Lipidomic analysis of biological samples by liquid chromatography coupled to mass spectrometry. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19763477	2009
CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice. Pharmacological research\| PubMed ID: 19778614	2010
Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chemistry & biology\| PubMed ID: 19875078	2009
A novel lipidomic strategy reveals plasma phospholipid signatures associated with respiratory disease severity in cystic fibrosis patients. PloS one\| PubMed ID: 19893743	2009
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19926854	2009
A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. Pharmacological research\| PubMed ID: 20044005	2010
Pitfalls and solutions in assaying anandamide transport in cells. Journal of lipid research\| PubMed ID: 20447929	2010
Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. PloS one\| PubMed ID: 20531936	2010
The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20554860	2010
Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 20571484	2010
Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. Journal of medicinal chemistry\| PubMed ID: 20604568	2010
Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biological psychiatry\| PubMed ID: 20801430	2011
Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PloS one\| PubMed ID: 20838618	2010
Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. Journal of Alzheimer's disease : JAD\| PubMed ID: 20847439	2010
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nature neuroscience\| PubMed ID: 20852626	2010
Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nature reviews. Neuroscience\| PubMed ID: 20852655	2010
PER2 controls lipid metabolism by direct regulation of PPARγ. Cell metabolism\| PubMed ID: 21035761	2010
Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. Psychopharmacology\| PubMed ID: 21042794	2011
Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. The Journal of clinical endocrinology and metabolism\| PubMed ID: 21177788	2011
Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity. Cell metabolism\| PubMed ID: 21195353	2011
Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. British journal of pharmacology\| PubMed ID: 21198549	2011
Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages. Molecular pharmacology\| PubMed ID: 21233218	2011
Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling. Chemical communications (Cambridge, England)\| PubMed ID: 21240393	2011
Plasma lipidomics reveals potential prognostic signatures within a cohort of cystic fibrosis patients. Journal of lipid research\| PubMed ID: 21335323	2011
Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21490214	2011
Diacylglycerol lipase-alpha and -beta control neurite outgrowth in neuro-2a cells through distinct molecular mechanisms. Molecular pharmacology\| PubMed ID: 21493725	2011
Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease. Prostaglandins, leukotrienes, and essential fatty acids\| PubMed ID: 21543199	2011
An amyloid Î²(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiology of aging\| PubMed ID: 21546126	2011
New lipidomic approaches in cystic fibrosis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21547738	2011
Endocannabinoid signal in the gut controls dietary fat intake. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21730161	2011
Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. The Journal of biological chemistry\| PubMed ID: 21757729	2011
The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system. Pharmacological research\| PubMed ID: 21767647	2011
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability. European journal of medicinal chemistry\| PubMed ID: 21820769	2011
Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas. Journal of medicinal chemistry\| PubMed ID: 21830831	2011
A thickening network of lipids. Pain\| PubMed ID: 22019134	2012
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PloS one\| PubMed ID: 22046234	2011
A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nature neuroscience\| PubMed ID: 22101642	2011
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. PloS one\| PubMed ID: 22140525	2011
Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp -/- mice. Journal of lipid research\| PubMed ID: 22327204	2012
Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts. Advances in nutrition (Bethesda, Md.)\| PubMed ID: 22332103	2012
A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations. PloS one\| PubMed ID: 22389698	2012
2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. Cell metabolism\| PubMed ID: 22405068	2012
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacological research\| PubMed ID: 22420940	2012
N-(2-oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships. Journal of medicinal chemistry\| PubMed ID: 22515328	2012
The thrifty lipids: endocannabinoids and the neural control of energy conservation. Trends in neurosciences\| PubMed ID: 22622030	2012
Selective cannabinoid-1 receptor blockade benefits fatty acid and triglyceride metabolism significantly in weight-stable nonhuman primates. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 22761159	2012
Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22787031	2012
Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. Pediatric research\| PubMed ID: 22821058	2012
Associations of fatty acids in cerebrospinal fluid with peripheral glucose concentrations and energy metabolism. PloS one\| PubMed ID: 22911803	2012
Peroxisome proliferator-activated receptor α mediates acute effects of palmitoylethanolamide on sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22972997	2012
Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nature communications\| PubMed ID: 23011134	2012
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. Journal of medicinal chemistry\| PubMed ID: 23033965	2012
Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. Journal of medicinal chemistry\| PubMed ID: 23043222	2012
Synergistic effects of galantamine and memantine in attenuating scopolamine-induced amnesia in mice. Journal of pharmacological sciences\| PubMed ID: 23149577	2012
Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain\| PubMed ID: 23218523	2013
A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase. Journal of the American Chemical Society\| PubMed ID: 23240907	2013
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Scientific reports\| PubMed ID: 23301156	2013
Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors. Journal of medicinal chemistry\| PubMed ID: 23425199	2013
Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease. PloS one\| PubMed ID: 23441223	2013
Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23463697	2013
Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity. Brain and behavior\| PubMed ID: 23532860	2013
A fatty gut feeling. Trends in endocrinology and metabolism: TEM\| PubMed ID: 23567058	2013
Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). Journal of medicinal chemistry\| PubMed ID: 23614460	2013
Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors. Journal of medicinal chemistry\| PubMed ID: 23822179	2013
Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH. Chembiochem : a European journal of chemical biology\| PubMed ID: 23918626	2013
More surprises lying ahead. The endocannabinoids keep us guessing. Neuropharmacology\| PubMed ID: 23954677	2014
Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. Journal of medicinal chemistry\| PubMed ID: 23991897	2013
Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease. Human molecular genetics\| PubMed ID: 24158850	2014
A glycosylated, labionin-containing lanthipeptide with marked antinociceptive activity. ACS chemical biology\| PubMed ID: 24191663	2014
Brown adipose tissue quantification in human neonates using water-fat separated MRI. PloS one\| PubMed ID: 24205024	2013
Fluorine NMR-based screening on cell membrane extracts. ChemMedChem\| PubMed ID: 24339446	2014
Effects of acute stress on cardiac endocannabinoids, lipogenesis, and inflammation in rats. Psychosomatic medicine\| PubMed ID: 24367128	2014
Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors. ChemMedChem\| PubMed ID: 24403170	2014
Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1. The Journal of biological chemistry\| PubMed ID: 24425865	2014
Peripheral gating of pain signals by endogenous lipid mediators. Nature neuroscience\| PubMed ID: 24473264	2014
A discount on cannabinoids. Biological psychiatry\| PubMed ID: 24560432	2014
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase. Chemical communications (Cambridge, England)\| PubMed ID: 24691497	2014
Sample preparation and orthogonal chromatography for broad polarity range plasma metabolomics: application to human subjects with neurodegenerative dementia. Analytical biochemistry\| PubMed ID: 24708938	2014
Advances in the discovery of N-acylethanolamine acid amidase inhibitors. Pharmacological research\| PubMed ID: 24798679	2014
Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 24820537	2014
3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration. ChemMedChem\| PubMed ID: 24828120	2014
Role of oleoylethanolamide as a feeding regulator in goldfish. The Journal of experimental biology\| PubMed ID: 24855680	2014
β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine. ACS medicinal chemistry letters\| PubMed ID: 24900487	2012
A mighty (ochondrial) fight? Molecular metabolism\| PubMed ID: 24944892	2014
Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain. Pharmacological research\| PubMed ID: 24993496	2014
O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors. ChemMedChem\| PubMed ID: 25338703	2015
Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N-acylethanolamine acid amidase (NAAA) inhibitors. Journal of medicinal chemistry\| PubMed ID: 25380517	2014
A lipid gate for the peripheral control of pain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25392487	2014
Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase. Angewandte Chemie (International ed. in English)\| PubMed ID: 25395373	2015
Intestinal lipid-derived signals that sense dietary fat. The Journal of clinical investigation\| PubMed ID: 25642767	2015
Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis. PloS one\| PubMed ID: 25671639	2015
Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids. Structure (London, England : 1993)\| PubMed ID: 25684574	2015
Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice. The Journal of physiology\| PubMed ID: 25728242	2015
Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LC-MS/MS. Analytical and bioanalytical chemistry\| PubMed ID: 25749796	2015
Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 25754762	2015
Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 25757568	2015
A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation. ACS chemical biology\| PubMed ID: 25874594	2015
Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacological research\| PubMed ID: 25882247	2015
Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. Chemistry & biology\| PubMed ID: 26000748	2015
Feeding-induced oleoylethanolamide mobilization is disrupted in the gut of diet-induced obese rodents. Biochimica et biophysica acta\| PubMed ID: 26024927	2015
Role of the satiety factor oleoylethanolamide in alcoholism. Addiction biology\| PubMed ID: 26037332	2016
Activity-Based Probe for N-Acylethanolamine Acid Amidase. ACS chemical biology\| PubMed ID: 26102511	2015
Monoglyceride lipase: Structure and inhibitors. Chemistry and physics of lipids\| PubMed ID: 26216043	2016
Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice. PloS one\| PubMed ID: 26263173	2015
Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 26290104	2015
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 26361059	2016
A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation. ChemMedChem\| PubMed ID: 26486424	2016
Endocannabinoid signaling mediates oxytocin-driven social reward. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26504214	2015
Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. The Journal of biological chemistry\| PubMed ID: 26553872	2016
Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats. Psychopharmacology\| PubMed ID: 26558620	2016
Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies. Journal of medicinal chemistry\| PubMed ID: 26560855	2015
Macrophage-derived lipid agonists of PPAR-α as intrinsic controllers of inflammation. Critical reviews in biochemistry and molecular biology\| PubMed ID: 26585314	2016
Wagging the Tail: Essential Role of Substrate Flexibility in FAAH Catalysis. Journal of chemical theory and computation\| PubMed ID: 26588763	2013
Fluorine nuclear magnetic resonance-based assay in living mammalian cells. Analytical biochemistry\| PubMed ID: 26686030	2016
Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies. European journal of medicinal chemistry\| PubMed ID: 26774927	2016
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies. European journal of medicinal chemistry\| PubMed ID: 26866968	2016
A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice. Psychopharmacology\| PubMed ID: 26873082	2016
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. Journal of medicinal chemistry\| PubMed ID: 26888301	2016
Vaccenic acid suppresses intestinal inflammation by increasing the endocannabinoid anandamide and non-cannabinoid signaling molecules in a rat model of the metabolic syndrome. Journal of lipid research\| PubMed ID: 26891736	2016
A simple and accurate protocol for absolute polar metabolite quantification in cell cultures using quantitative nuclear magnetic resonance. Analytical biochemistry\| PubMed ID: 26898303	2016
Ion mobility mass spectrometry enhances low-abundance species detection in untargeted lipidomics. Metabolomics : Official journal of the Metabolomic Society\| PubMed ID: 26900387	2016
Assay of Monoacylglycerol Lipase Activity. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27245902	2016
Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition. Metabolism: clinical and experimental\| PubMed ID: 27282869	2016
Absolute nutrient concentration measurements in cell culture media: (1)H q-NMR spectra and data to compare the efficiency of pH-controlled protein precipitation versus CPMG or post-processin... Data in brief\| PubMed ID: 27331118	2016
Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis. Angewandte Chemie (International ed. in English)\| PubMed ID: 27404798	2016
Endogenous N-acyl taurines regulate skin wound healing. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27412859	2016
Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL. Scientific reports\| PubMed ID: 27499063	2016
A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation. eNeuro\| PubMed ID: 27517090	2016
Bile Acid Recognition by NAPE-PLD. ACS chemical biology\| PubMed ID: 27571266	2016
A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena. Experimental neurology\| PubMed ID: 16022863	2005
Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels. Journal of Alzheimer's disease : JAD\| PubMed ID: 28035926	2017
Legal or Illegal, Cannabis Is Still Addictive. Cannabis and cannabinoid research\| PubMed ID: 28861480	2016
Medicinal Cannabis in California: An Interview with Igor Grant, MD. Cannabis and cannabinoid research\| PubMed ID: 28861482	2016
Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage. The Journal of clinical endocrinology and metabolism\| PubMed ID: 29300902	2018
Endocannabinoid Anandamide Mediates the Effect of Skeletal Muscle Sphingomyelins on Human Energy Expenditure. The Journal of clinical endocrinology and metabolism\| PubMed ID: 30113648	2018
Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study. Aging\| PubMed ID: 30620722	2019
Inhibition of ceramide biosynthesis affects aging phenotype in an model of neuronal senescence. Aging\| PubMed ID: 31467258	2019
Serum Endocannabinoid Levels in Patients With End-Stage Renal Disease. Journal of the Endocrine Society\| PubMed ID: 31583368	2019
Circulating Endocannabinoids and Mortality in Hemodialysis Patients. American journal of nephrology\| PubMed ID: 31935741	2020
Comparative Pharmacokinetics of Δ-Tetrahydrocannabinol in Adolescent and Adult Male Mice. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 32345621	2020
N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats. Psychopharmacology\| PubMed ID: 33037452	2021
Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy. Human molecular genetics\| PubMed ID: 33410456	2021
Impact of Circulating N-Acylethanolamine Levels with Clinical and Laboratory End Points in Hemodialysis Patients. American journal of nephrology\| PubMed ID: 33601382	2021
Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain. Pharmacological research\| PubMed ID: 33722712	2021
Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active -Acylethanolamine Acid Amidase I... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 33986036	2021
Persistent Exposure to Δ-Tetrahydrocannabinol during Adolescence Does Not Affect Nociceptive Responding in Adult Mice. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 34183435	2021
Frequent Δ- tetrahydrocannabinol exposure during adolescence impairs sociability in adult mice exposed to an aversive painful stimulus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology\| PubMed ID: 34358818	2021
Endocannabinoid-Based Therapies. Annual review of pharmacology and toxicology\| PubMed ID: 34516291	2022
NAAA-regulated lipid signaling governs the transition from acute to chronic pain. Science advances\| PubMed ID: 34678057	2021
Reduced DMPC and PMPC in lung surfactant promote SARS-CoV-2 infection in obesity. Metabolism: clinical and experimental\| PubMed ID: 35311662	2022
Diet-Induced Obesity Disrupts Histamine-Dependent Oleoylethanolamide Signaling in the Mouse Liver. Pharmacology\| PubMed ID: 35691287	2022
Frequent Low-Dose Δ-Tetrahydrocannabinol in Adolescence Disrupts Microglia Homeostasis and Disables Responses to Microbial Infection and Social Stress in Young Adulthood. Biological psychiatry\| PubMed ID: 35750512	2022
Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonism. Pharmacological research\| PubMed ID: 35781057	2022
Synergistic antinociceptive effects of concomitant NAAA and peripheral FAAH inhibition. Experimental neurology\| PubMed ID: 35932800	2022
A Decision 85 Years in the Making. Cannabis and cannabinoid research\| PubMed ID: 36350696	2022
Nasal accumulation and metabolism of Δ-tetrahydrocannabinol following aerosol ('vaping') administration in an adolescent rat model. Pharmacological research\| PubMed ID: 36481259	2023
Adolescent exposure to low-dose Δ9-tetrahydrocannabinol depletes the ovarian reserve in female mice. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 36912754	2023
Fatty acid amide hydrolase inhibition alleviates anxiety-like symptoms in a rat model used to study post-traumatic stress disorder. Psychopharmacology\| PubMed ID: 37017699	2025
Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood. Cell metabolism\| PubMed ID: 37267956	2023
Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice. Pharmacological research\| PubMed ID: 38159785	2024
A preclinical model of THC edibles that produces high-dose cannabimimetic responses. eLife\| PubMed ID: 38214701	2024
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. Journal of medicinal chemistry\| PubMed ID: 38241614	2024
NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice. Nature communications\| PubMed ID: 38402219	2024
Δ-Tetrahydrocannabinol Alleviates Hyperalgesia in a Humanized Mouse Model of Sickle Cell Disease. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 38955494	2024
Proteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation. Biomolecules\| PubMed ID: 39334909	2024
Metabolic reprogramming in the spinal cord drives the transition to pain chronicity. bioRxiv : the preprint server for biology\| PubMed ID: 39975205	2025
Adolescent exposure to Δ9-tetrahydrocannabinol (THC) impairs testicular function in young adult male mice. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 40127192	2025