Scott K. Durum

Laboratory of Molecular Immunoregulation, National Cancer Institute, National Institutes of Health

Affiliated withNational Cancer Institute, National Institutes of Health National Institutes of Health

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 2	2017
Publication title	2023

Other Publications

Article	Year
IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases. Cellular signalling\| PubMed ID: 12034357	2002
Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax. Blood\| PubMed ID: 12070030	2002
The role of cytokines in lymphocyte homeostasis. BioTechniques\| PubMed ID: 12395926	2002
Lymphocide: cytokines and the control of lymphoid homeostasis. Nature reviews. Immunology\| PubMed ID: 12415306	2002
Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity\| PubMed ID: 12433363	2002
Characterization of an interleukin-7-dependent thymic cell line derived from a p53(-/-) mouse. Journal of immunological methods\| PubMed ID: 12609543	2003
Interleukin-7 induces MUC1. Cancer biology & therapy\| PubMed ID: 12750562	2003
Death and Baxes: mechanisms of lymphotrophic cytokines. Immunological reviews\| PubMed ID: 12752670	2003
Bcl11: sibling rivalry in lymphoid development. Nature immunology\| PubMed ID: 12774073	2003
IL-7 induces tyrosine phosphorylation of clathrin heavy chain. Cellular signalling\| PubMed ID: 14636898	2004
Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival. The Journal of biological chemistry\| PubMed ID: 15123689	2004
Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members. Molecular and cellular biology\| PubMed ID: 15226449	2004
Cytokine-driven cell cycling is mediated through Cdc25A. The Journal of cell biology\| PubMed ID: 15928203	2005
Cell biology of IL-7, a key lymphotrophin. Cytokine & growth factor reviews\| PubMed ID: 15996891	2005
The adaptive immune response in neonatal cerebral white matter damage. Annals of neurology\| PubMed ID: 16250014	2005
Stat5a/b are essential for normal lymphoid development and differentiation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16418296	2006
IL-7 promotes T cell proliferation through destabilization of p27Kip1. The Journal of experimental medicine\| PubMed ID: 16492801	2006
Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations. Journal of leukocyte biology\| PubMed ID: 16793919	2006
Role of the intracellular domain of IL-7 receptor in T cell development. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17182559	2007
IL-7 induces myelopoiesis and erythropoiesis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17237404	2007
Interleukin-7 receptor expression: intelligent design. Nature reviews. Immunology\| PubMed ID: 17259970	2007
The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells. Journal of leukocyte biology\| PubMed ID: 18653463	2008
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. Blood\| PubMed ID: 18664628	2008
Live from the liver: hepatocyte IL-7. Immunity\| PubMed ID: 19303385	2009
Visualization and identification of IL-7 producing cells in reporter mice. PloS one\| PubMed ID: 19907640	2009
Synergy of IL-23 and Th17 cytokines: new light on inflammatory bowel disease. Neurochemical research\| PubMed ID: 19915978	2010
Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival. Molecular and cellular biology\| PubMed ID: 19933849	2010
Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7. Experimental hematology\| PubMed ID: 20831893	2010
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nature genetics\| PubMed ID: 21892159	2011
Detection of nuclear and membrane antigens by liquid-based cytology following long-term storage of d1 cells, karpas cells, and peripheral blood mononuclear cells. Annals of clinical and laboratory science\| PubMed ID: 22166505	2011
Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity\| PubMed ID: 22177921	2011
The human IL-7 receptor gene: deletions, polymorphisms and mutations. Seminars in immunology\| PubMed ID: 22425228	2012
The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes. Biochimica et biophysica acta\| PubMed ID: 22728771	2012
Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation. BMC immunology\| PubMed ID: 22897934	2012
Oral Delivery of IL27 Recombinant Bacteria Attenuates Immune Colitis in Mice. Gastroenterology\| PubMed ID: 24120477	2013
Stemness of T cells and the hematopoietic stem cells: fate, memory, niche, cytokines. Cytokine & growth factor reviews\| PubMed ID: 24231048	2013
Targeting interleukins for the treatment of inflammatory bowel disease-what lies beyond anti-TNF therapy? Inflammatory bowel diseases\| PubMed ID: 24356385	2014
Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. PLoS pathogens\| PubMed ID: 24603698	2014
IL-7 and TSLP receptors: twisted sisters. Blood\| PubMed ID: 24993875	2014
Adaptive immunity to murine skin commensals. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25002505	2014
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nature immunology\| PubMed ID: 25621825	2015
IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice. Frontiers in immunology\| PubMed ID: 26834739	2015
Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases. PloS one\| PubMed ID: 27171183	2016
Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature. Inflammatory bowel diseases\| PubMed ID: 27243591	2016
Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment. Blood\| PubMed ID: 27268088	2016
Th22 Cells Form a Distinct Th Lineage from Th17 Cells In Vitro with Unique Transcriptional Properties and Tbet-Dependent Th1 Plasticity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28100680	2017
The promise of Janus kinase inhibitors in the treatment of hematological malignancies. Cytokine\| PubMed ID: 28277287	2017
Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia. Leukemia\| PubMed ID: 29535426	2018
The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn's Disease-Like Ileitis. Inflammatory bowel diseases\| PubMed ID: 29554272	2018
Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations. Oncotarget\| PubMed ID: 29854301	2018
Cytokine Tuning of Intestinal Epithelial Function. Frontiers in immunology\| PubMed ID: 29922293	2018
Can We Target Endogenous Anti-inflammatory Responses as a Therapeutic Strategy for Inflammatory Bowel Disease? Inflammatory bowel diseases\| PubMed ID: 30020451	2018
Clonal Vγ6Vδ4 T cells promote IL-17-mediated immunity against skin infection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31088972	2019
IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis. The European respiratory journal\| PubMed ID: 31196943	2019
New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models. Leukemia\| PubMed ID: 31439943	2020
NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling. Oncogene\| PubMed ID: 31586130	2020
Mutations that collaborate with IL-7Ra signaling pathways to drive ALL. Advances in biological regulation\| PubMed ID: 33578108	2021
Trained ILC3 responses promote intestinal defense. Science (New York, N.Y.)\| PubMed ID: 35201883	2022
Joost J. Oppenheim (1934-2022). Nature immunology\| PubMed ID: 35835963	2022
IL-7: Comprehensive review. Cytokine\| PubMed ID: 36201890	2022
A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer. International journal of molecular sciences\| PubMed ID: 36675167	2023
IL-27 induces an IFN-like signature in murine macrophages which in turn modulate colonic epithelium. Frontiers in immunology\| PubMed ID: 37153622	2023