Johannes Loffing

Institute of Anatomy, University of Zürich

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 24	2016

Other Publications

Article	Year
A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. The Journal of biological chemistry\| PubMed ID: 11707463	2002
Cell-surface expression of the channel activating protease xCAP-1 is required for activation of ENaC in the Xenopus oocyte. Journal of the American Society of Nephrology : JASN\| PubMed ID: 11856761	2002
Human cortical distal nephron: distribution of electrolyte and water transport pathways. Journal of the American Society of Nephrology : JASN\| PubMed ID: 11912242	2002
Impaired renal Na(+) retention in the sgk1-knockout mouse. The Journal of clinical investigation\| PubMed ID: 12417564	2002
Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human. American journal of physiology. Renal physiology\| PubMed ID: 12620920	2003
SGK1: aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 12649599	2003
Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney. Kidney international\| PubMed ID: 12846750	2003
Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. The Journal of clinical investigation\| PubMed ID: 12925696	2003
Dysfunction of the epithelial sodium channel expressed in the kidney of a mouse model for Liddle syndrome. Journal of the American Society of Nephrology : JASN\| PubMed ID: 12937297	2003
Impaired regulation of renal K+ elimination in the sgk1-knockout mouse. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15034090	2004
A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes. American journal of physiology. Renal physiology\| PubMed ID: 15140763	2004
Loss-of-function mutations of the K(+) channel gene KCNJ2 constitute a rare cause of long QT syndrome. Journal of molecular and cellular cardiology\| PubMed ID: 15276028	2004
Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15339977	2004
Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule. American journal of physiology. Renal physiology\| PubMed ID: 15345493	2004
Paradoxical antidiuretic effect of thiazides in diabetes insipidus: another piece in the puzzle. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15504949	2004
Role of Sgk1 in salt and potassium homeostasis. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 15590995	2005
Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15743993	2005
Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys. Histochemistry and cell biology\| PubMed ID: 15856273	2005
Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. The Journal of clinical investigation\| PubMed ID: 15902302	2005
Sodium retention in rats with liver cirrhosis is associated with increased renal abundance of NaCl cotransporter (NCC). Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 15956070	2005
Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15958725	2005
Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism. The Journal of biological chemistry\| PubMed ID: 16172119	2005
Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus. American journal of physiology. Renal physiology\| PubMed ID: 16174864	2006
Functional domains of the epithelial sodium channel. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16192417	2005
Tissue kallikrein-deficient mice display a defect in renal tubular calcium absorption. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16251243	2005
Hyperaldosteronemia and activation of the epithelial sodium channel are not required for sodium retention in puromycin-induced nephrosis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16267158	2005
Sgk kinases and their role in epithelial transport. Annual review of physiology\| PubMed ID: 16460280	2006
Dietary sodium intake regulates the ubiquitin-protein ligase nedd4-2 in the renal collecting system. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16571785	2006
Pendrin regulation in mouse kidney primarily is chloride-dependent. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16825334	2006
Replication of segment-specific and intercalated cells in the mouse renal collecting system. Histochemistry and cell biology\| PubMed ID: 17186265	2007
Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor. Journal of the American Society of Nephrology : JASN\| PubMed ID: 17475815	2007
Renal expression of parvalbumin is critical for NaCl handling and response to diuretics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17804801	2007
Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins. American journal of physiology. Renal physiology\| PubMed ID: 18322017	2008
Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension. American journal of physiology. Renal physiology\| PubMed ID: 18480177	2008
Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC). Pflügers Archiv : European journal of physiology\| PubMed ID: 19277701	2009
Thiazide effects and adverse effects: insights from molecular genetics. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 19564550	2009
In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. American journal of physiology. Renal physiology\| PubMed ID: 20861076	2010
Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20921400	2010
alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21051735	2011
Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line. Kidney international\| PubMed ID: 21178974	2011
Inducible renal principal cell-specific mineralocorticoid receptor gene inactivation in mice. American journal of physiology. Renal physiology\| PubMed ID: 21383102	2011
Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney. Histochemistry and cell biology\| PubMed ID: 22466139	2012
A primary culture of distal convoluted tubules expressing functional thiazide-sensitive NaCl transport. American journal of physiology. Renal physiology\| PubMed ID: 22759396	2012
Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron. American journal of physiology. Renal physiology\| PubMed ID: 22933298	2012
Aldosterone deficiency adversely affects pregnancy outcome in mice. Pflugers Archiv : European journal of physiology\| PubMed ID: 22941338	2012
Low-dose oral sirolimus and the risk of menstrual-cycle disturbances and ovarian cysts: analysis of the randomized controlled SUISSE ADPKD trial. PloS one\| PubMed ID: 23071528	2012
Parvalbumin: calcium and magnesium buffering in the distal nephron. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 23144069	2012
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. The Journal of clinical investigation\| PubMed ID: 23348737	2013
Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice. Kidney international\| PubMed ID: 23447069	2013
Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure. American journal of physiology. Renal physiology\| PubMed ID: 23552861	2013
Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nature medicine\| PubMed ID: 24185693	2013
Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension. Journal of the American Society of Nephrology : JASN\| PubMed ID: 24231659	2014
The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation. Pflugers Archiv : European journal of physiology\| PubMed ID: 24310820	2014
Hydrochlorothiazide attenuates lithium-induced nephrogenic diabetes insipidus independently of the sodium-chloride cotransporter. American journal of physiology. Renal physiology\| PubMed ID: 24352504	2014
Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 24578125	2014
Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 24799612	2014
Mechanisms of renal control of potassium homeostasis in complete aldosterone deficiency. Journal of the American Society of Nephrology : JASN\| PubMed ID: 25071088	2015
Gitelman syndrome and glomerular proteinuria: a link between loss of sodium-chloride cotransporter and podocyte dysfunction? Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 25165177	2014
“Deletion of both Rab-GTPase–activating proteins TBC1D1 and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport [corrected]. Diabetes\| PubMed ID: 25249576	2015
Dietary potassium and the renal control of salt balance and blood pressure. Pflugers Archiv : European journal of physiology\| PubMed ID: 25559844	2015
Akt Substrate of 160 kD Regulates Na+,K+-ATPase Trafficking in Response to Energy Depletion and Renal Ischemia. Journal of the American Society of Nephrology : JASN\| PubMed ID: 25788531	2015
Deletion of both Rab-GTPase-activating proteins TBC14KO and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport. Diabetes 2015;64:746-759. Diabetes\| PubMed ID: 25805765	2015
ENaC activity in collecting ducts modulates NCC in cirrhotic mice. Pflugers Archiv : European journal of physiology\| PubMed ID: 26055235	2015
The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier. Kidney international\| PubMed ID: 26154927	2015
Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney. American journal of physiology. Renal physiology\| PubMed ID: 26336159	2015
An Integrated View of Potassium Homeostasis. The New England journal of medicine\| PubMed ID: 26510040	2015
Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26574046	2016
Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26701978	2016
Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype. Pflugers Archiv : European journal of physiology\| PubMed ID: 26762397	2016
The mineralocorticoid receptor (MR) regulates ENaC but not NCC in mice with random MR deletion. Pflugers Archiv : European journal of physiology\| PubMed ID: 26898302	2016
Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC. American journal of physiology. Renal physiology\| PubMed ID: 27009335	2016
The Authors Reply. Kidney international\| PubMed ID: 27083290	2016
TRPV4 is associated with central rather than nephrogenic osmoregulation. Pflugers Archiv : European journal of physiology\| PubMed ID: 27364478	2016
Extracellular K(+) rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl(-) -dependent and independent mechanisms. The Journal of physiology\| PubMed ID: 27457700	2016