Mitchell Kronenberg

Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology

Affiliated withLa Jolla Institute for Allergy and Immunology

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2007
Publication title Cited by 2	2007

Other Publications

Article	Year
Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. The Journal of experimental medicine\| PubMed ID: 11877484	2002
Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice. Clinical immunology (Orlando, Fla.)\| PubMed ID: 11890710	2002
Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides. Immunity\| PubMed ID: 11911821	2002
Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice. Gastroenterology\| PubMed ID: 12055591	2002
The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12133957	2002
Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs. Nature immunology\| PubMed ID: 12154358	2002
The unconventional lifestyle of NKT cells. Nature reviews. Immunology\| PubMed ID: 12154375	2002
CD1 tetramers: a powerful tool for the analysis of glycolipid-reactive T cells. Journal of immunological methods\| PubMed ID: 12213347	2002
Homeostasis of V alpha 14i NKT cells. Nature immunology\| PubMed ID: 12244311	2002
Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. Gastroenterology\| PubMed ID: 12360465	2002
Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12421950	2002
Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12482940	2002
Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12594262	2003
The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory. Immunity\| PubMed ID: 12594948	2003
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nature medicine\| PubMed ID: 12669034	2003
Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics. Immunogenetics\| PubMed ID: 12671739	2003
CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. The Journal of experimental medicine\| PubMed ID: 12682110	2003
Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes. European journal of immunology\| PubMed ID: 12731071	2003
NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. The Journal of experimental medicine\| PubMed ID: 12810685	2003
Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide. European journal of immunology\| PubMed ID: 12811841	2003
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12829795	2003
Cross-presentation of disialoganglioside GD3 to natural killer T cells. The Journal of experimental medicine\| PubMed ID: 12847141	2003
Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12902459	2003
An anti-inflammatory role for V alpha 14 NK T cells in Mycobacterium bovis bacillus Calmette-GuÃ©rin-infected mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12902499	2003
CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12947044	2003
Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14530322	2003
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. The Journal of experimental medicine\| PubMed ID: 14530376	2003
The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells. The Journal of experimental medicine\| PubMed ID: 14557411	2003
Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus. The Journal of clinical investigation\| PubMed ID: 14561706	2003
Natural killer T cells: natural or unnatural regulators of autoimmunity? Current opinion in immunology\| PubMed ID: 14630203	2003
MHC-dependent and -independent modulation of endogenous Ly49 receptors on NK1.1+ T lymphocytes directed by T-cell receptor type. Immunology\| PubMed ID: 14632658	2003
Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity. The Journal of experimental medicine\| PubMed ID: 14676294	2003
Presenting fats with SAPs. Nature immunology\| PubMed ID: 14749781	2004
Surface receptors identify mouse NK1.1+ T cell subsets distinguished by function and T cell receptor type. European journal of immunology\| PubMed ID: 14971030	2004
Expansion of human Valpha24+ NKT cells by repeated stimulation with KRN7000. Journal of immunological methods\| PubMed ID: 14980434	2004
NKT cells: what's in a name? Nature reviews. Immunology\| PubMed ID: 15039760	2004
CD1d1 displayed on cell size beads identifies and enriches an NK cell population negatively regulated by CD1d1. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15100269	2004
Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies. Immunology and cell biology\| PubMed ID: 15186254	2004
The Third Way: Progress on pathways of antigen processing and presentation by CD1. Immunology and cell biology\| PubMed ID: 15186261	2004
The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15304644	2004
Salmonella typhimurium infection halts development of type 1 diabetes in NOD mice. European journal of immunology\| PubMed ID: 15376194	2004
Going both ways: immune regulation via CD1d-dependent NKT cells. The Journal of clinical investigation\| PubMed ID: 15545985	2004
The role of innate immunity in autoimmunity. The Journal of experimental medicine\| PubMed ID: 15611284	2004
ICOS costimulates invariant NKT cell activation. Biochemical and biophysical research communications\| PubMed ID: 15629449	2005
Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15665086	2005
Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15684084	2005
IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2. Blood\| PubMed ID: 15746081	2005
The mouse CD1d cytoplasmic tail mediates CD1d trafficking and antigen presentation by adaptor protein 3-dependent and -independent mechanisms. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15749847	2005
Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15749886	2005
Toward an understanding of NKT cell biology: progress and paradoxes. Annual review of immunology\| PubMed ID: 15771592	2005
Cutting edge: IFN-gamma signaling to macrophages is required for optimal Valpha14i NK T/NK cell cross-talk. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15778340	2005
Recognition of bacterial glycosphingolipids by natural killer T cells. Nature\| PubMed ID: 15791257	2005
Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS biology\| PubMed ID: 15799695	2005
CD1 and MHC II find different means to the same end. Trends in immunology\| PubMed ID: 15866242	2005
A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/d-galactosamine. Virchows Archiv : an international journal of pathology\| PubMed ID: 15906084	2005
Regulation of immunity by self-reactive T cells. Nature\| PubMed ID: 15931212	2005
Mucosal T lymphocytes--peacekeepers and warriors. Springer seminars in immunopathology\| PubMed ID: 15931528	2005
Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15944246	2005
Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15944310	2005
Infection, autoimmunity, and glycolipids: T cells detect microbes through self-recognition. Immunity\| PubMed ID: 15963780	2005
Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16002697	2005
Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. The Journal of experimental medicine\| PubMed ID: 16087713	2005
Phenotypical and functional alterations during the expansion phase of invariant Valpha14 natural killer T (Valpha14i NKT) cells in mice primed with alpha-galactosylceramide. Immunology\| PubMed ID: 16108815	2005
Activation or anergy: NKT cells are stunned by alpha-galactosylceramide. The Journal of clinical investigation\| PubMed ID: 16138189	2005
Carboxylated glycans mediate colitis through activation of NF-kappa B. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16210648	2005
The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16322528	2006
Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH. The Journal of organic chemistry\| PubMed ID: 16323834	2005
V alpha14 i NKT cells are innate lymphocytes that participate in the immune response to diverse microbes. Journal of clinical immunology\| PubMed ID: 16380816	2005
Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16478801	2006
Immediate antigen-specific effector functions by TCR-transgenic CD8+ NKT cells. European journal of immunology\| PubMed ID: 16506291	2006
Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16537470	2006
CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. The New England journal of medicine\| PubMed ID: 16540612	2006
Elevated serum anti-I2 and anti-OmpW antibody levels in children with IBD. Inflammatory bowel diseases\| PubMed ID: 16670528	2006
A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16751279	2006
The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16751390	2006
Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16849474	2006
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nature immunology\| PubMed ID: 16921381	2006
Synergistic costimulation by both B7 molecules regulates colitis pathogenesis. Annals of the New York Academy of Sciences\| PubMed ID: 17057203	2006
Activation of natural killer T cells by glycolipids. Methods in enzymology\| PubMed ID: 17132506	2006
Frontline T cells: gammadelta T cells and intraepithelial lymphocytes. Immunological reviews\| PubMed ID: 17291274	2007
Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs. Immunological reviews\| PubMed ID: 17291288	2007
On the road: progress in finding the unique pathway of invariant NKT cell differentiation. Current opinion in immunology\| PubMed ID: 17303398	2007
Invariant NKT cells amplify the innate immune response to lipopolysaccharide. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17312112	2007
Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17371979	2007
Natural killer T cells: know thyself. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17389403	2007
Paradoxical effect of reduced costimulation in T cell-mediated colitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17442938	2007
The unique role of natural killer T cells in the response to microorganisms. Nature reviews. Microbiology\| PubMed ID: 17487145	2007
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science (New York, N.Y.)\| PubMed ID: 17569825	2007
Invariant natural killer cells in the response to bacteria: the advent of specific antigens. Future microbiology\| PubMed ID: 17661645	2006
Role of NKT cells in the digestive system. IV. The role of canonical natural killer T cells in mucosal immunity and inflammation. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 17947447	2008
CD1 mediated T cell recognition of glycolipids. Current opinion in structural biology\| PubMed ID: 17951048	2007
Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology (Baltimore, Md.)\| PubMed ID: 18098320	2008
Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18250405	2008
Villous B cells of the small intestine are specialized for invariant NK T cell dependence. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18354186	2008
Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18390724	2008
A crucial role for HVEM and BTLA in preventing intestinal inflammation. The Journal of experimental medicine\| PubMed ID: 18519647	2008
Acid test: lipid antigens get into the groove. Immunity\| PubMed ID: 18549793	2008
Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells. Chemistry & biology\| PubMed ID: 18635002	2008
RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis\| PubMed ID: 18689872	2008
Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18802047	2008
Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18802082	2008
Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18832683	2008
NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19060201	2008
NKG2A inhibits invariant NKT cell activation in hepatic injury. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19109156	2009
Detection of microbes by natural killer T cells. Advances in experimental medicine and biology\| PubMed ID: 19209678	2009
Unconventional ligand activation of herpesvirus entry mediator signals cell survival. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19332782	2009
Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells. Immunity\| PubMed ID: 19371709	2009
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners. Seminars in immunopathology\| PubMed ID: 19495760	2009
Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000. Bioorganic & medicinal chemistry letters\| PubMed ID: 19535248	2009
NKT cells turn ten. Nature immunology\| PubMed ID: 19536187	2009
Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells. Immunological reviews\| PubMed ID: 19594637	2009
Innate-like recognition of microbes by invariant natural killer T cells. Current opinion in immunology\| PubMed ID: 19646850	2009
The roles of 3' and 4' hydroxy groups in alpha-galactosylceramide stimulation of invariant natural killer T cells. ChemMedChem\| PubMed ID: 19780098	2009
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nature immunology\| PubMed ID: 19783988	2009
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19815501	2009
Transcriptional regulator Id2 controls survival of hepatic NKT cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19884494	2009
T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19915044	2009
Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19949076	2010
Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20048124	2010
Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080535	2010
A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20083656	2010
Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20190135	2010
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. The Journal of allergy and clinical immunology\| PubMed ID: 20304473	2010
Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. The Journal of experimental medicine\| PubMed ID: 20404101	2010
Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20660713	2010
The VÎ±14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode. The Journal of experimental medicine\| PubMed ID: 20921281	2010
Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signaling. Journal of leukocyte biology\| PubMed ID: 21106644	2011
Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21191069	2011
Hepatic stellate cells function as regulatory bystanders. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21460203	2011
Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 21499735	2011
Invariant NKT cells are required for airway inflammation induced by environmental antigens. The Journal of experimental medicine\| PubMed ID: 21624935	2011
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nature immunology\| PubMed ID: 21892173	2011
Cooling the fires of inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21949393	2011
Mucosal memory CD8âº T cells are selected in the periphery by an MHC class I molecule. Nature immunology\| PubMed ID: 21964609	2011
Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells. PLoS biology\| PubMed ID: 22069376	2011
Glycolipids that elicit IFN-Î³-biased responses from natural killer T cells. Chemistry & biology\| PubMed ID: 22195564	2011
Making memory at birth: understanding the differentiation of natural killer T cells. Current opinion in immunology\| PubMed ID: 22305304	2012