Bertrand Cariou

l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes

Affiliated withINSERM, CNRS, UNIV Nantes, CHU Nantes Nantes Université

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 18	2017
Publication title Cited by 1	2023

Other Publications

Article	Year
Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14. The Journal of biological chemistry\| PubMed ID: 11726652	2002
The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta. Molecular and cellular biology\| PubMed ID: 12242277	2002
Inhibition of FGF receptor signalling in Xenopus oocytes: differential effect of Grb7, Grb10 and Grb14. FEBS letters\| PubMed ID: 12885405	2003
Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice. Endocrinology\| PubMed ID: 14684612	2004
Regulation and functional roles of Grb14. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 14977573	2004
Increased adipose tissue expression of Grb14 in several models of insulin resistance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15059968	2004
Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties. Circulation research\| PubMed ID: 15539630	2004
Farnesoid X receptor: a new player in glucose metabolism? Endocrinology\| PubMed ID: 15713939	2005
Potential regulatory role of the farnesoid X receptor in the metabolic syndrome. Biochimie\| PubMed ID: 15733743	2005
The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition. The Journal of biological chemistry\| PubMed ID: 15899888	2005
Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS letters\| PubMed ID: 16023103	2005
Feasibility and benefit of fluorine 18-fluoro-2-deoxyglucose-guided surgery in the management of radioiodine-negative differentiated thyroid carcinoma metastases. Surgery\| PubMed ID: 16360406	2005
Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. The Journal of biological chemistry\| PubMed ID: 16407292	2006
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. The Journal of biological chemistry\| PubMed ID: 16446356	2006
The expanding role of the bile acid receptor FXR in the small intestine. Journal of hepatology\| PubMed ID: 16618512	2006
FXR: More than a bile acid receptor? Endocrinology\| PubMed ID: 16912235	2006
FXR: a promising target for the metabolic syndrome? Trends in pharmacological sciences\| PubMed ID: 17412431	2007
FXR-deficiency confers increased susceptibility to torpor. FEBS letters\| PubMed ID: 17950284	2007
Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9. The Journal of biological chemistry\| PubMed ID: 18245819	2008
Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes. FEBS letters\| PubMed ID: 18298956	2008
PCSK9 and LDL cholesterol: unravelling the target to design the bullet. Trends in biochemical sciences\| PubMed ID: 18672372	2008
Role of bile acids and bile acid receptors in metabolic regulation. Physiological reviews\| PubMed ID: 19126757	2009
Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19265033	2009
A corticotroph pituitary adenoma as the initial presentation of familial glucocorticoid deficiency. European journal of endocrinology\| PubMed ID: 19423561	2009
High protein intake reduces intrahepatocellular lipid deposition in humans. The American journal of clinical nutrition\| PubMed ID: 19710199	2009
PCSK9 dominant negative mutant results in increased LDL catabolic rate and familial hypobetalipoproteinemia. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19762784	2009
PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion. Biochemical and biophysical research communications\| PubMed ID: 19878649	2009
[Cholesterol metabolism and beta-cell function]. Medecine sciences : M/S\| PubMed ID: 20412743	2010
Association between plasma PCSK9 and gamma-glutamyl transferase levels in diabetic patients. Atherosclerosis\| PubMed ID: 20452593	2010
The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways. The Journal of biological chemistry\| PubMed ID: 20851881	2010
[Dyslipidemia]. La Revue du praticien\| PubMed ID: 21452556	2011
Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes\| PubMed ID: 21593203	2011
Clinical aspects of PCSK9. Atherosclerosis\| PubMed ID: 21596380	2011
Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults. Nutrition & metabolism\| PubMed ID: 21736725	2011
Effects of the new dual PPAR α/δ agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism. Diabetes care\| PubMed ID: 21816979	2011
Lack of association between plasma PCSK9 and LDL-apoB100 catabolism in patients with uncontrolled type 2 diabetes. Atherosclerosis\| PubMed ID: 21889145	2011
[Management of hypercholesterolemia: what target for LDL cholesterol?]. La Revue du praticien\| PubMed ID: 22135977	2011
DPP-4 inhibitors in the treatment of type 2 diabetes. Biochemical pharmacology\| PubMed ID: 22172989	2012
Thiazolidinediones and PPARγ agonists: time for a reassessment. Trends in endocrinology and metabolism: TEM\| PubMed ID: 22513163	2012
Phase II trial of anticarcinoembryonic antigen pretargeted radioimmunotherapy in progressive metastatic medullary thyroid carcinoma: biomarker response and survival improvement. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 22743249	2012
Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long). Diabetes care\| PubMed ID: 23043166	2012
New avenues for the pharmacological management of type 2 diabetes: an update. Annales d'endocrinologie\| PubMed ID: 23078974	2012
Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets. Nutrition & metabolism\| PubMed ID: 23298392	2013
Plasma PCSK9 is a late biomarker of severity in patients with severe trauma injury. The Journal of clinical endocrinology and metabolism\| PubMed ID: 23450051	2013
Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes. Molecular and cellular biology\| PubMed ID: 23530060	2013
Transintestinal cholesterol excretion is an active metabolic process modulated by PCSK9 and statin involving ABCB1. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23559630	2013
Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis... Hepatology (Baltimore, Md.)\| PubMed ID: 23703580	2013
Dual peroxisome proliferator-activated receptor α/δ agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. Diabetes care\| PubMed ID: 23715754	2013
Function of seipin: new insights from Bscl2/seipin knockout mouse models. Biochimie\| PubMed ID: 23831461	2014
A standardized vascular disease health check in europe: a cost-effectiveness analysis. PloS one\| PubMed ID: 23869204	2013
Surgery for 'asymptomatic' mild primary hyperparathyroidism improves some clinical symptoms postoperatively. European journal of endocrinology\| PubMed ID: 23956299	2013
Endocrine side effects of anti-cancer drugs: effects of anti-cancer targeted therapies on lipid and glucose metabolism. European journal of endocrinology\| PubMed ID: 24154684	2014
Mosaicism in HIF2A-related polycythemia-paraganglioma syndrome. The Journal of clinical endocrinology and metabolism\| PubMed ID: 24276449	2014
[Management of metabolic disorders induced by everolimus in patients with differentiated neuroendocrine tumors: expert proposals]. Bulletin du cancer\| PubMed ID: 24557872	2014
Congenital lipodystrophies and dyslipidemias. Current atherosclerosis reports\| PubMed ID: 25047893	2014
Preserved adrenal function in fully PCSK9-deficient subject. International journal of cardiology\| PubMed ID: 25062564	2014
GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes. Expert opinion on investigational drugs\| PubMed ID: 25164277	2014
The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated ... Diabetes & vascular disease research\| PubMed ID: 25212694	2014
Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of s... BMC cardiovascular disorders\| PubMed ID: 25240705	2014
PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet (London, England)\| PubMed ID: 25282519	2015
Long-term effects of Roux-en-Y gastric bypass on postprandial plasma lipid and bile acids kinetics in female non diabetic subjects: A cross-sectional pilot study. Clinical nutrition (Edinburgh, Scotland)\| PubMed ID: 25306425	2015
[Trans-intestinal cholesterol excretion (TICE): a new route for cholesterol excretion]. Medecine sciences : M/S\| PubMed ID: 25311025	2014
[Hormonal evaluation of adrenal incidentalomas]. Annales de biologie clinique\| PubMed ID: 25486661	2014
PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. Atherosclerosis\| PubMed ID: 25621930	2015
Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBO II random... European heart journal\| PubMed ID: 25687353	2015
Management of thyroid nodules incidentally discovered on MIBI scanning for primary hyperparathyroidism. Langenbeck's archives of surgery\| PubMed ID: 25694271	2015
Laparoscopic Gastric Banding in Obese Patients with Sleep Apnea: A 3-Year Controlled Study and Follow-up After 10 Years. Obesity surgery\| PubMed ID: 25702144	2015
Role of PCSK9 beyond liver involvement. Current opinion in lipidology\| PubMed ID: 25887680	2015
Letter from Le May and Cariou regarding article, "Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through ... Circulation\| PubMed ID: 25940972	2015
Clinical use of insulin degludec. Diabetes research and clinical practice\| PubMed ID: 25963320	2015
The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis. Diabetologia\| PubMed ID: 26049403	2015
Patient and Physician Perspectives on Mode of Administration of the PCSK9 Monoclonal Antibody Alirocumab, an Injectable Medication to Lower LDL-C Levels. Clinical therapeutics\| PubMed ID: 26278513	2015
Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. Circulation. Cardiovascular genetics\| PubMed ID: 26374825	2015
mTOR inhibitors and diabetes. Diabetes research and clinical practice\| PubMed ID: 26421362	2015
Vitamin D deficiency is an independent risk factor for PTDM after kidney transplantation. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 26426441	2016
Death, end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes. Diabetologia\| PubMed ID: 26486355	2016
Sotagliflozin as a potential treatment for type 2 diabetes mellitus. Expert opinion on investigational drugs\| PubMed ID: 26548423	2015
Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia. Disease models & mechanisms\| PubMed ID: 26586530	2016
PCSK9 Inhibition: Does Lipoprotein Size Matter? Journal of the American Heart Association\| PubMed ID: 26586733	2015
[A YOUNG MAN WHOSE LDL-CHOLESTEROL IS GREATER THAN 1.9 G/L]. La Revue du praticien\| PubMed ID: 26749708	2015
Identification of novel APOB mutations by targeted next-generation sequencing for the molecular diagnosis of familial hypobetalipoproteinemia. Atherosclerosis\| PubMed ID: 27179706	2016
Efficacy of lixisenatide in patients with type 2 diabetes: A post hoc analysis of patients with diverse β-cell function in the GetGoal-M and GetGoal-S trials. Journal of diabetes and its complications\| PubMed ID: 27267268	2016
Once-Daily Liraglutide Versus Lixisenatide as Add-on to Metformin in Type 2 Diabetes: A 26-Week Randomized Controlled Clinical Trial. Diabetes care\| PubMed ID: 27311491	2016
No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY Phase 3 studies. European heart journal\| PubMed ID: 27460890	2016
Lipid changes during basal insulin peglispro, insulin glargine, or NPH treatment in six IMAGINE trials. Diabetes, obesity & metabolism\| PubMed ID: 27486125	2016
FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency. Diabetes\| PubMed ID: 27554469	2016
Efficacy of alirocumab in high cardiovascular risk populations with or without heterozygous familial hypercholesterolemia: Pooled analysis of eight ODYSSEY Phase 3 clinical program trials. International journal of cardiology\| PubMed ID: 27573600	2016
PCSK9 and atherosclerosis: Beyond LDL-cholesterol lowering. Atherosclerosis\| PubMed ID: 27591126	2016
Glycaemic control influences the relationship between plasma PCSK9 and LDL cholesterol in type 1 diabetes. Diabetes, obesity & metabolism\| PubMed ID: 27804190	2017
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. The lancet. Diabetes & endocrinology\| PubMed ID: 27908689	2017
Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1-7 trials. Diabetes & metabolism\| PubMed ID: 30615985	2019
Severely uncontrolled diabetes: a new aetiology of acquired bisalbuminaemia. Diabetes & metabolism\| PubMed ID: 30660760	2020
EGF-A peptides: A promising strategy for PCSK9 inhibition. Atherosclerosis\| PubMed ID: 31784031	2020
Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes. Metabolism: clinical and experimental\| PubMed ID: 31785259	2020
Circulating PCSK9 levels are not associated with the conversion to type 2 diabetes. Atherosclerosis\| PubMed ID: 31835041	2020
Association between sleep disturbances, fear of hypoglycemia and psychological well-being in adults with type 1 diabetes mellitus, data from cross-sectional VARDIA study. Diabetes research and clinical practice\| PubMed ID: 31866527	2020
Plasma Trimethylamine N-Oxide and Risk of Cardiovascular Events in Patients With Type 2 Diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 32301490	2020
Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia\| PubMed ID: 32472191	2020
Correction to: Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia\| PubMed ID: 32617649	2020
Euglycaemic ketoacidosis during gestational diabetes with concomitant COVID-19 infection. Diabetes & metabolism\| PubMed ID: 32738403	2021
Comment on Chen et al. Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication. Diabetes Care 2020;43:1399-1407. Diabetes care\| PubMed ID: 32958626	2020
Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study. Diabetes & metabolism\| PubMed ID: 33091555	2021
Phenotypic characteristics and prognosis of newly diagnosed diabetes in hospitalized patients with COVID-19: Results from the CORONADO study. Diabetes research and clinical practice\| PubMed ID: 33577905	2021
Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study. Diabetologia\| PubMed ID: 33599800	2021
Impact of parathyroidectomy on cardiovascular risk in primary hyperparathyroidism: A narrative review. Nutrition, metabolism, and cardiovascular diseases : NMCD\| PubMed ID: 33612382	2021
PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs. Stem cell reports\| PubMed ID: 34739847	2021
Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes. Cardiovascular diabetology\| PubMed ID: 35130909	2022
Transintestinal cholesterol excretion in health and disease. Current atherosclerosis reports\| PubMed ID: 35138569	2022
COVID-19 and Diabetes Outcomes: Rationale for and Updates from the CORONADO Study. Current diabetes reports\| PubMed ID: 35171448	2022
Generation of a GPR146 knockout human induced pluripotent stem cell line (ITXi001-A-1). Stem cell research\| PubMed ID: 35247835	2022
CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants. International journal of molecular sciences\| PubMed ID: 35457099	2022
Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort. Cardiovascular diabetology\| PubMed ID: 35681209	2022
Impact of diabetes on COVID-19 prognosis beyond comorbidity burden: the CORONADO initiative. Diabetologia\| PubMed ID: 35701673	2022
Identification of a Gain-of-Function Variant as a Novel Cause of Familial Combined Hypocholesterolemia. Circulation\| PubMed ID: 35899625	2022
PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol. Biochimica et biophysica acta. Molecular and cell biology of lipids\| PubMed ID: 35985474	2022
Effect of the LDL receptor mutation type on incident major adverse cardiovascular events in familial hypercholesterolaemia. European journal of preventive cardiology\| PubMed ID: 36047048	2022
Variants in the Gene Are Associated With a Favorable Cardiometabolic Risk Profile. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 36047410	2022
Associations of microvascular complications with all-cause death in patients with diabetes and COVID-19: The CORONADO, ABCD COVID-19 UK national audit and AMERICADO study groups. Diabetes, obesity & metabolism\| PubMed ID: 36053971	2023
FACS-assisted CRISPR-Cas9 genome editing of human induced pluripotent stem cells. STAR protocols\| PubMed ID: 36115027	2022
Effects of parathyroidectomy on kidney function in patients with primary hyperparathyroidism: Results of a prospective study. Surgery\| PubMed ID: 36167701	2023
Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: A prospective cohort study. Diabetes & metabolism\| PubMed ID: 36174852	2023
Renal function decline and heart failure hospitalisation in patients with type 2 diabetes: Dynamic predictions from the prospective SURDIAGENE cohort. Diabetes research and clinical practice\| PubMed ID: 36375567	2022
A new 165-SNP low-density lipoprotein cholesterol polygenic risk score based on next generation sequencing outperforms previously published scores in routine diagnostics of familial hypercho... Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 36528340	2022
Lipid-lowering efficacy and safety of alirocumab in a real-life setting in France: Insights from the ODYSSEY APPRISE study. Archives of cardiovascular diseases\| PubMed ID: 36535853	2023
Early humoral response to COVID-19 vaccination in patients living with obesity and diabetes in France. The COVPOP OBEDIAB study with results from the ANRS0001S COV-POPART cohort. Metabolism: clinical and experimental\| PubMed ID: 36731720	2023