Andreas Bechthold

Department of Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-Universität Freiburg, Germany

Affiliated withAlbert-Ludwigs-Universität Freiburg, Germany

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2017

Other Publications

Article	Year
Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. Chemistry & biology\| PubMed ID: 16039521	2005
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chemistry & biology\| PubMed ID: 11927254	2002
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. Journal of the American Chemical Society\| PubMed ID: 12022840	2002
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem : a European journal of chemical biology\| PubMed ID: 12512084	2003
The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. Journal of the American Chemical Society\| PubMed ID: 12696864	2003
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. Journal of molecular biology\| PubMed ID: 12742024	2003
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. Molecular microbiology\| PubMed ID: 12828631	2003
Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene. FEMS microbiology letters\| PubMed ID: 14734170	2004
Rational saccharide extension by using the natural product glycosyltransferase LanGT4. Chembiochem : a European journal of chemical biology\| PubMed ID: 14997529	2004
The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angewandte Chemie (International ed. in English)\| PubMed ID: 15170316	2004
Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization. The Journal of antibiotics\| PubMed ID: 15323127	2004
Novel avilamycin derivatives with improved polarity generated by targeted gene disruption. Chemistry & biology\| PubMed ID: 15489167	2004
Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis. Chembiochem : a European journal of chemical biology\| PubMed ID: 15515090	2004
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. Journal of molecular biology\| PubMed ID: 15581897	2005
Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A. Applied and environmental microbiology\| PubMed ID: 15640214	2005
Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 191... The Journal of organic chemistry\| PubMed ID: 15651811	2005
Novel natural compounds obtained by genome-based screening and genetic engineering. Current opinion in drug discovery & development\| PubMed ID: 15782546	2005
Exploiting Pseudomonas putida for drug development. Chemistry & biology\| PubMed ID: 15797207	2005
Generation of novel landomycins M and O through targeted gene disruption. Chembiochem : a European journal of chemical biology\| PubMed ID: 15812784	2005
LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis. Chembiochem : a European journal of chemical biology\| PubMed ID: 15977274	2005
It works: combinatorial biosynthesis for generating novel glycosylated compounds. Molecular microbiology\| PubMed ID: 16164544	2005
Genes encoding enzymes responsible for biosynthesis of L-lyxose and attachment of eurekanate during avilamycin biosynthesis. Chemistry & biology\| PubMed ID: 16242656	2005
LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis. Chembiochem : a European journal of chemical biology\| PubMed ID: 16283688	2005
A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912. FEMS microbiology letters\| PubMed ID: 16448507	2006
The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme. The Journal of biological chemistry\| PubMed ID: 16537546	2006
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. Journal of bacteriology\| PubMed ID: 16547054	2006
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives. Chemistry & biology\| PubMed ID: 16632249	2006
Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Molecular bioSystems\| PubMed ID: 16880973	2005
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angewandte Chemie (International ed. in English)\| PubMed ID: 17061307	2006
Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces... Chembiochem : a European journal of chemical biology\| PubMed ID: 17139690	2007
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Natural product reports\| PubMed ID: 17268612	2007
Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chembiochem : a European journal of chemical biology\| PubMed ID: 17357167	2007
A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem : a European journal of chemical biology\| PubMed ID: 17407125	2007
SorF: a glycosyltransferase with promiscuous donor substrate specificity in vitro. Chembiochem : a European journal of chemical biology\| PubMed ID: 17407127	2007
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis. Applied microbiology and biotechnology\| PubMed ID: 17497146	2007
Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin. Journal of molecular biology\| PubMed ID: 17640665	2007
The future of natural products as a source of new antibiotics. Current opinion in investigational drugs (London, England : 2000)\| PubMed ID: 17668363	2007
Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes. Archives of microbiology\| PubMed ID: 17786405	2008
Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering. Chembiochem : a European journal of chemical biology\| PubMed ID: 18157854	2008
Functional expression of the Cre recombinase in actinomycetes. Applied microbiology and biotechnology\| PubMed ID: 18299828	2008
Glycosyltransferases, important tools for drug design. Current topics in medicinal chemistry\| PubMed ID: 18473892	2008
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Current topics in medicinal chemistry\| PubMed ID: 18473893	2008
Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS microbiology letters\| PubMed ID: 18537830	2008
Marker removal from actinomycetes genome using Flp recombinase. Gene\| PubMed ID: 18550297	2008
Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity. Applied microbiology and biotechnology\| PubMed ID: 18553079	2008
Features and applications of bacterial glycosyltransferases: current state and prospects. Applied microbiology and biotechnology\| PubMed ID: 18777021	2008
Engineering a function into a glycosyltransferase. Chemistry & biology\| PubMed ID: 19171303	2009
Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem : a European journal of chemical biology\| PubMed ID: 19266534	2009
Genes and enzymes involved in bacterial isoprenoid biosynthesis. Current opinion in chemical biology\| PubMed ID: 19318289	2009
Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis. Applied microbiology and biotechnology\| PubMed ID: 19352642	2009
Chapter 12. The power of glycosyltransferases to generate bioactive natural compounds. Methods in enzymology\| PubMed ID: 19374988	2009
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains. Chembiochem : a European journal of chemical biology\| PubMed ID: 19384899	2009
A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry\| PubMed ID: 19559449	2009
Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tü117. Applied microbiology and biotechnology\| PubMed ID: 19585113	2010
Production of avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators. The Journal of antibiotics\| PubMed ID: 19609289	2009
Functions of genes and enzymes involved in phenalinolactone biosynthesis. Chembiochem : a European journal of chemical biology\| PubMed ID: 20540056	2010
Combinatorial and synthetic biosynthesis in actinomycetes. Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles\| PubMed ID: 20556678	2010
Chemoenzymatic and bioenzymatic synthesis of carbohydrate containing natural products. Topics in current chemistry\| PubMed ID: 21495258	2010
Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase. Chemistry & biology\| PubMed ID: 21513888	2011
Genome sequence of Streptomyces sp. strain Tü6071. Journal of bacteriology\| PubMed ID: 21705604	2011
Cloning and heterologous expression of three type II PKS gene clusters from Streptomyces bottropensis. Chembiochem : a European journal of chemical biology\| PubMed ID: 22162248	2012
SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors. AMB Express\| PubMed ID: 22214346	2012
Site-specific recombination strategies for engineering actinomycete genomes. Applied and environmental microbiology\| PubMed ID: 22247163	2012
SnoaW/SnoaL2: a different two-component monooxygenase. Chemistry & biology\| PubMed ID: 22633406	2012
Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae. BMC genomics\| PubMed ID: 22958348	2012
A transposon-based strategy to identify the regulatory gene network responsible for landomycin E biosynthesis. FEMS microbiology letters\| PubMed ID: 23480614	2013
Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis. Applied and environmental microbiology\| PubMed ID: 23793643	2013
Development of intergeneric conjugal gene transfer system in Streptomyces diastatochromogenes 1628 and its application for improvement of toyocamycin production. Current microbiology\| PubMed ID: 24057064	2014
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chemistry & biology\| PubMed ID: 24120331	2013
Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open biology\| PubMed ID: 24153004	2013
Overexpression of ribosome recycling factor is responsible for improvement of nucleotide antibiotic-toyocamycin in Streptomyces diastatochromogenes 1628. Applied microbiology and biotechnology\| PubMed ID: 24509772	2014
Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8. Chembiochem : a European journal of chemical biology\| PubMed ID: 24554499	2014
Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae. BMC genomics\| PubMed ID: 25301375	2014
Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2. Angewandte Chemie (International ed. in English)\| PubMed ID: 25581707	2015
Functional characterization of different ORFs including luciferase-like monooxygenase genes from the mensacarcin gene cluster. Chembiochem : a European journal of chemical biology\| PubMed ID: 25907804	2015
The Gene bldA, a regulator of morphological differentiation and antibiotic production in streptomyces. Archiv der Pharmazie\| PubMed ID: 25917027	2015
Changing Biosynthetic Profiles by Expressing bldA in Streptomyces Strains. Chembiochem : a European journal of chemical biology\| PubMed ID: 26255983	2015
Minimum Information about a Biosynthetic Gene cluster. Nature chemical biology\| PubMed ID: 26284661	2015
Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA(UUA) Molecule. Chembiochem : a European journal of chemical biology\| PubMed ID: 26374477	2015
Bacillus cereus eﬄux protein BC3310 - a multidrug transporter of the unknown major facilitator family, UMF-2. Frontiers in microbiology\| PubMed ID: 26528249	2015
New Simocyclinones: Surprising Evolutionary and Biosynthetic Insights. ACS chemical biology\| PubMed ID: 26566170	2016
StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes. Nucleic acids research\| PubMed ID: 26615197	2016
Characterization of representative rpoB gene mutations leading to a significant change in toyocamycin production of Streptomyces diastatochromogenes 1628. Journal of industrial microbiology & biotechnology\| PubMed ID: 26790416	2016
An influence of the copy number of biosynthetic gene clusters on the production level of antibiotics in a heterologous host. Journal of biotechnology\| PubMed ID: 27264245	2016
Thailandins A and B, New Polyene Macrolactone Compounds Isolated from Actinokineospora bangkokensis Strain 44EHW(T), Possessing Antifungal Activity against Anthracnose Fungi and Pathogenic Y... Journal of agricultural and food chemistry\| PubMed ID: 27267862	2016
The Draft Genome Sequence of Actinokineospora bangkokensis 44EHW(T) Reveals the Biosynthetic Pathway of the Antifungal Thailandin Compounds with Unusual Butylmalonyl-CoA Extender Units. Molecules (Basel, Switzerland)\| PubMed ID: 27886115	2016
Selection of an efficient promoter and its application in toyocamycin production improvement in Streptomyces diastatochromogenes 1628. World journal of microbiology & biotechnology\| PubMed ID: 28058639	2017