Craig E. Wheelock

Department of Medical Biochemistry and Biophysics, Karolinska Institutet

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2017

Other Publications

Article	Year
Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochemical pharmacology\| PubMed ID: 12007563	2002
Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors. Journal of medicinal chemistry\| PubMed ID: 12459025	2002
Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). Environmental toxicology and chemistry\| PubMed ID: 12558165	2003
Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Analytical biochemistry\| PubMed ID: 12689831	2003
Juvenile hormone (JH) esterase: why are you so JH specific? Insect biochemistry and molecular biology\| PubMed ID: 14599498	2003
Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors. Bioorganic & medicinal chemistry\| PubMed ID: 14604674	2003
Pyrethroid tolerance in Culex pipiens pipiens var molestus from Marin County, California. Pest management science\| PubMed ID: 15119598	2004
Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. The Journal of biological chemistry\| PubMed ID: 15123619	2004
Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis. Archives of biochemistry and biophysics\| PubMed ID: 15369824	2004
Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity. Environmental toxicology and chemistry\| PubMed ID: 15559286	2004
A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. Biochemical and biophysical research communications\| PubMed ID: 15919052	2005
Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca. Aquatic toxicology (Amsterdam, Netherlands)\| PubMed ID: 15951033	2005
Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquatic toxicology (Amsterdam, Netherlands)\| PubMed ID: 16011852	2005
Evaluation of alpha-cyano ethers as fluorescent substrates for assay of cytochrome P450 enzyme activity. Analytical biochemistry\| PubMed ID: 16083846	2005
High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity. Bioorganic & medicinal chemistry\| PubMed ID: 16249087	2006
Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta. Biochemistry\| PubMed ID: 16566578	2006
Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations. Environmental toxicology and chemistry\| PubMed ID: 16629136	2006
Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds. Molecular pharmacology\| PubMed ID: 17167034	2007
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. International journal of cancer\| PubMed ID: 17443494	2007
PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malaria. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17895392	2007
Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). Bioorganic & medicinal chemistry\| PubMed ID: 18023188	2008
Identification of endocrine disruptor biodegradation by integration of structure-activity relationship with pathway analysis. Environmental science & technology\| PubMed ID: 18186328	2007
Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chemical research in toxicology\| PubMed ID: 18251509	2008
Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chemical research in toxicology\| PubMed ID: 18363382	2008
Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs). Reviews of environmental contamination and toxicology\| PubMed ID: 18418956	2008
Tissue distribution, isozyme abundance and sensitivity to chlorpyrifos-oxon of carboxylesterases in the earthworm Lumbricus terrestris. Environmental pollution (Barking, Essex : 1987)\| PubMed ID: 18775596	2009
varDB: a pathogen-specific sequence database of protein families involved in antigenic variation. Bioinformatics (Oxford, England)\| PubMed ID: 18776192	2008
From Genome to Proteome: Integration and proteome completion - 8th Siena Meeting. IDrugs : the investigational drugs journal\| PubMed ID: 18988122	2008
Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. Bioorganic & medicinal chemistry\| PubMed ID: 19062296	2009
Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics : Official journal of the Metabolomic Society\| PubMed ID: 19079556	2007
GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome. Bioinformatics (Oxford, England)\| PubMed ID: 19398447	2009
Systems biology approaches and pathway tools for investigating cardiovascular disease. Molecular bioSystems\| PubMed ID: 19462016	2009
varDB: a database of antigenic variant sequences--current status and future prospects. Acta tropica\| PubMed ID: 19539588	2010
HPLC/MS/MS-based approaches for detection and quantification of eicosanoids. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19763475	2009
Bioinformatics strategies for the analysis of lipids. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19784609	2009
The use of network analyses for elucidating mechanisms in cardiovascular disease. Molecular bioSystems\| PubMed ID: 20094647	2010
Tools for investigating mechanisms of antigenic variation: new extensions to varDB. Genome informatics. International Conference on Genome Informatics\| PubMed ID: 20180261	2009
Advances in eicosanoid research, novel therapeutic implications. Biochemical and biophysical research communications\| PubMed ID: 20494126	2010
Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration. The Journal of allergy and clinical immunology\| PubMed ID: 20728205	2010
12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms. Atherosclerosis\| PubMed ID: 21316676	2011
Lipid mediator profiling in pulmonary disease. Current pharmaceutical biotechnology\| PubMed ID: 21466458	2011
Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure. PloS one\| PubMed ID: 21897859	2011
Phylogenetic analysis of lipid mediator GPCRs. Genome informatics. International Conference on Genome Informatics\| PubMed ID: 22081594	2010
Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PloS one\| PubMed ID: 22438998	2012
Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics. BMC medical genomics\| PubMed ID: 22713245	2012
Building multivariate systems biology models. Analytical chemistry\| PubMed ID: 22856472	2012
Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations. Journal of lipid research\| PubMed ID: 23034214	2013
Application of metabolomics approaches to the study of respiratory diseases. Bioanalysis\| PubMed ID: 23046268	2012
Application of 'omics technologies to biomarker discovery in inflammatory lung diseases. The European respiratory journal\| PubMed ID: 23397306	2013
Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. Molecular nutrition & food research\| PubMed ID: 23824870	2013
Quantitative metabolic profiling of lipid mediators. Molecular nutrition & food research\| PubMed ID: 23828856	2013
Quantification of lipid mediator metabolites in human urine from asthma patients by electrospray ionization mass spectrometry: controlling matrix effects. Analytical chemistry\| PubMed ID: 23863083	2013
Dendritic cell reprogramming by endogenously produced lactic acid. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23956421	2013
Trials and tribulations of 'omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine. Molecular bioSystems\| PubMed ID: 23999822	2013
Lipid mediator profiles differ between lung compartments in asthmatic and healthy humans. The European respiratory journal\| PubMed ID: 24036245	2014
Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma. The Journal of allergy and clinical immunology\| PubMed ID: 24461582	2014
Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans. The American journal of clinical nutrition\| PubMed ID: 24500154	2014
Cord blood mesenchymal stem cells suppress DC-T Cell proliferation via prostaglandin B2. Stem cells and development\| PubMed ID: 24649980	2014
Network analysis in the investigation of chronic respiratory diseases. From basics to application. American journal of respiratory and critical care medicine\| PubMed ID: 25254605	2014
The effect of omega-3 fatty acids on bronchial hyperresponsiveness, sputum eosinophilia, and mast cell mediators in asthma. Chest\| PubMed ID: 25321659	2015
LC-MS metabolomics of psoriasis patients reveals disease severity-dependent increases in circulating amino acids that are ameliorated by anti-TNFα treatment. Journal of proteome research\| PubMed ID: 25361234	2015
Hexosylceramides as intrathecal markers of worsening disability in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 25480867	2015
High-dose simvastatin exhibits enhanced lipid-lowering effects relative to simvastatin/ezetimibe combination therapy. Circulation. Cardiovascular genetics\| PubMed ID: 25516625	2014
Effects of long-term dietary nitrate supplementation in mice. Redox biology\| PubMed ID: 26068891	2015
Urinary excretion of lipid mediators in response to repeated eucapnic voluntary hyperpnea in asthmatic subjects. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 26112240	2015
Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment. Scientific reports\| PubMed ID: 26174087	2015
Peri-ovulatory endocrine regulation of the prostanoid pathways in the bovine uterus at early dioestrus. Reproduction, fertility, and development\| PubMed ID: 26462544	2015
Lipid mediator profile in vernix caseosa reflects skin barrier development. Scientific reports\| PubMed ID: 26521946	2015
Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung. The Journal of allergy and clinical immunology\| PubMed ID: 26792210	2016
Metabolite Profiling and Stable Isotope Tracing in Sorted Subpopulations of Mammalian Cells. Analytical chemistry\| PubMed ID: 26855138	2016
Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD. The European respiratory journal\| PubMed ID: 26965288	2016
Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia. Nitric oxide : biology and chemistry\| PubMed ID: 27234508	2016
Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus. The Journal of clinical endocrinology and metabolism\| PubMed ID: 27399350	2016
Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension. Journal of the American Heart Association\| PubMed ID: 27431647	2016
Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation. Free radical biology & medicine\| PubMed ID: 27474450	2016
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27481843	2016
New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia. Redox biology\| PubMed ID: 28006722	2016
Aspirin-triggered lipoxin inhibits atherosclerosis progression in ApoE(-/-) mice. British journal of pharmacology\| PubMed ID: 28071789	2017