Leonid Margolis

Section on Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health

Affiliated withEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health National Institutes of Health

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 9	2017
Publication title Cited by 30	2018

Other Publications

Article	Year
Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo. The Journal of clinical investigation\| PubMed ID: 10487781	1999
Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue. Journal of virology\| PubMed ID: 10799612	2000
Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue. Journal of virology\| PubMed ID: 10933717	2000
CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo. Journal of virology\| PubMed ID: 11581379	2001
Human immunodeficiency virus type 1 (HIV-1) non-B subtypes are similar to HIV-1 subtype B in that coreceptor specificity is a determinant of cytopathicity in human lymphoid tissue infected e... Journal of virology\| PubMed ID: 11581424	2001
Segregation of R5 and X4 HIV-1 variants to memory T cell subsets differentially expressing CD62L in ex vivo infected human lymphoid tissue. AIDS (London, England)\| PubMed ID: 12045489	2002
Cytokines--strategic weapons in germ warfare? Nature biotechnology\| PubMed ID: 12511900	2003
Bystander CD4+ T lymphocytes survive in HIV-infected human lymphoid tissue. AIDS research and human retroviruses\| PubMed ID: 12689413	2003
Real-time PCR assay of individual human immunodeficiency virus type 1 variants in coinfected human lymphoid tissues. Journal of clinical microbiology\| PubMed ID: 12734258	2003
Multilineage differentiation of rhesus monkey embryonic stem cells in three-dimensional culture systems. Stem cells (Dayton, Ohio)\| PubMed ID: 12743323	2003
Isolation and clonal analysis of human epidermal keratinocyte stem cells in long-term culture. Stem cells (Dayton, Ohio)\| PubMed ID: 12832701	2003
Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo. Journal of virology\| PubMed ID: 12857897	2003
Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14612561	2003
CXCR4-tropic HIV-1 suppresses replication of CCR5-tropic HIV-1 in human lymphoid tissue by selective induction of CC-chemokines. The Journal of infectious diseases\| PubMed ID: 14745709	2004
Noninfectious X4 but not R5 human immunodeficiency virus type 1 virions inhibit humoral immune responses in human lymphoid tissue ex vivo. Journal of virology\| PubMed ID: 15194782	2004
A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function. Journal of virology\| PubMed ID: 15331753	2004
Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue. Journal of virology\| PubMed ID: 15367617	2004
Depletion of CD4 T lymphocytes in human lymphoid tissue infected ex vivo with doxycycline-dependent HIV-1. Virology\| PubMed ID: 15380352	2004
Vpr and Vpu are important for efficient human immunodeficiency virus type 1 replication and CD4+ T-cell depletion in human lymphoid tissue ex vivo. Journal of virology\| PubMed ID: 15507658	2004
Complex extracellular matrices promote tissue-specific stem cell differentiation. Stem cells (Dayton, Ohio)\| PubMed ID: 15671151	2005
Invasion of human tissue ex vivo by Borrelia burgdorferi. The Journal of infectious diseases\| PubMed ID: 15838803	2005
Inhibition of HIV-1 replication in human lymphoid tissues ex vivo by measles virus. The Journal of infectious diseases\| PubMed ID: 15942896	2005
Pertussis toxin B-oligomer dissociates T cell activation and HIV replication in CD4 T cells released from infected lymphoid tissue. AIDS (London, England)\| PubMed ID: 15958831	2005
Differential pathogenesis of primary CCR5-using human immunodeficiency virus type 1 isolates in ex vivo human lymphoid tissue. Journal of virology\| PubMed ID: 16103166	2005
The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells. Journal of virology\| PubMed ID: 16103169	2005
Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved? Nature reviews. Microbiology\| PubMed ID: 16541138	2006
Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides. AIDS (London, England)\| PubMed ID: 16816551	2006
Differentiation of rhesus monkey embryonic stem cells in three-dimensional collagen matrix. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 16846041	2006
Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation. Journal of virology\| PubMed ID: 17065205	2007
Evolution of CXCR4-using human immunodeficiency virus type 1 SF162 is associated with two unique envelope mutations. Journal of virology\| PubMed ID: 17202224	2007
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood\| PubMed ID: 17289812	2007
Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation. Stem cells (Dayton, Ohio)\| PubMed ID: 17332514	2007
HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS (London, England)\| PubMed ID: 17545702	2007
Design and cellular kinetics of dansyl-labeled CADA derivatives with anti-HIV and CD4 receptor down-modulating activity. Biochemical pharmacology\| PubMed ID: 17603023	2007
Measles virus vaccine attenuation: suboptimal infection of lymphatic tissue and tropism alteration. The Journal of infectious diseases\| PubMed ID: 17624839	2007
Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells. The American journal of pathology\| PubMed ID: 17690187	2007
HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo. Blood\| PubMed ID: 17909079	2008
Semen-derived amyloid fibrils drastically enhance HIV infection. Cell\| PubMed ID: 18083097	2007
Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS research and human retroviruses\| PubMed ID: 18327985	2008
Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study. Analytical chemistry\| PubMed ID: 18484740	2008
The lymph node in HIV pathogenesis. Seminars in immunology\| PubMed ID: 18620868	2008
Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Cell host & microbe\| PubMed ID: 18779052	2008
A highly sensitive and dynamic immunofluorescent cytometric bead assay for the detection of HIV-1 p24. Journal of virological methods\| PubMed ID: 19100289	2009
Unsung hero Robert C. Gallo. Science (New York, N.Y.)\| PubMed ID: 19131607	2009
Coinfecting viruses as determinants of HIV disease. Current HIV/AIDS reports\| PubMed ID: 19149991	2009
Integrating integrins into HIV pathogenesis. Blood\| PubMed ID: 19196869	2009
Use of human tissue explants to study human infectious agents. Nature protocols\| PubMed ID: 19197269	2009
Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. PLoS pathogens\| PubMed ID: 19247438	2009
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase. The Journal of biological chemistry\| PubMed ID: 19509419	2009
Measurement of human immunodeficiency virus type 1 preintegration transcription by using Rev-dependent Rev-CEM cells reveals a sizable transcribing DNA population comparable to that from pro... Journal of virology\| PubMed ID: 19553325	2009
Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A. Retrovirology\| PubMed ID: 19573243	2009
Immune suppression of human lymphoid tissues and cells in rotating suspension culture and onboard the International Space Station. In vitro cellular & developmental biology. Animal\| PubMed ID: 19609626	2009
The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition. Journal of medicinal chemistry\| PubMed ID: 19645484	2009
Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo. Microbes and infection\| PubMed ID: 19671446	2009
A missed point in deciphering the viral synergy between herpes simplex virus and HIV. The Lancet. Infectious diseases\| PubMed ID: 19695487	2009
Movements of HIV-virions in human cervical mucus. Biomacromolecules\| PubMed ID: 19711976	2009
Multisite comparison of anti-human immunodeficiency virus microbicide activity in explant assays using a novel endpoint analysis. Journal of clinical microbiology\| PubMed ID: 19726602	2009
Acyclovir: a new use for an old drug. Current opinion in infectious diseases\| PubMed ID: 19726982	2009
War and peace between microbes: HIV-1 interactions with coinfecting viruses. Cell host & microbe\| PubMed ID: 19917495	2009
A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2. The Journal of infectious diseases\| PubMed ID: 20085496	2010
HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model. Mucosal immunology\| PubMed ID: 20147895	2010
Contrasting roles for TLR ligands in HIV-1 pathogenesis. PloS one\| PubMed ID: 20862220	2010
Determinants of protection among HIVâ€exposed seronegative persons: an overview. The Journal of infectious diseases\| PubMed ID: 20887220	2010
Cervico-vaginal tissue ex vivo as a model to study early events in HIV-1 infection. American journal of reproductive immunology (New York, N.Y. : 1989)\| PubMed ID: 21223429	2011
Selective transmission of R5 HIV-1 variants: where is the gatekeeper? Journal of translational medicine\| PubMed ID: 21284905	2011
CD4+ T cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors. Journal of virology\| PubMed ID: 21471231	2011
Activation of T lymphocytes in atherosclerotic plaques. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21960562	2011
Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication. Cell host & microbe\| PubMed ID: 22018238	2011
Semen of HIV-1-infected individuals: local shedding of herpesviruses and reprogrammed cytokine network. The Journal of infectious diseases\| PubMed ID: 22107749	2012
Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin. Antimicrobial agents and chemotherapy\| PubMed ID: 22314523	2012
HIV-1 is not a major driver of increased plasma IL-6 levels in chronic HIV-1 disease. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 22659649	2012
Microbicides: still a long road to success. Trends in microbiology\| PubMed ID: 22705107	2012
HIV-1 imposes rigidity on blood and semen cytokine networks. American journal of reproductive immunology (New York, N.Y. : 1989)\| PubMed ID: 23006048	2012
HIV-1 expressing the envelopes of transmitted/founder or control/reference viruses have similar infection patterns of CD4 T-cells in human cervical tissue ex vivo. PloS one\| PubMed ID: 23236398	2012
It takes more than two for this tango. Cell host & microbe\| PubMed ID: 23332149	2013
Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle. Mucosal immunology\| PubMed ID: 23385427	2013
Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo. PLoS pathogens\| PubMed ID: 23408885	2013
Nanoparticle-based flow virometry for the analysis of individual virions. The Journal of clinical investigation\| PubMed ID: 23925291	2013
A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity. PLoS pathogens\| PubMed ID: 23935482	2013
Histocultures (tissue explants) in human retrovirology. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24158827	2014
Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. European journal of medicinal chemistry\| PubMed ID: 24177359	2013
HIV-1 vaginal transmission: cell-free or cell-associated virus? American journal of reproductive immunology (New York, N.Y. : 1989)\| PubMed ID: 24730358	2014
A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo. Antiviral research\| PubMed ID: 25010891	2014
Antigenic composition of single nano-sized extracellular blood vesicles. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 25481806	2015
Immunoactivation at the crossroads of human disease. The American journal of medicine\| PubMed ID: 25637756	2015
Valacyclovir Decreases Plasma HIV-1 RNA in HSV-2 Seronegative Individuals: A Randomized Placebo-Controlled Crossover Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 25740794	2015
An ex vivo Model of HIV-1 Infection in Human Lymphoid Tissue and Cervico-vaginal Tissue. Bio-protocol\| PubMed ID: 25774380	2014
Genital Cytomegalovirus Replication Predicts Syphilis Acquisition among HIV-1 Infected Men Who Have Sex with Men. PloS one\| PubMed ID: 26061824	2015
Evidence of perturbations of the cytokine network in preterm labor. American journal of obstetrics and gynecology\| PubMed ID: 26232508	2015
Distinct cytokine/chemokine network in semen and blood characterize different stages of HIV infection. AIDS (London, England)\| PubMed ID: 26558730	2016
Evaluation of the maturation of individual Dengue virions with flow virometry. Virology\| PubMed ID: 26590794	2016
Systemic inflammation and liver damage in HIV/hepatitis C virus coinfection. HIV medicine\| PubMed ID: 27187749	2016
Extracellular vesicles and viruses: Are they close relatives? Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27432966	2016
Modulation of Immune Responses by Extracellular Vesicles From Retinal Pigment Epithelium. Investigative ophthalmology & visual science\| PubMed ID: 27537259	2016
Cytomegalovirus-Productive Infection Is Associated With Acute Coronary Syndrome. Journal of the American Heart Association\| PubMed ID: 27543799	2016
Monocytes but Not Lymphocytes Carrying HIV-1 on Their Surface Transmit Infection to Human Tissue Ex Vivo. Journal of virology\| PubMed ID: 27558419	2016
Flow analysis of individual blood extracellular vesicles in acute coronary syndrome. Platelets\| PubMed ID: 27595614	2016
Flow virometry analysis of envelope glycoprotein conformations on individual HIV virions. Scientific reports\| PubMed ID: 28424455	2017
Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue. Scientific reports\| PubMed ID: 28490736	2017
Vaginal Inhibits HIV-1 Replication in Human Tissues . Frontiers in microbiology\| PubMed ID: 28579980	2017
The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery. American journal of reproductive immunology (New York, N.Y. : 1989)\| PubMed ID: 28585708	2017
A common anti-cytomegalovirus drug, ganciclovir, inhibits HIV-1 replication in human tissues ex vivo. AIDS (London, England)\| PubMed ID: 28657962	2017
Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine. Cell host & microbe\| PubMed ID: 28704658	2017
Dual-targeted anti-TB/anti-HIV heterodimers. Antiviral research\| PubMed ID: 28743447	2017
Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides. Journal of medicinal chemistry\| PubMed ID: 28829913	2017
Addition of thrombin reduces the recovery of extracellular vesicles from blood plasma. Journal of circulating biomarkers\| PubMed ID: 28936260	2016
Ex vivo culture of human atherosclerotic plaques: A model to study immune cells in atherogenesis. Atherosclerosis\| PubMed ID: 29101840	2017
CD63, MHC class 1, and CD47 identify subsets of extracellular vesicles containing distinct populations of noncoding RNAs. Scientific reports\| PubMed ID: 29416092	2018
Histoculture and Infection with HIV of Functional Human Lymphoid Tissue on Gelfoam. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29572804	2018
Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors. American journal of reproductive immunology (New York, N.Y. : 1989)\| PubMed ID: 29726582	2018
A System of Cytokines Encapsulated in ExtraCellular Vesicles. Scientific reports\| PubMed ID: 29895824	2018
Human cytomegalovirus-infected cells release extracellular vesicles that carry viral surface proteins. Virology\| PubMed ID: 30165311	2018
Monocytes of Different Subsets in Complexes with Platelets in Patients with Myocardial Infarction. Thrombosis and haemostasis\| PubMed ID: 30300910	2018