Stephen Rittenhouse

Antibacterial Discovery Performance Unit, GlaxoSmithKline

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 17	2017

Other Publications

Article	Year
Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. Journal of medicinal chemistry\| PubMed ID: 11985462	2002
Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases. Antimicrobial agents and chemotherapy\| PubMed ID: 12019104	2002
Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). Journal of medicinal chemistry\| PubMed ID: 12109908	2002
Discovery of a novel and potent class of FabI-directed antibacterial agents. Antimicrobial agents and chemotherapy\| PubMed ID: 12234833	2002
Defining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureus. Antimicrobial agents and chemotherapy\| PubMed ID: 12384334	2002
Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity. Bioorganic & medicinal chemistry letters\| PubMed ID: 12639554	2003
Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity. Bioorganic & medicinal chemistry letters\| PubMed ID: 12657260	2003
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK. Journal of medicinal chemistry\| PubMed ID: 12699381	2003
Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes. Antimicrobial agents and chemotherapy\| PubMed ID: 12760849	2003
New benzylidenethiazolidinediones as antibacterial agents. Bioorganic & medicinal chemistry letters\| PubMed ID: 14552776	2003
Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues. Bioorganic & medicinal chemistry letters\| PubMed ID: 15225702	2004
Selection of retapamulin, a novel pleuromutilin for topical use. Antimicrobial agents and chemotherapy\| PubMed ID: 17065625	2006
Use of the surgical wound infection model to determine the efficacious dosing regimen of retapamulin, a novel topical antibiotic. Antimicrobial agents and chemotherapy\| PubMed ID: 17065626	2006
Stepwise exposure of Staphylococcus aureus to pleuromutilins is associated with stepwise acquisition of mutations in rplC and minimally affects susceptibility to retapamulin. Antimicrobial agents and chemotherapy\| PubMed ID: 17404009	2007
Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. Antimicrobial agents and chemotherapy\| PubMed ID: 18838584	2008
A rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential. Journal of microbiological methods\| PubMed ID: 20801170	2010
Challenges of antibacterial discovery revisited. Annals of the New York Academy of Sciences\| PubMed ID: 21058956	2010
Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases. Bioorganic & medicinal chemistry letters\| PubMed ID: 22030032	2011
Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases. Bioorganic & medicinal chemistry letters\| PubMed ID: 22047689	2011
Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrobial agents and chemotherapy\| PubMed ID: 25348524	2015
Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infectio... Antimicrobial agents and chemotherapy\| PubMed ID: 26482300	2015
In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains. Antimicrobial agents and chemotherapy\| PubMed ID: 26574013	2016
In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria. The Journal of antimicrobial chemotherapy\| PubMed ID: 26645269	2016