Edward W. Tate

Chemical Biology Section, Imperial College London

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 14	2017

Other Publications

Article	Year
Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum. The Biochemical journal\| PubMed ID: 17714074	2007
A highly enantioselective total synthesis of (+)-goniodiol. Organic & biomolecular chemistry\| PubMed ID: 16633562	2006
Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II. Chemical communications (Cambridge, England)\| PubMed ID: 17007393	2006
Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins. Chembiochem : a European journal of chemical biology\| PubMed ID: 17526063	2007
Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry. Chemical communications (Cambridge, England)\| PubMed ID: 18188474	2008
N-myristoyltransferase: a prospective drug target for protozoan parasites. ChemMedChem\| PubMed ID: 18324715	2008
Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides. Organic & biomolecular chemistry\| PubMed ID: 18385853	2008
N-Myristoyl transferase-mediated protein labelling in vivo. Organic & biomolecular chemistry\| PubMed ID: 18563263	2008
Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation. Chemical communications (Cambridge, England)\| PubMed ID: 18633492	2008
Recent advances in chemical proteomics: exploring the post-translational proteome. Journal of chemical biology\| PubMed ID: 19568795	2008
Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold. Journal of medicinal chemistry\| PubMed ID: 19772295	2009
Protein myristoylation in health and disease. Journal of chemical biology\| PubMed ID: 19898886	2009
N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis. Journal of molecular biology\| PubMed ID: 20036251	2010
Chemical probes of surface layer biogenesis in Clostridium difficile. ACS chemical biology\| PubMed ID: 20067320	2010
Getting a chemical handle on protein post-translational modification. Organic & biomolecular chemistry\| PubMed ID: 20135026	2010
Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite. Molecular bioSystems\| PubMed ID: 20174678	2010
Rapid multilabel detection of geranylgeranylated proteins by using bioorthogonal ligation chemistry. Chembiochem : a European journal of chemical biology\| PubMed ID: 20209562	2010
Membrane enhanced peptide synthesis. Chemical communications (Cambridge, England)\| PubMed ID: 20369190	2010
Comparing experimental and computational alanine scanning techniques for probing a prototypical protein-protein interaction. Protein engineering, design & selection : PEDS\| PubMed ID: 20656696	2011
Activity-based probes: discovering new biology and new drug targets. Chemical Society reviews\| PubMed ID: 20886146	2011
Bioorthogonal chemical tagging of protein cholesterylation in living cells. Chemical communications (Cambridge, England)\| PubMed ID: 21221452	2011
Activity-based profiling for drug discovery. Chemistry & biology\| PubMed ID: 21513874	2011
Roles of cysteine proteases Cwp84 and Cwp13 in biogenesis of the cell wall of Clostridium difficile. Journal of bacteriology\| PubMed ID: 21531808	2011
Novel inhibitors of surface layer processing in Clostridium difficile. Bioorganic & medicinal chemistry\| PubMed ID: 21752656	2012
Highlights from the 46th EUCHEM Conference on stereochemistry, Bürgenstock, Switzerland, May 2011. Chemical communications (Cambridge, England)\| PubMed ID: 21874182	2011
A fluorescence-based assay for N-myristoyltransferase activity. Analytical biochemistry\| PubMed ID: 22051857	2012
Application of activity-based protein profiling to the study of microbial pathogenesis. Topics in current chemistry\| PubMed ID: 22102218	2012
Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry. Nature protocols\| PubMed ID: 22193303	2012
A new chemical handle for protein AMPylation at the host-pathogen interface. Chembiochem : a European journal of chemical biology\| PubMed ID: 22213418	2012
Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode. Journal of medicinal chemistry\| PubMed ID: 22439843	2012
Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs. PLoS neglected tropical diseases\| PubMed ID: 22545171	2012
A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei. Biochimica et biophysica acta\| PubMed ID: 22609302	2012
Regulation of the Plasmodium motor complex: phosphorylation of myosin A tail-interacting protein (MTIP) loosens its grip on MyoA. The Journal of biological chemistry\| PubMed ID: 22932904	2012
Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery. Journal of medicinal chemistry\| PubMed ID: 23035716	2012
Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase. Journal of medicinal chemistry\| PubMed ID: 23170970	2013
Automated fluorescence lifetime imaging plate reader and its application to Förster resonant energy transfer readout of Gag protein aggregation. Journal of biophotonics\| PubMed ID: 23184449	2013
Chemical proteomics: a powerful tool for exploring protein lipidation. Biochemical Society transactions\| PubMed ID: 23356258	2013
N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis. Parasitology\| PubMed ID: 23611109	2014
Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite. Biology open\| PubMed ID: 24244852	2013
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nature chemistry\| PubMed ID: 24451586	2014
Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells. PloS one\| PubMed ID: 24608521	2014
Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP). Journal of medicinal chemistry\| PubMed ID: 24641010	2014
A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5. Organic & biomolecular chemistry\| PubMed ID: 24848608	2014
Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation. Cell host & microbe\| PubMed ID: 25011111	2014
Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors. IUCrJ\| PubMed ID: 25075346	2014
Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction. ACS chemical biology\| PubMed ID: 25084543	2014
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites. Organic & biomolecular chemistry\| PubMed ID: 25230674	2014
Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors. Journal of medicinal chemistry\| PubMed ID: 25238611	2014
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nature communications\| PubMed ID: 25255805	2014
Targeting a dynamic protein-protein interaction: fragment screening against the malaria myosin A motor complex. ChemMedChem\| PubMed ID: 25367834	2015
Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions. Structure (London, England : 1993)\| PubMed ID: 25435325	2014
Global profiling of protein lipidation using chemical proteomic technologies. Current opinion in chemical biology\| PubMed ID: 25461723	2015
Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein. The Journal of biological chemistry\| PubMed ID: 25505265	2015
Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity. Organic & biomolecular chemistry\| PubMed ID: 25515724	2015
Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes. PLoS neglected tropical diseases\| PubMed ID: 25522361	2014
New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish. Chemical science\| PubMed ID: 25574372	2014
Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics. Chemical communications (Cambridge, England)\| PubMed ID: 25598414	2015
Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines. The Journal of organic chemistry\| PubMed ID: 25713927	2015
Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani. Chemistry & biology\| PubMed ID: 25728269	2015
The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain. The Journal of biological chemistry\| PubMed ID: 25802338	2015
Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. Angewandte Chemie (International ed. in English)\| PubMed ID: 25807930	2015
Membrane bound O-acyltransferases and their inhibitors. Biochemical Society transactions\| PubMed ID: 25849925	2015
Cholesterylation: a tail of hedgehog. Biochemical Society transactions\| PubMed ID: 25849927	2015
Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors. Canadian journal of microbiology\| PubMed ID: 26059316	2015
Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26079733	2015
Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor. Infection and immunity\| PubMed ID: 26216420	2015
Myristoylation profiling in human cells and zebrafish. Data in brief\| PubMed ID: 26217820	2015
Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics. Chemistry & biology\| PubMed ID: 26256475	2015
Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase. Analytical biochemistry\| PubMed ID: 26334609	2015
Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1. Advances in biological regulation\| PubMed ID: 26482290	2016
Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation. Chemistry & biology\| PubMed ID: 26584780	2015
Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach. Molecular & cellular proteomics : MCP\| PubMed ID: 26604261	2016
The Rab-binding Profiles of Bacterial Virulence Factors during Infection. The Journal of biological chemistry\| PubMed ID: 26755725	2016
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase. MedChemComm\| PubMed ID: 26962429	2015
Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase. MedChemComm\| PubMed ID: 26962430	2015
Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling. Molecular bioSystems\| PubMed ID: 27021930	2016
Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase. Data in brief\| PubMed ID: 27077078	2016
N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells. ACS chemical biology\| PubMed ID: 27267252	2016
Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei. ACS infectious diseases\| PubMed ID: 27331140	2016
Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design. Current topics in medicinal chemistry\| PubMed ID: 27530972	2017
Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS chemical biology\| PubMed ID: 27779380	2016
Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells. ACS chemical biology\| PubMed ID: 27779865	2016
Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET. Scientific reports\| PubMed ID: 28045057	2017