Douglas A. Melton

Department of Molecular and Cell Biology, Harvard

Affiliated withHarvard

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 12	2007

Other Publications

Article	Year
Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. The International journal of developmental biology\| PubMed ID: 11934148	2002
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (Cambridge, England)\| PubMed ID: 11973276	2002
Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes\| PubMed ID: 12086925	2002
"Stemness": transcriptional profiling of embryonic and adult stem cells. Science (New York, N.Y.)\| PubMed ID: 12228720	2002
Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mechanisms of development\| PubMed ID: 12490294	2003
Insulin staining of ES cell progeny from insulin uptake. Science (New York, N.Y.)\| PubMed ID: 12532008	2003
Single-cell transcript analysis of pancreas development. Developmental cell\| PubMed ID: 12636919	2003
Endothelial signaling during development. Nature medicine\| PubMed ID: 12778164	2003
Role of VEGF-A in vascularization of pancreatic islets. Current biology : CB\| PubMed ID: 12814555	2003
Genes, signals, and lineages in pancreas development. Annual review of cell and developmental biology\| PubMed ID: 14570564	2003
Notch signaling controls multiple steps of pancreatic differentiation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14657333	2003
Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development (Cambridge, England)\| PubMed ID: 14660441	2004
Derivation of embryonic stem-cell lines from human blastocysts. The New England journal of medicine\| PubMed ID: 14999088	2004
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature\| PubMed ID: 15129273	2004
The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. The Journal of biological chemistry\| PubMed ID: 15148312	2004
How important are adult stem cells for tissue maintenance? Cell cycle (Georgetown, Tex.)\| PubMed ID: 15326371	2004
Altered nuclear transfer in stem-cell research - a flawed proposal. The New England journal of medicine\| PubMed ID: 15625329	2004
The molecular biography of the cell. Cell\| PubMed ID: 15797372	2005
Direct regulation of intestinal fate by Notch. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16107537	2005
Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (New York, N.Y.)\| PubMed ID: 16123299	2005
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell\| PubMed ID: 16153702	2005
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer cell\| PubMed ID: 16169464	2005
Beta-catenin is essential for pancreatic acinar but not islet development. Development (Cambridge, England)\| PubMed ID: 16192304	2005
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Developmental cell\| PubMed ID: 16516842	2006
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell\| PubMed ID: 16630818	2006
Reversal of type 1 diabetes in mice. The New England journal of medicine\| PubMed ID: 16823003	2006
Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mechanisms of development\| PubMed ID: 17196797	2007
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature\| PubMed ID: 17259975	2007
Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Developmental biology\| PubMed ID: 17328885	2007
A multipotent progenitor domain guides pancreatic organogenesis. Developmental cell\| PubMed ID: 17609113	2007
Recovery from diabetes in mice by beta cell regeneration. The Journal of clinical investigation\| PubMed ID: 17786244	2007
A gene regulatory network in mouse embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17940043	2007
Genetic targeting of the endoderm with claudin-6CreER. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 18213590	2008
Facultative endocrine progenitor cells in the adult pancreas. Cell\| PubMed ID: 18243094	2008
Marked differences in differentiation propensity among human embryonic stem cell lines. Nature biotechnology\| PubMed ID: 18278034	2008
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (Cambridge, England)\| PubMed ID: 18367557	2008
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nature biotechnology\| PubMed ID: 18568017	2008
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature\| PubMed ID: 18754011	2008
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature biotechnology\| PubMed ID: 18849973	2008
Extreme makeover: converting one cell into another. Cell stem cell\| PubMed ID: 18940730	2008
Transcriptional dynamics of endodermal organ formation. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 19097184	2009
Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell stem cell\| PubMed ID: 19200798	2009
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell stem cell\| PubMed ID: 19341624	2009
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (Cambridge, England)\| PubMed ID: 19369400	2009
Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19720998	2009
How to make beta cells? Current opinion in cell biology\| PubMed ID: 19781928	2009
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes & development\| PubMed ID: 20123909	2010
Wnt signaling specifies and patterns intestinal endoderm. Mechanisms of development\| PubMed ID: 21854845	2011
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nature communications\| PubMed ID: 21971503	2011
Impracticality of egg donor recruitment in the absence of compensation. Cell stem cell\| PubMed ID: 21982228	2011