Federica Franciosi

Department of Health, University of Milan

Research Area

Biography

CURRENT POSITION

Since 2017 Assistant Professor, Animal Anatomy and Physiology, Department of Health Animal Science and Food Safety, Università degli Studi di Milano, Italy

EDUCATION

2009 PhD, Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Italy

2005 DVM, Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Italy, 110/110 with honor

PREVIOUS POSITIONS (last 5 years)

2014 – 2017 Fellow of the Marie Curie - International Outgoing Fellowship program

Outgoing Phase: Center for Reproductive Sciences, University of California San Francisco, USA - Returning Phase: Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, Italy

2013 – 2014 PostDoctoral Researcher, Center for Reproductive Sciences, University of California San Francisco, USA

RESEARCH ACTIVITY

My field of research is Reproductive and Developmental Biology. Within this area, I developed a special interest on oocyte biology and the mechanisms controlling the oocyte to embryo transition. I strongly believe that a deeper knowledge of the mechanisms controlling oocyte nuclear reprogramming into a totipotent cell will improve the current approach to treat female infertility, while also impacting regenerative medicine. Given the difficulties in using human oocytes and embryos for research, and the fact that these cells cannot be propagated in culture, my research is mainly conducted on animal models.

JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 21	2017
Publication title Cited by 9	2020
Publication title	2021

Other Publications

Article	Year
Large-scale chromatin remodeling in germinal vesicle bovine oocytes: interplay with gap junction functionality and developmental competence. Molecular reproduction and development\| PubMed ID: 17075796	2007
Oocyte morphology and transcriptional silencing in relation to chromatin remodeling during the final phases of bovine oocyte growth. Molecular reproduction and development\| PubMed ID: 17948251	2008
Bovine alpha-1 acid glycoprotein can reduce the chemotaxis of bovine monocytes and modulate CD18 expression. Veterinary research\| PubMed ID: 18577362	2008
Alpha(1)-acid glycoprotein is contained in bovine neutrophil granules and released after activation. Veterinary immunology and immunopathology\| PubMed ID: 18584879	2008
Developmental competence of gametes reconstructed by germinal vesicle transplantation from fresh and cryopreserved bovine oocytes. Fertility and sterility\| PubMed ID: 18976992	2010
Down-regulatory effect of alpha 1-acid glycoprotein on bovine neutrophil degranulation. Comparative immunology, microbiology and infectious diseases\| PubMed ID: 19167758	2010
Effect of different cryopreservation protocols on cytoskeleton and gap junction mediated communication integrity in feline germinal vesicle stage oocytes. Cryobiology\| PubMed ID: 19460364	2009
Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte maturation (IVM) test within ReProTect. Reproductive toxicology (Elmsford, N.Y.)\| PubMed ID: 20156549	2010
Progesterone receptor membrane component 1 expression and putative function in bovine oocyte maturation, fertilization, and early embryonic development. Reproduction (Cambridge, England)\| PubMed ID: 20739377	2010
Phylogenomic evidence for the presence of a flagellum and cbb(3) oxidase in the free-living mitochondrial ancestor. Molecular biology and evolution\| PubMed ID: 21690562	2011
Gap junction-mediated communications regulate chromatin remodeling during bovine oocyte growth and differentiation through cAMP-dependent mechanism(s). Biology of reproduction\| PubMed ID: 21816847	2011
Changes in histone H4 acetylation during in vivo versus in vitro maturation of equine oocytes. Molecular human reproduction\| PubMed ID: 22155671	2012
Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora... Biology of reproduction\| PubMed ID: 23325810	2013
Reductions in the number of mid-sized antral follicles are associated with markers of premature ovarian senescence in dairy cows. Reproduction, fertility, and development\| PubMed ID: 23327793	2014
Role of gap junction-mediated communications in regulating large-scale chromatin configuration remodeling and embryonic developmental competence acquisition in fully grown bovine oocyte. Journal of assisted reproduction and genetics\| PubMed ID: 23881161	2013
The effect of cilostamide on gap junction communication dynamics, chromatin remodeling, and competence acquisition in pig oocytes following parthenogenetic activation and nuclear transfer. Biology of reproduction\| PubMed ID: 23926281	2013
Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nature cell biology\| PubMed ID: 24270888	2013
Changes in large-scale chromatin structure and function during oogenesis: a journey in company with follicular cells. Animal reproduction science\| PubMed ID: 25028181	2014
Natriuretic peptide precursor C delays meiotic resumption and sustains gap junction-mediated communication in bovine cumulus-enclosed oocytes. Biology of reproduction\| PubMed ID: 25078681	2014
Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte fertilization test. Reproductive toxicology (Elmsford, N.Y.)\| PubMed ID: 25625651	2015
Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome. Journal of ovarian research\| PubMed ID: 26437930	2015
In vitro maturation affects chromosome segregation, spindle morphology and acetylation of lysine 16 on histone H4 in horse oocytes. Reproduction, fertility, and development\| PubMed ID: 26651296	2015
FSH Regulates mRNA Translation in Mouse Oocytes and Promotes Developmental Competence. Endocrinology\| PubMed ID: 26653334	2016
DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. Journal of cell science\| PubMed ID: 26826184	2016
Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26864200	2016
Ultra-low Doses of Follicle Stimulating Hormone and Progesterone Attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized Mouse Model. Journal of reproduction & infertility\| PubMed ID: 29062793	2017
A prematuration approach to equine IVM: considering cumulus morphology, seasonality, follicle of origin, gap junction coupling and large-scale chromatin configuration in the germinal vesicle... Reproduction, fertility, and development\| PubMed ID: 31630726	2019
Recreating the Follicular Environment: A Customized Approach for In Vitro Culture of Bovine Oocytes Based on the Origin and Differentiation State. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33604842	2021