Derek J. Wilson

Department of Chemistry, York University

Research Area

Biochemistry

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2017

Other Publications

Article	Year
Mechanistic studies on enzymatic reactions by electrospray ionization MS using a capillary mixer with adjustable reaction chamber volume for time-resolved measurements. Analytical chemistry\| PubMed ID: 15117195	2004
Subunit disassembly and unfolding kinetics of hemoglobin studied by time-resolved electrospray mass spectrometry. Biochemistry\| PubMed ID: 15544350	2004
Kinetic unfolding mechanism of the inducible nitric oxide synthase oxygenase domain determined by time-resolved electrospray mass spectrometry. Biochemistry\| PubMed ID: 15709740	2005
Pulsed hydrogen exchange and electrospray charge-state distribution as complementary probes of protein structure in kinetic experiments: implications for ubiquitin folding. Biochemistry\| PubMed ID: 15952769	2005
Ultrarapid desalting of protein solutions for electrospray mass spectrometry in a microchannel laminar flow device. Analytical chemistry\| PubMed ID: 16255586	2005
A capillary mixer with adjustable reaction chamber volume for millisecond time-resolved studies by electrospray mass spectrometry. Analytical chemistry\| PubMed ID: 16465695	2003
Protein folding mechanisms studied by time-resolved electrospray mass spectrometry. BioTechniques\| PubMed ID: 16526400	2006
Hydrogen/deuterium scrambling during quadrupole time-of-flight MS/MS analysis of a zinc-binding protein domain. Analytical chemistry\| PubMed ID: 17194133	2007
A versatile microfluidic chip for millisecond time-scale kinetic studies by electrospray mass spectrometry. Journal of the American Society for Mass Spectrometry\| PubMed ID: 18845447	2009
Binding interactions in early- and late-stage amyloid aggregates of TTR(105-115). Biophysical chemistry\| PubMed ID: 19501449	2009
A microfluidic reactor for rapid, low-pressure proteolysis with on-chip electrospray ionization. Rapid communications in mass spectrometry : RCM\| PubMed ID: 20049884	2010
Rational manipulation of amyloidogenesis using an atomic level map of peptide-fibril interactions. Biochemistry\| PubMed ID: 20560641	2010
Understanding and optimizing electrospray ionization techniques for proteomic analysis. Expert review of proteomics\| PubMed ID: 21501013	2011
Kinetic capillary electrophoresis with mass-spectrometry detection (KCE-MS) facilitates label-free solution-based kinetic analysis of protein-small molecule binding. Chembiochem : a European journal of chemical biology\| PubMed ID: 22012742	2011
Measuring dynamics in weakly structured regions of proteins using microfluidics-enabled subsecond H/D exchange mass spectrometry. Analytical chemistry\| PubMed ID: 22458633	2012
Specific disruption of transthyretin(105-115) fibrilization using "stabilizing" inhibitors of transthyretin amyloidogenesis. Biochemistry\| PubMed ID: 22482799	2012
Time-resolved mass spectrometry for monitoring millisecond time-scale solution-phase processes. European journal of mass spectrometry (Chichester, England)\| PubMed ID: 22641726	2012
Conformer selection and intensified dynamics during catalytic turnover in chymotrypsin. Angewandte Chemie (International ed. in English)\| PubMed ID: 22936643	2012
An electrospray ms-coupled microfluidic device for sub-second hydrogen/deuterium exchange pulse-labelling reveals allosteric effects in enzyme inhibition. Lab on a chip\| PubMed ID: 23426018	2013
Measuring kinetic isotope effects in enzyme reactions using time-resolved electrospray mass spectrometry. Analytical chemistry\| PubMed ID: 23461634	2013
Characterizing rapid, activity-linked conformational transitions in proteins via sub-second hydrogen deuterium exchange mass spectrometry. The FEBS journal\| PubMed ID: 23663649	2013
Oxidative protein labeling with analysis by mass spectrometry for the study of structure, folding, and dynamics. Antioxidants & redox signaling\| PubMed ID: 24512178	2014
An improved rapid mixing device for time-resolved electrospray mass spectrometry measurements. ChemistryOpen\| PubMed ID: 25050229	2014
Kinetic size-exclusion chromatography with mass spectrometry detection: an approach for solution-based label-free kinetic analysis of protein-small molecule interactions. Analytical chemistry\| PubMed ID: 25275785	2014
Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization. The Journal of biological chemistry\| PubMed ID: 25288792	2014
Unambiguous characterization of analytical markers in complex, seized opiate samples using an enhanced ion mobility trace detector-mass spectrometer. Analytical chemistry\| PubMed ID: 25302672	2014
Pre-equilibration kinetic size-exclusion chromatography with mass spectrometry detection (peKSEC-MS) for label-free solution-based kinetic analysis of protein-small molecule interactions. The Analyst\| PubMed ID: 25611307	2015
Hyperphosphorylation of intrinsically disordered tau protein induces an amyloidogenic shift in its conformational ensemble. PloS one\| PubMed ID: 25767879	2015
Comparing equilibrium and kinetic protein unfolding using time-resolved electrospray-coupled ion mobility mass spectrometry. The Analyst\| PubMed ID: 26115375	2015
Dimerization of the type IV pilin from Pseudomonas aeruginosa strain K122-4 results in increased helix stability as measured by time-resolved hydrogen-deuterium exchange. Structural dynamics (Melville, N.Y.)\| PubMed ID: 26798830	2016
Conformational Dynamics and Allostery in Pyruvate Kinase. The Journal of biological chemistry\| PubMed ID: 26879751	2016
Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent. Oncotarget\| PubMed ID: 26942696	2016
Differential Mobility Spectrometry-Hydrogen Deuterium Exchange (DMS-HDX) as a Probe of Protein Conformation in Solution. Journal of the American Society for Mass Spectrometry\| PubMed ID: 26965162	2016
Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development - A review. Analytica chimica acta\| PubMed ID: 27662755	2016
Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic. Biochemistry\| PubMed ID: 27933795	2016
Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif. Biochemistry\| PubMed ID: 27959512	2016