Derek J. Wilson

Department of Chemistry, York University

Research Area

Biography

Derek J. Wilson has not added Biography.
If you are Derek J. Wilson and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2017

Other Publications

Article	Year
Mechanistic studies on enzymatic reactions by electrospray ionization MS using a capillary mixer with adjustable reaction chamber volume for time-resolved measurements. Analytical chemistry\| PubMed ID: 15117195	2004
Subunit disassembly and unfolding kinetics of hemoglobin studied by time-resolved electrospray mass spectrometry. Biochemistry\| PubMed ID: 15544350	2004
Kinetic unfolding mechanism of the inducible nitric oxide synthase oxygenase domain determined by time-resolved electrospray mass spectrometry. Biochemistry\| PubMed ID: 15709740	2005
Pulsed hydrogen exchange and electrospray charge-state distribution as complementary probes of protein structure in kinetic experiments: implications for ubiquitin folding. Biochemistry\| PubMed ID: 15952769	2005
Ultrarapid desalting of protein solutions for electrospray mass spectrometry in a microchannel laminar flow device. Analytical chemistry\| PubMed ID: 16255586	2005
A capillary mixer with adjustable reaction chamber volume for millisecond time-resolved studies by electrospray mass spectrometry. Analytical chemistry\| PubMed ID: 16465695	2003
Protein folding mechanisms studied by time-resolved electrospray mass spectrometry. BioTechniques\| PubMed ID: 16526400	2006
Hydrogen/deuterium scrambling during quadrupole time-of-flight MS/MS analysis of a zinc-binding protein domain. Analytical chemistry\| PubMed ID: 17194133	2007
A versatile microfluidic chip for millisecond time-scale kinetic studies by electrospray mass spectrometry. Journal of the American Society for Mass Spectrometry\| PubMed ID: 18845447	2009
Binding interactions in early- and late-stage amyloid aggregates of TTR(105-115). Biophysical chemistry\| PubMed ID: 19501449	2009
A microfluidic reactor for rapid, low-pressure proteolysis with on-chip electrospray ionization. Rapid communications in mass spectrometry : RCM\| PubMed ID: 20049884	2010
Rational manipulation of amyloidogenesis using an atomic level map of peptide-fibril interactions. Biochemistry\| PubMed ID: 20560641	2010
Understanding and optimizing electrospray ionization techniques for proteomic analysis. Expert review of proteomics\| PubMed ID: 21501013	2011
Kinetic capillary electrophoresis with mass-spectrometry detection (KCE-MS) facilitates label-free solution-based kinetic analysis of protein-small molecule binding. Chembiochem : a European journal of chemical biology\| PubMed ID: 22012742	2011
Measuring dynamics in weakly structured regions of proteins using microfluidics-enabled subsecond H/D exchange mass spectrometry. Analytical chemistry\| PubMed ID: 22458633	2012
Specific disruption of transthyretin(105-115) fibrilization using "stabilizing" inhibitors of transthyretin amyloidogenesis. Biochemistry\| PubMed ID: 22482799	2012
Time-resolved mass spectrometry for monitoring millisecond time-scale solution-phase processes. European journal of mass spectrometry (Chichester, England)\| PubMed ID: 22641726	2012
Conformer selection and intensified dynamics during catalytic turnover in chymotrypsin. Angewandte Chemie (International ed. in English)\| PubMed ID: 22936643	2012
An electrospray ms-coupled microfluidic device for sub-second hydrogen/deuterium exchange pulse-labelling reveals allosteric effects in enzyme inhibition. Lab on a chip\| PubMed ID: 23426018	2013
Measuring kinetic isotope effects in enzyme reactions using time-resolved electrospray mass spectrometry. Analytical chemistry\| PubMed ID: 23461634	2013
Characterizing rapid, activity-linked conformational transitions in proteins via sub-second hydrogen deuterium exchange mass spectrometry. The FEBS journal\| PubMed ID: 23663649	2013
Oxidative protein labeling with analysis by mass spectrometry for the study of structure, folding, and dynamics. Antioxidants & redox signaling\| PubMed ID: 24512178	2014
An improved rapid mixing device for time-resolved electrospray mass spectrometry measurements. ChemistryOpen\| PubMed ID: 25050229	2014
Kinetic size-exclusion chromatography with mass spectrometry detection: an approach for solution-based label-free kinetic analysis of protein-small molecule interactions. Analytical chemistry\| PubMed ID: 25275785	2014
Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization. The Journal of biological chemistry\| PubMed ID: 25288792	2014
Unambiguous characterization of analytical markers in complex, seized opiate samples using an enhanced ion mobility trace detector-mass spectrometer. Analytical chemistry\| PubMed ID: 25302672	2014
Pre-equilibration kinetic size-exclusion chromatography with mass spectrometry detection (peKSEC-MS) for label-free solution-based kinetic analysis of protein-small molecule interactions. The Analyst\| PubMed ID: 25611307	2015
Hyperphosphorylation of intrinsically disordered tau protein induces an amyloidogenic shift in its conformational ensemble. PloS one\| PubMed ID: 25767879	2015
Comparing equilibrium and kinetic protein unfolding using time-resolved electrospray-coupled ion mobility mass spectrometry. The Analyst\| PubMed ID: 26115375	2015
Dimerization of the type IV pilin from Pseudomonas aeruginosa strain K122-4 results in increased helix stability as measured by time-resolved hydrogen-deuterium exchange. Structural dynamics (Melville, N.Y.)\| PubMed ID: 26798830	2016
Conformational Dynamics and Allostery in Pyruvate Kinase. The Journal of biological chemistry\| PubMed ID: 26879751	2016
Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent. Oncotarget\| PubMed ID: 26942696	2016
Differential Mobility Spectrometry-Hydrogen Deuterium Exchange (DMS-HDX) as a Probe of Protein Conformation in Solution. Journal of the American Society for Mass Spectrometry\| PubMed ID: 26965162	2016
Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development - A review. Analytica chimica acta\| PubMed ID: 27662755	2016
Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic. Biochemistry\| PubMed ID: 27933795	2016
Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif. Biochemistry\| PubMed ID: 27959512	2016