Matthew D. Neal

Department of Surgery, University of Pittsburgh

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 18	2017
Publication title Cited by 3	2024

Other Publications

Article	Year
Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions. The Journal of biological chemistry\| PubMed ID: 15169791	2004
Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis. The Journal of trauma\| PubMed ID: 19741387	2009
The use of pre-operative imaging and intraoperative parathyroid hormone level to guide surgical management of tertiary hyperparathyroidism from X-linked hypophosphatemic rickets: a case repo... Cases journal\| PubMed ID: 19918472	2009
Tension pneumopericardium in an infant. Surgery\| PubMed ID: 19962168	2011
Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness. The Journal of biological chemistry\| PubMed ID: 20007974	2010
Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium. Gastroenterology\| PubMed ID: 20580721	2010
Intestinal stem cells and their roles during mucosal injury and repair. The Journal of surgical research\| PubMed ID: 20599211	2011
DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21233273	2011
Over reliance on computed tomography imaging in patients with severe abdominal injury: is the delay worth the risk? The Journal of trauma\| PubMed ID: 21307722	2011
An appraisal of endoscopic retrograde cholangiopancreatography (ERCP) for pancreaticobiliary disease in children: our institutional experience in 231 cases. Surgical endoscopy\| PubMed ID: 21359895	2011
Diverting loop ileostomy and colonic lavage: an alternative to total abdominal colectomy for the treatment of severe, complicated Clostridium difficile associated disease. Annals of surgery\| PubMed ID: 21865943	2011
Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22461698	2012
Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way. The journal of trauma and acute care surgery\| PubMed ID: 22491601	2012
Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22733781	2012
Massive transfusion: an evidence-based review of recent developments. Archives of surgery (Chicago, Ill. : 1960)\| PubMed ID: 22786545	2012
Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology\| PubMed ID: 22796522	2012
Endoscopic retrograde cholangiopancreatography is safe and effective for the diagnosis and treatment of pancreaticobiliary disease following abdominal organ transplant in children. Pediatric transplantation\| PubMed ID: 22905881	2012
Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. The Journal of biological chemistry\| PubMed ID: 22955282	2012
Innate immune activation after transfusion of stored red blood cells. Transfusion medicine reviews\| PubMed ID: 23434246	2013
A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23455503	2013
Use of a massive transfusion protocol in nontrauma patients: activate away. Journal of the American College of Surgeons\| PubMed ID: 23571144	2013
Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23650378	2013
Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PloS one\| PubMed ID: 23776545	2013
Simultaneous extracorporeal membrane oxygenation and therapeutic plasma exchange procedures are tolerable in both pediatric and adult patients. Transfusion\| PubMed ID: 24117674	2014
Prehospital use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of trauma-induced coagulopathy. Annals of surgery\| PubMed ID: 24424149	2014
Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. The Journal of biological chemistry\| PubMed ID: 24519940	2014
A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants. Journal of pediatric surgery\| PubMed ID: 24952787	2014
Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation. Circulation. Cardiovascular genetics\| PubMed ID: 25049041	2014
Design of the Study of Tranexamic Acid during Air Medical Prehospital Transport (STAAMP) Trial: Addressing the Knowledge Gaps. Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors\| PubMed ID: 25076119	2015
X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury. Annals of surgery\| PubMed ID: 25203887	2014
Massive transfusion protocol activation does not result in preferential use of older red blood cells. Journal of blood transfusion\| PubMed ID: 25295222	2014
Taking the Blood Bank to the Field: The Design and Rationale of the Prehospital Air Medical Plasma (PAMPer) Trial. Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors\| PubMed ID: 25658881	2015
Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron letters\| PubMed ID: 26236050	2015
Platelet-derived HMGB1 is a critical mediator of thrombosis. The Journal of clinical investigation\| PubMed ID: 26551681	2015
Platelet-derived high-mobility group box 1 promotes recruitment and suppresses apoptosis of monocytes. Biochemical and biophysical research communications\| PubMed ID: 27449608	2016
Dysbiosis Across Multiple Body Sites in Critically Ill Adult Surgical Patients. Shock (Augusta, Ga.)\| PubMed ID: 27454385	2016
Aged Human Stored Red Blood Cell Supernatant Inhibits Macrophage Phagocytosis in an HMGB1 Dependent Manner After Trauma in a Murine Model. Shock (Augusta, Ga.)\| PubMed ID: 27488090	2017
The confusion continues: results from an American Association for the Surgery of Trauma survey on massive transfusion practices among United States trauma centers. Transfusion\| PubMed ID: 27515056	2016
Abnormalities in fibrinolysis at the time of admission are associated with deep vein thrombosis, mortality, and disability in a pediatric trauma population. The journal of trauma and acute care surgery\| PubMed ID: 27779597	2017
Platelet Transfusion in Critical Care and Surgery: Evidence-Based Review of Contemporary Practice and Future Directions. Shock (Augusta, Ga.)\| PubMed ID: 27849676	2017
Surgical rescue: The next pillar of acute care surgery. The journal of trauma and acute care surgery\| PubMed ID: 27893639	2017
In vitro characterization of SynthoPlate™ (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 27925685	2017
Management of anticoagulation with rivaroxaban in trauma and acute care surgery: Complications and reversal strategies as compared to warfarin therapy. The journal of trauma and acute care surgery\| PubMed ID: 28045742	2017
Is Coagulopathy an Appropriate Therapeutic Target During Critical Illness Such as Trauma or Sepsis? Shock (Augusta, Ga.)\| PubMed ID: 28234791	2017
Should All Massively Transfused Patients Be Treated Equally? An Analysis of Massive Transfusion Ratios in the Nontrauma Setting. Critical care medicine\| PubMed ID: 28537938	2017
Trending Fibrinolytic Dysregulation: Fibrinolysis Shutdown in the Days After Injury Is Associated With Poor Outcome in Severely Injured Children. Annals of surgery\| PubMed ID: 28650356	2017
Precision Correction of Coagulopathy or Prothrombin Complex Concentrates?: Reversal Options for Dabigatran following Trauma. Anesthesiology\| PubMed ID: 28857805	2017
Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation. Thrombosis and haemostasis\| PubMed ID: 28981554	2017
Principal component analysis of coagulation assays in severely injured children. Surgery\| PubMed ID: 29248181	2018
Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA. Scientific reports\| PubMed ID: 29391442	2018
Overresuscitation with plasma is associated with sustained fibrinolysis shutdown and death in pediatric traumatic brain injury. The journal of trauma and acute care surgery\| PubMed ID: 29443859	2018
Intravenous synthetic platelet (SynthoPlate) nanoconstructs reduce bleeding and improve 'golden hour' survival in a porcine model of traumatic arterial hemorrhage. Scientific reports\| PubMed ID: 29449604	2018
Intravenous administration of synthetic platelets (SynthoPlate) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis. The journal of trauma and acute care surgery\| PubMed ID: 29538234	2018
Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice. Blood advances\| PubMed ID: 29563120	2018
Heme Oxygenase-2 Localizes to Mitochondria and Regulates Hypoxic Responses in Hepatocytes. Oxidative medicine and cellular longevity\| PubMed ID: 29849867	2018
A qualitative study of gender differences in the experiences of general surgery trainees. The Journal of surgical research\| PubMed ID: 29907201	2018
Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps. BMC cancer\| PubMed ID: 29929491	2018
Blunt cerebrovascular injury in elderly fall patients: are we screening enough? World journal of emergency surgery : WJES\| PubMed ID: 29997683	2018
Design and implementation of the Western Pennsylvania regional Stop the Bleed initiative. The journal of trauma and acute care surgery\| PubMed ID: 30020225	2018
Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock. The New England journal of medicine\| PubMed ID: 30044935	2018
ADAMTS13: origins, applications, and prospects. Transfusion\| PubMed ID: 30208220	2018
Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism. The journal of trauma and acute care surgery\| PubMed ID: 30239375	2019
Reversing anti-factor Xa agents and the unmet needs in trauma patients. Blood\| PubMed ID: 30309890	2018
Bacterial contamination of platelets for transfusion: strategies for prevention. Critical care (London, England)\| PubMed ID: 30367640	2018
Risk of Venous Thromboembolism for Patients with Pancreatic Ductal Adenocarcinoma Undergoing Preoperative Chemotherapy Followed by Surgical Resection. Annals of surgical oncology\| PubMed ID: 30652227	2019
A Systematic Review of Gender-Based Differences in Hirsch Index Among Academic Surgeons. The Journal of surgical research\| PubMed ID: 30694759	2019
Perceptions Regarding Mentorship Among General Surgery Trainees With Academic Career Intentions. Journal of surgical education\| PubMed ID: 30704954	2019
Implementation of a prehospital air medical thawed plasma program: Is it even feasible? The journal of trauma and acute care surgery\| PubMed ID: 31205211	2019
Early versus late venous thromboembolism: A secondary analysis of data from the PROPPR trial. Surgery\| PubMed ID: 31230842	2019
Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 31294514	2019
Pass interference: Getting in the way of platelets. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 31301115	2019
Window of Opportunity to Mitigate Trauma-induced Coagulopathy: Fibrinolysis Shutdown not Prevalent Until 1 Hour Post-injury. Annals of surgery\| PubMed ID: 31305285	2019
Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications. Anesthesia and analgesia\| PubMed ID: 31425218	2019
Platelet Extracellular Vesicles Drive Inflammasome-IL-1β-Dependent Lung Injury in Sickle Cell Disease. American journal of respiratory and critical care medicine\| PubMed ID: 31498653	2020
Prehospital plasma in injured patients is associated with survival principally in blunt injury: Results from two randomized prehospital plasma trials. The journal of trauma and acute care surgery\| PubMed ID: 31524836	2020
A comparison between the TEG 6s and TEG 5000 analyzers to assess coagulation in trauma patients. The journal of trauma and acute care surgery\| PubMed ID: 31738314	2020
Correlation of Thromboelastography with Apparent Rivaroxaban Concentration: Has Point-of-Care Testing Improved? Anesthesiology\| PubMed ID: 31939843	2020
Alterations in platelet behavior after major trauma: adaptive or maladaptive? Platelets\| PubMed ID: 31986948	2021
Accelerating availability of clinically-relevant parameter estimates from thromboelastogram point-of-care device. The journal of trauma and acute care surgery\| PubMed ID: 32032282	2020
Defining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 32112533	2020
A systematic review and meta-analysis of traumatic intracranial hemorrhage in patients taking prehospital antiplatelet therapy: Is there a role for platelet transfusions? The journal of trauma and acute care surgery\| PubMed ID: 32118818	2020
Massive transfusion and the response to prehospital plasma: It is all in how you define it. The journal of trauma and acute care surgery\| PubMed ID: 32118820	2020
Prehospital plasma is associated with distinct biomarker expression following injury. JCI insight\| PubMed ID: 32229722	2020
Association Between Preoperative Metformin Exposure and Postoperative Outcomes in Adults With Type 2 Diabetes. JAMA surgery\| PubMed ID: 32267474	2020
Forgot calcium? Admission ionized-calcium in two civilian randomized controlled trials of prehospital plasma for traumatic hemorrhagic shock. The journal of trauma and acute care surgery\| PubMed ID: 32317575	2020
Venous thromboembolism after tranexamic acid administration: legitimate risk or statistical confounder? ANZ journal of surgery\| PubMed ID: 32339430	2020
Whole-Blood Resuscitation of Injured Patients: Innovating from the Past. JAMA surgery\| PubMed ID: 32401295	2020
Effects of Gender Bias and Stereotypes in Surgical Training: A Randomized Clinical Trial. JAMA surgery\| PubMed ID: 32432669	2020
Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity. Transfusion\| PubMed ID: 32441353	2020
Characterization of unexpected survivors following a prehospital plasma randomized trial. The journal of trauma and acute care surgery\| PubMed ID: 32472902	2020
High-School Students Can Stop the Bleed: A Randomized, Controlled Educational Trial. Academic pediatrics\| PubMed ID: 32473216	2021
Von Willebrand factor as a thrombotic and inflammatory mediator in critical illness. Transfusion\| PubMed ID: 32478907	2020
The great platelet paradox: evolution of platelet contribution to hemostasis, inflammation, and thrombosis after injury. Blood advances\| PubMed ID: 32516417	2020
Hepatic Surgical Stress Promotes Systemic Immunothrombosis That Results in Distant Organ Injury. Frontiers in immunology\| PubMed ID: 32528475	2020
Intravascular hemolysis triggers ADP-mediated generation of platelet-rich thrombi in pre-capillary pulmonary arterioles. JCI insight\| PubMed ID: 32544100	2020
Defining a Research Agenda for Layperson Prehospital Hemorrhage Control: A Consensus Statement. JAMA network open\| PubMed ID: 32663307	2020
Platelet-Monocyte Aggregates: Understanding Mechanisms and Functions in Sepsis. Shock (Augusta, Ga.)\| PubMed ID: 32694394	2021
Pharmacologic Prehabilitation-What About "the Polypill"? JAMA surgery\| PubMed ID: 32805047	2020
The New Zealand white rabbit animal model of acute radiation syndrome: hematopoietic and coagulation-based parameters by radiation dose following supportive care. International journal of radiation biology\| PubMed ID: 32909860	2021
Whole Blood is Superior to Component Transfusion for Injured Children: A Propensity Matched Analysis. Annals of surgery\| PubMed ID: 32932312	2020
Patient and surrogate attitudes via an interviewer-administered survey on exception from informed consent enrollment in the Prehospital Air Medical Plasma (PAMPer) trial. BMC emergency medicine\| PubMed ID: 33004018	2020
Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury: A Double-blind, Placebo-Controlled, Randomized Clinical Trial. JAMA surgery\| PubMed ID: 33016996	2020
Whole-Blood Resuscitation of Injured Patients' Plasma. JAMA surgery\| PubMed ID: 33052388	2021
Association of Prehospital Plasma With Survival in Patients With Traumatic Brain Injury: A Secondary Analysis of the PAMPer Cluster Randomized Clinical Trial. JAMA network open\| PubMed ID: 33057642	2020
Evidence-Based and Clinically Relevant Outcomes for Hemorrhage Control Trauma Trials. Annals of surgery\| PubMed ID: 33065652	2021
Viscoelastic monitoring in trauma resuscitation. Transfusion\| PubMed ID: 33089933	2020
Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness. Research square\| PubMed ID: 33442677	2021
Coupled Model of Blood Volume and Activated Clotting Factor Concentration during Childbirth. IFAC-PapersOnLine\| PubMed ID: 33598665	2018
Age of thawed plasma does not affect clinical outcomes or biomarker expression in patients receiving prehospital thawed plasma: a PAMPer secondary analysis. Trauma surgery & acute care open\| PubMed ID: 33634214	2021
Injured recipients of low-titer group O whole blood have similar clinical outcomes compared to recipients of conventional component therapy: A single-center, retrospective study. Transfusion\| PubMed ID: 33811640	2021
Trauma-induced coagulopathy. Nature reviews. Disease primers\| PubMed ID: 33927200	2021
Early Prehospital Tranexamic Acid Following Injury Is Associated With a 30-day Survival Benefit: A Secondary Analysis of a Randomized Clinical Trial. Annals of surgery\| PubMed ID: 34132695	2021
Does routine postoperative contrast radiography improve outcomes for patients with perforated peptic ulcer? A multicenter retrospective cohort study. Surgery\| PubMed ID: 34175115	2021
Anti-D alloimmunization in Rh(D) negative adults with severe traumatic injury. Transfusion\| PubMed ID: 34269429	2021
Preventing Thrombohemorrhagic Complications of Heparinized COVID-19 Patients Using Adjunctive Thromboelastography: A Retrospective Study. Journal of clinical medicine\| PubMed ID: 34300263	2021
Utilizing natural language processing in the diagnosis and treatment of venous thromboembolism. Surgery\| PubMed ID: 34325905	2021
Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. The New England journal of medicine\| PubMed ID: 34351721	2021
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. The New England journal of medicine\| PubMed ID: 34351722	2021
The role of viscoelastic testing in assessing peri-interventional platelet function and coagulation. Platelets\| PubMed ID: 34369848	2022
Bioinspired artificial platelets: past, present and future. Platelets\| PubMed ID: 34455908	2022
Platelets amplify endotheliopathy in COVID-19. Science advances\| PubMed ID: 34516880	2021
Platelet HMGB1 in Platelet-Rich Plasma (PRP) promotes tendon wound healing. PloS one\| PubMed ID: 34529657	2021
The emerging therapeutic potential of extracellular vesicles in trauma. Journal of leukocyte biology\| PubMed ID: 34533241	2022
Evaluating the Cost-effectiveness of Prehospital Plasma Transfusion in Unstable Trauma Patients: A Secondary Analysis of the PAMPer Trial. JAMA surgery\| PubMed ID: 34550318	2021
Rapid detection of platelet inhibition and dysfunction in traumatic brain injury: A prospective observational study. The journal of trauma and acute care surgery\| PubMed ID: 34629458	2022
The Epidemiology of Extremity Threat and Amputation after Vasopressor-Dependent Sepsis. Annals of the American Thoracic Society\| PubMed ID: 34644242	2022
Reduced cleavage of von willebrand factor by ADAMTS13 is associated with microangiopathic acute kidney injury following trauma. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis\| PubMed ID: 34889809	2022
The Pathobiological Basis for Thrombotic Complications in COVID-19: a Review of the Literature. Current pathobiology reports\| PubMed ID: 34900401	2021
Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses. Cell reports. Medicine\| PubMed ID: 35028617	2021
Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA\| PubMed ID: 35040887	2022
Hemorrhagic Resuscitation Guided by Viscoelastography in Far-Forward Combat and Austere Civilian Environments: Goal-Directed Whole-Blood and Blood-Component Therapy Far from the Trauma Cente... Journal of clinical medicine\| PubMed ID: 35054050	2022
Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding. Science translational medicine\| PubMed ID: 35080915	2022
The National Blood Shortage-An Impetus for Change. Annals of surgery\| PubMed ID: 35081570	2022
Prehospital low titer group O whole blood is feasible and safe: Results of a prospective randomized pilot trial. The journal of trauma and acute care surgery\| PubMed ID: 35081595	2022
Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion. Annals of surgery\| PubMed ID: 35129530	2023
Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices. Journal of clinical medicine\| PubMed ID: 35160311	2022
Investigation into the Cost-Effectiveness of Extended Posttraumatic Thromboprophylaxis. Journal of the American College of Surgeons\| PubMed ID: 35213466	2022
Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA\| PubMed ID: 35315874	2022
Neutrophil extracellular traps regulate ischemic stroke brain injury. The Journal of clinical investigation\| PubMed ID: 35358095	2022
Prehospital synergy: Tranexamic acid and blood transfusion in patients at risk for hemorrhage. The journal of trauma and acute care surgery\| PubMed ID: 35393385	2022
Author Correction: Trauma-induced coagulopathy. Nature reviews. Disease primers\| PubMed ID: 35459275	2022
Immuno-Thrombotic Complications of COVID-19: Implications for Timing of Surgery and Anticoagulation. Frontiers in surgery\| PubMed ID: 35599794	2022
An adaptive platform trial for evaluating treatments in patients with life-threatening hemorrhage from traumatic injuries: Planning and execution. Transfusion\| PubMed ID: 35748672	2022
Platelet dysfunction after trauma: From mechanisms to targeted treatment. Transfusion\| PubMed ID: 35748694	2022
Emerging clinical trial designs may accelerate translation in hematology: lessons from COVID-19. Blood advances\| PubMed ID: 35764486	2022
Toward a more complete understanding of who will benefit from prehospital transfusion. Transfusion\| PubMed ID: 35796302	2022
Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress. Research and practice in thrombosis and haemostasis\| PubMed ID: 35814801	2022
Association Between Time to Source Control in Sepsis and 90-Day Mortality. JAMA surgery\| PubMed ID: 35830181	2022
Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an α-antitrypsin-derived peptide motif. Nature nanotechnology\| PubMed ID: 35851383	2022
High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI. Annals of surgery\| PubMed ID: 35861072	2022
Platelet-Inspired Intravenous Nanomedicine for Injury-Targeted Direct Delivery of Thrombin to Augment Hemostasis in Coagulopathies. ACS nano\| PubMed ID: 35916497	2022
Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients. Metabolites\| PubMed ID: 36144179	2022
Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, ... Seminars in thrombosis and hemostasis\| PubMed ID: 36174604	2022
Proteomics of Coagulopathy Following Injury Reveals Limitations of Using Laboratory Assessment to Define Trauma-Induced Coagulopathy to Predict Massive Transfusion. Annals of surgery open : perspectives of surgical history, education, and clinical approaches\| PubMed ID: 36177090	2022
Lipidomic signatures align with inflammatory patterns and outcomes in critical illness. Nature communications\| PubMed ID: 36357394	2022
EFFECT OF IRRIGATION FLUID COMPOSITION ON HEMOSTASIS IN MOUSE BLEEDING MODELS. Shock (Augusta, Ga.)\| PubMed ID: 36399097	2022
Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial. JAMA\| PubMed ID: 36525245	2023
Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patien... Frontiers in immunology\| PubMed ID: 36532045	2022
MACROPHAGE SWITCHING: POLARIZATION AND MOBILIZATION AFTER TRAUMA. Shock (Augusta, Ga.)\| PubMed ID: 36669229	2023
Evaluation of critical care burden following traumatic injury from two randomized controlled trials. Scientific reports\| PubMed ID: 36670216	2023
Anticoagulation in adult patients supported with extracorporeal membrane oxygenation: guidance from the Scientific and Standardization Committees on Perioperative and Critical Care Haemostas... Journal of thrombosis and haemostasis : JTH\| PubMed ID: 36700496	2023
High-dimensional proteomics identifies organ injury patterns associated with outcomes in human trauma. The journal of trauma and acute care surgery\| PubMed ID: 36787435	2023
Long-term Outcomes of Parastomal Hernia Repair-The Defect in Knowledge (and Abdominal Wall) Remains. JAMA surgery\| PubMed ID: 36790802	2023
Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19. JAMA\| PubMed ID: 36942550	2023
Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior. Frontiers in immunology\| PubMed ID: 36999030	2023
Hemostatic In Vitro Properties of Novel Plasma Supernatants Produced from Late-storage Low-titer Type O Whole Blood. Anesthesiology\| PubMed ID: 37027803	2023
A rapid ABO and RhD test demonstrates high fidelity to blood bank testing for RhD typing. Transfusion\| PubMed ID: 37067381	2023
Prehospital tranexamic acid is associated with a dose-dependent decrease in syndecan-1 after trauma: A secondary analysis of a prospective randomized trial. The journal of trauma and acute care surgery\| PubMed ID: 37125811	2023
Early lyophilized cryoprecipitate enhances the ADAMTS13/VWF ratio to reduce systemic endotheliopathy and lessen lung injury in a mouse multiple-trauma hemorrhage model. The journal of trauma and acute care surgery\| PubMed ID: 37211640	2023
Effect of P2Y12 Inhibitors on Organ Support-Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial. JAMA network open\| PubMed ID: 37227729	2023
Effect of the P-Selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial. Circulation\| PubMed ID: 37356038	2023
High Dose of Metformin Decreases Susceptibility to Occlusive Arterial Thrombosis in Diabetic Mice. Research square\| PubMed ID: 37503167	2023
Mechanisms and management of the coagulopathy of trauma and sepsis: trauma-induced coagulopathy, sepsis-induced coagulopathy, and disseminated intravascular coagulation. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 37722532	2023
Effect of therapeutic-dose heparin on severe acute kidney injury and death in noncritically ill patients hospitalized for COVID-19: a prespecified secondary analysis of the ACTIV4a and ATTAC... Research and practice in thrombosis and haemostasis\| PubMed ID: 37727846	2023
Evaluating potential disparities in geospatial access to American College of Surgeons/American Association for the Surgery of Trauma-verified emergency general surgery centers. The journal of trauma and acute care surgery\| PubMed ID: 37751150	2024
Precision in Transfusion Medicine. JAMA\| PubMed ID: 37824169	2023
Effects of inflammation on thrombosis and outcomes in COVID-19: secondary analysis of the ATTACC/ACTIV-4a trial. Research and practice in thrombosis and haemostasis\| PubMed ID: 37854455	2023
Simvastatin in Critically Ill Patients with Covid-19. The New England journal of medicine\| PubMed ID: 37888913	2023
High Dose of Metformin Decreases Susceptibility to Occlusive Arterial Thrombosis in Diabetic Mice. Journal of pharmacy and pharmacology research\| PubMed ID: 37975061	2023
Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ... Chest\| PubMed ID: 37979717	2024
Platelet-inspired synthetic nanoparticles improve hemostasis and hemodynamics in a rabbit model of abdominal hemorrhage. The journal of trauma and acute care surgery\| PubMed ID: 38057963	2024
Long wavelength light exposure reduces systemic inflammation coagulopathy and acute organ injury following multiple injuries in mice. The journal of trauma and acute care surgery\| PubMed ID: 38079258	2024
Restoring glucose balance: Conditional HMGB1 knockdown mitigates hyperglycemia in a Streptozotocin induced mouse model. Heliyon\| PubMed ID: 38187339	2024
Contemporary management of major haemorrhage in critical care. Intensive care medicine\| PubMed ID: 38189930	2024
The Hemostatic Resuscitation and Trauma Induced Coagulopathy (HERETIC) meeting: challenging dogma. Trauma surgery & acute care open\| PubMed ID: 38196933	2024
Therapeutic plasma exchange is feasible and tolerable in severely injured patients with trauma-induced coagulopathy. Trauma surgery & acute care open\| PubMed ID: 38196934	2024
Correction: Contemporary management of major haemorrhage in critical care. Intensive care medicine\| PubMed ID: 38285053	2024
Time to First Whole Blood Associated With Survival-First (Whole) Blood? JAMA surgery\| PubMed ID: 38294800	2024
Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury. American journal of respiratory cell and molecular biology\| PubMed ID: 38301257	2024
Mechanism matters: mortality and endothelial cell damage marker differences between blunt and penetrating traumatic injuries across three prehospital clinical trials. Scientific reports\| PubMed ID: 38302619	2024
Transforming research to improve therapies for trauma in the twenty-first century. Critical care (London, England)\| PubMed ID: 38350971	2024
Missingness matters: a secondary analysis of thromboelastography measurements from a recent prehospital randomized tranexamic acid clinical trial. Trauma surgery & acute care open\| PubMed ID: 38375027	2024
Advanced and alternative research methods for the acute care surgeon scientist. Trauma surgery & acute care open\| PubMed ID: 38390469	2024
Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again? Transfusion\| PubMed ID: 38461482	2024
Prehospital tranexamic acid is associated with a survival benefit without an increase in complications: Results of two harmonized randomized clinical trials. The journal of trauma and acute care surgery\| PubMed ID: 38523128	2024
Sex dimorphisms in coagulation: Implications in trauma-induced coagulopathy and trauma resuscitation. American journal of hematology\| PubMed ID: 38567625	2024
Four-factor prothrombin complex concentrate is not inferior to andexanet alfa for the reversal or oral factor Xa inhibitors: An Eastern Association for the Surgery of Trauma multicenter stud... The journal of trauma and acute care surgery\| PubMed ID: 38685190	2024
Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial. Annals of surgery\| PubMed ID: 38708880	2024
Whole Blood and Blood Component Resuscitation in Trauma: Interaction and Association with Mortality. Annals of surgery\| PubMed ID: 38708894	2024
A comparison of computational algorithms for the Bayesian analysis of clinical trials. Clinical trials (London, England)\| PubMed ID: 38752434	2024
Characterization of adverse events in injured patients at risk of hemorrhagic shock: a secondary analysis of three harmonized prehospital randomized clinical trials. Trauma surgery & acute care open\| PubMed ID: 38933603	2024
Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19. JACC. Advances\| PubMed ID: 38938844	2024
Trauma patients have reduced ex vivo flow-dependent platelet hemostatic capacity in a microfluidic model of vessel injury. PloS one\| PubMed ID: 38985805	2024
Association between timing of operative interventions and mortality in emergency general surgery. Trauma surgery & acute care open\| PubMed ID: 39027653	2024
Early GFAP and UCH-L1 point-of-care biomarker measurements for the prediction of traumatic brain injury and progression in patients with polytrauma and hemorrhagic shock. Journal of neurosurgery\| PubMed ID: 39076152	2024
Effect of sodium-glucose co-transporter-2 inhibitors on survival free of organ support in patients hospitalised for COVID-19 (ACTIV-4a): a pragmatic, multicentre, open-label, randomised, con... The lancet. Diabetes & endocrinology\| PubMed ID: 39250922	2024
Sodium-glucose co-transporter-2 inhibitors for hospitalised patients with COVID-19: a prospective meta-analysis of randomised trials. The lancet. Diabetes & endocrinology\| PubMed ID: 39250923	2024
TEMPORARY REMOVAL: Alterations in visible light exposure modulate platelet function and regulate thrombus formation. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 39299611	2024
A surface-functionalized whole blood-based dielectric microsensor for assessment of clot firmness in a fibrinolytic environment. Biosensors & bioelectronics\| PubMed ID: 39332249	2025