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JoVE Journal Medicine
Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring
 

Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring

Article doi: 10.3791/55554
May 21st, 2017 •
1, 1, 1, 1, 2, 1
1Department of Surgery, University of Pittsburgh, 2Department of Biomedical Engineering, Case Western Reserve University

Summary
Automatic Translation
May 21st, 2017

Uncontrolled hemorrhage, an important cause of mortality among trauma patients, can be modeled using a standard liver laceration in a murine model. This model results in consistent blood loss, survival, and allows for testing hemostatic agents. This article provides the step-by-step process to perform this valuable model.

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