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Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring
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Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring

Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring

DOI:
10.3791/55554-v

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06:11 min

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May 21, 2017

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, , , , ,
1Department of Surgery,University of Pittsburgh, 2Department of Biomedical Engineering,Case Western Reserve University

Chapters

  • 00:05Title
  • 00:47Catheter Placement
  • 02:34Liver Laceration
  • 03:42Results: Representative Liver Laceration Analyses
  • 05:04Conclusion

Summary

Automatic Translation

Automatic Translation

Uncontrolled hemorrhage, an important cause of mortality among trauma patients, can be modeled using a standard liver laceration in a murine model. This model results in consistent blood loss, survival, and allows for testing hemostatic agents. This article provides the step-by-step process to perform this valuable model.

Tags

Keywords: Uncontrolled HemorrhageHemorrhagic ShockResuscitationHemostatic DrugsMolecular MechanismsLiver LacerationMurine ModelReal-time Hemodynamic MonitoringFemoral Artery CatheterizationLaparotomyBlood Pressure

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