Martin Yarmush

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children

Affiliated withMassachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children

Research Area

Bioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 39	2011

Other Publications

Article	Year
Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNA. Biophysical journal\| PubMed ID: 11751323	2002
Metabolic pre-conditioning of cultured cells in physiological levels of insulin: generating resistance to the lipid-accumulating effects of plasma in hepatocytes. Biotechnology and bioengineering\| PubMed ID: 12001167	2002
Polybrene increases retrovirus gene transfer efficiency by enhancing receptor-independent virus adsorption on target cell membranes. Biophysical chemistry\| PubMed ID: 12050007	2002
Advances in proteomic technologies. Annual review of biomedical engineering\| PubMed ID: 12117762	2002
Antiproteolytic action of insulin in burn-injured rats. The Journal of surgical research\| PubMed ID: 12121712	2002
Bioartificial liver process monitoring and control systems with integrated systems capability. Tissue engineering\| PubMed ID: 12167233	2002
Long-term stable cultures of rat hepatocytes: an in vitro model to study acute and chronic hepatic inflammation. Tissue engineering\| PubMed ID: 12202007	2002
Interferon gamma modulates trauma-induced muscle wasting and immune dysfunction. Annals of surgery\| PubMed ID: 12409672	2002
Metabolic flux analysis of cultured hepatocytes exposed to plasma. Biotechnology and bioengineering\| PubMed ID: 12432579	2003
Influence of insulin therapy on burn wound healing in rats. The Journal of surgical research\| PubMed ID: 12643849	2003
Bioengineering of liver assist devices. Journal of hepato-biliary-pancreatic surgery\| PubMed ID: 12658402	2002
Application of multivariate analysis to optimize function of cultured hepatocytes. Biotechnology progress\| PubMed ID: 12675604	2003
Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma. Metabolic engineering\| PubMed ID: 12749840	2003
Profiling of dynamic changes in hypermetabolic livers. Biotechnology and bioengineering\| PubMed ID: 12800135	2003
Efficacy of an extracorporeal flat-plate bioartificial liver in treating fulminant hepatic failure. The Journal of surgical research\| PubMed ID: 12842448	2003
Control analysis of mitochondrial metabolism in intact hepatocytes: effect of interleukin-1beta and interleukin-6. Metabolic engineering\| PubMed ID: 12850133	2003
Metabolic engineering: advances in modeling and intervention in health and disease. Annual review of biomedical engineering\| PubMed ID: 14527316	2003
Induction of a hypermetabolic state in cultured hepatocytes by glucagon and H2O2. Metabolic engineering\| PubMed ID: 14642350	2003
Growth factors and nonparenchymal cell conditioned media induce mitogenic responses in stable long-term adult rat hepatocyte cultures. Experimental cell research\| PubMed ID: 14729461	2004
Charged polymers modulate retrovirus transduction via membrane charge neutralization and virus aggregation. Biophysical journal\| PubMed ID: 14747357	2004
Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data. Bioinformatics (Oxford, England)\| PubMed ID: 14751977	2004
Technique for expanding the donor liver pool: heat shock preconditioning in a rat fatty liver model. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society\| PubMed ID: 14762865	2004
Dispensable role for interferon-gamma in the burn-induced acute phase response: a proteomic analysis. Proteomics\| PubMed ID: 15174149	2004
Dynamic gene expression profiling using a microfabricated living cell array. Analytical chemistry\| PubMed ID: 15253648	2004
A mouse serum two-dimensional gel map: application to profiling burn injury and infection. Electrophoresis\| PubMed ID: 15349948	2004
Quantitative dynamics of in vivo bone marrow neutrophil production and egress in response to injury and infection. Annals of biomedical engineering\| PubMed ID: 15446507	2004
Quantitative effects of thermal injury and insulin on the metabolism of the skeletal muscle using the perfused rat hindquarter preparation. Biotechnology and bioengineering\| PubMed ID: 15470703	2004
Hepatic tissue engineering for adjunct and temporary liver support: critical technologies. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society\| PubMed ID: 15497161	2004
Insulin concentration during preconditioning mediates the regulation of urea synthesis during exposure to amino acid-supplemented plasma. Tissue engineering\| PubMed ID: 15684682	2004
Evaluation of an in vitro model of hepatic inflammatory response by gene expression profiling. Tissue engineering\| PubMed ID: 15738661	2005
Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a D-galactosamine-induced rat liver failure model. Metabolic engineering\| PubMed ID: 15781418	2005
Microfabricated grooved substrates as platforms for bioartificial liver reactors. Biotechnology and bioengineering\| PubMed ID: 15834948	2005
Designing a hepatocellular microenvironment with protein microarraying and poly(ethylene glycol) photolithography. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 15875819	2004
Effects of dehydroepiandrosterone administration on rat hepatic metabolism following thermal injury. The Journal of surgical research\| PubMed ID: 15882877	2005
Identification of neutrophil gelatinase-associated lipocalin (NGAL) as a discriminatory marker of the hepatocyte-secreted protein response to IL-1beta: a proteomic analysis. Biotechnology and bioengineering\| PubMed ID: 15918168	2005
Immunodepletion of albumin for two-dimensional gel detection of new mouse acute-phase protein and other plasma proteins. Proteomics\| PubMed ID: 16130172	2005
Optimization of reporter cells for expression profiling in a microfluidic device. Biomedical microdevices\| PubMed ID: 16133809	2005
Selective enhancement of cytochrome p-450 activity in rat hepatocytes by in vitro heat shock. Tissue engineering\| PubMed ID: 16259607	2005
Alginate-PLL microencapsulation: effect on the differentiation of embryonic stem cells into hepatocytes. Biotechnology and bioengineering\| PubMed ID: 16345081	2006
Liver endothelial cells promote LDL-R expression and the uptake of HCV-like particles in primary rat and human hepatocytes. Hepatology (Baltimore, Md.)\| PubMed ID: 16440337	2006
Proteomic analysis of altered protein expression in skeletal muscle of rats in a hypermetabolic state induced by burn sepsis. The Biochemical journal\| PubMed ID: 16483253	2006
Heat shock preconditioning inhibits CD4+ T lymphocyte activation in transplanted fatty rat livers. The Journal of surgical research\| PubMed ID: 16600305	2006
Modulation of single-chain antibody affinity with temperature-responsive elastin-like polypeptide linkers. Biomacromolecules\| PubMed ID: 16602713	2006
Treatment of fulminant hepatic failure in rats using a bioartificial liver device containing porcine hepatocytes producing interleukin-1 receptor antagonist. Tissue engineering\| PubMed ID: 16771644	2006
Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes. Analytical chemistry\| PubMed ID: 16808435	2006
Embryoid body-mediated differentiation of mouse embryonic stem cells along a hepatocyte lineage: insights from gene expression profiles. Tissue engineering\| PubMed ID: 16846348	2006
Polyelectrolyte nano-scaffolds for the design of layered cellular architectures. Tissue engineering\| PubMed ID: 16846351	2006
Contribution of gene expression to metabolic fluxes in hypermetabolic livers induced through burn injury and cecal ligation and puncture in rats. Biotechnology and bioengineering\| PubMed ID: 17009336	2007
Oxygen uptake rates and liver-specific functions of hepatocyte and 3T3 fibroblast co-cultures. Biotechnology and bioengineering\| PubMed ID: 17054120	2007
Development of an array of ion-selective microelectrodes aimed for the monitoring of extracellular ionic activities. Analytical chemistry\| PubMed ID: 17073412	2006
A novel formulation of oxygen-carrying matrix enhances liver-specific function of cultured hepatocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17077286	2006
A bioartificial liver device secreting interleukin-1 receptor antagonist for the treatment of hepatic failure in rats. The Journal of surgical research\| PubMed ID: 17081566	2007
A high-throughput microfluidic real-time gene expression living cell array. Lab on a chip\| PubMed ID: 17180208	2007
Integration of technologies for hepatic tissue engineering. Advances in biochemical engineering/biotechnology\| PubMed ID: 17195468	2007
Bioinformatics analysis of the early inflammatory response in a rat thermal injury model. BMC bioinformatics\| PubMed ID: 17214898	2007
Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates. Macromolecular bioscience\| PubMed ID: 17370273	2007
Control of hepatic differentiation via cellular aggregation in an alginate microenvironment. Biotechnology and bioengineering\| PubMed ID: 17390383	2007
Integrated energy and flux balance based multiobjective framework for large-scale metabolic networks. Annals of biomedical engineering\| PubMed ID: 17393337	2007
Engineering protein and peptide building blocks for nanotechnology. Journal of nanoscience and nanotechnology\| PubMed ID: 17450770	2007
Elevated hepatocyte-specific functions in fetal rat hepatocytes co-cultured with adult rat hepatocytes. Tissue engineering\| PubMed ID: 17518664	2006
A model for normothermic preservation of the rat liver. Tissue engineering\| PubMed ID: 17596120	2007
Amphipathic peptide-based fusion peptides and immunoconjugates for the targeted ablation of prostate cancer cells. Cancer research\| PubMed ID: 17616696	2007
Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates. Biotechnology and bioengineering\| PubMed ID: 17626294	2008
Microfabrication-based modulation of embryonic stem cell differentiation. Lab on a chip\| PubMed ID: 17653344	2007
Osmotic selection of human mesenchymal stem/progenitor cells from umbilical cord blood. Tissue engineering\| PubMed ID: 17665999	2007
Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochemical and biophysical research communications\| PubMed ID: 17869217	2007
Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. PloS one\| PubMed ID: 17895982	2007
Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells: applications for the treatment of liver failure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17942827	2008
The use of elastin-like polypeptide-polyelectrolyte complexes to control hepatocyte morphology and function in vitro. Biomaterials\| PubMed ID: 18006054	2008
Burn-induced immunosuppression: attenuated T cell signaling independent of IFN-gamma- and nitric oxide-mediated pathways. Journal of leukocyte biology\| PubMed ID: 18024716	2008
Activin alters the kinetics of endoderm induction in embryonic stem cells cultured on collagen gels. Stem cells (Dayton, Ohio)\| PubMed ID: 18065398	2008
A microfluidic bioreactor for increased active retrovirus output. Lab on a chip\| PubMed ID: 18094764	2008
Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments. Lab on a chip\| PubMed ID: 18094768	2008
Functional modulation of ES-derived hepatocyte lineage cells via substrate compliance alteration. Annals of biomedical engineering\| PubMed ID: 18266108	2008
Three-dimensional primary hepatocyte culture in synthetic self-assembling peptide hydrogel. Tissue engineering. Part A\| PubMed ID: 18333775	2008
Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin. Hepatology (Baltimore, Md.)\| PubMed ID: 18393287	2008
Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology (Baltimore, Md.)\| PubMed ID: 18395843	2008
Site-directed mutagenesis of the hinge peptide from the hemagglutinin protein: enhancement of the pH-responsive conformational change. Protein engineering, design & selection : PEDS\| PubMed ID: 18411225	2008
Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells. Stem cells (Dayton, Ohio)\| PubMed ID: 18420833	2008
Vitrification by ultra-fast cooling at a low concentration of cryoprotectants in a quartz micro-capillary: a study using murine embryonic stem cells. Cryobiology\| PubMed ID: 18462712	2008
A new technique for primary hepatocyte expansion in vitro. Biotechnology and bioengineering\| PubMed ID: 18465801	2008
Cell-cell interaction modulates neuroectodermal specification of embryonic stem cells. Neuroscience letters\| PubMed ID: 18467031	2008
Enhanced differentiation of embryonic stem cells using co-cultivation with hepatocytes. Biotechnology and bioengineering\| PubMed ID: 18571804	2008
Steatosis reversibly increases hepatocyte sensitivity to hypoxia-reoxygenation injury. The Journal of surgical research\| PubMed ID: 18599084	2009
Moloney murine leukemia virus decay mediated by retroviral reverse transcriptase degradation of genomic RNA. Virology\| PubMed ID: 18706668	2008
Gene expression profiling of long-term changes in rat liver following burn injury. The Journal of surgical research\| PubMed ID: 18755477	2009
Transient gene delivery for functional enrichment of differentiating embryonic stem cells. Biotechnology and bioengineering\| PubMed ID: 18942772	2008
Transcription factor network reconstruction using the living cell array. Journal of theoretical biology\| PubMed ID: 18996398	2009
Development of an in vitro cell culture model of hepatic steatosis using hepatocyte-derived reporter cells. Biotechnology and bioengineering\| PubMed ID: 19061238	2009
Microfluidics and multielectrode array-compatible organotypic slice culture method. Journal of neuroscience methods\| PubMed ID: 19100768	2009
Dissimilar hepatic protein expression profiles during the acute and flow phases following experimental thermal injury. Proteomics\| PubMed ID: 19137545	2009
Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion. Transplantation\| PubMed ID: 19155970	2009
Augmentation of EB-directed hepatocyte-specific function via collagen sandwich and SNAP. Biotechnology progress\| PubMed ID: 19194923	2008
Enrichment of hepatocyte-like cells with upregulated metabolic and differentiated function derived from embryonic stem cells using S-NitrosoAcetylPenicillamine. Tissue engineering. Part C, Methods\| PubMed ID: 19196121	2009
Amino acid-mediated heterotypic interaction governs performance of a hepatic tissue model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 19246486	2009
High-throughput single cell arrays as a novel tool in biopreservation. Cryobiology\| PubMed ID: 19303403	2009
Reversible pH-controlled DNA-binding peptide nanotweezers: an in-silico study. International journal of nanomedicine\| PubMed ID: 19337419	2008
Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure. Tissue engineering. Part A\| PubMed ID: 19397469	2009
Living-cell microarrays. Annual review of biomedical engineering\| PubMed ID: 19413510	2009
Nest making and oxytocin comparably promote wound healing in isolation reared rats. PloS one\| PubMed ID: 19436750	2009
Metabolic preconditioning of donor organs: defatting fatty livers by normothermic perfusion ex vivo. Metabolic engineering\| PubMed ID: 19508897	2009
DNA-triggered innate immune responses are propagated by gap junction communication. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19617563	2009
Dynamic effect of heat shock pretreatment on apoptotic responses to TNF-alpha in liver cells. Journal of biomechanical engineering\| PubMed ID: 19640128	2009
Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19720996	2009
Stem cells for liver repopulation. Current opinion in organ transplantation\| PubMed ID: 19779345	2009
High throughput single cell bioinformatics. Biotechnology progress\| PubMed ID: 19830811	2009
Effects of burn injury on markers of hypermetabolism in rats. Journal of burn care & research : official publication of the American Burn Association\| PubMed ID: 19898103	2009
A microfluidic hepatic coculture platform for cell-based drug metabolism studies. Biochemical pharmacology\| PubMed ID: 19925779	2010
Layered patterning of hepatocytes in co-culture systems using microfabricated stencils. BioTechniques\| PubMed ID: 20078427	2010
What came first: fully functional or metabolically mature liver? Critical reviews in biomedical engineering\| PubMed ID: 20092431	2008
The fabrication of low-impedance nanoporous gold multiple-electrode arrays for neural electrophysiology studies. Nanotechnology\| PubMed ID: 20203356	2010
Adipocyte-derived basement membrane extract with biological activity: applications in hepatocyte functional augmentation in vitro. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20233948	2010
Lytic peptide-mediated sensitization of TRAIL-resistant prostate cancer cells to death receptor agonists. Cancer letters\| PubMed ID: 20347216	2010
Building and manipulating neural pathways with microfluidics. Lab on a chip\| PubMed ID: 20358106	2010
An integer programming formulation to identify the sparse network architecture governing differentiation of embryonic stem cells. Bioinformatics (Oxford, England)\| PubMed ID: 20363729	2010
Cell delivery: from cell transplantation to organ engineering. Cell transplantation\| PubMed ID: 20525441	2010
Mesenchymal stem cells: Mechanisms of immunomodulation and homing. Cell transplantation\| PubMed ID: 20525442	2010
Retinal pigment epithelium differentiation of stem cells: current status and challenges. Critical reviews in biomedical engineering\| PubMed ID: 20528731	2009
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nature medicine\| PubMed ID: 20543851	2010
Soft constraints-based multiobjective framework for flux balance analysis. Metabolic engineering\| PubMed ID: 20553945	2010
Engineering of an hepatic organoid to develop liver assist devices. Cell transplantation\| PubMed ID: 20573303	2010
Human immune reactivity against liver sinusoidal endothelial cells from GalTÎ±(1,3)GalT-deficient pigs. Cell transplantation\| PubMed ID: 20573304	2010
Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn. Cell transplantation\| PubMed ID: 20573305	2010
Serum starvation improves transient transfection efficiency in differentiating embryonic stem cells. Biotechnology progress\| PubMed ID: 20574993	2010
Metabolic flux determination in perfused livers by mass balance analysis: effect of fasting. Biotechnology and bioengineering\| PubMed ID: 20661905	2010
Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20664529	2010
Tissue-Engineered Model for Real-Time Monitoring of Liver Inflammation. Tissue engineering. Part C, Methods\| PubMed ID: 20684748	2010
Impact of co-culture on pancreatic differentiation of embryonic stem cells. Journal of tissue engineering and regenerative medicine\| PubMed ID: 20717889	2011
Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. PloS one\| PubMed ID: 20811644	2010
Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. Biosensors & bioelectronics\| PubMed ID: 20888750	2011
A mesenchymal stem cell potency assay. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20941614	2011
Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes. Gastroenterology\| PubMed ID: 20955701	2011
In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnology and bioengineering\| PubMed ID: 21077107	2010
Ultrasensitive Detection of Low-Abundance Surface-Marker Protein Using Isothermal Rolling Circle Amplification in a Microfluidic Nanoliter Platform. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 21188713	2010
Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21193639	2011
Ultrasensitive detection of low-abundance surface-marker protein using isothermal rolling circle amplification in a microfluidic nanoliter platform. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 21294269	2011
Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism. Journal of hepatology\| PubMed ID: 21354229	2011
In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnology and bioengineering\| PubMed ID: 21404258	2011
Differentiating stem cells into liver. Biotechnology & genetic engineering reviews\| PubMed ID: 21412354	2008
Neural lineage differentiation of embryonic stem cells within alginate microbeads. Biomaterials\| PubMed ID: 21481927	2011
Enhancement of naringenin bioavailability by complexation with hydroxypropoyl-Î²-cyclodextrin. PloS one\| PubMed ID: 21494673	2011
In vitro models of traumatic brain injury. Annual review of biomedical engineering\| PubMed ID: 21529164	2011
Novel ligands that target the mitochondrial membrane protein mitoNEET. Journal of molecular graphics & modelling\| PubMed ID: 21531159	2011
Subnormothermic Machine Perfusion at Both 20Â°C and 30Â°C Recovers Ischemic Rat Livers for Successful Transplantation. The Journal of surgical research\| PubMed ID: 21550058	2011
Metabolic profiling based quantitative evaluation of hepatocellular metabolism in presence of adipocyte derived extracellular matrix. PloS one\| PubMed ID: 21603575	2011
The inflammatory response to double stranded DNA in endothelial cells is mediated by NFÎºB and TNFÎ±. PloS one\| PubMed ID: 21611132	2011
Encapsulated mesenchymal stromal cells for in vivo transplantation. Biotechnology and bioengineering\| PubMed ID: 21656712	2011
Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors. Journal of tissue engineering and regenerative medicine\| PubMed ID: 21710576	2011
Aire controls mesenchymal stem cell-mediated suppression in chronic colitis. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21952165	2012
Suppressive Effects of Interleukin-18 on Liver Function in Rat Liver Allografts. The Journal of surgical research\| PubMed ID: 21962809	2011
A novel 3D liver organoid system for elucidation of hepatic glucose metabolism. Biotechnology and bioengineering\| PubMed ID: 22006574	2012
Environmental enrichment with nesting material accelerates wound healing in isolation-reared rats. Behavioural brain research\| PubMed ID: 22008380	2012
Optimality and thermodynamics determine the evolution of transcriptional regulatory networks. Molecular bioSystems\| PubMed ID: 22076617	2012
Excorporeal Normothermic Machine Perfusion Resuscitates Pig DCD Livers with Extended Warm Ischemia. The Journal of surgical research\| PubMed ID: 22099594	2011
Solving medical problems with BioMEMS. IEEE pulse\| PubMed ID: 22147069	2011
Trehalose transporter from African chironomid larvae improves desiccation tolerance of Chinese hamster ovary cells. Cryobiology\| PubMed ID: 22155480	2012
A metabolic index of ischemic injury for perfusion-recovery of cadaveric rat livers. PloS one\| PubMed ID: 22194843	2011
Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure. Nature biotechnology\| PubMed ID: 22252509	2012