Michele Simonato

Department of Medical Sciences, University of ferrara

Affiliated withUniversity of ferrara University of Ferrara and National Institute of Neuroscience Universita degli Studi di Ferrara

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 3	2018
Publication title Cited by 2	2018
Publication title Cited by 1	2023

Other Publications

Article	Year
Involvement of the neuropeptide nociceptin/orphanin FQ in kainate seizures. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12427860	2002
Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist. Neuroreport\| PubMed ID: 12438928	2002
Pro-nociceptin/orphanin FQ and NOP receptor mRNA levels in the forebrain of food deprived rats. Brain research\| PubMed ID: 12445978	2002
Changes in NPY-mediated modulation of hippocampal [3H]D-aspartate outflow in the kindling model of epilepsy. Synapse (New York, N.Y.)\| PubMed ID: 12740867	2003
Delayed epileptogenesis in nociceptin/orphanin FQ-deficient mice. Neuroreport\| PubMed ID: 12858040	2003
Mechanisms of action of CHF3381 in the forebrain. British journal of pharmacology\| PubMed ID: 12890713	2003
On the role of somatostatin in seizure control: clues from the hippocampus. Reviews in the neurosciences\| PubMed ID: 14513869	2003
Kainate seizures increase nociceptin/orphanin FQ release in the rat hippocampus and thalamus: a microdialysis study. Journal of neurochemistry\| PubMed ID: 15379884	2004
Alterations in seizure susceptibility and in seizure-induced plasticity after pharmacologic and genetic manipulation of the fibroblast growth factor-2 system. Epilepsia\| PubMed ID: 15987254	2005
BODIPY-conjugated neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypes. British journal of pharmacology\| PubMed ID: 16231000	2005
Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16237164	2005
Angels and demons: neurotrophic factors and epilepsy. Trends in pharmacological sciences\| PubMed ID: 17055067	2006
Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis. Psychopharmacology\| PubMed ID: 17989958	2008
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18809912	2008
Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19052202	2008
Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19366663	2009
The biocompatibility of materials used in printed circuit board technologies with respect to primary neuronal and K562 cells. Biomaterials\| PubMed ID: 19878988	2010
Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133704	2010
Brain interstitial nociceptin/orphanin FQ levels are elevated in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 20589874	2010
Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis? Epilepsia\| PubMed ID: 20618400	2010
Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures. Journal of neuroinflammation\| PubMed ID: 21087489	2010
Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. Epilepsia\| PubMed ID: 21269288	2011
Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia\| PubMed ID: 22292566	2012
Bystander effect on brain tissue of mesoangioblasts producing neurotrophins. Cell transplantation\| PubMed ID: 22525962	2012
Loss of cortical GABA terminals in Unverricht-Lundborg disease. Neurobiology of disease\| PubMed ID: 22538221	2012
Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design. Epilepsia\| PubMed ID: 22708847	2012
Finding a better drug for epilepsy: antiepileptogenesis targets. Epilepsia\| PubMed ID: 23061663	2012
Nociceptin/orphanin FQ receptor agonists attenuate L-DOPA-induced dyskinesias. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23152595	2012
Issues for new antiepilepsy drug development. Current opinion in neurology\| PubMed ID: 23406913	2013
Increased excitability in tat-transgenic mice: role of tat in HIV-related neurological disorders. Neurobiology of disease\| PubMed ID: 23454193	2013
Progress in gene therapy for neurological disorders. Nature reviews. Neurology\| PubMed ID: 23609618	2013
Bradykinin B₂ receptors increase hippocampal excitability and susceptibility to seizures in mice. Neuroscience\| PubMed ID: 23811399	2013
Changes in the sensitivity of GABAA current rundown to drug treatments in a model of temporal lobe epilepsy. Frontiers in cellular neuroscience\| PubMed ID: 23874269	2013
Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development. Epilepsia\| PubMed ID: 23909855	2013
Implication of fibroblast growth factors in epileptogenesis-associated circuit rearrangements. Frontiers in cellular neuroscience\| PubMed ID: 24062643	2013
Gene therapy for epilepsy. Epilepsy & behavior : E&B\| PubMed ID: 24100249	2014
Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy. Experimental neurology\| PubMed ID: 24768627	2014
The challenge and promise of anti-epileptic therapy development in animal models. The Lancet. Neurology\| PubMed ID: 25127174	2014
Identification of miRNAs differentially expressed in human epilepsy with or without granule cell pathology. PloS one\| PubMed ID: 25148080	2014
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nature communications\| PubMed ID: 25615886	2015
Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats. Neuroscience\| PubMed ID: 26073699	2015
Opportunities for improving animal welfare in rodent models of epilepsy and seizures. Journal of neuroscience methods\| PubMed ID: 26376175	2016
MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy--comparison with human epileptic samples. Scientific reports\| PubMed ID: 26382856	2015
Silencing Status Epilepticus-Induced BDNF Expression with Herpes Simplex Virus Type-1 Based Amplicon Vectors. PloS one\| PubMed ID: 26954758	2016
Advances in the development of biomarkers for epilepsy. The Lancet. Neurology\| PubMed ID: 27302363	2016
Common data elements and data management: Remedy to cure underpowered preclinical studies. Epilepsy research\| PubMed ID: 28038337	2017
WONOEP appraisal: Development of epilepsy biomarkers-What we can learn from our patients? Epilepsia\| PubMed ID: 28387933	2017
Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioural alterations associated with chronic mild stress. Journal of psychopharmacology (Oxford, England)\| PubMed ID: 28417659	2017
Engineered HSV vector achieves safe long-term transgene expression in the central nervous system. Scientific reports\| PubMed ID: 28473703	2017
Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes. Molecular therapy. Methods & clinical development\| PubMed ID: 28702475	2017
eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology. Scientific reports\| PubMed ID: 28874824	2017
Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs. Epilepsia\| PubMed ID: 28960286	2017
Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational... Epilepsia\| PubMed ID: 29105071	2017
Harmonization in preclinical epilepsy research: A joint AES/ILAE translational initiative. Epilepsia\| PubMed ID: 29105072	2017
Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy. eNeuro\| PubMed ID: 29291240	2017
Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy. Molecular therapy. Methods & clinical development\| PubMed ID: 29766029	2018
New Tools for Epilepsy Therapy. Frontiers in cellular neuroscience\| PubMed ID: 29896092	2018
Corrigendum: New Tools for Epilepsy Therapy. Frontiers in cellular neuroscience\| PubMed ID: 30034326	2018