Dominique Bonnet

Haematopoietic Stem Cell Laboratory, The Francis Crick Institute

Affiliated withThe Francis Crick Institute

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 28	2017

Other Publications

Article	Year
WTX is rarely mutated in acute myeloid leukemia. Haematologica\| PubMed ID: 18460646	2008
Haematopoietic stem cells. The Journal of pathology\| PubMed ID: 12115860	2002
Male cells in female recipients of hematopoietic-cell transplants. The New England journal of medicine\| PubMed ID: 12125713	2002
C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12140365	2002
Solid-phase synthesis of tetrahydro-beta-carbolinehydantoins via the N-acyliminium Pictet-Spengler reaction and cyclative cleavage. Journal of combinatorial chemistry\| PubMed ID: 12425597	2002
Simultaneous lipidation of a characterized peptide mixture by chemoselective ligation. Bioconjugate chemistry\| PubMed ID: 12643762	2003
Expansion of human SCID-repopulating cells under hypoxic conditions. The Journal of clinical investigation\| PubMed ID: 12840067	2003
Solid-phase functionalization of peptides by an alpha-hydrazinoacetyl group. The Journal of organic chemistry\| PubMed ID: 12946145	2003
Multiparameter analysis of murine bone marrow side population cells. Blood\| PubMed ID: 14644998	2004
Hematopoietic stem cells. Birth defects research. Part C, Embryo today : reviews\| PubMed ID: 14671775	2003
In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions. Journal of cell science\| PubMed ID: 15494370	2004
Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3. British journal of haematology\| PubMed ID: 15667533	2005
Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples. Stem cells (Dayton, Ohio)\| PubMed ID: 15917471	2005
Stem cells of the alveolar epithelium. Lancet (London, England)\| PubMed ID: 16023517	2005
Normal and leukaemic stem cells. British journal of haematology\| PubMed ID: 16098060	2005
Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16099415	2005
Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood\| PubMed ID: 16131573	2005
Effect of glycoamphiphiles on the solubilization and dendritic cell uptake of a lipopeptide: a preliminary study. Molecular pharmaceutics\| PubMed ID: 16196495	2005
AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. Blood\| PubMed ID: 16234360	2006
Telomerase vaccination has no detectable effect on SCID-repopulating and colony-forming activities in the bone marrow of cancer patients. Experimental hematology\| PubMed ID: 16263411	2005
In vivo formation of unstable heterokaryons after liver damage and hematopoietic stem cell/progenitor transplantation. Stem cells (Dayton, Ohio)\| PubMed ID: 16282440	2006
Leukemic stem cells show the way. Folia histochemica et cytobiologica\| PubMed ID: 16382881	2005
Implications of the expression of myeloid markers on normal and leukemic stem cells. Cell cycle (Georgetown, Tex.)\| PubMed ID: 16397415	2006
Development of a quantitative real-time polymerase chain reaction method for monitoring CEBPA mutations in normal karyotype acute myeloid leukaemia. British journal of haematology\| PubMed ID: 16512836	2006
Out of the blue: a comparison of Hoechst side population (SP) analysis of murine bone marrow using 325, 363 and 407 nm excitation sources. Journal of immunological methods\| PubMed ID: 16513131	2006
Nonhematopoietic/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment. Blood\| PubMed ID: 17003364	2007
Use of a fluorescent polarization based high throughput assay to identify new calmodulin ligands. Biochimica et biophysica acta\| PubMed ID: 17081635	2006
A rapid and versatile method to label receptor ligands using "click" chemistry: Validation with the muscarinic M1 antagonist pirenzepine. Bioconjugate chemistry\| PubMed ID: 17105244	2006
Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging. Stem cells (Dayton, Ohio)\| PubMed ID: 17158238	2007
Convenient method to access new 4,4-dialkoxy- and 4,4-diaryloxy-diaza-s-indacene dyes: Synthesis and spectroscopic evaluation. The Journal of organic chemistry\| PubMed ID: 17194109	2007
Solid-phase preparation of a pilot library derived from the 2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-amine scaffold. Journal of combinatorial chemistry\| PubMed ID: 17358083	2007
Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung. Stem cells (Dayton, Ohio)\| PubMed ID: 17363552	2007
Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells. European journal of haematology\| PubMed ID: 17378892	2007
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells. Experimental hematology\| PubMed ID: 17656008	2007
Flexible and dynamic organization of bone marrow stromal compartment. British journal of haematology\| PubMed ID: 17910627	2007
Ageing within the hematopoietic stem cell compartment. Mechanisms of ageing and development\| PubMed ID: 18502471	2009
Solid-phase organic tagging resins for labeling biomolecules by 1,3-dipolar cycloaddition: application to the synthesis of a fluorescent non-peptidic vasopressin receptor ligand. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18512866	2008
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood\| PubMed ID: 18523148	2008
Small neutralizing molecules to inhibit actions of the chemokine CXCL12. The Journal of biological chemistry\| PubMed ID: 18556651	2008
Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Counci... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18591546	2008
Isolation, culture, and differentiation potential of mouse marrow stromal cells. Current protocols in stem cell biology\| PubMed ID: 18972375	2008
In vivo evaluation of leukemic stem cells through the xenotransplantation model. Current protocols in stem cell biology\| PubMed ID: 19085977	2008
Humanized mouse models to study the human haematopoietic stem cell compartment. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19110636	2009
Humanized model to study leukemic stem cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19277589	2009
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo. Cancer research\| PubMed ID: 19366807	2009
Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19729439	2009
Circulating microparticles and procoagulant activity in elderly patients. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 19942591	2010
Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PloS one\| PubMed ID: 19956603	2009
Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20040517	2010
Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction. Blood\| PubMed ID: 20053758	2010
alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. International journal of cancer. Journal international du cancer\| PubMed ID: 20099278	2010
Neutralizing endogenous chemokines with small molecules. Principles and potential therapeutic applications. Pharmacology & therapeutics\| PubMed ID: 20117133	2010
Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis. Haematologica\| PubMed ID: 20179085	2010
"Microenvironmental contaminations" induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking. Blood\| PubMed ID: 20215639	2010
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. The Journal of experimental medicine\| PubMed ID: 20479117	2010
An antagonistic pair of FT homologs mediates the control of flowering time in sugar beet. Science (New York, N.Y.)\| PubMed ID: 21127254	2010
Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter. PloS one\| PubMed ID: 21152427	2010
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer cell\| PubMed ID: 21156284	2010
Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation. Leukemia\| PubMed ID: 21339756	2011
Prospective identification and isolation of murine bone marrow derived multipotent mesenchymal progenitor cells. Best practice & research. Clinical haematology\| PubMed ID: 21396589	2011
Age-related changes in human hematopoietic stem/progenitor cells. Aging cell\| PubMed ID: 21418508	2011
Involvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastoma. International journal of cancer. Journal international du cancer\| PubMed ID: 21901744	2012
Aerodynamically assisted bio-jetting of hematopoietic stem cells. The Analyst\| PubMed ID: 22297267	2012
Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors. Journal of medicinal chemistry\| PubMed ID: 22329602	2012
Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice. Blood\| PubMed ID: 22438253	2012
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. Blood\| PubMed ID: 22442345	2012
Combinatorial aid for underprivileged scaffolds: solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (Aza-DKP). ACS combinatorial science\| PubMed ID: 22458603	2012
Human mesenchymal stromal cells senesce with exogenous OCT4. Cytotherapy\| PubMed ID: 22746537	2012
Engraftment defect of cytokine-cultured adult human mobilized CD34(+) cells is related to reduced adhesion to bone marrow niche elements. British journal of haematology\| PubMed ID: 22816563	2012
Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms. Stem cells (Dayton, Ohio)\| PubMed ID: 22851508	2012
CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis. European journal of immunology\| PubMed ID: 22936024	2012
Selective fluorescent nonpeptidic antagonists for vasopressin V₂ GPCR: application to ligand screening and oligomerization assays. Journal of medicinal chemistry\| PubMed ID: 22984902	2012
Cancer stem cell definitions and terminology: the devil is in the details. Nature reviews. Cancer\| PubMed ID: 23051844	2012
Heterogeneity of neoplastic stem cells: theoretical, functional, and clinical implications. Cancer research\| PubMed ID: 23345162	2013
Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor. British journal of haematology\| PubMed ID: 23432359	2013
An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in mice. The Journal of biological chemistry\| PubMed ID: 23449983	2013
Exploration of the orthosteric/allosteric interface in human M1 muscarinic receptors by bitopic fluorescent ligands. Molecular pharmacology\| PubMed ID: 23604140	2013
Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells. Blood\| PubMed ID: 23814020	2013
Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23901108	2013
CD34(-) cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures. Cell stem cell\| PubMed ID: 23910083	2013
DNA methylation analysis of murine hematopoietic side population cells during aging. Epigenetics\| PubMed ID: 23949429	2013
Active RHOA favors retention of human hematopoietic stem/progenitor cells in their niche. Journal of biomedical science\| PubMed ID: 24024707	2013
HIF-2α protects human hematopoietic stem/progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic reticulum stress. Cell stem cell\| PubMed ID: 24095676	2013
A novel model of dormancy for bone metastatic breast cancer cells. Cancer research\| PubMed ID: 24145351	2013
Forgotten gems: human CD34(-) hematopoietic stem cells. Cell cycle (Georgetown, Tex.)\| PubMed ID: 24419157	2014
Red fluorescent turn-on ligands for imaging and quantifying G protein-coupled receptors in living cells. Chembiochem : a European journal of chemical biology\| PubMed ID: 24449564	2014
A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: a new tool to decipher their chemoresistance and self-renewal mechanisms. Stem cells translational medicine\| PubMed ID: 24493855	2014
Structure-activity relationship studies toward the discovery of selective apelin receptor agonists. Journal of medicinal chemistry\| PubMed ID: 24625069	2014
Mesenchymal stem cell biodistribution, migration, and homing in vivo. Stem cells international\| PubMed ID: 24738002	2014
Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo. ACS medicinal chemistry letters\| PubMed ID: 24900366	2012
Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process. Chemical communications (Cambridge, England)\| PubMed ID: 25019687	2014
CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics? Oncoimmunology\| PubMed ID: 25083319	2014
Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer. ACS chemical biology\| PubMed ID: 25350273	2015
Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging. Journal of the American Chemical Society\| PubMed ID: 25506627	2015
Increasing cellular immunogenicity to peptide-based vaccine candidates using a fluorocarbon antigen delivery system. Vaccine\| PubMed ID: 25573036	2015
Selective nonpeptidic fluorescent ligands for oxytocin receptor: design, synthesis, and application to time-resolved FRET binding assay. Journal of medicinal chemistry\| PubMed ID: 25642985	2015
APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts. PloS one\| PubMed ID: 25807502	2015
Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo. Blood\| PubMed ID: 25896651	2015
Characteristics of human primary mantle cell lymphoma engraftment in NSG mice. British journal of haematology\| PubMed ID: 26215849	2016
New fluorescein precursors for live bacteria detection. Analytical chemistry\| PubMed ID: 26260548	2015
[Heroin makes asthma difficult and sometimes nearly fatal]. Presse medicale (Paris, France : 1983)\| PubMed ID: 26337357	2015
A strategy to discover decoy chemokine ligands with an anti-inflammatory activity. Scientific reports\| PubMed ID: 26442456	2015
Different Motile Behaviors of Human Hematopoietic Stem versus Progenitor Cells at the Osteoblastic Niche. Stem cell reports\| PubMed ID: 26455414	2015
Natural Killer Cells Improve Hematopoietic Stem Cell Engraftment by Increasing Stem Cell Clonogenicity In Vitro and in a Humanized Mouse Model. PloS one\| PubMed ID: 26465138	2015
The Wilms Tumor-1 (WT1) rs2234593 variant is a prognostic factor in normal karyotype acute myeloid leukemia. Annals of hematology\| PubMed ID: 26499507	2016
A 4-gene expression score associated with high levels of Wilms Tumor-1 (WT1) expression is an adverse prognostic factor in acute myeloid leukaemia. British journal of haematology\| PubMed ID: 26597595	2016
SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment. Nature communications\| PubMed ID: 26643973	2015
Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact. Expert opinion on biological therapy\| PubMed ID: 26679619	2016
Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26682530	2016
Frequency and Dynamics of Leukemia-Initiating Cells during Short-term Ex Vivo Culture Informs Outcomes in Acute Myeloid Leukemia Patients. Cancer research\| PubMed ID: 26960976	2016
Perturbed hematopoiesis in mice lacking ATMIN. Blood\| PubMed ID: 27581360	2016
A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis. Organic & biomolecular chemistry\| PubMed ID: 27722636	2016
T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments. Nature\| PubMed ID: 27750279	2016
Myelodysplastic syndrome can propagate from the multipotent progenitor compartment. Haematologica\| PubMed ID: 27758823	2017
Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 27815337	2017
Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells. Blood\| PubMed ID: 27899358	2017
Versatile humanized niche model enables study of normal and malignant human hematopoiesis. The Journal of clinical investigation\| PubMed ID: 28067666	2017
Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines. The Journal of organic chemistry\| PubMed ID: 28230990	2017
A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor. ChemMedChem\| PubMed ID: 28374567	2017
Acute myeloid leukemia including favorable-risk group samples engraft in NSG mice: just be patient. Haematologica\| PubMed ID: 28458252	2017
Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions. Journal of materials chemistry. C, Materials for optical and electronic devices\| PubMed ID: 28491320	2016
Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation. Stem cell reports\| PubMed ID: 28648895	2017
Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors. Cell reports\| PubMed ID: 28723558	2017