David Lillicrap

Department of Pathology and Molecular Medicine, Queen's University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2017

Other Publications

Article	Year
Genetic basis of familial Meniere's disease. The Journal of otolaryngology\| PubMed ID: 11883436	2002
Recombinant factor IX recovery and inhibitor safety: a Canadian post-licensure surveillance study. Thrombosis and haemostasis\| PubMed ID: 11916075	2002
Aberrant splicing and premature termination of transcription of the FVIII gene as a cause of severe canine hemophilia A: similarities with the intron 22 inversion mutation in human hemophili... Thrombosis and haemostasis\| PubMed ID: 12008949	2002
Dangerous liaisons: the role of "danger" signals in the immune response to gene therapy. Blood\| PubMed ID: 12149189	2002
A 4% solution of bovine serum albumin may be used in place of factor VIII:C deficient plasma in the control sample in the Nijmegen Modification of the Bethesda factor VIII:C inhibitor assay. Thrombosis and haemostasis\| PubMed ID: 12195715	2002
The canine factor VIII 3'-untranslated region and a concatemeric hepatocyte nuclear factor 1 regulatory element enhance factor VIII transgene expression in vivo. Human gene therapy\| PubMed ID: 12228013	2002
Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors. Blood\| PubMed ID: 12406898	2003
A survey of recommendations by gynecologists in Canada regarding oral contraceptive use in the perioperative period. American journal of obstetrics and gynecology\| PubMed ID: 12501060	2002
Gene expression: overview and clinical implications. Vox sanguinis\| PubMed ID: 12617108	2002
Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease. Blood\| PubMed ID: 12649144	2003
Sustained phenotypic correction of canine hemophilia A using an adeno-associated viral vector. Blood\| PubMed ID: 12738670	2003
Helper-dependent adenoviral vectors mediate therapeutic factor VIII expression for several months with minimal accompanying toxicity in a canine model of severe hemophilia A. Blood\| PubMed ID: 14512318	2004
Preclinical animal models for hemophilia gene therapy: predictive value and limitations. Seminars in thrombosis and hemostasis\| PubMed ID: 15118932	2004
A novel type 2A von Willebrand factor mutation located at the last nucleotide of exon 26 (3538G>A) causes skipping of 2 nonadjacent exons. Blood\| PubMed ID: 15226181	2004
Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15233948	2004
Reliability and reproducibility of classification of children as "bleeders" versus "non-bleeders" using a questionnaire for significant mucocutaneous bleeding. Journal of pediatric hematology/oncology\| PubMed ID: 15284585	2004
Molecular modeling of the von Willebrand factor A2 Domain and the effects of associated type 2A von Willebrand disease mutations. Journal of molecular modeling\| PubMed ID: 15322948	2004
Heterogeneity of the immune response to adenovirus-mediated factor VIII gene therapy in different inbred hemophilic mouse strains. The journal of gene medicine\| PubMed ID: 15493040	2004
Cell type-specific regulation of von Willebrand factor expression by the E4BP4 transcriptional repressor. Blood\| PubMed ID: 15498853	2005
Identification and functional characterization of a novel 27-bp deletion in the macroglycopeptide-coding region of the GPIBA gene resulting in platelet-type von Willebrand disease. Blood\| PubMed ID: 15705799	2005
Aminoglycoside suppression of nonsense mutations in severe hemophilia. Blood\| PubMed ID: 16051741	2005
Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells. Stem cells (Dayton, Ohio)\| PubMed ID: 16339997	2006
Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs. Blood\| PubMed ID: 16522813	2006
Inhibitor development in hemophiliacs: the roles of genetic versus environmental factors. Seminars in thrombosis and hemostasis\| PubMed ID: 16804830	2006
Genetic testing for von Willebrand disease: the Canadian experience. Seminars in thrombosis and hemostasis\| PubMed ID: 16862529	2006
The role of immunomodulation in the management of factor VIII inhibitors. Hematology. American Society of Hematology. Education Program\| PubMed ID: 17124093	2006
Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance. Blood\| PubMed ID: 17148587	2007
The mutational spectrum of type 1 von Willebrand disease: Results from a Canadian cohort study. Blood\| PubMed ID: 17190853	2007
Correction of the bleeding time in von Willebrand factor (VWF)-deficient mice using murine VWF. Blood\| PubMed ID: 17312004	2007
Theories of blood coagulation. Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses\| PubMed ID: 17475978	2007
Von Willebrand: the scientist, the disease, the factor, and the treatment. Thrombosis research\| PubMed ID: 17482240	2007
Von Willebrand disease - phenotype versus genotype: deficiency versus disease. Thrombosis research\| PubMed ID: 17490730	2007
Distinguishing between non-identical twins: platelet type and type 2B von Willebrand disease. British journal of haematology\| PubMed ID: 17608761	2007
Ex vivo gene therapy for hemophilia A that enhances safe delivery and sustained in vivo factor VIII expression from lentivirally engineered endothelial progenitors. Stem cells (Dayton, Ohio)\| PubMed ID: 17615271	2007
Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A. Blood\| PubMed ID: 17978172	2008
Von Willebrand disease. Pediatric clinics of North America\| PubMed ID: 18381092	2008
Anti-CD3 prevents factor VIII inhibitor development in hemophilia A mice by a regulatory CD4+CD25+-dependent mechanism and by shifting cytokine production to favor a Th1 response. Blood\| PubMed ID: 18815284	2009
Coagulation factors--molecular attributes and their clinical impact. Thrombosis research\| PubMed ID: 18929520	2008
Extending half-life in coagulation factors: where do we stand? Thrombosis research\| PubMed ID: 18929522	2008
ADAMTS13 cleavage efficiency is altered by mutagenic and, to a lesser extent, polymorphic sequence changes in the A1 and A2 domains of von Willebrand factor. British journal of haematology\| PubMed ID: 18986390	2008
The role of molecular genetics in diagnosing von Willebrand disease. Seminars in thrombosis and hemostasis\| PubMed ID: 19085649	2008
Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice. Blood\| PubMed ID: 19411636	2009
A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T re... Blood\| PubMed ID: 19458355	2009
[Application studies on the gene diagnosis and carrier detection of hemophilia A by using polymerase chain reaction-conformation sensitive gel electrophoresis]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics\| PubMed ID: 20017302	2009
Mutation-specific hemostatic variability in mice expressing common type 2B von Willebrand disease substitutions. Blood\| PubMed ID: 20371742	2010
Characterization of viability and proliferation of alginate-poly-L-lysine-alginate encapsulated myoblasts using flow cytometry. Journal of biomedical materials research. Part B, Applied biomaterials\| PubMed ID: 20586078	2010
Improvements in factor concentrates. Current opinion in hematology\| PubMed ID: 20613509	2010
Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease. Blood\| PubMed ID: 20696945	2010
Hierarchical scaffold design for mesenchymal stem cell-based gene therapy of hemophilia B. Biomaterials\| PubMed ID: 20864158	2011
Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy. Blood\| PubMed ID: 20876851	2010
Challenges and innovations in the treatment of bleeding disorders. Thrombosis research\| PubMed ID: 21056903	2011
Functional analysis of three recombinant A1-VWF domain mutants in comparison to wild type and plasma-derived VWF facilitates subtyping in type 2 von Willebrand disease. Thrombosis research\| PubMed ID: 21094983	2011
Early intraoperative blood collection does not affect complete blood counts, von Willebrand factor or factor VIII levels in normal children. Journal of pediatric hematology/oncology\| PubMed ID: 21178707	2011
A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21285959	2011
Frequency of platelet type versus type 2B von Willebrand disease. An international registry-based study. Thrombosis and haemostasis\| PubMed ID: 21301777	2011
Pathologic mechanisms of type 1 VWD mutations R1205H and Y1584C through in vitro and in vivo mouse models. Blood\| PubMed ID: 21346256	2011
Therapeutic consequences for misdiagnosis of type 2N von Willebrand disease. Pediatric blood & cancer\| PubMed ID: 21425451	2011
The diagnosis and management of von Willebrand disease in Canada. Seminars in thrombosis and hemostasis\| PubMed ID: 22102195	2011
Solulin increases clot stability in whole blood from humans and dogs with hemophilia. Blood\| PubMed ID: 22234684	2012
von Willebrand disease: Clinical and laboratory lessons learned from the large von Willebrand disease studies. American journal of hematology\| PubMed ID: 22389132	2012
The World Federation of Hemophilia and research. Haemophilia : the official journal of the World Federation of Hemophilia\| PubMed ID: 22726078	2012
A complex substitute: antibody therapy for hemophilia. Nature medicine\| PubMed ID: 23042345	2012
The future of hemostasis management. Pediatric blood & cancer\| PubMed ID: 23109347	2013
Alloantibodies in von Willebrand disease. Blood\| PubMed ID: 23297130	2013
The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels. Blood\| PubMed ID: 23529928	2013
Introduction to a series of reviews on cancer-associated thrombotic disease. Blood\| PubMed ID: 23798712	2013
The Canadian "National Program for hemophilia mutation testing" database: a ten-year review. American journal of hematology\| PubMed ID: 23913812	2013
Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A. Nature medicine\| PubMed ID: 24037092	2013
von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy. Blood\| PubMed ID: 24065240	2013
Genetic sequence analysis of inherited bleeding diseases. Blood\| PubMed ID: 24124085	2013
von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy. Hematology. American Society of Hematology. Education Program\| PubMed ID: 24319188	2013
A novel cell-sheet technology that achieves durable factor VIII delivery in a mouse model of hemophilia A. PloS one\| PubMed ID: 24358271	2013
Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response. Blood\| PubMed ID: 24829206	2014
FVIII stabilization: VWF D'D3 will do. Blood\| PubMed ID: 25035147	2014
Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation. Blood\| PubMed ID: 25051961	2014
Syntaxin-binding protein 5 exocytosis regulation: differential role in endothelial cells and platelets. The Journal of clinical investigation\| PubMed ID: 25244090	2014
Rapid acquisition of immunologic tolerance to factor VIII and disappearance of anti-factor VIII IgG4 after prophylactic therapy in a hemophilia A patient with high-titer factor VIII inhibito... Journal of pediatric hematology/oncology\| PubMed ID: 25411864	2015
Alloantibodies to therapeutic factor VIII in hemophilia A: the role of von Willebrand factor in regulating factor VIII immunogenicity. Haematologica\| PubMed ID: 25638804	2015
Introduction to a series of reviews on inherited bleeding disorders. Blood\| PubMed ID: 25712995	2015
Journal of Thrombosis and Haemostasis. Special Issue: State of the Art 2015. Preface. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 26149009	2015
To clear or to fear: An innate perspective on factor VIII immunity. Cellular immunology\| PubMed ID: 26547364	2016
Transgene-host cell interactions mediate significant influences on the production, stability, and function of recombinant canine FVIII. Molecular therapy. Methods & clinical development\| PubMed ID: 26636112	2015
War and peace: Factor VIII and the adaptive immune response. Cellular immunology\| PubMed ID: 26676073	2016
Foreword. European journal of haematology\| PubMed ID: 26679391	2015
Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice. Cellular immunology\| PubMed ID: 26775174	2016
Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States. Blood\| PubMed ID: 26862110	2016
Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A. Blood\| PubMed ID: 27034428	2016
Gene Therapy for Coagulation Disorders. Circulation research\| PubMed ID: 27126652	2016
How much do we really know about von Willebrand disease? Current opinion in hematology\| PubMed ID: 27428891	2016
Functional characterisation of the type 1 von Willebrand disease candidate VWF gene variants: p.M771I, p.L881R and p.P1413L. Blood transfusion = Trasfusione del sangue\| PubMed ID: 27483487	2016
Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A. Blood\| PubMed ID: 27587878	2016
Summary report of the First International Conference on inhibitors in haemophilia A. Blood transfusion = Trasfusione del sangue\| PubMed ID: 27893354	2016
Utility of factor VIII and factor VIII to von Willebrand factor ratio in identifying 277 unselected carriers of hemophilia A. American journal of hematology\| PubMed ID: 28249352	2017
Biological considerations of plasma-derived and recombinant factor VIII immunogenicity. Blood\| PubMed ID: 28432221	2017
Bispecific Antibody Therapy in Hemophilia. The New England journal of medicine\| PubMed ID: 28691560	2017