Paul C. Blainey

Broad Institute, Massachusetts Institute of Technology and Harvard Medical School

Affiliated withMassachusetts Institute of Technology and Harvard Medical School Massachusetts Institute of Technology

Research Area

Biography

Paul C. Blainey has not added Biography.
If you are Paul C. Blainey and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2017

Other Publications

Article	Year
Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder. Science (New York, N.Y.)\| PubMed ID: 12947199	2003
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16585517	2006
Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA. Nature methods\| PubMed ID: 17435763	2007
Diffusion constant of a nonspecifically bound protein undergoing curvilinear motion along DNA. The journal of physical chemistry. B\| PubMed ID: 18321088	2008
Digital PCR provides sensitive and absolute calibration for high throughput sequencing. BMC genomics\| PubMed ID: 19298667	2009
Nonspecifically bound proteins spin while diffusing along DNA. Nature structural & molecular biology\| PubMed ID: 19898474	2009
Digital MDA for enumeration of total nucleic acid contamination. Nucleic acids research\| PubMed ID: 21071419	2011
Genome of a low-salinity ammonia-oxidizing archaeon determined by single-cell and metagenomic analysis. PloS one\| PubMed ID: 21364937	2011
Partial genome assembly for a candidate division OP11 single cell from an anoxic spring (Zodletone Spring, Oklahoma). Applied and environmental microbiology\| PubMed ID: 21908640	2011
Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB). Genome research\| PubMed ID: 22434425	2012
Quantitative analysis of the human airway microbial ecology reveals a pervasive signature for cystic fibrosis. Science translational medicine\| PubMed ID: 23019655	2012
A Single-cell genome for Thiovulum sp. Applied and environmental microbiology\| PubMed ID: 23023751	2012
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: I. binding to DNA AND to hexon of the precursor to protein VI, pVI, of human adenovirus. The Journal of biological chemistry\| PubMed ID: 23043136	2013
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction. The Journal of biological chemistry\| PubMed ID: 23043137	2013
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates. The Journal of biological chemistry\| PubMed ID: 23043138	2013
The future is now: single-cell genomics of bacteria and archaea. FEMS microbiology reviews\| PubMed ID: 23298390	2013
Single-cell and metagenomic analyses indicate a fermentative and saccharolytic lifestyle for members of the OP9 lineage. Nature communications\| PubMed ID: 23673639	2013
Optofluidic cell selection from complex microbial communities for single-genome analysis. Methods in enzymology\| PubMed ID: 24060116	2013
Dissecting genomic diversity, one cell at a time. Nature methods\| PubMed ID: 24524132	2014
Laser microdissection of the alveolar duct enables single-cell genomic analysis. Frontiers in oncology\| PubMed ID: 25309876	2014
Optimal estimation of diffusion coefficients from single-particle trajectories. Physical review. E, Statistical, nonlinear, and soft matter physics\| PubMed ID: 25353527	2014
Tools for the Microbiome: Nano and Beyond. ACS nano\| PubMed ID: 26695070	2016
A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages. Nature communications\| PubMed ID: 26732280	2016
Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA. Nature communications\| PubMed ID: 26831565	2016
Molecular sled sequences are common in mammalian proteins. Nucleic acids research\| PubMed ID: 26857546	2016
Virtual microfluidics for digital quantification and single-cell sequencing. Nature methods\| PubMed ID: 27479330	2016
Funding: Interdisciplinary challenges. Nature microbiology\| PubMed ID: 27573117	2016
Sliding on DNA: From Peptides to Small Molecules. Angewandte Chemie (International ed. in English)\| PubMed ID: 27813331	2016
High-throughput automated microfluidic sample preparation for accurate microbial genomics. Nature communications\| PubMed ID: 28128213	2017
Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples. eLife\| PubMed ID: 28678007	2017