Martin Hirst

Department of Microbiology and Immunology, University of British Columbia

Affiliated withUniversity of British Columbia BC Cancer Agency

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 12	2017

Other Publications

Article	Year
A two-hybrid system for transactivator bait proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11447261	2001
Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hy... The Biochemical journal\| PubMed ID: 12864730	2003
Novel avian influenza H7N3 strain outbreak, British Columbia. Emerging infectious diseases\| PubMed ID: 15663859	2004
A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16352711	2005
Transcriptome analysis for Caenorhabditis elegans based on novel expressed sequence tags. BMC biology\| PubMed ID: 18611272	2008
In-depth characterization of the microRNA transcriptome in a leukemia progression model. Genome research\| PubMed ID: 18849523	2008
ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult. Developmental biology\| PubMed ID: 19111532	2009
De novo genome sequence assembly of a filamentous fungus using Sanger, 454 and Illumina sequence data. Genome biology\| PubMed ID: 19747388	2009
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nature genetics\| PubMed ID: 20081860	2010
SNVMix: predicting single nucleotide variants from next-generation sequencing of tumors. Bioinformatics (Oxford, England)\| PubMed ID: 20130035	2010
Digital gene expression by tag sequencing on the illumina genome analyzer. Current protocols in human genetics\| PubMed ID: 20373513	2010
Whole-genome profiling of mutagenesis in Caenorhabditis elegans. Genetics\| PubMed ID: 20439774	2010
Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver. Genome research\| PubMed ID: 20551221	2010
System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20651058	2010
ARID1A mutations in endometriosis-associated ovarian carcinomas. The New England journal of medicine\| PubMed ID: 20942669	2010
Genome and transcriptome analyses of the mountain pine beetle-fungal symbiont Grosmannia clavigera, a lodgepole pine pathogen. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21262841	2011
Next generation sequencing based approaches to epigenomics. Briefings in functional genomics\| PubMed ID: 21266347	2010
DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs. Cell stem cell\| PubMed ID: 21624812	2011
deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data. PLoS computational biology\| PubMed ID: 21625565	2011
Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. Cancer cell\| PubMed ID: 21741595	2011
Using next-generation sequencing for the diagnosis of rare disorders: a family with retinitis pigmentosa and skeletal abnormalities. The Journal of pathology\| PubMed ID: 21792934	2011
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature\| PubMed ID: 21796119	2011
Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms. PLoS genetics\| PubMed ID: 21980304	2011
Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. The Journal of pathology\| PubMed ID: 22072542	2012
Feature-based classifiers for somatic mutation detection in tumour-normal paired sequencing data. Bioinformatics (Oxford, England)\| PubMed ID: 22084253	2012
Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target. Molecular cancer therapeutics\| PubMed ID: 22252602	2012
JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data. Bioinformatics (Oxford, England)\| PubMed ID: 22285562	2012
Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer. The Journal of pathology\| PubMed ID: 22294438	2012
The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature\| PubMed ID: 22495314	2012
Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer. Genome research\| PubMed ID: 22637570	2012
Use of mutation profiles to refine the classification of endometrial carcinomas. The Journal of pathology\| PubMed ID: 22653804	2012
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer cell\| PubMed ID: 22897847	2012
Mutation discovery in regions of segmental cancer genome amplifications with CoNAn-SNV: a mixture model for next generation sequencing of tumors. PloS one\| PubMed ID: 22916110	2012
Spark: a navigational paradigm for genomic data exploration. Genome research\| PubMed ID: 22960372	2012
DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution. Nature methods\| PubMed ID: 23042453	2012
The genetic landscape of high-risk neuroblastoma. Nature genetics\| PubMed ID: 23334666	2013
Epigenomics: sequencing the methylome. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23412782	2013
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nature genetics\| PubMed ID: 23708189	2013
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome research\| PubMed ID: 23804400	2013
Estimating absolute methylation levels at single CpG resolution from methylation enrichment and restriction enzyme sequencing methods. Genome research\| PubMed ID: 23804401	2013
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature\| PubMed ID: 23812591	2013
Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice. Blood\| PubMed ID: 24030380	2013
A clinically validated diagnostic second-generation sequencing assay for detection of hereditary BRCA1 and BRCA2 mutations. The Journal of molecular diagnostics : JMD\| PubMed ID: 24094589	2013
Complete Bordetella avium, Bordetella hinzii and Bordetella trematum lipid A structures and genomic sequence analyses of the loci involved in their modifications. Innate immunity\| PubMed ID: 24127384	2014
Regulatory variation: an emerging vantage point for cancer biology. Wiley interdisciplinary reviews. Systems biology and medicine\| PubMed ID: 24254976	2014
Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells. Cell stem cell\| PubMed ID: 24440600	2014
Draft Genome Sequences of Six Rhodobacter capsulatus Strains, YW1, YW2, B6, Y262, R121, and DE442. Genome announcements\| PubMed ID: 24526637	2014
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis. Blood\| PubMed ID: 24802772	2014
Regulatory network decoded from epigenomes of surface ectoderm-derived cell types. Nature communications\| PubMed ID: 25421844	2014
Loss of the Notch effector RBPJ promotes tumorigenesis. The Journal of experimental medicine\| PubMed ID: 25512468	2015
DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts. Nature communications\| PubMed ID: 25532760	2014
Epigenetic and transcriptional determinants of the human breast. Nature communications\| PubMed ID: 25690954	2015
Intermediate DNA methylation is a conserved signature of genome regulation. Nature communications\| PubMed ID: 25691127	2015
Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden. The Journal of pathology\| PubMed ID: 25692284	2015
Integrative analysis of 111 reference human epigenomes. Nature\| PubMed ID: 25693563	2015
Epigenome data release: a participant-centered approach to privacy protection. Genome biology\| PubMed ID: 26185018	2015
MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation. Nature communications\| PubMed ID: 26245647	2015
Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells. Nature\| PubMed ID: 26633636	2015
The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy. BMC cancer\| PubMed ID: 26680454	2015
Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways. Cancer cell\| PubMed ID: 26977886	2016
Putative BRAF activating fusion in a medullary thyroid cancer. Cold Spring Harbor molecular case studies\| PubMed ID: 27148585	2016
Robust high-performance nanoliter-volume single-cell multiple displacement amplification on planar substrates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27412862	2016
Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks. Cell reports\| PubMed ID: 27851968	2016
Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility. Cell reports\| PubMed ID: 27851972	2016
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell\| PubMed ID: 27863232	2016
SnapShot: Epigenomic Assays. Cell\| PubMed ID: 27863253	2016
Atrophin controls developmental signaling pathways via interactions with Trithorax-like. eLife\| PubMed ID: 28327288	2017
Draft Genome Sequence of the Pelagic Photoferrotroph Chlorobium phaeoferrooxidans. Genome announcements\| PubMed ID: 28360175	2017
Automated high throughput nucleic acid purification from formalin-fixed paraffin-embedded tissue samples for next generation sequence analysis. PloS one\| PubMed ID: 28570594	2017
Whole-genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia. Experimental hematology\| PubMed ID: 28602946	2017
Increasing quality, throughput and speed of sample preparation for strand-specific messenger RNA sequencing. BMC genomics\| PubMed ID: 28679365	2017
Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b. Epigenetics & chromatin\| PubMed ID: 28706564	2017
Characterization of the human thyroid epigenome. The Journal of endocrinology\| PubMed ID: 28808080	2017
The [PSI +] yeast prion does not wildly affect proteome composition whereas selective pressure exerted on [PSI +] cells can promote aneuploidy. Scientific reports\| PubMed ID: 28814753	2017
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy. Nature\| PubMed ID: 28854171	2017