Ulrik Gether

Molecular Neuropharmacology and Genetics Laboratory, University of Copenhagen

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 20	2017

Other Publications

Article	Year
Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor. Methods in enzymology\| PubMed ID: 11665566	2002
Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11818545	2002
The role of zinc ions in reverse transport mediated by monoamine transporters. The Journal of biological chemistry\| PubMed ID: 11940571	2002
Zn(2+) site engineering at the oligomeric interface of the dopamine transporter. FEBS letters\| PubMed ID: 12135746	2002
Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes. The Journal of physiology\| PubMed ID: 12154181	2002
Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1. The Journal of physiology\| PubMed ID: 12381817	2002
N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization. The Journal of biological chemistry\| PubMed ID: 12464618	2003
Structural basis for activation of G-protein-coupled receptors. Pharmacology & toxicology\| PubMed ID: 12688373	2002
Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1. The Journal of biological chemistry\| PubMed ID: 12764157	2003
Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter. The Journal of biological chemistry\| PubMed ID: 12773538	2003
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding. The Journal of biological chemistry\| PubMed ID: 14597628	2004
Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy. European journal of pharmacology\| PubMed ID: 14612134	2003
Probing dopamine transporter structure and function by Zn2+-site engineering. European journal of pharmacology\| PubMed ID: 14612149	2003
Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15295038	2004
Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter. The Journal of biological chemistry\| PubMed ID: 15358780	2004
Purification and fluorescent labeling of the human serotonin transporter. Biochemistry\| PubMed ID: 15736959	2005
Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2. Journal of cell science\| PubMed ID: 15769853	2005
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1. The Journal of biological chemistry\| PubMed ID: 15774468	2005
Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2. The Journal of biological chemistry\| PubMed ID: 16107343	2005
Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8. Neuropharmacology\| PubMed ID: 16129457	2005
Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter. Journal of medicinal chemistry\| PubMed ID: 16302792	2005
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16477036	2006
Regulation of dopamine transporter trafficking by intracellular amphetamine. Molecular pharmacology\| PubMed ID: 16684900	2006
Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization. The Journal of biological chemistry\| PubMed ID: 16740633	2006
Neurotransmitter transporters: molecular function of important drug targets. Trends in pharmacological sciences\| PubMed ID: 16762425	2006
Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron\| PubMed ID: 16908408	2006
Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites. European journal of pharmacology\| PubMed ID: 17499240	2007
Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching. Biochemistry\| PubMed ID: 17711354	2007
Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors. Molecular pharmacology\| PubMed ID: 17978168	2008
Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1. The European journal of neuroscience\| PubMed ID: 18184314	2008
Glycine transporter dimers: evidence for occurrence in the plasma membrane. The Journal of biological chemistry\| PubMed ID: 18252709	2008
An intracellular interaction network regulates conformational transitions in the dopamine transporter. The Journal of biological chemistry\| PubMed ID: 18426798	2008
Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling. Neuropharmacology\| PubMed ID: 18455202	2008
Membrane localization is critical for activation of the PICK1 BAR domain. Traffic (Copenhagen, Denmark)\| PubMed ID: 18466293	2008
The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature neuroscience\| PubMed ID: 18568020	2008
Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Molecular pharmacology\| PubMed ID: 18617632	2008
Correlation between genetic and geographic structure in Europe. Current biology : CB\| PubMed ID: 18691889	2008
An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population. European journal of human genetics : EJHG\| PubMed ID: 19156175	2009
Do stressful life events predict medical treatment outcome in first episode of depression? Social psychiatry and psychiatric epidemiology\| PubMed ID: 19209372	2009
Validity of the diagnosis of a single depressive episode in a case register. Clinical practice and epidemiology in mental health : CP & EMH\| PubMed ID: 19216741	2009
Interaction between genetic polymorphisms and stressful life events in first episode depression. Journal of affective disorders\| PubMed ID: 19339052	2009
Elucidating conformational changes in the gamma-aminobutyric acid transporter-1. The Journal of biological chemistry\| PubMed ID: 19363027	2009
Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19474307	2009
A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation. Neuropharmacology\| PubMed ID: 19500602	2009
Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression an... Trials\| PubMed ID: 19671139	2009
Does bereavement-related first episode depression differ from other kinds of first depressions? Social psychiatry and psychiatric epidemiology\| PubMed ID: 19693418	2010
How curved membranes recruit amphipathic helices and protein anchoring motifs. Nature chemical biology\| PubMed ID: 19749743	2009
PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system. The Journal of comparative neurology\| PubMed ID: 19757495	2009
Amphipathic motifs in BAR domains are essential for membrane curvature sensing. The EMBO journal\| PubMed ID: 19816406	2009
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20018661	2010
No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology\| PubMed ID: 20022223	2010
Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges. Journal of neurochemistry\| PubMed ID: 20085610	2010
The N terminus of monoamine transporters is a lever required for the action of amphetamines. The Journal of biological chemistry\| PubMed ID: 20118234	2010
Gender differences among patients with a single depressive episode. Psychopathology\| PubMed ID: 20197709	2010
The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression. Psychopathology\| PubMed ID: 20375542	2010
David versus Goliath. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 20417315	2010
Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. The Journal of biological chemistry\| PubMed ID: 20551317	2010
Clinical utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) among patients with first episode depression. Journal of affective disorders\| PubMed ID: 20579743	2010
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1. Organic & biomolecular chemistry\| PubMed ID: 20668766	2010
The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology\| PubMed ID: 20816875	2011
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nature methods\| PubMed ID: 21037590	2010
Tandem facial amphiphiles for membrane protein stabilization. Journal of the American Chemical Society\| PubMed ID: 21049926	2010
Copy number variations in affective disorders and meta-analysis. Psychiatric genetics\| PubMed ID: 21451435	2011
A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain. Combinatorial chemistry & high throughput screening\| PubMed ID: 21534917	2011
Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial. PloS one\| PubMed ID: 21738622	2011
SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacological reviews\| PubMed ID: 21752877	2011
Differences between early and late onset adult depression. Clinical practice and epidemiology in mental health : CP & EMH\| PubMed ID: 21866230	2011
Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes. The Journal of biological chemistry\| PubMed ID: 21969376	2011
Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding. Biochemistry\| PubMed ID: 22129425	2012
Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway. The Journal of biological chemistry\| PubMed ID: 22303009	2012
Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial. PloS one\| PubMed ID: 22393376	2012
The solute carrier 6 family of transporters. British journal of pharmacology\| PubMed ID: 22519513	2012
The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial. Psychiatry research\| PubMed ID: 22703642	2012
A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 22730191	2012
A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT. Molecular membrane biology\| PubMed ID: 22908980	2012
Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. The Journal of biological chemistry\| PubMed ID: 23007398	2012
Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study. Chemical communications (Cambridge, England)\| PubMed ID: 23165475	2013
A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Nature communications\| PubMed ID: 23481388	2013
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. PLoS biology\| PubMed ID: 23630454	2013
Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort. PloS one\| PubMed ID: 23823136	2013
Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. The Journal of biological chemistry\| PubMed ID: 23884410	2013
AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23940334	2013
A randomized trial of the effect of escitalopram versus placebo on cognitive function in healthy first-degree relatives of patients with depression. Therapeutic advances in psychopharmacology\| PubMed ID: 23983938	2011
Novel tripod amphiphiles for membrane protein analysis. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 24123610	2013
Serotonin-induced down-regulation of cell surface serotonin transporter. Neurochemistry international\| PubMed ID: 24462583	2014
Reply to Wilkinson et al.: Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24596955	2014
In vivo amphetamine action is contingent on αCaMKII. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 24871545	2014
Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. The Journal of clinical investigation\| PubMed ID: 24911152	2014
Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. ACS medicinal chemistry letters\| PubMed ID: 24944746	2014
The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation. The Journal of biological chemistry\| PubMed ID: 24973209	2014
Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands. The Journal of biological chemistry\| PubMed ID: 25023278	2014
The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. The Journal of biological chemistry\| PubMed ID: 25063810	2014
The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25100601	2014
Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation. The Biochemical journal\| PubMed ID: 25761794	2015
Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors. EBioMedicine\| PubMed ID: 25774383	2015
Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. The Journal of biological chemistry\| PubMed ID: 25869126	2015
Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26019340	2015
Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering. Structure (London, England : 1993)\| PubMed ID: 26073603	2015
A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. The European journal of neuroscience\| PubMed ID: 26286107	2015
[Optogenetics brings hidden neural mechanisms into the light and could become a future therapy]. Ugeskrift for laeger\| PubMed ID: 26320592	2015
Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter. The Journal of biological chemistry\| PubMed ID: 26363074	2015
No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial. Acta neuropsychiatrica\| PubMed ID: 26573431	2016
Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter. British journal of pharmacology\| PubMed ID: 26699847	2016
Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from... Nordic journal of psychiatry\| PubMed ID: 26752119	2016
Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini. The Journal of biological chemistry\| PubMed ID: 26786096	2016
Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression. Acta neuropsychiatrica\| PubMed ID: 26952950	2012
A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function. Neurochemistry international\| PubMed ID: 27020406	2016
Structural biology: Antidepressants at work. Nature\| PubMed ID: 27049942	2016
Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice. The European journal of neuroscience\| PubMed ID: 27453291	2017
Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290. The Journal of biological chemistry\| PubMed ID: 27474737	2016
Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter. Nature communications\| PubMed ID: 27678200	2016
The Environment Shapes the Inner Vestibule of LeuT. PLoS computational biology\| PubMed ID: 27835643	2016
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR. eLife\| PubMed ID: 28117663	2017
The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway. The Journal of biological chemistry\| PubMed ID: 28280242	2017
Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer. Scientific reports\| PubMed ID: 28417952	2017
Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research. Basic & clinical pharmacology & toxicology\| PubMed ID: 28609587	2017
Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm. Journal of neuroscience methods\| PubMed ID: 28711378	2017