Grant A. Ramm

Hepatic Fibrosis Group, QIMR Berghofer Medical Research Institute

Affiliated withQIMR Berghofer Medical Research Institute The University of Queensland

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 14	2017
Publication title Cited by 16	2020

Other Publications

Article	Year
The role of hepatic stellate cells and transforming growth factor-beta(1) in cystic fibrosis liver disease. The American journal of pathology\| PubMed ID: 12000722	2002
Aldehydic products of lipid peroxidation do not directly activate rat hepatic stellate cells. Journal of gastroenterology and hepatology\| PubMed ID: 12121509	2002
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet (London, England)\| PubMed ID: 12606179	2003
Evidence for a sub-morphological inflammatory process in the liver in haemochromatosis. Journal of hepatology\| PubMed ID: 12663233	2003
Identification and characterization of the hepatic stellate cell transferrin receptor. The American journal of pathology\| PubMed ID: 12707050	2003
Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation. Digestive diseases and sciences\| PubMed ID: 12741473	2003
Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR. Journal of lipid research\| PubMed ID: 14729857	2004
Signals for Hepatic Figrogenesis in Pediatric Cholestatic Liver Disease: Review and Hypothesis. Comparative hepatology\| PubMed ID: 14960157	2004
Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosis. Hepatology (Baltimore, Md.)\| PubMed ID: 15185309	2004
Serum markers of hepatic fibrogenesis in cystic fibrosis liver disease. Journal of hepatology\| PubMed ID: 15464237	2004
Hemojuvelin (HJV)-associated hemochromatosis: analysis of HJV and HFE mutations and iron overload in three families. Haematologica\| PubMed ID: 15710580	2005
Is HFE involved in increased hepcidin expression and hypoferremia in inflammation and anemia of chronic disease? Hepatology (Baltimore, Md.)\| PubMed ID: 15791616	2005
Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity. Surgery\| PubMed ID: 16153442	2005
Lymphotoxin-beta production following bile duct ligation: possible role for Kupffer cells. Journal of gastroenterology and hepatology\| PubMed ID: 16246198	2005
Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis. Seminars in liver disease\| PubMed ID: 16315137	2005
Outcome after portoenterostomy in biliary atresia: pivotal role of degree of liver fibrosis and intensity of stellate cell activation. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 16385261	2006
Screening for hemochromatosis in asymptomatic subjects with or without a family history. Archives of internal medicine\| PubMed ID: 16476869	2006
A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis. International journal for parasitology\| PubMed ID: 16806222	2006
A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. The American journal of pathology\| PubMed ID: 16936262	2006
The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 16979952	2006
Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice. Journal of hepatology\| PubMed ID: 17112626	2007
A novel mutation in ferroportin implicated in iron overload. Journal of hepatology\| PubMed ID: 17383046	2007
Role of iron in hepatic fibrosis: one piece in the puzzle. World journal of gastroenterology\| PubMed ID: 17729396	2007
Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 17845534	2007
The function of serotonin within the liver. Journal of hepatology\| PubMed ID: 18280000	2008
Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis. Blood\| PubMed ID: 18316631	2008
Hepatic macrophages promote the neutrophil-dependent resolution of fibrosis in repairing cholestatic rat livers. Surgery\| PubMed ID: 18436015	2008
Hereditary hemochromatosis in the post-HFE era. Hepatology (Baltimore, Md.)\| PubMed ID: 18752323	2008
Assessment of hepatic steatosis: comparison of quantitative and semiquantitative methods in 108 liver biopsies. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 19018987	2009
How much iron is too much? Expert review of gastroenterology & hepatology\| PubMed ID: 19072377	2008
Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury. Hepatology (Baltimore, Md.)\| PubMed ID: 19111021	2009
Fibrogenesis in pediatric cholestatic liver disease: role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment. Hepatology (Baltimore, Md.)\| PubMed ID: 19115220	2009
Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis. Hepatology (Baltimore, Md.)\| PubMed ID: 19177571	2009
Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells. Hepatology (Baltimore, Md.)\| PubMed ID: 19241483	2009
Identification of ferritin receptors: their role in iron homeostasis, hepatic injury, and inflammation. Gastroenterology\| PubMed ID: 19789086	2009
Chemokine (C-C motif) receptors in fibrogenesis and hepatic regeneration following acute and chronic liver disease. Hepatology (Baltimore, Md.)\| PubMed ID: 19877298	2009
Neutrophil depletion blocks early collagen degradation in repairing cholestatic rat livers. The American journal of pathology\| PubMed ID: 20110408	2010
Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasis. PLoS neglected tropical diseases\| PubMed ID: 20161726	2010
Co-ordinated gene expression in the liver and spleen during Schistosoma japonicum infection regulates cell migration. PLoS neglected tropical diseases\| PubMed ID: 20502518	2010
Iron homeostasis, hepatocellular injury, and fibrogenesis in hemochromatosis: the role of inflammation in a noninflammatory liver disease. Seminars in liver disease\| PubMed ID: 20665379	2010
Importance of hepatic fibrosis in cystic fibrosis and the predictive value of liver biopsy. Hepatology (Baltimore, Md.)\| PubMed ID: 21254170	2011
High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8(+) T cell-mediated immune pathology. Infection and immunity\| PubMed ID: 21343349	2011
Cystic fibrosis-cirrhosis, portal hypertension, and liver biopsy: Reply. Hepatology (Baltimore, Md.)\| PubMed ID: 21374683	2011
Paediatric cholestatic liver disease: Diagnosis, assessment of disease progression and mechanisms of fibrogenesis. World journal of gastrointestinal pathophysiology\| PubMed ID: 21607144	2010
Differential expression of chemokine and matrix re-modelling genes is associated with contrasting schistosome-induced hepatopathology in murine models. PLoS neglected tropical diseases\| PubMed ID: 21666794	2011
Anti-chemokine therapy for the treatment of hepatic fibrosis: an attractive approach. Hepatology (Baltimore, Md.)\| PubMed ID: 21710472	2011
Possible role of WT1 in a human fetus with evolving bronchial atresia, pulmonary malformation and renal agenesis. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society\| PubMed ID: 21985433	2012
Transcriptional basis for hepatic fibrosis in cystic fibrosis-associated liver disease. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 22157922	2012
Abnormal WT1 expression in human fetuses with bilateral renal agenesis and cardiac malformations. Birth defects research. Part A, Clinical and molecular teratology\| PubMed ID: 22246978	2012
Clinical cofactors and hepatic fibrosis in hereditary hemochromatosis: the role of diabetes mellitus. Hepatology (Baltimore, Md.)\| PubMed ID: 22422567	2012
A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma. Biomaterials\| PubMed ID: 22681975	2012
Hepatic iron deposition does not predict extrahepatic iron loading in mouse models of hereditary hemochromatosis. The American journal of pathology\| PubMed ID: 22858058	2012
Role of resident liver cells in the pathogenesis of schistosomiasis. Trends in parasitology\| PubMed ID: 23099112	2012
Spatial and temporal transcriptomics of Schistosoma japonicum-induced hepatic granuloma formation reveals novel roles for neutrophils. Journal of leukocyte biology\| PubMed ID: 23709687	2013
Schistosomajaponicum Eggs Induce a Proinflammatory, Anti-Fibrogenic Phenotype in Hepatic Stellate Cells. PloS one\| PubMed ID: 23840855	2013
Iron and hepatic carcinogenesis. Critical reviews in oncogenesis\| PubMed ID: 23879586	2013
Ductular reaction in hereditary hemochromatosis: the link between hepatocyte senescence and fibrosis progression. Hepatology (Baltimore, Md.)\| PubMed ID: 24037895	2014
Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses. Hepatology (Baltimore, Md.)\| PubMed ID: 24038142	2014
Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis. World journal of gastroenterology\| PubMed ID: 24409064	2013
TWEAK and LTβ Signaling during Chronic Liver Disease. Frontiers in immunology\| PubMed ID: 24592262	2014
Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society\| PubMed ID: 25241637	2014
Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology (Baltimore, Md.)\| PubMed ID: 25605615	2015
Circulating microRNAs as noninvasive diagnostic biomarkers of liver disease in children with cystic fibrosis. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 25625579	2015
Reduced mortality due to phlebotomy in moderately iron-loaded HFE haemochromatosis? The need for clinical trials. Journal of hepatology\| PubMed ID: 25839407	2015
Reply: To PMID 25605615. Hepatology (Baltimore, Md.)\| PubMed ID: 25914125	2015
Type 2 diabetes mellitus: limitations of conventional therapies and intervention with nucleic acid-based therapeutics. Chemical reviews\| PubMed ID: 25918949	2015
An ex vivo model for studying hepatic schistosomiasis and the effect of released protein from dying eggs. PLoS neglected tropical diseases\| PubMed ID: 25965781	2015
Case Report: Fetal Bilateral Diaphragmatic Agenesis, Ectopic Liver and Abnormal Pancreas. Fetal and pediatric pathology\| PubMed ID: 26030091	2015
Transcriptional profiling of chronic clinical hepatic schistosomiasis japonica indicates reduced metabolism and immune responses. Parasitology\| PubMed ID: 26216487	2015
Aspartate aminotransferase to platelet ratio and fibrosis-4 as biomarkers in biopsy-validated pediatric cystic fibrosis liver disease. Hepatology (Baltimore, Md.)\| PubMed ID: 26223427	2015
The development of hepatic stellate cells in normal and abnormal human fetuses - an immunohistochemical study. Physiological reports\| PubMed ID: 26265759	2015
Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron). BMJ open\| PubMed ID: 26270952	2015
Reply. Hepatology (Baltimore, Md.)\| PubMed ID: 26417986	2016
The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 26608186	2016
Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica. International journal for parasitology\| PubMed ID: 26812024	2016
Reply. Hepatology (Baltimore, Md.)\| PubMed ID: 26845080	2016
Value of the 8-oxodG/dG ratio in chronic liver inflammation of patients with hepatocellular carcinoma. Redox biology\| PubMed ID: 26890046	2016
Mechanism of pancreatic and liver malformations in human fetuses with short-rib polydactyly syndrome. Birth defects research. Part A, Clinical and molecular teratology\| PubMed ID: 26970085	2016
Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury. The American journal of pathology\| PubMed ID: 27181403	2016
Transient liver elastography in unsedated control children: Impact of age and intercurrent illness. Journal of paediatrics and child health\| PubMed ID: 27203205	2016
Caveolin-1 Function in Liver Physiology and Disease. Trends in molecular medicine\| PubMed ID: 27633517	2016
Function and Regulation of MicroRNAs and Their Potential as Biomarkers in Paediatric Liver Disease. International journal of molecular sciences\| PubMed ID: 27801781	2016
Diagnosing schistosomiasis-induced liver morbidity: implications for global control. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases\| PubMed ID: 27816660	2017
GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes. Blood cells, molecules & diseases\| PubMed ID: 27936396	2017
Reply. Hepatology (Baltimore, Md.)\| PubMed ID: 28010035	2017
Serum ferritin concentration predicts hepatic fibrosis better than hepatic iron concentration in human HFE-Haemochromatosis. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 28231420	2017
Filling the Gap on Caveolin-1 in Liver Carcinogenesis. Trends in cancer\| PubMed ID: 28741517	2016
Extracellular vesicles for personalized therapy decision support in advanced metastatic cancers and its potential impact for prostate cancer. The Prostate\| PubMed ID: 28856701	2017
Taurocholate induces biliary differentiation of liver progenitor cells causing hepatic stellate cell chemotaxis in the Ductular Reaction: Role in pediatric cystic fibrosis liver disease. The American journal of pathology\| PubMed ID: 28935574	2017