John K. Olynyk

Fiona Stanley and Fremantle Hospitals

Affiliated withFiona Stanley and Fremantle Hospitals Edith Cowan University Fiona Stanley and Fremantle Hospital Group

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 14	2017
Publication title Cited by 16	2020

Other Publications

Article	Year
A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation. Gastroenterology\| PubMed ID: 11874997	2002
Liver biopsy in the 21st century: where and why? The Medical journal of Australia\| PubMed ID: 11936283	2002
Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11943867	2002
Iron and the response to treatment of hepatitis C. The American journal of gastroenterology\| PubMed ID: 12003411	2002
Flexible sigmoidoscopy screening for colorectal neoplasia in average-risk people: evaluation of a five-year rescreening interval. The Medical journal of Australia\| PubMed ID: 12041631	2002
Aldehydic products of lipid peroxidation do not directly activate rat hepatic stellate cells. Journal of gastroenterology and hepatology\| PubMed ID: 12121509	2002
Effects of body iron stores and haemochromatosis genotypes on coronary heart disease outcomes in the Busselton health study. Journal of cardiovascular risk\| PubMed ID: 12394323	2002
Oval cell-mediated liver regeneration: Role of cytokines and growth factors. Journal of gastroenterology and hepatology\| PubMed ID: 12519217	2003
Iron overload in blacks: ironing out the issues. The American journal of gastroenterology\| PubMed ID: 12873563	2003
Cost-effectiveness of colorectal cancer screening: comparison of community-based flexible sigmoidoscopy with fecal occult blood testing and colonoscopy. Journal of gastroenterology and hepatology\| PubMed ID: 14675241	2004
Differential effects of gadolinium chloride on Kupffer cells in vivo and in vitro. The international journal of biochemistry & cell biology\| PubMed ID: 14687926	2004
Screening for hemochromatosis: patients with liver disease, families, and populations. Current gastroenterology reports\| PubMed ID: 14720453	2004
Evolution of untreated hereditary hemochromatosis in the Busselton population: a 17-year study. Mayo Clinic proceedings\| PubMed ID: 15008603	2004
Screening sigmoidoscopy for colorectal cancer: further pieces in the jigsaw. The Medical journal of Australia\| PubMed ID: 15139823	2004
Kupffer cell cytokines interleukin-1beta and interleukin-10 combine to inhibit phosphoenolpyruvate carboxykinase and gluconeogenesis in cultured hepatocytes. The international journal of biochemistry & cell biology\| PubMed ID: 15147725	2004
Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis. Blood\| PubMed ID: 15155457	2004
Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology (Baltimore, Md.)\| PubMed ID: 15185318	2004
Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood\| PubMed ID: 15256427	2005
CD14-positive hepatic monocytes/macrophages increase in hereditary hemochromatosis. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 15482341	2004
Duration of hepatic iron exposure increases the risk of significant fibrosis in hereditary hemochromatosis: a new role for magnetic resonance imaging. The American journal of gastroenterology\| PubMed ID: 15784029	2005
Is HFE involved in increased hepcidin expression and hypoferremia in inflammation and anemia of chronic disease? Hepatology (Baltimore, Md.)\| PubMed ID: 15791616	2005
Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture. Experimental cell research\| PubMed ID: 15878349	2005
Iron overload. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 15885682	2005
Hepatic expression of the tumor necrosis factor family member lymphotoxin-beta is regulated by interleukin (IL)-6 and IL-1beta: transcriptional control mechanisms in oval cells and hepatoma ... Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 15910501	2005
Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta. Carcinogenesis\| PubMed ID: 15917308	2005
Hereditary haemochromatosis: to screen or not to screen? Journal of hepatology\| PubMed ID: 15923055	2005
Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury. Immunology and cell biology\| PubMed ID: 16033531	2005
Effects of HFE gene mutations and alcohol on iron status, liver biochemistry and morbidity. Journal of gastroenterology and hepatology\| PubMed ID: 16105133	2005
Jekyll and Hyde: evolving perspectives on the function and potential of the adult liver progenitor (oval) cell. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 16237666	2005
Lymphotoxin-beta production following bile duct ligation: possible role for Kupffer cells. Journal of gastroenterology and hepatology\| PubMed ID: 16246198	2005
Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse. Journal of hepatology\| PubMed ID: 16271796	2006
Screening for HFE and iron overload. Seminars in liver disease\| PubMed ID: 16315134	2005
Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor. Carcinogenesis\| PubMed ID: 16497703	2006
Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo. Hepatology (Baltimore, Md.)\| PubMed ID: 16628647	2006
Population-based study of the relationship between mutations in the hemochromatosis (HFE) gene and arthritis. Journal of gastroenterology and hepatology\| PubMed ID: 16638105	2006
Differential findings for CD14-positive hepatic monocytes/macrophages in primary biliary cirrhosis, chronic hepatitis C and nonalcoholic steatohepatitis. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 16762000	2006
Normal iron metabolism and the pathophysiology of iron overload disorders. The Clinical biochemist. Reviews\| PubMed ID: 16886043	2006
Evaluation of the "Cellscreen" system for proliferation studies on liver progenitor cells. European journal of cell biology\| PubMed ID: 17049406	2006
Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice. Journal of hepatology\| PubMed ID: 17112626	2007
Waiting times for colonoscopy and colorectal cancer diagnosis. The Medical journal of Australia\| PubMed ID: 17371207	2007
Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet. The international journal of biochemistry & cell biology\| PubMed ID: 17693121	2007
Liver iron transport. World journal of gastroenterology\| PubMed ID: 17729394	2007
Outcomes after 10 years of a community-based flexible sigmoidoscopy screening program for colorectal carcinoma. The Medical journal of Australia\| PubMed ID: 17767431	2007
Clinical expression of hemochromatosis gene (HFE) variants. Hepatology (Baltimore, Md.)\| PubMed ID: 17894321	2007
Interferon-gamma exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury. Journal of hepatology\| PubMed ID: 17923165	2007
The regulation of cellular iron metabolism. Critical reviews in clinical laboratory sciences\| PubMed ID: 17943492	2007
Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron. Journal of hepatology\| PubMed ID: 18083267	2008
HCV, iron, and oxidative stress: the new choreography of hepcidin. Gastroenterology\| PubMed ID: 18166363	2008
Iron-overload-related disease in HFE hereditary hemochromatosis. The New England journal of medicine\| PubMed ID: 18199861	2008
The role of Hfe in transferrin-bound iron uptake by hepatocytes. Hepatology (Baltimore, Md.)\| PubMed ID: 18393371	2008
Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations. Mayo Clinic proceedings\| PubMed ID: 18452683	2008
Body mass index is a stronger predictor of alanine aminotransaminase levels than alcohol consumption. Journal of gastroenterology and hepatology\| PubMed ID: 18557801	2008
Prevalence, characteristics, and prognostic significance of HFE gene mutations in type 2 diabetes: the Fremantle Diabetes Study. Diabetes care\| PubMed ID: 18566337	2008
C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice. Gastroenterology\| PubMed ID: 18602920	2008
Clinical perspectives on hereditary hemochromatosis. Critical reviews in clinical laboratory sciences\| PubMed ID: 18712630	2008
Hereditary hemochromatosis in the post-HFE era. Hepatology (Baltimore, Md.)\| PubMed ID: 18752323	2008
The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis. Gastroenterology\| PubMed ID: 18848943	2008
Predicting iron overload in hyperferritinemia. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 19095082	2009
Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury. Hepatology (Baltimore, Md.)\| PubMed ID: 19111021	2009
Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age. International journal of cancer\| PubMed ID: 19291797	2009
NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. The American journal of gastroenterology\| PubMed ID: 19293782	2009
Making sense of differing bowel cancer screening guidelines. The Medical journal of Australia\| PubMed ID: 19351305	2009
Screening for coeliac disease using anti-tissue transglutaminase antibody assays, and prevalence of the disease in an Australian community. The Medical journal of Australia\| PubMed ID: 19374615	2009
Serum alanine aminotransferase, metabolic syndrome, and cardiovascular disease in an Australian population. The American journal of gastroenterology\| PubMed ID: 19491832	2009
HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity. Hepatology (Baltimore, Md.)\| PubMed ID: 19554541	2009
A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis. British journal of haematology\| PubMed ID: 19673882	2009
The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells. American journal of physiology. Cell physiology\| PubMed ID: 19828835	2009
Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma. Stem cells and development\| PubMed ID: 19874130	2010
Mutations in the HFE gene and cardiovascular disease risk: an individual patient data meta-analysis of 53 880 subjects. Circulation. Cardiovascular genetics\| PubMed ID: 20031541	2008
HFE C282Y homozygotes are at increased risk of breast and colorectal cancer. Hepatology (Baltimore, Md.)\| PubMed ID: 20099304	2010
Relationship between brain R(2) and liver and serum iron concentrations in elderly men. Magnetic resonance in medicine\| PubMed ID: 20099321	2010
Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis. Journal of hepatology\| PubMed ID: 20133002	2010
Iron: an emerging factor in colorectal carcinogenesis. World journal of gastroenterology\| PubMed ID: 20135713	2010
PAHA model: an alternative non-invasive predictor of liver cirrhosis in patients with chronic hepatitis B infection. Journal of gastroenterology and hepatology\| PubMed ID: 20136968	2010
A cross-sectional community study of serum iron measures and cognitive status in older adults. Journal of Alzheimer's disease : JAD\| PubMed ID: 20182059	2010
Phenotypic expression of hereditary hemochromatosis: what have we learned from the population studies? Current gastroenterology reports\| PubMed ID: 20425479	2010
Pentoxifylline improves haemoglobin and interleukin-6 levels in chronic kidney disease. Nephrology (Carlton, Vic.)\| PubMed ID: 20470305	2010
Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells. Hepatology (Baltimore, Md.)\| PubMed ID: 20578156	2010
HFE Cys282Tyr homozygotes with serum ferritin concentrations below 1000 microg/L are at low risk of hemochromatosis. Hepatology (Baltimore, Md.)\| PubMed ID: 20583211	2010
Hepatic iron loading in mice increases cholesterol biosynthesis. Hepatology (Baltimore, Md.)\| PubMed ID: 20683946	2010
Serum iron markers are inadequate for guiding iron repletion in chronic kidney disease. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 20876673	2011
Diagnosis and management of iron deficiency anaemia: a clinical update. The Medical journal of Australia\| PubMed ID: 21034387	2010
Clinical penetrance of C282Y homozygous HFE hemochromatosis. Expert review of hematology\| PubMed ID: 21082925	2008
Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.)\| PubMed ID: 21374659	2011
Liver and serum iron: discrete regulators of hepatic hepcidin expression. Hepatology (Baltimore, Md.)\| PubMed ID: 21618572	2011
Natural history and management of HFE-hemochromatosis. Seminars in liver disease\| PubMed ID: 21901659	2011
Significant association between thyroid hormones and erythrocyte indices in euthyroid subjects. Clinical endocrinology\| PubMed ID: 21913954	2012
A comparison of self-reported and record-linked blood donation history in an Australian cohort. Transfusion\| PubMed ID: 21985049	2011
Screening for hereditary haemochromatosis. Pathology\| PubMed ID: 22198253	2012
Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loading. Brain research\| PubMed ID: 22370144	2012
Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice. Hepatology (Baltimore, Md.)\| PubMed ID: 22383097	2012
Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity. Journal of gastroenterology and hepatology\| PubMed ID: 22414273	2012
Changes in brain transcripts related to Alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased Alzheimer's disease risk. Journal of Alzheimer's disease : JAD\| PubMed ID: 22466002	2012
Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study. Age and ageing\| PubMed ID: 23019140	2012
Assessing iron overload: are we there yet? Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23052256	2012
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.)\| PubMed ID: 23213074	2013
Pharmacokinetics and safety of deferasirox in subjects with chronic kidney disease undergoing haemodialysis. Nephrology (Carlton, Vic.)\| PubMed ID: 23332024	2013
The Western dietary pattern is prospectively associated with nonalcoholic fatty liver disease in adolescence. The American journal of gastroenterology\| PubMed ID: 23545714	2013
Diagnostic performance of a rapid magnetic resonance imaging method of measuring hepatic steatosis. PloS one\| PubMed ID: 23555650	2013
Importance of cardiometabolic risk factors in the association between nonalcoholic fatty liver disease and arterial stiffness in adolescents. Hepatology (Baltimore, Md.)\| PubMed ID: 23703776	2013
Iron and hepatic carcinogenesis. Critical reviews in oncogenesis\| PubMed ID: 23879586	2013
Factors that affect serum levels of ferritin in Australian adults and implications for follow-up. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 23906872	2014
Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses. Hepatology (Baltimore, Md.)\| PubMed ID: 24038142	2014
Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice. PloS one\| PubMed ID: 24223168	2013
Lower fructose intake may help protect against development of nonalcoholic fatty liver in adolescents with obesity. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 24345826	2014
Texture-based classification of liver fibrosis using MRI. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 24347292	2015
TWEAK and LTβ Signaling during Chronic Liver Disease. Frontiers in immunology\| PubMed ID: 24592262	2014
Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity. Journal of gastroenterology and hepatology\| PubMed ID: 24611991	2014
Higher ferritin levels, but not serum iron or transferrin saturation, are associated with Type 2 diabetes mellitus in adult men and women free of genetic haemochromatosis. Clinical endocrinology\| PubMed ID: 24953981	2015
Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents. Journal of gastroenterology and hepatology\| PubMed ID: 24989077	2015
Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society\| PubMed ID: 25241637	2014
Natural history of HFE simple heterozygosity for C282Y and H63D: a prospective 12-year study. Journal of gastroenterology and hepatology\| PubMed ID: 25311314	2015
The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial. Hepatology (Baltimore, Md.)\| PubMed ID: 25524401	2015
Authors' response. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 25564814	2015
Reduced mortality due to phlebotomy in moderately iron-loaded HFE haemochromatosis? The need for clinical trials. Journal of hepatology\| PubMed ID: 25839407	2015
Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration. Hepatology (Baltimore, Md.)\| PubMed ID: 26173184	2015
Reply: To PMID 25524401. Hepatology (Baltimore, Md.)\| PubMed ID: 26238272	2015
Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron). BMJ open\| PubMed ID: 26270952	2015
Adverse metabolic phenotype of adolescent girls with non-alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys. Journal of gastroenterology and hepatology\| PubMed ID: 26589977	2016
The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 26608186	2016
Red blood cell transfusion is associated with further bleeding and fresh-frozen plasma with mortality in nonvariceal upper gastrointestinal bleeding. Transfusion\| PubMed ID: 26718025	2016
Characterization of hepatic and cardiac iron deposition during standard treatment of anaemia in haemodialysis. Nephrology (Carlton, Vic.)\| PubMed ID: 26824431	2017
Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et biophysica acta\| PubMed ID: 26844773	2016
Association between serum hepcidin-25 and primary resistance to erythropoiesis-stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial. Nephrology (Carlton, Vic.)\| PubMed ID: 27171136	2017
Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury. The American journal of pathology\| PubMed ID: 27181403	2016
Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib. European journal of medicinal chemistry\| PubMed ID: 27208658	2016
Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomes. The American journal of clinical nutrition\| PubMed ID: 27488234	2016
Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases. Rare diseases (Austin, Tex.)\| PubMed ID: 27500074	2016
Stereological Analysis of Liver Biopsy Histology Sections as a Reference Standard for Validating Non-Invasive Liver Fat Fraction Measurements by MRI. PloS one\| PubMed ID: 27501242	2016
Evaluation of Different Normalization and Analysis Procedures for Illumina Gene Expression Microarray Data Involving Small Changes. Microarrays (Basel, Switzerland)\| PubMed ID: 27605185	2013
Dysregulated Erythropoietin, Hepcidin, and Bone Marrow Iron Metabolism Contribute to Interferon-Induced Anemia in Hepatitis C. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 27617496	2016
Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial : A randomized trial of IV iron in critical illness. Intensive care medicine\| PubMed ID: 27686346	2016
HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women. Journal of gastroenterology and hepatology\| PubMed ID: 27784128	2017
Diagnosing and preventing iron overload. Hemodialysis international. International Symposium on Home Hemodialysis\| PubMed ID: 28328144	2017
Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescents. Journal of hepatology\| PubMed ID: 28619255	2017
Association of Transferrin Saturation With the Arthropathy of Hereditary Hemochromatosis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 28624652	2017
Gender differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents. Hepatology (Baltimore, Md.)\| PubMed ID: 28665032	2017
Taurocholate induces biliary differentiation of liver progenitor cells causing hepatic stellate cell chemotaxis in the Ductular Reaction: Role in pediatric cystic fibrosis liver disease. The American journal of pathology\| PubMed ID: 28935574	2017
Reduction of body iron in HFE-related haemochromatosis and moderate iron overload (Mi-Iron): a multicentre, participant-blinded, randomised controlled trial. The Lancet. Haematology\| PubMed ID: 29195602	2017
A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study. BMC cancer\| PubMed ID: 30176879	2018