N. Joan Abbott

Institute of Pharmaceutical Science, King's College London

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 31	2017

Other Publications

Article	Year
Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society\| PubMed ID: 11390805	1998
Drug resistance in epilepsy: the role of the blood-brain barrier. Novartis Foundation symposium\| PubMed ID: 11990780	2002
Ionic currents in isolated and in situ squid Schwann cells. The Journal of physiology\| PubMed ID: 12068039	2002
Astrocyte-endothelial interactions and blood-brain barrier permeability. Journal of anatomy\| PubMed ID: 12162730	2002
Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrier. Journal of drug targeting\| PubMed ID: 12164376	2002
Bradykinin increases permeability by calcium and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood-brain barrier. Brain research\| PubMed ID: 12384249	2002
Interaction between flavonoids and the blood-brain barrier: in vitro studies. Journal of neurochemistry\| PubMed ID: 12641740	2003
Vascular and parenchymal mechanisms in multiple drug resistance: a lesson from human epilepsy. Current drug targets\| PubMed ID: 12699350	2003
Lipids in blood-brain barrier models in vitro I: Thin-layer chromatography and high-performance liquid chromatography for the analysis of lipid classes and long-chain polyunsaturated fatty a... In vitro cellular & developmental biology. Animal\| PubMed ID: 12762837	2002
Lipids in blood-brain barrier models in vitro II: Influence of glial cells on lipid classes and lipid fatty acids. In vitro cellular & developmental biology. Animal\| PubMed ID: 12762838	2002
Functional characterisation of nucleoside transport in rat brain endothelial cells. Neuroreport\| PubMed ID: 12802208	2003
An overview of in vitro techniques for blood-brain barrier studies. Methods in molecular medicine\| PubMed ID: 12958429	2003
In vitro trans-monolayer permeability calculations: often forgotten assumptions. Drug discovery today\| PubMed ID: 14643163	2003
Flavonoid permeability across an in situ model of the blood-brain barrier. Free radical biology & medicine\| PubMed ID: 14980703	2004
Cross reactivity of polyclonal GFAP antiserum: implications for the in-vitro characterisation of brain endothelium. Brain research\| PubMed ID: 15158176	2004
Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochemistry international\| PubMed ID: 15186921	2004
Brain to blood efflux transport of adenosine: blood-brain barrier studies in the rat. Journal of neurochemistry\| PubMed ID: 15228584	2004
Blood-brain barrier opened by stimulation of the parasympathetic sphenopalatine ganglion: a new method for macromolecule delivery to the brain. Journal of neurosurgery\| PubMed ID: 15309923	2004
Interaction of nucleoside analogues with nucleoside transporters in rat brain endothelial cells. Journal of drug targeting\| PubMed ID: 15512777	2004
Induction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture. Journal of neurochemistry\| PubMed ID: 15857386	2005
Dynamics of CNS barriers: evolution, differentiation, and modulation. Cellular and molecular neurobiology\| PubMed ID: 15962506	2005
Astrocyte-endothelial interactions at the blood-brain barrier. Nature reviews. Neuroscience\| PubMed ID: 16371949	2006
P-Glycoprotein expression in human retinal pigment epithelium cell lines. Experimental eye research\| PubMed ID: 16530756	2006
Strategies to advance translational research into brain barriers. The Lancet. Neurology\| PubMed ID: 18093565	2008
All vertebrates started out with a glial blood-brain barrier 4-500 million years ago. Glia\| PubMed ID: 18338790	2008
Structure and function of the blood-brain barrier. Neurobiology of disease\| PubMed ID: 19664713	2010
An improved in vitro blood-brain barrier model: rat brain endothelial cells co-cultured with astrocytes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22144323	2012
Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance. Brain research\| PubMed ID: 22789905	2013
Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier. International journal of pharmaceutics\| PubMed ID: 23089576	2013
Overview and introduction: the blood-brain barrier in health and disease. Epilepsia\| PubMed ID: 23134489	2012
A detailed method for preparation of a functional and flexible blood-brain barrier model using porcine brain endothelial cells. Brain research\| PubMed ID: 23603406	2013
Blood-brain barrier structure and function and the challenges for CNS drug delivery. Journal of inherited metabolic disease\| PubMed ID: 23609350	2013
A multi-system approach assessing the interaction of anticonvulsants with P-gp. PloS one\| PubMed ID: 23741405	2013
A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1. PloS one\| PubMed ID: 24204733	2013
Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models. Drug discovery today. Technologies\| PubMed ID: 24981621	2004
In vitro porcine blood-brain barrier model for permeability studies: pCEL-X software pKa(FLUX) method for aqueous boundary layer correction and detailed data analysis. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 25239510	2014
Primary porcine brain microvessel endothelial cell isolation and culture. Current protocols in neuroscience\| PubMed ID: 25297692	2014
Characterization of a novel brain barrier ex vivo insect-based P-glycoprotein screening model. Pharmacology research & perspectives\| PubMed ID: 25505597	2014
The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo. Biomaterials\| PubMed ID: 25890741	2015
LRP-1-mediated intracellular antibody delivery to the Central Nervous System. Scientific reports\| PubMed ID: 26189707	2015
Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood-brain barrier in vitro and in vivo. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26809004	2016
In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26868179	2016
Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 28337939	2017
Impact of capillary flow hydrodynamics on carrier-mediated transport of opioid derivatives at the blood-brain barrier, based on pH-dependent Michaelis-Menten and Crone-Renkin analyses. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 28614733	2017
Uptake and metabolism of sulphated steroids by the blood-brain barrier in the adult male rat. Journal of neurochemistry\| PubMed ID: 28665486	2017
The blood-brain barrier in psychosis. The lancet. Psychiatry\| PubMed ID: 28781208	2017